The steady-state levels of oxidative DNA damage and of lipid peroxidation (F2-isoprostanes) are not correlated in healthy human subjects

Free Radical Research

Volumn 32, Issue 4, 2000, Pages 355-362

  England, Timothy ^a   Beatty, Emily ^a   Rehman, Almas ^a   Nourooz Zadeh, Jaffar ^b   Pereira, Paulo ^c   O'Reilly, James ^a   Wiseman, Helen ^a   Geissler, Catherine ^a   Halliwell, Barry ^a,d  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Center of Ophthalmology   (Portugal)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

8 hydroxyguanine; Antioxidant; F2 isoprostanes; Isoprostanes; Lipid peroxidation; Oxidative DNA damage

Indexed keywords

8 HYDROXYGUANINE; 8 ISOPROSTAGLANDIN F2 ALPHA; ARACHIDONIC ACID; CELL DNA; ISOPROSTANE DERIVATIVE;

ADULT; AGED; ANALYTIC METHOD; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DNA DAMAGE; DNA DETERMINATION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LEUKOCYTE; LIPID PEROXIDATION; MALE; NORMAL HUMAN; OXIDATIVE STRESS;

EID: 0034023134     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760000300351     Document Type: Article

References (46)

1. R.A. Floyd (1990) The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis 11, 1447-1450.
2. H. Kasai (1997) Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutation Research 387, 147-163.
3. B.N. Ames (1989) Endogenous oxidative DNA damage, aging and cancer. Free Radical Research Communications 7, 121-128.
4. J.R. Totter (1980) Spontaneous cancer and its possible relationship to oxygen metabolism. Proceedings of the National Academy of Sciences of the USA 77, 1763-1767.
5. B.N. Ames, M.K. Shigenaga and T.M. Hagen (1993) Oxidants, antioxidants and the degenerative diseases of aging. Proceedings of the National Academy of Sciences of the USA 90, 7915-7922.
6. K.B. Beckman and B.N. Ames (1998) Oxidative DNA damage: assessing its role in cancer and aging. In: O.I. Aruoma and B. Halliwell (Eds.), DNA and Free Radicals. Techniques, Mechanisms and Applications. OICA International Press, St. Lucia.
7. D. Steinberg and A. Lewis (1997) Oxidative modification of LDL and atherogenesis. Circulation 95, 1062-1071
8. H. Esterbauer, R. Schmidt and M. Hayn (1997) Relationships among oxidation of low-density lipoprotein, antioxidant protection, and atherosclerosis. Advances in Pharmacology 38, 425-456.
9. S. Yla-Herttuala (1998) Is oxidized LDL present in vivo? Current Opinions in Lipidology 9, 337-344.
10. B. Halliwell and J.M.C. Gutteridge (1999) Free Radicals in Biology and Medicine, Chapter 9, 3rd edn., Clarendon Press, Oxford, UK.
11. B. Halliwell (1998) Can oxidative damage be used as a biomarker of cancer risk in humans? Free Radical Research 29, 469-486.
12. H. Verhagen, H.E. Poulsen, S. Loft, G. van Poppel, M.I. Willems and P.J. van Bladeren (1995) Reduction of oxidative DNA damage in humans by Brussels sprouts. Carcinogenesis 16, 969-970.
13. S.J. Duthie, A. Ma, M.A. Ross and A.R. Collins (1996) Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Research 56, 1291-1295.
14. D. Pratico, R.K. Tangirala, D.J. Rader, J. Rokach and G.A. FitzGerald (1998) Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in Apo E-deficient mice. Nature Medicine 4, 1189-1192.
15. S. Loft, E.B. Thorling and H.E. Poulsen (1998) High fat diet induced oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in rats. Free Radical Research 29, 595-600.
16. S. Asami, T. Hirano, R. Yamaguchi, H. Ito and H. Kasai (1998) Reduction of 8-hydroxyguanine in human leukocyte DNA by physical exercise. Free Radical Research 29, 581-584.
17. S. Loft, K. Vistisen, M. Ewertz, A. Tjonneland, K. Overvad and H.E. Poulsen (1992) Oxidative DNA damage estimated by 8-hydroxyguanosine excretion in man: influence of smoking, gender and body mass index. Carcinogenesis 13, 2241-2247.
18. J.A. Drury, G. Jeffers and R.W.I. Cooke (1998) Urinary 8-hydroxydeoxyguanosine in infants and children. Free Radical Research 28, 423-428.
19. B. Halliwell (1996) Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. Free Radical Research 25, 57-74.
20. B. Halliwell (1999) Establishing the significance and optimal intake of dietary antioxidants: the biomarker concept. Nutrition Reviews 57, 104-113.
21. L.J. Roberts II and J.D. Morrow (1997) The generation and actions of isoprostanes. Biochimica et Biophysica Acta 1345, 121-135.
