Development and validation of a recirculatory physiological model of the myocardial concentrations of lignocaine after intravenous administration in sheep

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 2, 2000, Pages 181-189

  Upton, Richard N ^a   Zheng, D A ^a   Grant, Cliff ^a   Martinez, Allison M ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LIDOCAINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TISSUE LEVEL; HEART MUSCLE BLOOD FLOW; LUNG CIRCULATION; NONHUMAN; SHEEP;

EID: 0034007606     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001773832     Document Type: Article

References (31)

1. Audi, S. H., Dawson, C. A., Linehan, J. H., Krenz, G. S., Ahlf, S. B., Roerig, D. L. (1998) Pulmonary disposition of lipophilic amine compounds in the isolated perfused rabbit lung. J. Appl. Physiol. 84: 516-530
2. Benowitz, N., Forsyth, R. P., Melmon, K. L., Rowland, M. (1974) Lidocaine disposition kinetics in monkey and man. 1. Prediction by a perfusion model. Clin. Pharmacol. Ther. 16: 87-98
3. Bertler, A., Lewis, D. H., Lofstrom, J. B., Post, C. (1978) In vivo lung uptake of lidocaine in pigs. Acta Anaesthesiol. Scand. 22: 530-536
4. Chiou, W. L. (1980) Potential effect of early blood sampling schedule on calculated pharmacokinetic parameters of drugs after intravenous administration. J. Pharm. Sci. 69: 867-869
5. Gardner, M. J., Altman, D. G. (1989) Statistics with confidence -confidence intervals and statistical guidelines. Br. Med. J.
6. Grant, C., Lpton, R. N., Kuchel, T. R. (1996) An assessment of the efficacy of intramuscular analgesics for acute pain in the sheep. Aust. Vet. J. 73: 129-132
7. Horowitz, J. D., Dynon, M. K., Woodward, E., Benjamin, S. T., Macdonald, P. S., Morgan, D. J., Goble, A. J., Louis, W. J. (1986) Short-term myocardial uptake of lidocaine and mexiletine in patients with ischemic heart disease. Circulation 5: 987-996
8. Huang, Y. F., Upton, R. N., Mather, L. E., Runciman, W. B. (1991) An assessment of methods for sampling blood to characterise rapidly changing blood drug concentrations. J. Pharm. Sci. 80: 847-851
9. Huang, Y. F., Upton, R. N., Rutten, A. J., Runciman, W. B. (1992) Intravenous holus administration of subconvulsive doses of lignocaine to conscious sheep. Effect on circulatory function. Br. J. Anaesth. 69: 368-374
10. Huang, Y. F., Upton, R. N., Runciman, W. B. (1993a) Intravenous bolus administration of subconvulsive doses of lignocaine to conscious sheep. Relationships between myocardial pharmacokinetics and pharmacodynamics. Br. J. Anaesth. 70: 556-561
11. Huang, Y. F., Upton, R. N., Runciman, W. B. (1993b) Intravenous bolus administration of subconvulsive doses of lignocaine to conscious sheep. Myocardial pharmacokinetics. Br. J. Anaesth. 70: 326-332
12. Huang, Y. F., Upton, R. N., Zheng, D., McLean, C., Gray, E. C., Grant, C. (1998) The enantiomer specific kinetics and dynamics of verapamil after rapid intravenous administration to sheep - physiological analysis and modelling. J. Pharmacol. Exp. Ther. 284: 1048-1057
13. Krejcie, T. C., Henthorn, T. K., Shanks, C. A., Avram, M. J. (1994) A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in the dog. J. Pharmacol. Exp. Ther. 269: 609-616
14. Krejcie, T. C., Avram, M. J., Gentry, W. B., Neimann, C. U., Janowski, M. P., Henthorn, T. K. (1997) A recirculatory pharmacokinetic model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs. J. Pharmacokinet. Biopharm. 25: 169-190
