Myocardial pharmacokinetics of thiopental in sheep after short-term administration: Relationship to thiopental-induced reductions in myocardial contractility

Journal of Pharmaceutical Sciences

Volumn 85, Issue 8, 1996, Pages 863-867

  Upton, Richard N ^a   Huang, Yi Fei ^a,b   Grant, Cliff ^a   Gray, Elke C ^a   Ludbrook, Guy L ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

THIOPENTAL;

ANIMAL EXPERIMENT; ARTERIAL BLOOD; ARTICLE; CARDIOVASCULAR EFFECT; COMPARTMENT MODEL; CONTROLLED STUDY; CORONARY SINUS; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; HEART LEFT VENTRICLE DP-DT; HEART MUSCLE BLOOD FLOW; HEART MUSCLE CONTRACTILITY; HYSTERESIS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; SHEEP;

EID: 9444226446     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js950461w     Document Type: Article

References (26)

1. Wood, M. In Drugs and Anesthesia, Pharmacology for Anesthesiologists, 2nd ed.; Wood, M., Wood, A. J. J., Eds.; Williams and Wilkins: Baltimore, 1990; pp 179-223.
2. Davies, A. E.; McCans, J. L. Effect of barbiturate anesthetics and ketamine on the force-frequency relation of cardiac muscle. Eur. J. Pharmacol. 1979, 59, 65-73.
3. Mouren, S.; Baron, J. F.; Albo, C.; Szekely, B.; Arthaud, M.; Viars, P. Effects of propofol and thiopental on coronary blood flow and myocardial performance in an isolated rabbit heart. Anesthesiology 1994, 80, 634-641.
4. Kavanagh, B. P.; Ryan, M. P.; Cunningham, A. J. Myocardial contractility and ischaemia in the isolated perfused rat heart with propofol and thiopental. Can. J. Anaesth. 1991, 38, 634-639.
5. Huang, Y. F.; Upton, R. N.; Rutten, A. J.; Runciman, W. B. Intravenous bolus administration of subconvulsive doses of lignocaine to conscious sheep Effect on circulatory function. Br. J. Anaesth. 1992, 69, 368-374.
6. Runciman, W. B.; Ilsley, A. H.; Mather, L. E.; Carapetis, R. J.; Rao, M. M. A sheep preparation for studying interactions between blood flow and drug disposition I: Physiological profile. Br. J. Anaesth. 1984, 56, 1015-1028.
7. Mason, D. T. Usefulness and limitations of the rate of rise of left ventricular pressure (dp/dt) in the evaluation of myocardial contractility in man. Am. J. Cardiol. 1969, 23, 516-527.
8. Huang, Y. F.; Upton, R. N.; Mather, L. E.; Runciman, W. B. An assessment of methods for sampling blood to characterise rapidly changing blood drug concentrations. J. Pharm. Sci. 1991, 80, 847-851.
9. Upton, R. N.; Mather, L. E.; Runciman, W. B.; Nancarrow, C.; Carapetis, R. J. The use of mass balance principles to describe regional drug distribution and elimination. J. Pharmacokinet. Biopharm. 1988, 16, 13-29.
10. Upton, R. N. An analysis of errors arising from the direct use of mass balance principles to describe regional drug uptake and elution. J. Pharmacokinet. Biopharm. 1994, 22, 309-321.
11. Igari, Y.; Sugiyama, Y.; Awazu, S.; Hanano, M. Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital, and thiopental in the rat. J. Pharmacokinet. Biopharm. 1982, 10, 53-75.
12. Ebling, W. F.; Wada, D. R.; Stanski, D. R. From piecewise to full physiologic modeling: Applied to thiopental disposition in the rat. J. Pharmacokinet. Biopharm. 1994, 22, 259-292.
13. Altman, P. L., Dittmer, D. S., Eds. Biological Handbooks-Respiration and Circulation; Federation of American Societies for Experimental Biology: Bethesda, MD, 1971; pp 383-385.
14. Intaglietta, M.; Johnson, P. C. Principles of capillary exchange. In Peripheral Circulation; Johnson, P. C., Ed.; John Wiley and Sons: New York, 1978; pp 141-166.
15. Sheiner, L. B.; Stanski, D. R.; Vozeh, S.; Miller, R. D.; Ham, J. Simultaneous modelling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin. Pharmacol. Ther. 1979, 25, 358-371.
16. 2 uptake in hypoxia. Respir. Physiol. 1981, 46, 193-208.
17. Huang, Y. F. Myocardial pharmacokinetics and pharmacodynamics in the sheep. Ph.D. Thesis, University of Adelaide, 1991.
18. Runciman, W. B.; Upton, R. N. Pharmacokinetics and pharmacodynamics - what is of value to anaesthetists? Anaesth. Pharmacol. Rev. 1994, 2, 280-293.
19. Grounds, R. M.; Twigley, A. J.; Carli, F.; Whitwam, J. G.; Morgan, M. The haemodynamic effects of intravenous induction. Comparison of the effects of thiopentone and propofol. Anaesthesia 1985, 40, 735-740.
20. Chamberlain, J. H.; Seed, R. G. F. L.; Chung, D. C. W. Effect of thiopental on myocardial function. Br. J. Anaesth. 1977, 49, 865-870.
21. Huang, Y. F.; Upton, R. N.; Runciman, W. B. Intravenous bolus administration of subconvulsive doses of lignocaine to conscious sheep. II. Myocardial pharmacokinetics Br. J. Anaesth. 1993, 70, 326-332.
22. Huang, Y. F.; Upton, R. N.; Rutten, A; Mather, L. E. The myocardial pharmacokinetics of meperidine in conscious sheep Anesth. Analg. 1994, 79, 987-994.
23. Shipley, R. A.; Clark, R. E. Tracer methods for in vivo kinetics. Theory and applications; Academic Press: New York, 1972; pp 1-20.
24. Bischoff, K. B.; Dedrick R. L. Thiopental pharmacokinetics. J. Pharm. Sci. 1968, 57, 1346-1351.
25. Wilkinson, G. R. Plasma and tissue binding considerations in drug disposition. Drug Metab. Rev. 1983, 4, 427-465.
26. Burch, P. G.; Stanski D. R. Decreased protein binding and thiopental kinetics. Clin. Pharmacol. Ther. 1982, 32, 212-217.