Photodynamic anticancer agent merocyanine 540 inhibits cell growth by apoptosis

Anticancer Research

Volumn 16, Issue 5 A, 1996, Pages 2781-2788

  Chen, Yen Chou ^a   Lin, Jen Kun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Cell growth; Merocyanine 540; Photodynamic anticancer activity

Indexed keywords

ANTINEOPLASTIC AGENT; MEROCYANINE; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL DEATH; CELL GROWTH; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; LIGHT; PHOTODYNAMICS; PHOTOSENSITIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CARCINOMA; CELL CYCLE; CELL DIVISION; COLORECTAL NEOPLASMS; DNA FRAGMENTATION; DNA, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NECROSIS; PHOTOTHERAPY; PYRIMIDINONES; RADIATION-SENSITIZING AGENTS; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029964850     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Waffoner AS, Wang CH and Tolles RL: Mechanism of potential dependent light adsorption changes of lipid bilayer membranes in the presence of cyanine and oxonol dyes. J Membr Biol 33: 109-140, 1977.
2. Varlinsky IE, Eston TG and Reich E: Merocyanine540 as a fluorescent probe of membranes: selective staining of leukemic and immature hemapoietic cells. Cell 13: 487-490, 1978.
3. Sieber FS, Pivak JL and Suteliffe AM: Selective killing of leukemic cells by membrane 540-mediated photosensitization. Pro Natl Acad Sci USA 81: 7584-7587, 1987.
4. O'Brien JM, Montgomery RR, Burns WH, Gaffney DK And Sieber F: Evaluation of merocyanine 540- sensitized photoirradiation as a means to inactivate enveloped viruses in blood products. J Lab Clin Med 116: 439-447, 1990.
5. Kalyanaraman B, Feix JB, Sieber F, Thomas JP and Girotti AW: Photodynamic action of merocyanine540 on artificial and natural cell membranes: involvement of singlet molecular oxygen. Pro Natl Acad Sci USA 84: 2999-3003, 1987.
6. Gaffiney DK, Schober SL and Sieber F: Merocyanine 540-sensitized photoinactivation of leukemia cells: role of oxygen and effects on plasma membrane integrity and mitochondria respiration. Exp Hematol 18: 23-26, 1990.
7. Hoeheke M, Seret A, Piette J and Van de vorst A: Destruction of stearic acid nitroxyl radicals mediated by photoexicited merocyanine 540 in liposomal and micellular systems. Biochem 32: 2730-2736.
8. Feix JB, Bachowski GJ And Girotti AW: Photodynamic action of merocyanine540 on erythrocyte membranes: structural perturbations of lipid and protein constituents. Biochem Biophys Acta 1075: 28-35, 1991.
9. Peter FL, Geiger G and Girotti SW: Delenoperoxidase-mediated cytoprotection against merocyanine540 -sensitized photopeloxidation and photokilling of leukemia cells. Cancer Res 52: 5282-5290, 1992.
10. Trainer DL, Kline T, McCabe FL, Faucette LF, Feild J, Chaikin M, Anzano M, Rieman D, Hoffstein S, Li DJ, Gennaro D, Buscarino C, Lynch M, Poste G and Greig R: Biological characterization and oncogens expression in human colorectal carcinoma cell lines. Int J Cancer 41: 287-296, 1988.
11. Stokke T, Erikstein B, Smedshammer L, Boye E and Steen HB: The retinoblastoma gene product is hound in the nucleus in the early Gl phase. Exp Cell Res 204: 147155, 1993.
12. Singh RJ, Feix JB, Pintar TJ, Girotti AW and Kalyanaraman B: Photodynamic action of merocyanine540 in artificial bilayers and natural membranes: action spectra and quantum yields. Photochem Photobiol 53: 493-500, 1991.
13. Atzpodien J, Gulati SC and Clarkson BD: Comparison of the cytotoxic effects of mereyanine540 on leukemic cells and human bone morrow. Cancer Res 46: 4892-4895, 1986.
14. Darzynkiewicz Z and Carter SP: Photosensitizing effects of the Tricyclic heteroaromatic cationic dues Pyronin Y and Toluidine blue O (Tolonoum Chloride). Cancer Res 48: 1295-1299, 1988.
15. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A and Oren M: Wild type p53 induces apoptosis in myeloid leukemic cells that is inhibited by interleukin-6. Nature 352: 345-347,1991.
16. Mower DJ, Peckham DW, Illera VA, Fishbaugh JK, Stung L and Ashman RF: Decreased membrane phospholipid packing and decreased cell size preceed DNA cleavage in mature mouse B cell apoptosis. J Immune 152(10): 4832-4842, 1994.
17. Max J: Cell death studies yield cancer clues. Science 259: 760-761, 1993.
18. Stanbridge EJ and Nowell PC: Origins of human cancer revisited. Cell 63: 867-874, 1990.
19. Wyllie AH, Kerr JRR and Currie AR: Int. Rev. Cytol.. 68: 251-307.
20. Diller L, Kassel J, Neson CK, Gryka MA, Litwak G, Gebhart M, Bressac B, Ozturk M, Baker SJ, Vogelstein B and Friend SH: p53 functions as a cell cycle control protein in Osteosarcoma. Mol Cell Biol 10: 5772-5781, 1990.
21. Lin BT-Y, Gruenward S, Morla AO, Lee WH, and Wang JY: Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. EMBO J 10: 857-864, 1991.
22. Chen PL, Scully P, Shew JY, Wang JY-J and Lee WH: Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58: 1193-1198, 1989.
23. Ludlow JW, Shon J, Pipas JM, Livingston DM and DeCaprio JA: The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and bounding to release from SV40 large T. Cell 60: 387-396, 1990.
24. Goodrch DW, Wang NP, Qian YHP and Lee WH: Rb protein arrests progression through Gl. Cell 67: 293-302, 1991.
25. Semple TU, Quinn LA, Woods LK and Moore GE: Tumor and lymphoid celis lines from a patient with carcinoma ofthe colon for a cytotoxcity model. Cancer Res 38: 1345-1355, 1978.
26. Park DJ, Nakamura H, Chumakov AM, Said JW, Miller CW, Chen D L and Koeffler HP: Transactivation and DNA binding abilities of endogenous p53 in mutant cell lines. Oncogene 9: 1899-1906, 1994.
27. Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, Kinzler KW and Vogelstein B: Science 256: 827-830, 1992.
28. Fan S, El-Dicry W S, Bae I, Freeman J, Jondle D, Bhatia K, Fornace AJ, Magrath I, Kohn KW And O'Connor PM: p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res 54: 5824-5830, 1994.
29. Xia F, Wang X Wang YH, Tsang NM, Yandell DW, Kelsey KT And Liber HL: Altered p53 status corrects with differences in sensitivity to Radiation-induced mutation and apoptosis in two closely related human lymphoblastic lines. Cancer Res 55: 12-15, 1995.
30. Oltival ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo conserved Homologue, Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993.