The enantiomer-specific kinetics and dynamics of verapamil after rapid intravenous administration to sheep: Physiological analysis and modeling

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 3, 1998, Pages 1048-1057

  Huang, Yi Fei ^a,b   Upton, Richard N ^a   Zheng, Da ^a   Mclean, Colin ^a   Gray, Elke C ^a   Grant, Cliff ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; ENANTIOMER; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; HEART OUTPUT; INTRAVENOUS DRUG ADMINISTRATION; LUNG; NONHUMAN; P WAVE; PHARMACODYNAMICS; PHYSIOLOGY; PRIORITY JOURNAL; R WAVE; RACEMIC MIXTURE; SHEEP;

ANIMALS; CALCIUM CHANNEL BLOCKERS; LUNG; MODELS, BIOLOGICAL; MYOCARDIUM; SHEEP; STEREOISOMERISM; VERAPAMIL;

EID: 6844255207     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Chiba S, Kobayashi M and Furukawa Y (1978) Effects of optical isomers of verapamil on SA nodal pacemaker activity and contractility of the isolated dog heart. Jpn Heart J 19:409-414.
2. Chiou WL (1979) Potential pitfalls in the conventional pharmacokinetic studies: Effects of initial mixing of drug in blood and the pulmonary first pass elimination. J Pharmacokinet Biopharm 7:527-536.
3. Christensen JH, Andreasen F, Jansen JA (1982) Pharmacokinetics and pharmacodynamics of thiopentone. A comparison between young and elderly patients. Anaesthesia 37:398-404.
4. Cohen L, Vereault D, Wasserstrom JA, Retzinger GS and Kezdy FJ (1987 ) Evidence that uncharged verapamil inhibits myocardial contractility. J Pharmacol Exp Ther 242:721-725.
5. Colburn WA, Brazzell RK and Holazo AA (1986) Verapamil pharmacodynamics after intravenous and oral dosing: Theoretic consideration. Clin Pharmacol 26:71-73.
6. Eichelbaum M, Mikus G and Vogelgesang B (1984) Pharmacokinetics of (+)-, (-)-and (±)-verapamil after intravenous administration. Br J Clin Pharmacol 17:453-458.
7. Gloor HO and Urthaler F (1983) Differential effect of verapamil isomers on sinus node and AV junctional region. Am J Physiol 244:H80-H88.
8. Golenhofen K and Lammel E (1972) Selective suppression of some components of spontaneous activity in various types of smooth muscle by iproveratril (Verapamil). Pflugers Arch 331:233-243.
9. Henthorn TK, Krejcie TC and Avram MJ (1992) The relationship between alfentanil distribution kinetics and cardiac output. Clin Pharmacol Ther 52:190-196.
10. Huang YF (1991) Myocardial Pharmacokinetics and Pharmacodynamics in the Sheep. Ph.D. Thesis, University of Adelaide.
11. Huang YF and Upton RN (1993) An estimate of the rate of drug diffusion from the surface of heart and kidney: Implications for representation as compartments. Biopharm Drug Dispos 14:647-658.
12. Huang YF, Upton RN, Mather LE and Runciman WB (1991) An assessment of methods for sampling blood to characterise rapidly changing blood drug concentrations. J Pharm Sci 80:847-851.
13. Huang YF, Upton RN and Runciman WB (1993) Intravenous bolus administration of subconvulsive doses of lignocaine to conscious sheep. Relationships between myocardial pharmacokinetics and pharmacodynamics. Br J Anaesth 70:556-561.
14. Huang YF, Upton RN, Rutten AJ and Runciman WB (1992) Intravenous bolus administration of subconvulsive doses of lignocaine to conscious sheep: Effect on circulatory function. Br J Anaesth 69:368-374.
15. Intaglietta M and Johnson PC (1978) Principles of capillary exchange, in Peripheral Circulation (Johnson PC, ed) pp 141-166, John Wiley and Sons, New York.
16. Jones ME and Nicholas TE (1981) The pharmacokinetics of the intravenous anaesthetic alphaxolone in the isolated perfused rat lung. J Pharmacokinet Biopharm 9:343-355.
17. Kaumann AJ and Serur JR (1975) Optical isomers of verapamil on canine heart. Prevention of ventricular fibrillation induced by coronary artery occlusion, impaired atrioventricular conductance and negative inotropic and chronotropic effects. Naunyn Schmiedebergs Arch Pharmacol 291:347-358.
18. Keefe DL and Kates RE (1982) Myocardial disposition and cardiac pharmacodynamics of verapamil in the dog. J Pharmacol Exp Ther 220:91-96.
