Expansion of Vγ9Vδ2 T cells is triggered by Francisella tularensis- derived phosphoantigens in tularemia but not after tularemia vaccination

Infection and Immunity

Volumn 66, Issue 5, 1998, Pages 2107-2114

  Poquet, Yannick ^a   Kroca, Michal ^b,c   Halary, Franck ^d   Stenmark, Stephan ^c   Peyrat, Marie Alix ^d   Bonneville, Marc ^d   Fournié, Jean Jacques ^a   Sjöstedt, Anders ^c,e  

^a CHU PURPAN   (France)

^b PMMA   (Czech Republic)

^c UMEÅ UNIVERSITY   (Sweden)

^d INSTITUT DE BIOLOGIE   (France)

^e SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN RECOGNITION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FRANCISELLA TULARENSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TULAREMIA; VACCINATION; ADULT; AGED; ANIMAL; IMMUNOLOGY; MIDDLE AGED; MOUSE;

FRANCISELLA TULARENSIS;

BACTERIAL ANTIGEN; BACTERIAL VACCINE; LYMPHOCYTE ANTIGEN RECEPTOR; PYROPHOSPHATE;

ADULT; AGED; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; DIPHOSPHATES; FRANCISELLA TULARENSIS; HUMANS; MICE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; TULAREMIA; VACCINATION;

EID: 0031596515     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.5.2107-2114.1998     Document Type: Article

References (30)

