A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 25, Issue 2, 1997, Pages 169-190

  Krejcie, Tom C ^a   Avram, Michael J ^a   Gentry, W Brooks ^a   Niemann, Claus U ^a   Janowski, Mary P ^a   Henthorn, Thomas K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antipyrine; Arteriovenous difference; Dogs; Indocyanine green; Lidocaine; Physiologic models; Pulmonary uptake; Tissue distribution

Indexed keywords

INDOCYANINE GREEN; LIDOCAINE; PHENAZONE; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG UPTAKE; HEART RIGHT ATRIUM; HEMATOCRIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRACARDIAC DRUG ADMINISTRATION; LUNG; MALE; MODEL; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TOTAL BODY WATER; VENOUS BLOOD;

EID: 0030670025     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025780012960     Document Type: Article

References (38)

1. C. Post. Studies on the pharmacokinetic function of the lung with special reference to lidocaine. Acta Pharmacol. Toxicol. 44(Suppl. 1):1-53 (1979).
2. R. E. Howell and P. N. Lanken. Pulmonary accumulation of propranolol in vivo: Sites and physiochemical mechanism. J. Pharmacol. Exp. Ther. 263:130-135 (1992).
3. D. L. Roerig, K. J. Kotrly, E. J. Vucins, S. B. Ahlf, C. A. Dawson, and J. P. Kampine. First pass uptake of fentanyl, meperidine, and morphine in the human lung. Anesthesiology 67:466-472 (1987).
4. P. M. Bokesch, A. R. Castaneda, G. Ziemer, and J. M. Wilson. The influence of a right-to-left cardiac shunt on lidocaine pharmacokinetics. Anesthesiology 67:739-744 (1987).
5. C. Post, R. G. Andersson, A. Ryrfeldt, and E. Nilsson. Transport and binding of lidocaine by lung slices and perfused lung of rats. Acta Pharmacol. Toxicol. 43:156-163 (1978).
6. K. Taeger, E. Weninger, F. Schmelzer, M. Adt, N. Franke, and K. Peter. Pulmonary kinetics of fentanyl and alfentanil in surgical patients. Br. J. Anaesth. 61:425-434 (1988).
7. W. L. Chiou. Potential pitfalls in the conventional pharmacokinetic studies: Effects of the initial mixing of drug in blood and the pulmonary first-pass elimination. J. Pharmacokin. Biopharm. 7:527-536 (1979).
8. T. C. Krejcie, T. K. Henthorn, C. A. Shanks, and M. J. Avram. A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in dogs. J. Pharmacol. Exp. Ther. 269:609-616 (1994).
9. Y. F. Huang, R. N. Upton, L. E. Mather, and W. B. Runciman. An assessment of methods for sampling blood to characterize rapidly changing blood drug concentrations. J. Pharm. Sci. 80:847-851 (1991).
10. D. M. Grasela, M. L. Rocci, Jr, and P. H. Vlasses. Experimental impact of assay-dependent differences in plasma indocyanine green concentration determinations. J. Pharmacokin. Biopharm. 15:601-613 (1987).
11. T. K. Henthorn, M. J. Avram, T. C. Krejcie, C. A. Shanks, A. Asada, and D. A. Kaczynski. Minimal compartmental model of circulatory mixing of indocyanine green. Am. J. Physiol. 262:H903-H910 (1992).
12. K. Ahmad and F. Medzihradsky. Distribution of lidocaine in blood and tissue after single doses and steady infusion. Res. Commun. Chem. Pathol. Pharmacol. 2:813-828 (1971).
13. T. C. Krejcie, J. A. Jacquez, M. J. Avram, C. U. Niemann, C. A. Shanks, and T. K. Henthorn. Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs. J. Pharmacokin. Biopharm. 24:569-588 (1996).
14. K. L. Zierler. In W. F. Hamilton (ed.), Handbook of Physiology, Section 2, Circulation, Vol. 1. American Physiological Society, Washington, DC, 1962, pp. 585-615.
15. Y. W. Zhen, S. E. Cross, and M. S. Roberts. Influence of physicochemical parameters and perfusate flow rate on the distribution of solutes in the isolated perfused rat hindlimb determined by the impulse-response technique. J. Pharm. Sci. 84:1020-1027 (1995).
16. B. S. Berman, E. Shahn, and M. J. Weiss. The routine fitting of kinetic data to models: A mathematical formalism for digital computers. Biophys. J. 2:275-287 (1962).