15. Mather, L. E., Runciman, W. B., Carapetis, R. J., Ilsley, A. H., Upton, R., N. (1986) Hepatic and renal clearances of lidocaine in conscious and anesthetized sheep. Anesth. Analg. 65: 943-949
16. Mazoit, J. X., Kantelip, J. P., Orhant, E. E., Talmant, J. M. (1990) Myocardial uptake of lignocaine: pharmacokinetics and pharmacodynamics in the isolated perfused heart of the rabbit. Br. J. Pharmacol. 101: 843-846
17. Mazoit, J. X., Orhant, E. E., Boico, O., Kantelip, J. P., Samii, K. (1993) Myocardial uptake of bupivacaine: I. Pharmacokinetics and pharmacodynamics of lidocaine and bupivacaine in the isolated perfused rabbit heart. Anesth. Analg. 77: 469-476
18. Morgan, D. J., Horowitz, J. D., Louis, W. J. (1989) Prediction of acute myocardial disposition of antiarrythmic drugs. J. Pharm. Sci. 78: 384-388
19. Nancarrow, C., Runciman, W. B., Mather, L. E., Upton, R. N., Plummer, J. L. (1987) The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep. Anesth. Analg. 66: 925-935
20. Ritchie, R. H., Morgan, D. J., Horowitz, J. D. (1998) Myocardial effect compartment modelling of metoprolol and sotalol: importance of myocardial subsite drug concentration. J. Pharm. Sci. 87: 177-182
21. Upton, R. N. (1996) A model of the first pass passage of drugs from their intravenous injection site to the heart - parameter estimates for lignocaine. Br. J. Anaesth. 77: 764-772
22. Upton, R. N., Doolette, D. J. (1999) Kinetic aspects of drug disposition in the lungs. Clin. Pharmacol. Exp. Ther. 26: 381-391
23. Upton, R. N., Huang, Y. F. (1993) The influence of cardiac-output, injection time and injection volume on the initial mixing of drugs with venous blood after i.v. bolus administration to sheep. Br. J. Anaesth. 70: 333-338
24. Upton, R. N., Ludhrook, G. L. (1997) A physiological model of the induction of anaesthesia with propofol in sheep. 1. Structure and estimation of parameters. Br. J. Anaesth. 79: 497-504
25. Upton, R. N., Ludbrook, G. L. (1999) A model of the kinetics and dynamics of the induction of anesthesia in sheep. Parameter estimation for thiopentone and comparison with propofol. Br. J. Anaesth. 82: 890-899
26. Upton, R. N., Runciman, W. B., Mather, L. E., Carapetis, R. J., McLean, C. F. (1988) The uptake and elution of lignocaine and procainamide in the hindquarters of the sheep described using mass balance principles. J. Pharmacokin. Biopharm. 16:31-40
27. Upton, R. N., Huang, Y. F., Grant, C., Gray, E. C., Ludbrook, G. L. (1996) The myocardial pharmacokinetics of thiopental in sheep after short term administration - relationship to thiopental induced reductions in myocardial contractility. J. Pharm. Sci. 85: 863-867
28. Upton, R. N., Huang, Y. F., Mather, L. E., Doolelte, D. J. (1999) The relationship between the myocardial kinetics of meperidine and its effect on myocardial contractility -model independent analysis and optimal regional model. J. Pharmacol. Exp. Ther. 290: 694-701
29. Vaughan, D. P., Tucker, G. T. (1976) General derivation of the ideal intravenous drug input required to achieve and maintain a constant plasma drug concentration. Theoretical application to lignocaine therapy. Eur. J. Clin. Pharmacol. 10: 433-440
30. Vuyk, J., Engbers, F. H. M., Burm, A. G. L., Vletter, A. A., Bovill, J. G. (1995) Performance of computer controlled infusion of propofol: an evaluation of five pharmacokinetic parameter sets. Anesth. Analg. 81: 1275-1282
31. Wada, D. R., Ward, D. S. (1994) The hybrid model: a new pharmacokinetic model for computer-controlled infusion pumps. IEEE Transcripts Biomed. Eng. 41: 134-142