Regulatable systems: Applications in gene therapy and replicating viruses

Journal of Clinical Investigation

Volumn 105, Issue 9, 2000, Pages 1177-1183

  Agha Mohammadi, Siamak ^a   Lotze, Michael T ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECDYSONE; PROGESTERONE; RAPAMYCIN; TETRACYCLINE; VIRUS VECTOR;

CANCER THERAPY; CHIMERA; GENE CONTROL; GENE EXPRESSION SYSTEM; GENE TARGETING; GENE THERAPY; HUMAN; NONHUMAN; OPERON; PRIORITY JOURNAL; REVIEW; VIRUS REPLICATION;

EID: 0034019281     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10027     Document Type: Review

References (43)

1. Dranoff, G., et al. 1993. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA. 90:3539-3543.
2. Schmidt, W., et al. 1995. Cancer vaccines: the interleukin 2 dosage effect. Proc. Natl. Acad. Sci. USA. 92:4711-4714.
3. Naffakh, N., and Danos, O. 1996. Gene transfer for erythropoiesis enhancement. Mol. Med. Today. 2:343-348.
4. Agha-Mohammadi, S., and Lotze, M.T. 2000. Immunomodulation of cancer potential use of selectively replicating agents. J. Clin. Invest. 105:1173-1176.
5. Springer, C.J., and Niculescu-Duvaz, I. 2000. Prodrug-activating systems in suicide gene therapy. J. Clin. Invest. 105:1161-1167.
6. Gossen, M., and Bujard, H. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA. 89:5547-5551.
7. Wang, Y., DeMayo, F.J., Tsai, S.Y., and O'Malley, B.W. 1996. Ligand-inducible and liver-specific target gene expression in transgenic mice. Nat. Biotechnol. 15:239-243.
8. No, D., Yao, T.-P., and Evans, R.M. 1996. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. USA. 93:3346-3351.
9. Rivera, V.M., et al. 1996. A humanized system for pharmacologic control of gene expression. Nat. Med. 2:1028-1032.
10. Serguera, C., Bohl, D., Rolland, E., Prevost, P., and Heard, J.M. 1999. Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymer-encapsulated engineered cells. Hum. Gene Ther. 10:375-383.
11. Oligino, T., et al. 1998. Drug inducible transgene expression in brain using a herpes simplex virus vector. Gene Ther. 5:491-496.
12. Burcin, M.M., Schiedner, G., Kochanek, S., Tsai, S.Y., and O'Malley, B.W. 1999. Adenovirus-mediated regulable target gene expression in vivo. Proc. Natl. Acad. Sci. USA. 96:355-360.
13. Magari, S.R., Rivera, V.M., Iuliucci, J.D., Gilman, M., and Cerasoli, F. 1997. Pharmacologic control of a humanized gene therapy system implanted into nude mice. J. Clin. Invest. 100:2865-2872.
14. Ye, X., et al. 1999. Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer. Science. 283:88-91.
15. Agha-Mohammadi, S., and Hawkins, R.E. 1998. Efficient transgene regulation from a single tetracycline-controlled positive feedback regulatory system. Gene Ther. 5:76-84.
16. Agha-Mohammadi, S., Alvarez-Vallina, L., Ashworth, L.J., and Hawkins, R.E. 1997. Delay in resumption of the activity of tetracycline-regulatable promoter following removal of tetracycline analogues. Gene Ther. 4:993-997.
17. Gossen, M., et al. 1995. Transcriptional activation of tetracyclines in mammalian cells. Science. 268:1766-1769.
18. Deuschle, U., Meyer, W.K.H., and Thiesen, H.J. 1995. Tetracycline-reversible silencing of eukaryotic promoters. Mol. Cell. Biol. 15:1907-1914.
19. Kim, H.J., Gatz, C., Hillen, W., and Jones, T.R. 1995. Tetracycline repressor-regulated gene repression in recombinant human cytomegalovirus. J. Virol. 69:2565-2573.
20. Baron, U., et al. 1999. Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proc. Natl. Acad. Sci. USA. 96:1013-1018.
21. Yao, F., et al. 1998. Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells. Hum. Gene Ther. 9:1939-1950.
22. Rose, S.D., and MacDonald, R.J. 1997. Integration of tetracycline regulation into a cell-specific transcriptional enhancer. J. Biol. Chem. 272:4735-4739.