1. Balbi, B., M. T. Valle, S. Oddera, D. Giunti, F. Manca, G. A. Rossi, and L. Allegra. 1993. T-lymphocytes with gamma delta+ V delta2+ antigen receptors are present in increased proportions in a fraction of patients with tuberculosis or with sarcoidosis. Am. Rev. Respir. Dis. 148:1685-1690.
2. Behr, C., R. Poupot, M.-A. Peyrat, Y. Poquet, P. Constant, P. Dubois, M. Bonneville, and J.-J. Fournié. 1996. Plasmodium falciparum stimuli for human γδ T cells are related to the phosphorylated antigens of mycobacteria. Infect. Immun. 64:2892-2896.
3. Bukowski, J. F., C. T. Morita, Y. Tanaka, B. R. Bloom, M. B. Brenner, and H. Band. 1995. Vgamma 2 Vdelta 2 TCR-dependent recognition of nonpeptide antigens and Daudi cells analyzed by TCR gene transfer. J. Immunol. 154:998-1006.
4. Burk, M. R., L. Mori, and G. De Libero. 1995. Human Vγ9-Vδ2 cells are stimulated in a cross-reactive fashion by a variety of phosphorylated metabolites. Eur. J. Immunol. 25:2052-2058.
5. Burke, D. S. 1977. Immunization against tularemia: analysis of the effectiveness of live Francisella tularensis vaccine in prevention of laboratory-acquired tularemia. J. Infect. Dis. 135:55-60.
6. Chamberlain, R. E. 1965. Evaluation of live tularemia vaccine prepared in a chemically defined medium. Appl. Microbiol. 13:232-235.
7. Constant, P., F. Davodeau, M. A. Peyrat, Y. Poquet, G. Puzo, M. Bonneville, and J. J. Fournié. 1994. Stimulation of human gamma delta T cells by nonpeptidic niycobacterial ligands. Science 264:267-270.
8. Constant, P., Y. Poquet, M.-A. Peyrat, F. Davodeau, M. Bonneville, and J.-J. Fournié. 1995. The antituberculous Mycobacterium bovis BCG vaccine is an attenuated mycobacterial producer of phosphorylated nonpeptidic antigens for human γδ T cells. Infect. Immun. 63:4628-4633.
9. Eigelsbach, H., S. Saslaw, J. Tulis, and R. Hornick. 1968. Tularemia: the monkey as a model for man, p. 230-248. In H. Vagtborg (ed.), Use of nonhuman primates in drug evaluation. A symposium. Southwestern Foundation of Research and Education, San Antonio, Tex.
10. + T cells or cytokines that signal through components of the IL-2R. J. Immunol. 157:2096-2102.
11. Fournié, J. J., and M. Bonneville. 1996. Stimulation of γδ T cells by phosphoantigens. Res. Immunol. 147:338-347.
12. Ito, M., N. Kojiro, T. Ikeda, T. Ito, J. Funada, and T. Kokubu. 1992. Increased proportions of peripheral blood gamma delta T cells in patients with pulmonary tuberculosis. Chest 102:195-197.
13. Kroca, M., et al. Unpublished data.
14. Lang, F., M. A. Peyrat, P. Constant, F. Davodeau, J. David-Ameline, Y. Poquet, H. Vie, J. J. Fournié, and M. Bonneville. 1995. Early activation of human Vγ9Vδ2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands. J. Immunol. 154:5986-5994.
15. Poquet, Y., P. Constant, F. Halary, M. A. Peyrat, M. Gilleron, F. Davodeau, M. Bonneville, and J. J. Fournié. 1996. A novel nucleotide-containing antigen for human blood γδ T lymphocytes. Eur. J. Immunol. 26:2344-2349.
16. Sandström, G., A. Tärnvik, and H. Wolf-Watz. 1984. Antigen from Francisella tularensis: nonidentity between determinants participating in cell-mediated and humoral reactions. Infect. Immun. 45:101-106.
17. Schoel, B., S. Sprenger, and S. H. E. Kaufmann. 1994. Phosphate is essential for stimulation of Vgamma 9Vdelta 2 T lymphocytes by mycobacterial low molecular weight ligand. Eur. J. Immunol. 24:1886-1892.
18. Shijubo, N., F. Nakanishi, M. Hirasawa, K. Sigehara, H. Sasaki, M. Asakawa, and A. Suzuki. 1992. Phenotypic analysis in peripheral blood lymphocytes of patients with pulmonary tuberculosis. Kekkaku 67:581-585.
19. Sjöstedt, A., G. Sandström, and A. Tärnvik. 1990. Nucleotide sequence and T cell epitopes of a membrane protein of Francisella tularensis. J. Immunol. 145:311-317.
20. Sjöstedt, A., G. Sandström, and A. Tärnvik. 1990. Several membrane polypeptides of the live vaccine strain Francisella tularensis LVS stimulate T cells from naturally infected individuals. J. Clin. Microbiol. 28:43-48.
21. Sjöstedt, A., A. Tärnvik, and G. Sandström. 1991. The T-cell-stimulating 17-kilodalton protein of Francisella tularensis LVS is a lipoprotein. Infect. Immun. 59:3163-3168.
22. + T cells of primed humans. Immunology 76:584-592.
23. Sumida, T., T. Maeda, H. Takahashi, S. Yoshida, F. Yonaha, A. Sakamoto, H. Tomioka, T. Koike, and S. Yoshida. 1992. Predominant expansion of Vγ9/Vδ2 T cells in a tularemia patient. Infect. Immun. 60:2554-2558.
24. Syrjälä, H., E. Herva, J. Ilonen, K. Saukkonen, and A. Salminen. 1984. A whole-blood lymphocyte stimulation test for the diagnosis of tularemia. J. Infect. Dis. 150:912-915.
25. Tanaka, Y., C. T. Morita, Y. Tanaka, E. Nieves, M. B. Brenner, and B. R. Bloom. 1995. Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature 375:155-158.
26. Tanaka, Y., S. Sano, E. Nieves, G. De Libero, D. Rosa, R. L. Modlin, M. B. Brenner, B. R. Bloom, and C. T. Morita. 1994. Nonpeptide ligands for human gamma delta T cells. Proc. Natl. Acad. Sci. USA 91:8175-8179.
27. Tärnvik, A. 1989. Nature of protective immunity to Francisella tularensis. Rev. Infect. Dis. 11:440-451.
28. Tazi, A., I. Fajac, P. Soler, D. Valeyre, J. P. Battesti, and A. J. Hance. 1991. Gamma/delta T-lymphocytes are not increased in number in granulomatous lesions of patients with tuberculosis or sarcoidosis. Am. Rev. Respir. Dis. 144:1373-1375.
29. + αβ T cell and γδ T cell responses to Mycobacterium tuberculosis. Similarities and differences in antigen recognition, cytotoxic effector function and cytokine production. J. Immunol. 154:1786-1796.
30. Ueta, C., I. Tsuyuguchi, H. Kawasumi, T. Takashima, H. Toba, and S. Kishimoto. 1994. Increase of γ/δ T cells in hospital workers who are in close contact with tuberculosis patients. Infect. Immun. 62:5434-5441.