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24 Kato S, Luyckx VA, Ots M, Lee K-W, Ziai F, Troy JL, et al. Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats. Kidney Int 1999; 56:1037-1048. This study provides evidence that chemokines and inflammatory cells may play a role in diabetic nephropathy.
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25 Mervaala EMA, Muller DN, Park J-K, Schmidt F, Lohn M, Breu V, et al. Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension. Hypertension 1999; 33:389-395. The authors use a novel transgenic rat that contains the human renin and angiotensin genes to examine renal injury in high renin hypertension. This model displays elevated urinary MCP-1 levels, proteinuria, and interstitial monocyte infiltration, which can be reversed with angiotensin converting enzyme inhibition. These deleterious effects are not due to hypertension alone.
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