17. S. Siegel. Nonparametric Statistics for the Behavioral Sciences. McGraw-Hill, New York, 1956.
18. P. Caldini, S. Permutt, J. A. Waddell, and R. L. Riley. Effect of epinephrine on pressure, flow, and volume relationships in the systemic circulation of dogs. Circ. Res. 34:606-623 (1974).
19. K. L. Brigham, L. H. Ramsey, J. D. Snell, and C. R. Merritt, III. On defining the pulmonary extravascular water volume. Circ. Res. 29:385-397 (1971).
20. R. M. Effros, G. R. Mason, E. Reid, L. Graham, and P. Silverman. Diffusion of labeled water and lipophilic solutes in the lung. Microvasc. Res. 29:45-55 (1985).
21. C. M. Metzler. In M. Rowland and G. T. Tucker (eds.), International Encyclopedia of Pharmacology and Therapeutics. Section 122, Pharmacokinetics: Theory and Methodology, Pergamon, New York, 1986, pp. 407-420.
22. W. O. Cua, G. Basset, F. Bouchonnet, R. A. Garrick, G. Saumon, and F. P. Chinard. Endothelial and epithelial permeabilities to antipyrine in rat and dog lungs. Am. J. Physiol. 258:H1321-H1333 (1990).
23. L. Jorfeldt, D. H. Lewis, J. B. Lofstrom, and C. Post. Lung uptake of lidocaine in healthy volunteers. Acta Anaesth. Scand. 23:567-574 (1979).
24. W. L. Chiou. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part I). [Review]. Clin. Pharmacokin. 17:175-199 (1989).
25. W. L. Chiou. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part II). [Review]. Clin. Pharmacokin. 17:275-290 (1989).
26. 125I-iodoantipyrine among erythrocytes, plasma, and renal cortex in the dog. Acta Physiol. Scand. 107:63-68 (1979).
27. C. A. Dawson, C. W. Christensen, D. A. Rickaby, J. H. Linehan, and M. R. Johnston. Lung damage and pulmonary uptake of serotonin in intact dogs. J. Appl. Physiol. 58:1761- 1766 (1985).
28. N. Benowitz, R. P. Forsyth, K. L. Melmon, and M. Rowland. Lidocaine disposition kinetics in monkey and man . II. Effects of hemorrhage and sympathomimetic drug administration. Clin. Pharmacol. Ther. 16:99-109 (1974).
29. K. Tanaka, Y. Oda, A. Asada, M. Fujimori, and Y. Funae. Metabolism of lidocaine by rat pulmonary cytochrome P450. Biochem. Pharmacol. 47:1061-1066 (1994).
30. D. L. Roerig, R. R. Dahl, C. A. Dawson, and R. I. Wang. Effect of plasma protein binding on the uptake of methadone and diazepam in the isolated perfused rat lung. Drug Metab. Dispos. 12:536-542 (1984).
31. G. S. Sedek, T. I. Ruo, M. C. Frederiksen, J. W. Frederiksen, S. R. Shih, and A. J. Atkinson, Jr. Splanchnic tissues are a major part of the rapid distribution spaces of inulin, urea and theophylline. J. Pharmacol. Exp. Ther. 251:1026-1031 (1989).
32. D. R. Wada and D. S. Ward. The hybrid model: A new pharmacokinetic model for computer-controlled infusion pumps. IEEE Trans. Biomed. Eng. 41:134-142 (1994).
33. E. M. Renkin. Effects of blood flow on diffusion kinetics in isolated perfused hindlegs of cats. Am. J. Physiol. 183:125-136 (1955).
34. S. Bjorkman, D. R. Wada, D. R. Stanski, and W. F. Ebling. Comparative physiological pharmacokinetics of fentanyl and alfentanil in rats and humans based on parametric single- tissue models. J. Pharmacokin. Biopharm. 22:381-410 (1994).
35. W. F. Ebling, D. R. Wada, and D. R. Stanski. From piecewise to full physiologic pharmacokinetic modeling: applied to thiopental disposition in the rat. J. Pharmacokin. Biopharm. 22:259-292 (1994).
36. T. G. Coleman, R. D. Manning, Jr, R. A. Norman, Jr, and A. C. Guyton. Dynamics of water isotope distribution. Am. J. Physiol. 223:1371-1375 (1972).
37. A. Rescigno and J. S. Beck. The use and abuse of models. J. Pharmacokin. Biopharm. 15:327-344 (1987).
38. T. C. Krejcie, T. K. Henthorn, C. U. Niemann, C. Klein, D. K. Gupta, W. B. Gentry, C. A. Shanks, and M. J. Avram. Recirculatory pharmacokinetic models of markers of blood, extracellular fluid, and total body water administered concomitantly. J. Pharmacol. Exp. Ther. 278:1051-1057 (1996).