The vasodilating effect of insulin is dependent on local glucose uptake: A double blind, placebo-controlled study

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 6, 1998, Pages 2126-2131

  Ueda, Shinichiro ^a,b   Petrie, John R ^a   Cleland, Stephen J ^a   Elliott, Henry L ^a   Connell, John M C ^a  

^a WESTERN INFIRMARY   (United Kingdom)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; NEUTRAL INSULIN;

ADULT; ARTICLE; BRACHIAL ARTERY; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; FOREARM BLOOD FLOW; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERINSULINEMIA; INSULIN TREATMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEREOISOMERISM; VASODILATATION;

ADULT; BLOOD FLOW VELOCITY; BLOOD GLUCOSE; DOUBLE-BLIND METHOD; FOREARM; GLUCOSE; HUMANS; INFUSIONS, INTRA-ARTERIAL; INSULIN; KINETICS; MALE; PLACEBOS; VASODILATION;

EID: 0031732301     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.6.2126     Document Type: Article

References (35)

1. DeFronzo RA, Bonadonna RC, Ferrannini E. 1992 Pathogenesis of NIDDM: a balanced overview. Diabetes Care. 15:318-367.
2. Bonadonna RC, Groop LC, Kraemer N, Feraninni E. 1990 Obesity and insulin resistance in humans: a dose-response study. Metabolism. 39:452-459.
3. Ferraninni E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L, Pedrinelli R, Brandi L, Bevilqacqua S. 1987 Insulin resistance in essential hypertension. N Engl J Med. 317:350-357.
4. Modan M, Halkin H, Almog S, et al. 1985 Hyperinsulinaemia: a link between hypertension, obesity and glucose intolerance. J Clin Invest. 75:809-817.
5. Despres J-P, Lamarche B, Mauriege P, et al. 1996 Hyperinsulinaemia as an independent risk factor for ischemic heart disease. N Engl J Med. 334:952-957.
6. Stout RW. 1990 Insulin and atheroma. 20-year perspective. Diabetes Care. 13:631-654.
7. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. 1991 Hyperinsulinaemia produces both sympathetic neural activation and vasodilatation in normal human. J Clin. Invest. 87:2246-2252.
8. Bennett NW, Connacher AA, Scrimgeour CM, Jung RT, Rennie MJ. 1990 Euglycaemic hyperinsulinaemia augments amino acid uptake by human tissue during hyperaminoacidemia. Am J Physiol. 259:E185-E194.
9. Laakso M, Edelman SV, Brechtel G, Baron AD. 1990 Decreased effort of insulin to stimulate muscle blood flow in obese man: a novel mechanism for insulin resistance. J Clin Invest. 85:1844-1853.
10. Vollenweider P, Tappy L, Randin D, et al. 1993 Differential effects of hyperinsulinaemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans. J Clin Invest. 92:147-154.
11. Baron A. 1994 Hemodynamic actions of insulin. Am J Physiol. 267:E187-E202.
12. Utriainen TR, Malmstrom S, Makimattila S, Yki-Jarvinen H. 1995 Methodological aspects and dose-response characteristics and causes of inter-individual variation in insulin stimulation of limb blood flow in normal subjects. Diabetologia. 38:555-564.
13. 18F]fluoro-2-deoxy-D-glucose, and positron emission tomography. Diabetes. 45:1471-1477.
14. Utriainen T, Nuutila P, Takala T, et al. 1997 Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus. J Clin Invest. 100:777-785.
15. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. 1994 Insulin mediated skeletal muscle vasodilatation is nitric oxide dependent. J Clin Invest. 94:1172-1179.
16. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P. 1994 Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest. 94:2511-2515.
17. Tack CJ, Lutterman JA, Vervoort G, Thien T, Smits P. 1996 Activation of the sodium-potassium pump contributes to insulin-induced vasodilation in humans. Hypertension. 28:426-432.
18. Natali A, Buzzigoli G, Taddei S, et al. 1990 Haemodynamics and metabolism in human forearm: effects of insulin. Diabetes. 39:490-500.
19. Natali A, Santoro D, Palombo C, Cerri M, Ghione S, Ferrannini E. 1991 Impaired insulin action on skeletal muscle metabolism in essential hypertension. Hypertension. 17:170-178.
20. Sakai K, Imaizumi T, Masaki H, Takeshita A. 1993 Intra-arterial insulin infusion attenuates vasoreactivity in human forearm. Hypertension. 22:67-73.
21. Neahring JM, Stepniakowski K, Greene AS, Egan BM. 1993 Insulin does not reduce forearm α vasoreactivity in obese hypertensive or lean normotensive men. Hypertension. 22:584-590.
22. Tack CJ, Schefman AEP, Willems JL, Thien T, Lutterman JA, Smits P. 1996 Direct vasodilating effects of physiological hyperinsulinemia in human skeletal muscle. Eur J Clin Invest. 26:772-778.
23. Lembo G, Iaccarino G, Rendina V, Massimo V, Trimarco B. 1994 Insulin blunts sympathetic vasoconstriction through the α2-adrenergic pathway in human. Hypertension. 24:429-438.
24. Benjamin N, Calver A, Collier J, Robinson BF, Vallance P, Webb DJ. 1995 Measuring forearm blood flow and interpreting the responses to drugs and mediators. Hypertension. 25:918-923.
25. Matthews JNS, Altman DG, Campbell MJ, Royston P. 1990 Analysis of serial measures in medical research. Br Med J. 300:230-235.
26. Baron AD. 1993 Cardiovascular actions of insulin in humans. Implications for insulin sensitivity and vascular tone. Bailliere Clin Endocrinol Metab. 7:961-987.
27. Yki-Jarvinen H, Young AA, Lamkin C, Foley JE. 1987 Kinetics of glucose disposal in whole body and across the forearm in man. J Clin Invest. 79:1713-1719.
28. 18F]fluoro-deoxy-glucose and positron emission tomography. J Clin Invest. 97:1741-1747.
29. Petrie JR, Ueda S, Morris AD, Elliott HL, Connell JMC. 1998 How reproducible is bilateral forearm venous occlusion plethysmography in man? Br J Clin Pharmacol. 45:131-139
30. Petrie JR, Ueda S, Morris AD, Elliott HL, Connell JMC. 1996 Potential confounding effect of hand-warming in the measurement of insulin sensitivity. Clin Sci. 91:65-71.
31. Graier WF, Wascher TC, Lackener L, Tplak H, Krejs GJ, Kukovetz WR. 1993 Exposure to elevated D-glucose concentrations modulates vascular endothelial cell vasodilatory response. Diabetes. 42:1497-1505.
32. 2+ muscle cells. Circulation. 92:1597-1603.
33. Baron AD, Laakso M, Brechtel G, Edelman SV. 1991 Reduced capacity and affinity of skeletal muscle for insulin mediated glucose uptake in non-insulin dependent diabetic subjects. J Clin Invest. 87:1186-1194.
34. Laakso M, Edelman SV, Brechtel G, Baron AD. 1992 Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes. 41:1076-1083.
35. Dela F, Larsen JJ, Mikines KJ, Galbo H. 1995 Normal effect of insulin to stimulate leg blood flow in NTDDM. Diabetes. 44:221-225.