RNA splicing: What has phosphorylation got to do with it?

Current Biology

Volumn 9, Issue 6, 1999, Pages

  Misteli, Tom ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; EUKARYOTA;

EID: 0033602473     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80128-6     Document Type: Note

References (12)

1. Staley JP, Guthrie C: Mechanical devices of the spliceosome: Motors, clocks, springs, and things. Cell 1998, 92:315-326.
2. Hamm J, Lamond AI: The unwinding role of dead-box proteins. Curr Biol 1998, 8:R532-R534.
3. Fu X-D: The superfamily of arginine/serine-rich splicing factors. RNA 1995, 1:663-680.
4. Mermoud JE, Cohen PTW, Lamond AI: Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. Embo J 1994, 13:5679-5688.
5. Wang C, Chua K, Seghezzi W, Lees E, Gozani O, Reed R: Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Genes Dev 1998, 12:1409-1414.
6. Xiao SH, Manley JL: Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev 1997, 11:334-344.
7. Xiao SH, Manley JL: Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. Embo J 1998, 17:6359-6367.
8. Murray MV, Kobayashi R, Krainer AR: The type 2C ser/thr phosphatase PP2Cg is a pre-mRNA splicing factor. Genes Dev 1999, 13:87-97.
9. Horowitz DS, Krainer AR: Mechanisms for selecting 5′ splice sites in mammalian pre-mRNA splicing. Trends Genet 1994, 10:100-106.
10. Duncan PI, Stojdl DF, Marius RM, Bell JC: In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase. Mol Cell Biol 1997, 17:5996-6001.
11. Kanopka A, Mühlemann O, Petersen-Mahrt S, Estmer C, Ohrmalm C, Akusjarvi G: Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins. Nature 1998, 393:185-187.
12. Misteli T, Cáceres JF, Clement JQ, Krainer AR, Wilkinson MF, Spector DL: Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol 1998, 143:297-307.