Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice

Clinical Cancer Research

Volumn 6, Issue 5, 2000, Pages 2021-2027

  Whitacre, Cecilia M ^a,b   Feyes, Denise K ^a   Satoh, Taroh ^a   Grossmann, Johannes ^a,c   Mulvihill, John W ^a   Mukhtar, Hasan ^a   Oleinick, Nancy L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Alzheimer Research Laboratory   (United States)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHTHALOCYANINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; COLON CANCER; CONTROLLED STUDY; DIODE LASER; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; OXIDATIVE STRESS; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; TUMOR REGRESSION; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; CELL DIVISION; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FEMALE; HUMANS; INDOLES; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM TRANSPLANTATION; ORGANOSILICON COMPOUNDS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; SILANES; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0034026145     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Dougherty, T. J., Gomer C. J., Henderson, B. W., Jori, G., Kessel, D., Korbelik, M., Moan, J., and Peng, Q. Photodynamic therapy (Review). J. Natl. Cancer Inst., 90: 889-905, 1998.
2. Agarwal, R., Athar, M., Urban, S. A., Bickers, D. R., and Mukhtar, H. Involvement of singlet oxygen in chloroaluminum phthalocyanine tetrasulfonate-mediated photoenhancement of lipid peroxidation in rat epidermal microsomes. Cancer Lett., 56: 125-129, 1991.
3. Weishaupt, K. R., Gomer, C. J., and Dougherty, T. J. Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor. Cancer Res., 36: 2316-2329, 1976.
4. Gomer, C. J. Preclinical examination of first and second-generation photosensitizers used in photodynamic therapy. Photochem. Photobiol., 54: 1093-1107, 1991.
5. Henderson, B. W., and Dougherty, T. J. How does photodynamic therapy work? Photochem. Photobiol., 55: 145-157, 1992.
6. Peng, Q., Moan, J., and Nesland, J. M. Correlation of subcellular and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy. Ultrastruct. Pathol., 20: 109-129, 1996.
7. Oleinick, N. L. Apoptosis in response to photodynamic therapy. Photodynamic News, 1: 6-9, 1998.
8. Oleinick, N. L., and Evans, H. H. The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat. Res., 150: S146-S156, 1998.
9. Moan, J., and Berg, K. Photochemotherapy of cancer: experimental research. Photochem. Photobiol., 55: 931-948, 1992.
10. He, J., Whitacre, C. M., Xue, L., Berger, N. A., and Oleinick, N. L. Protease activation and cleavage of poly(ADP-ribose) polymerase: an integral part of apoptosis in response to photodynamic treatment. Cancer Res., 58: 940-946, 1998.
11. Agarwal, M. L., Clay, M. E., Harvey, E. J., Evans, H. H., Antunez, A. R., and Oleinick, N. L. Photodynamic therapy induces rapid cell death by apoptosis in L5178Y mouse lymphoma cells. Cancer Res., 51: 5993-5996, 1991.
12. He, X. Y., Sikes, R. A., Thomsen, S., Chung, L. W. K., and Jacques, S. L. Photodynamic therapy with Photofrin n induces programmed cell death in carcinoma cell lines. Photochem. Photobiol., 59: 468-473, 1994.
13. Laukka, M. A., Wang, K. K., and Bonner, J. A. Apoptosis occurs in lymphoma cells but not in hepatoma cells following ionizing radiation and photodynamic therapy. Dig. Dis. Sci., 39: 2467-2475, 1994.
14. Luo, Y., Chang, C. K., and Kessel, D. Rapid initiation of apoptosis by photodynamic therapy. Photochem. Photobiol., 63: 528-534, 1996.
15. Colussi, V. C., Feyes, D. K., Mulvihill, J. W., Li, Y. S., Kenney, M. E., Elmets, C. A., Oleinick, N. L., and Mukhtar, H. Phthalocyanine 4 (Pc 4) photodynamic therapy of human OVCAR-3 tumor xenografts. Photochem. Photobiol., 69: 236-241, 1999.
16. Kaufmann, S. H., Desnoyers, S., Ottaviano, Y., Davidson, N. E., and Poirier, G. G. Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res., 53: 3976-3985, 1993.
17. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T-T., Yu. V. L., and Miller, D. K. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (Lond.), 376: 37-43, 1995.
18. Whitacre, C. M., and Berger, N. A. Factors affecting topotecan-induced programmed cell death: adhesion protects cells from apoptosis and impairs cleavage of poly(ADP-ribose) polymerase. Cancer Res., 57: 2157-2163, 1997.