23. O'Brien, K., Otto, K., and Rao, R.N. 1997. Construction and characterization of a one-plasmid system for the controlled expression of genes in mammalian cells by tetracycline. Gene. 184:115-120.
24. Liang, X., Hartikka, J., Sukhu, L., Manthorpe, M., and Hobart, P. 1996. Novel, high expressing and antibiotic-controlled plasmid vectors designed for use in gene therapy. Gene Ther. 3:350-356.
25. Neering, S.J., Hardy, S.F., Minamoto, D., Spratt, S.K., and Jordan, C.T. 1996. Transduction of primitive human hematopoietic cells with recombinant adenovirus vectors. Blood. 88:1147-1155.
26. Bohl, D., Naffakh, N., and Heard, J.M. 1997. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Nat. Med. 3:299-305.
27. Bohl, D., and Heard, J.M. 1997. Modulation of erythropoietin delivery from engineered muscles in mice. Hum. Gene Ther. 8:195-204.
28. Pitzer, C., Schindowski, K., Pomer, S., Wirth, T., and Zoller, M. 1999. In vivo manipulation of interleukin-2 expression by a retroviral tetracycline (tet)-regulated system. Cancer Gene Ther. 6:139-146.
29. Heise, C.C., Williams, A.M., Xue, S., Propst, M., and Kirn, D.H. 1999. Intravenous administration of ONYX-015, a selectively replicating adenovirus, induces antitumoral efficacy. Cancer Res. 59:2623-2628.
30. Heise, C., and Kirn, D.H. 2000. Replication-selective adenoviruses as oncolytic agents. J. Clin. Invest. 105:847-851.
31. Rittner, K., Schultz, H., Pavirani, A., and Mehtali, M. 1997. Conditional repression of the E2 transcription unit in E1-E3-deleted adenovirus vectors is correlated with a strong reduction in viral DNA replication and late gene expression in vitro. J. Virol. 71:3307-3311.
32. Caplen, N.J., et al. 1999. Adeno-retroviral chimeric viruses as in vivo transducing agents. Gene Ther. 6:454-459.
33. Yao, F., and Eriksson, E. 1999. A novel tetracycline-inducible viral replication switch. Hum. Gene Ther. 10:419-427.
34. Fishman, G.L., Kaplan, M.L., and Buttrick, P.M. 1994. Tetracycline-regulated cardiac gene expression in vivo. J. Clin. Invest. 93:1864-1868.
35. Dhawan, J., Rando, T.A., Elson, S.L., Bujard, H., and Blau, H.M. 1995. Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle. Somat. Cell Mol. Genet. 21:233-240.
36. Harding, T.C., Geddes, B.J., Noel, J.D., Murphy, D., and Uney, J.B. 1997. Tetracycline-regulated transgene expression in hippocampal neurones following transfection with adenoviral vectors. J. Neurochem. 69:2620-2623.
37. Yoshida, Y., and Hamada, H. 1997. Adenovirus-mediated inducible gene expression through tetracycline-controllable transactivator with nuclear localization signal. Biochim. Biophys. Res. Commun. 230:426-430.
38. Paulus, W., Baur, I., Boyce, F.M., Breakefield, X.O., and Reeves, S.A. 1996. Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells. J. Virol. 70:62-67.
39. Hwang, J.J., Scuric, Z., and Anderson, W.F. 1996. Novel retroviral vector transferring a suicide gene and a selectable marker gene with enhanced gene expression by using a tetracycline-responsive expression system. J. Virol. 70:8138-8141.
40. Yu, J.S., Sena-Esteves, M., Paulus, W., Breakefield, X.O., and Reeves, S.A. 1996. Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells. Cancer Res. 56:5423-5427.
41. Haberman, R.P., McCown, T.J., and Samulski, R.J. 1998. Inducible long-term gene expression in brain with adeno-associated virus gene transfer. Gene Ther. 5:1604-1611.
42. Ho, D.Y., McLaughlin, J.R., and Sapolsky, R.M. 1996. Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system. Brain Res. Mol. Brain Res. 41:200-209.
43. Hu, S.X., Ji, W., Zhou, Y., Logothetis, C., and Xu, H.J. 1997. Development of an adenovirus vector with tetracycline-regulatable human tumor necrosis factor alpha gene expression. Cancer Res. 57:3339-3343.