Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 278, Issue 2 22-2, 2000, Pages

  Boota, Ahmad ^a   Johnson, Bruce ^a   Lee, Kee L ^b   Blaskovich, Michelle A ^a,c   Liu, Shang Xi ^b   Kagan, Valerian E ^b   Hamilton, Andrew ^b   Pitt, Bruce ^a   Sebti, Saïd M ^a,c   Davies, Paul ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Farnesyltransferase; Geranylgeranyltransferase; Interleukin ; Platelet derived growth factor; Ras

Indexed keywords

ANTIOXIDANT; DIMETHYLALLYLTRANSFERASE; DIPHENYLIODONIUM SALT; ENZYME INHIBITOR; INTERLEUKIN 1BETA; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; NITRIC OXIDE; PEROXYNITRITE; PLATELET DERIVED GROWTH FACTOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD VESSEL REACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; IMMUNOBLOTTING; INFLAMMATION; LUNG; NONHUMAN; ONCOGENE H RAS; OXIDATIVE STRESS; PRENYLATION; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0034011189     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2000.278.2.l329     Document Type: Article

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