19. Shah, G. M., Shah, R. G., and Poirier, G. G. Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells. Biochem. Biophys. Res. Commun., 229: 838-844, 1996.
20. Margolin, N., Raybuck, S. A., Wilson, K. P., Chen, W., Fox, T., Gu, Y., and Livingston, D. G. Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases. J. Biol. Chem., 272: 7223-7228, 1997.
21. Van de Craen, M., Vandenabeele, P., Declercq, W., Van den Brande, I., Van Loo, G., Molemans, F., Schotte, P., van Criekinge, W., Beyaert, R., and Fiers, W. Characterization of seven murine caspase family members. FEBS Lett., 403: 61-69, 1997.
22. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., and Eamshaw, W. C. Cleavage of poly (ADP-ribose) polymerase by a protein-ase with properties like ICE. Nature (Lond.), 371: 346-347, 1994.
23. Granville, D. J., Levy, J. G., and Hunt, D. W. C. Photodynamic therapy induces caspase-3 activation in HL-60 cells. Cell Death Differ., 4: 623-628, 1997.
24. Kessel, D., and Luo, Y. Photodynamic therapy: a mitochondrial inducer of apoptosis. Cell Death Differ., 6: 28-35, 1999.
25. Separovic, D., Mann, K. J., and Oleinick, N. L. Association of ceramide accumulation with photodynamic treatment-induced cell death. Photochem. Photobiol., 68: 101-109, 1998.
26. Ahmad, N., Feyes, D. K., Agarwal, R., and Mukhtar, H. Photodynamic therapy results in induction of WAF1/Cip1/P21 leading to cell cycle arrest and apoptosis. Proc. Natl. Acad. Sci. USA, 95: 6977-6982, 1998.
27. Gupta, S., Ahmad, N., and Mukhtar, H. Involvement of nitric oxide during phthalocyanine (Pc 4) photodynamic therapy-mediated apoptosis. Cancer Res., 58: 1785-1788, 1998.
28. Tao, J., Sanghera, J. S., Pelech, S. L., Wong, G., and Levy, J. G. Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative. J. Biol. Chem., 271: 27101-27115, 1996.
29. Xue, L. Y., He, J., and Oleinick, N. L. Rapid tyrosine phosphorylation of HS1 in the response of mouse lymphoma L5178Y-R cells to photodynamic treatment sensitized by the phthalocyanine Pc 4. Photochem. Photobiol., 66: 105-113, 1997.
30. Xue, L. Y., He, J., and Oleinick, N. L. Promotion of photodynamic therapy-induced apoptosis by stress kinases. Cell Death Differ., 6: 855-864, 1999.
31. Matroule, J.-Y., Bonizzi, G., Morliere, P., Paillous, N., Santus, R., Bours. V., and Piette, J. Pyropheophorbide-1 methyl ester-mediated photosensitization activates transcription factor NF-KB through the interleukin-1 receptor-dependent signaling pathway. J. Biol. Chem., 274: 2988-3000, 1999.
32. Luna, M. C., Wong, S., and Comer, C. J. Photodynamic therapy mediated induction of early response genes. Cancer Res., 54: 1374-1380, 1994.
33. Gomer, C. J., Luna, M., Ferrario, A., and Rucker, N. Increased transcription and translation of heme oxygenase in Chinese hamster fibroblasts following photodynamic stress or Photofrin II incubation. Photochem. Photobiol., 53: 275-279, 1991.
34. Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., and Nebreda, A. R. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell, 78: 1027-1037, 1994.
35. Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Heys, J. R., Landvatter, S. W., Strickler, J. E., McLaughlin, M. M., Siemens, I. R., Fisher, S. M., Livi, G. P., White, J. R., Adams, J. L., and Young, P. R. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature (Lond.), 372: 739-746, 1994.
36. Han, J., Lee, J. D., Bibbs, L., and Ulevitch, R. J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science (Washington DC), 265: 808-811, 1994.
37. Freshney, N. W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J., and Saklatvala, J. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell, 78: 1039-1049, 1994.
38. Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., and Davis, R. J. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem., 270: 7420-7426, 1995.
39. Klotz, L. O., Fritsch, C., Briviba, K., Tsacmacidis, N., Schliess, F., and Sies, H. Activation of JNK and p38 but not ERK MAP kinases in human skin cells by 5-aminolevulinate-pnotodynamic therapy. Cancer Res., 58: 4297-4300, 1998.