19. Krejcie TC, Henthorn TK, Shanks CA and Avram MJ (1994) A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in the dog. J Pharmacol Exp Ther 269:609-616.
20. Laethem ME, Belpaire FM, Wijnant P and Bogaert MG (1995) Stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil: species differences and influence of endotoxin. Chirality 7:616-622.
21. Ludbrook GL and Upton RN (1997) A physiological model of the induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirements. Br J Anaesth 79:505-513.
22. McAllister RG and Kirsten EB (1982) The pharmacology of verapamil. IV Kinetic and dynamic effects after single intravenous and oral doses. Clin Pharmacol Ther 31:418-426.
23. McAllister RG, Bourne DW and Dittert LW (1977) The pharmacology of verapamil. I Elimination kinetics in dogs and correlation of plasma levels with effect on the electrocardiogram. J Pharmacol Exp Ther 202:38-44.
24. Nawrath H and Raschack M (1987) Effects of (-)-desmethoxyverapamil on heart and vascular smooth muscle. J Pharmacol Exp Ther 242:1090-1097.
25. Padrini R, Barbieri E, Piovan D, Toffoli M, Motta A, Trevi G-P and Ferrari M (1985) Plasma levels and myocardial content of verapamil, norverapamil and two N-dealkyl-metabolites in man. Eur J Clin Pharmacol 28:653-657.
26. 2 uptake in hypoxia. Respir Physiol 46:193-208.
27. Powell AC, Horowitz JD, Kertes PJ, Hasin Y, Syrjanen ML, Henry CA, Sartor DM and Louis WJ (1990) Determinants of acute hemodynamic and electrophysiologic effects of verapamil in humans: Role of myocardial drug uptake. J Cardiovasc Pharmacol 16:572-583.
28. Raschack M (1976) Relationship of antiarrhythmic to inotropic activity and antiarrhythmic qualities of the optical isomers of verapamil. Naunyn Schmiedebergs Arch Pharmacol 294:285-291.
29. Roerig DR, Kotrly KJ, Dawson CA, Ahlf SB, Gualtieri JF and Kampine JP (1989) First-pass uptake of verapamil, diazepam, and thiopental in the human lung Anesth Analg 69:461-466.
30. Runciman WB, Ilsley AH, Mather LE, Carapetis RJ and Rao MM (1984) A sheep preparation for studying interactions between blood flow and drug disposition. I: Physiological profile. Br J Anaesth 56:1015-1028.
31. Runciman WB and Upton RN (1994) Pharmacokinetics and pharmacodynamics: What is of value to anaesthetists? Anaesth Pharmacol Rev 2:280-293.
32. Satoh K, Yanagisawa T and Taira N (1979) Effects on atrioventricular conduction and blood flow of enantiomers of verapamil and of tetrodotoxin injected into the posterior and the anterior septal artery of the atrioventricular node preparation of the dog. Naunyn Schmiedegergs Arch Pharmacol 308:89-98.
33. Satoh K, Yanagisawa T and Taira N (1980) Coronary vasodilator and cardiac effects of optical isomers of verapamil in the dog. J Cardiovasc Pharmacol 2:309-318.
34. Schwartz JB, Verotta D and Sheiner LB (1989) Pharmacodynamic modeling of verapamil effects under steady-state and nonsteady-state conditions. J Pharmacol Exp Ther 261:1032-1038.
35. Upton RN (1996) A model of the first pass passage of drugs from their intravenous injection site to the heart: Parameter estimates for lignocaine. Br J Anaesth 77:764-772.
36. Upton RN and Huang YF (1993) The influence of cardiac output, injection time and injection volume on the initial mixing of drugs with venous blood after i. v. bolus administration to sheep. Br J Anaesth 70:333-338.
37. Upton RN, Huang YF, Grant C, Gray EC and Ludbrook GL (1996) The myocardial pharmacokinetics thiopental in sheep after short term administration: Relationship to thiopental induced reductions in myocardial contractility. J Pharm Sci 85:863-867.
38. Upton RN and Ludbrook GL (1997) A physiological model of the induction of anaesthesia with propofol in sheep. 1. Structure and estimation of parameters. Br J Anaesth 79:497-504.
39. Wagner JG (1993) Pharmacokinetics for the Pharmaceutical Scientist, pp 293-298, Technomic Publishing Co., Lancaster,.
40. Watt SJ, Cook LB, Ohri S and Lockwood GG (1996) The relationship between anaesthetic uptake and cardiac output. Anaesthesia 51:24-28.