Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis

Journal of Investigative Dermatology

Volumn 114, Issue 4, 2000, Pages 712-717

  Schaller, Martin ^a,b   Schackert, Carolin ^a   Korting, Hans C ^a   Januschke, Elfriede ^a   Hube, Bernhard ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c NONE

Author keywords

Cutaneous candidiasis; Immunoelectron microscopy; RT PCR

Indexed keywords

ASPARTIC PROTEINASE; GENE PRODUCT; PEPSTATIN;

ARTICLE; CANDIDA ALBICANS; DERMATOMYCOSIS; FUNGUS HYPHAE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; MUCOCUTANEOUS CANDIDIASIS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRATUM CORNEUM; ULTRASTRUCTURE; VIRULENCE;

EID: 0034004415     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00935.x     Document Type: Article

References (31)

1. Borg-von Zepelin M, Beggah S, Boggian K, Sanglard D, Monod M: The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages. Mol Microbiol 28:543-554, 1998
2. Colina AR, Aumont F, Deslauriers N, Belhumeur P, De Repenigny L: Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase. Infect Immun 64:4514-4519, 1996
3. Cutler JE: Putative virulence factors of Candida albicans. Annu Rev Microbiol 45:187-218, 1991
4. De Bernardis F, Cassone A, Sturvetant J, Calderone R: Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis. Infect Immun 63:1887-1892, 1995
5. De Bernardis F, Arancia S, Morelli L, Hube B, Sanglard D, Schäfer W, Cassone A: Evidence that members of secretory aspartyl proteinases gene family, in particular SAP2, are virulence factor for Candida vaginitis. J Infect Dis 179:201-208, 1999
6. Gillum AM, Tsay EYH, Kirsch DR: Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet 198:179-182, 1984
7. Hube B: Candida albricans secreted aspartyl proteinases. Curr Top Med Mycol 7:55-69, 1996
8. Hube B: Possible role of proteinases in Candida infections. Rev Iberoam Micol 15:65-68, 1998
9. Hube B, Monod M, Schofield DA, Brown AJP, Gow NAR: Expression of seven members of the gene family encoding secretory aspartyl proteinase in Candida albicans. Mol Microbiol 14:87-99, 1994
10. Hube B, Sanglard D, Odds FC, et al: Gene disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2 and SAP3 in Candida albicans attenuates virulence. Infect Immun 65:3529-3538, 1997
11. Korting HC, Patzak U, Schaller M, Maibach HI: A model of human cutaneous candidiasis based on reconstructed human epidermis for the light and electron microscopic study of pathogenesis and treatment. J Injection 36:259-267, 1998
12. Korting HC, Schaller M, Eder G, Hamm G, Böhmer U, Hube B: Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on the in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients. Antimicrob Agents Chemother 43:2038-2042, 1999
13. Kretschmar M, Hube B, Bertsch T, Sanglard D, Merker R, Schröder M, Hof H, Nichterlein T: Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis. Infect Immun 67:6637-6642, 1999
14. Luna MA, Tortoledo ME: Histologic identification and pathologic patterns of disease caused by Candida. In: Bodey GP (ed.). Candidiasis Pathogenesis, Diagnosis, and Treatment. New York: Raven Press, 1993, pp 21-42
15. Maneu V, Cervera AM, Martinez JP, Gozalbo D: Molecular cloning and characterization of a Candida albicans gene (EFB1) coding for the elongation factor EF-1β. FEMS Microbiol Letters 145:157-162, 1996
16. Monod M, Togni G, Hube B, Sanglard D: Multiplicity of genes encoding secreted aspartic proteinases in Candida species. Mol Microbiol 13:357-368, 1994
17. Monod M, Togni G, Hube B, Heß D, Sanglard D: Cloning, sequencing and expression of two new members of the secreted aspartyl proteinase family of Candida albicans. Microbiology 144:2731-2737, 1998
18. Naglik J, Newport G, White TC, et al: In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis. Infect Immun 67:2482-2490, 1999
19. Odds FC: Candida and Candidosis, 2nd edn. London: Baillière Tindall, 1988
20. Odds FC: Candida species and virulence. ASM News 60:313-318, 1994
21. Ollert MW, Söhnchen R, Korting HC, Ollert U, Bräutigam S, Bräutigam W: Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes. Infect Immun 61:4560-4568, 1993
22. Rosdy M, Claus LC: Terminal epidermal differentiation of human keratinocytes grown in chemically defined medium on inert filter substrates at the air-liquid interface. J Invest Dermatol 95:409-414, 1990
23. Rosdy M, Pisani A, Ortonne JP: Production of basement membrane components by a reconstructed epidermis in the absence of serum or dermal factors. Br J Dermatol 129:227-234, 1993
24. Sanglard D, Hube B, Monod M, Odds FC, Gow NAR: A triple deletion in SAP4, SAP5 and SAP6 secretory aspartyl proteinase genes of Candida albicans causes attenuated virulence. Inject Immun 65:3539-3546, 1997
25. Schaller M, Schäfer W, Korting HC, Hube B: Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Mol Microbiol 29:605-615, 1998
26. Schaller M, Hube B, Ollert MW, Schäfer W, Borg-von Zepelin M, Thoma-Greber E, Korting HC: In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. J Invest Dermatol 112:383-386, 1999a
27. Schaller M, Preidel H, Korting HC: Light and electron microscopic findings in a model of human cutaneous candidosis based on reconstructed human epidermis upon the topical application of different econazole formulations. J Drug Target 6:361-372, 1999b
28. Schaller M, Korting HC, Schäfer W, Bastert J, Chen WC, Hube B: Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol 34:169-180, 1999c
29. Sohnle PG, Hahn BL: The fate of individual organisms during clearance of experimental cutaneous Candida albicans infections in mice. Acta Derm Venereol (Stockh) 72:241-244, 1992
30. Sohnle PG, Kirkpatrick CH: Epidermal proliferation in the defense against experimental cutaneous candidiasis. J Invest Dermatol 70:130-133, 1978
31. Stringaro A, Crateri P, Pellegrini G, Arancia G, Cassone A, De Bernardis F: Ultrastructural localization of the secretory aspartyl proteinase in Candida albicans cell wall in vitro and in experimentally infected rat vagina. Mycopathologia 137:95-105, 1997