40. Anderson, C. Y., Freye, K., Tubesing, K. A., Li, Y-S., Kenney, M. E., Mukhtar, H., and Elmets, C. A. A comparative analysis of silicon phthalocyanine photosensitizers for in vivo photodynamic therapy of RIF-1 tumors in C3H mice. Photochem. Photobiol., 67: 332-336, 1998.
41. Zaidi, S. I. A., Oleinick, N. L., Zaim, M. T., and Mukhtar, H. Apoptosis during photodynamic therapy-induced ablation of RIF-I tumors. Photochem. Photobiol., 58: 771-776, 1993.
42. Agarwal, R., Korman, N. J., Mohan, R. R., Feyes, D. K., Jawed, S., Zaim, M. T., and Mukhtar, H. Apoptosis is an early event during phthalocyanine photodynamic therapy-induced ablation of chemically induced squamous papillomas in mouse skin. Photochem. Photobiol., 63: 547-552, 1996.
43. Whitacre, C. M., Zborowska, E., Gordon, N. H., Mackay, W., and Berger, N. A. Topotecan increases topoisomerase IIα levels and sensitivity to treatment with etoposide in schedule-dependent process. Cancer Res., 57: 1425-1428, 1997.
44. Whitacre, C. M., Zborowska, E., Willson, J. K. V., and Berger, N. A. Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness. Clin. Cancer Res., 5: 665-672, 1999.
45. Chen, Y. C., and Lin, J. K. Photodynamic anticancer agent merocyanine 540 inhibits cell growth by apoptosis. Anticancer Res., 16: 2781-2788, 1996.
46. Oleinick, N. L., Antunez, A. R., Clay, M. E., Rihter, B. D., and Kenney, M. E. New phthalocyanine photosensitizers for photodynamic therapy. Photochem. Photobiol., 57: 243-247, 1993.
47. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
48. Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D. D., and Kirn, D. H. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat. Med., 3: 639-645, 1997.
49. Fisher, A. M. R., Danenberg, K., Banerjee, D., Bertino, J. R., Danenberg, P., and Gomer, C. J. Increased photosensitivity in HL60 cells expressing wild-type p53. Photochem. Photobiol., 66: 265-270, 1997.
50. Fisher, A. M. R., Rucker, N., Wong, S., and Gomer, C. J. Differential photosensitivity in wild-type and mutant p53 human colon carcinioma cell lines. J. Photochem. Photobiol., 42: 104-107, 1998.
51. Fisher, A. M. R., Ferrario, A., Rucker, N., Zhang, S., and Gomer, C. J. Photodynamic therapy sensitivity is not altered in human tumor cells after abrogation of p53 function. Cancer Res., 59: 331-335, 1999.
52. Trivedi, N. S., Wang, H. W., Nieminen, A. L., Oleinick, N. L., and Izatt, J. A. Quantitative analysis of Pc 4 localization in mouse lymphoma (LY-R) cells via double-label confocal fluorescence microscopy. Photochem. Photobiol., in press, 2000.
53. Varnes, M. E., Chiu, S. M., Xue, L. Y., and Oleinick, N. L. Photodynamic therapy-induced apoptosis in lymphoma cells: translocation of cytochrome c causes inhibition of respiration as well as caspase activation. Biochem. Biophys. Res. Commun., 255: 673-679, 1999.
54. L in response to DNA damage. J. Biol. Chem., 275: 322-327, 2000.
55. He. J., Agarwal, M. L., Larkin, H. E., Friedman, L. R., Xue, L. Y., and Oleinick, N. L. The induction of partial resistance to photodynamic therapy by the protooncogene Bcl-2. Photochem. Photobiol., 64: 845-852, 1996.
56. Granville, D. J., Jiang, H., An, M. T., Levy, J. G., McManus, B. M., and Hunt, D. W. Overexpression of Bcl-XL prevents caspase-3-mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD-MA. FEBS Lett., 422: 151-154, 1998.
57. Granville, D. J., Jiang, H., An, M. T., Levy, J. G., McManus, B. M., and Hunt, D. W. Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy. Br. J. Cancer, 79: 95-100, 1999.
58. Zhang, W. G., Ma, L. P., Wang, S. W., Zhang, Z. Y., and Cao, G. D. Antisense bcl-2 retrovirus vector increases the sensitivity of a human gastric adenocarcinoma cell line to photodynamic therapy. Photochem. Photobiol., 69: 582-586, 1999.
59. L as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc. Natl. Acad. Sci. USA, 94: 6939-6942, 1997.
60. Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T. I., Jones, D. P., and Wang, X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (Washington DC), 275: 1129-1132, 1997.
61. Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science (Washington DC), 275: 1132-1136, 1997.