22. 2-isoprostanes in human atherosclerotic lesions. Journal of Clinical Investigation 100, 2028-2034.
23. 2α is increased in hypercholesterolaemia. Arteriosclerosis Thrombosis and Vascular Biology 17, 3230-3235.
24. 2α in pericardial fluid of patients with heart failure. Circulation 97, 1536-1539.
25. 2-isoprostanes) in smokers. New England Journal of Medicine 332, 1198-1203.
26. 2α. FEBS Letters 428, 32-36.
27. 3-isoprostanes during peroxidation of eicosapentaenoic acid. Biochemical and Biophysical Research Communications 236, 467-472.
28. 4-isoprostanes: a novel class of prostanoids formed during peroxidation of docosahexaenoic acid. Biochemical and Biophysical Research Communications 242, 338-344.
29. J.L. Roberts II, T.J. Montine, W.R. Markesbery, A.R. Tapper, P Hardy, S. Chemtob, W.D. Dettbarn and J.D. Morrow (1998) Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. Journal of Biological Chemistry 273, 13605-13612.
30. 4-isoprostanes as a specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. Journal of Neurochemistry 72, 734-740.
31. 2-isoprostanes as indicators of non-enzymatic lipid peroxidation in vivo by gas chromatography-mass spectrometry: development of a solid-phase extraction procedure. Journal of Chromatography B 667, 119-208.
32. G. Davi, G. Ciabattoni, A. Consoli, A. Mezzetti, A. Falco, S. Santarone, E. Pennese, E. Vitacolonna, T. Bucciarelli, F. Costantini, F. Capani and C. Patrono (1999) In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 99, 224-229.
33. 2α levels are elevated in individuals with non-insulin dependent diabetes mellitus. FEBS Letters 368, 223-229.
34. J. Nourooz-Zadeh, J. Tajaddini-Sarmadi, S. McCarthy, D.J. Betteridge and S.P. Wolff (1995) Elevated levels of authentic plasma hydroperoxides in non-insulin dependent diabetes mellitus. Diabetes 44, 1054-1058.
35. Special issue. Measurement and mechanism of oxidative DNA damage (1998) Free Radical Research 29, 461-624.
36. M. Dizdaroglu (1990) Gas-chromatography mass-spectrometry of free radical-induced products of pyrimidines and purines in DNA. Methods in Enzymology 193, 842-857.
37. S. Senturker and M. Dizdaroglu (1999) The effects of experimental conditions on the levels of oxidatively modified bases in DNA as measured by gas chromatography-mass spectrometry. How many modified bases are involved? Prepurification or not? Free Radical Biology and Medicine 27, 370-380.
38. T. Douki, T. Delatour, F. Bianchini and J. Cadet (1996) Observation and prevention of an artifactual formation of oxidized DNA bases and nucleosides in the GC-EIMS method. Carcinogenesis 17, 347-353.
39. A. Jenner, T.G. England, O.I. Aruoma and B. Halliwell (1998) Measurement of oxidative DNA damage by gas chromatography-mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases. Biochemical Journal 331, 365-369.
40. A. Rehman, A. Jenner and B. Halliwell (2000) Gas chromatography-mass spectrometry analysis of DNA: optimisation of protocols for isolation and analysis of DNA from human blood. Methods in Enzymology (in press).
41. A.R. Collins, C.M. Gedik, B. Olmedilla, S. Southon and M. Bellizzi (1998) Oxidative DNA damage measured in human lymphocytes: large differences between sexes and between countries, and correlations with heart disease mortality rates. FASEB Journal 12, 1397-1400.
42. M. Dizdaroglu and D.S. Bertgold (1986) Characterization of free-radical induced base damage in DNA at biologically relevant levels. Analytical Biochemistry 156, 182-188.
43. P. Mecocci, G. Fano, S. Fulle, U. MacGarvey, L. Shinobu, M.C. Polidori, A. Cherubini, J. Vecchet, U. Senin and M.F. Beal (1999) Age-dependent increases in oxidative damage to DNA, lipids and proteins in human skeletal muscle. Free Radical Biology and Medicine 26, 303-308.
44. M. Dizdaroglu (1998) Facts about the artifacts in the measurement of oxidative DNA base damage by gas chromatography-mass spectrometry. Free Radical Research 29, 551-563.
45. J. Lunec (1998) ESCODD: European standards committee on oxidative DNA damage. Free Radical Research 29, 601-608.
46. ESCODD, European standards committee on oxidative DNA damage. (2000) Comparison of different methods of measuring oxidative DNA damage. Free Radical Research (in press).