Inhibition of AMPA receptor-stimulated 57Co2+ influx by D- and L-2-amino-4-phosphonobutanoic acid (D- and L-AP4) and L-serine-O-phosphate (L-SOP) in cultured cerebellar granule cells

Neuropharmacology

Volumn 36, Issue 3, 1997, Pages 335-343

  Toms, N J ^a   Hawkins, L M ^a   Roberts, P J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

AMPA receptor; cobalt; cyclothiazide; L 2 amino 4 phosphonobutanoic acid (L AP4); L serine O phosphate (L SOP); metabotropic glutamate receptor

Indexed keywords

2 (CARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 3,5 DIHYDROXYPHENYLGLYCINE; 5 FLUOROWILLARDIINE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ALPHA CYCLOPROPYL 4 PHOSPHONOPHENYLGLYCINE; AMPA RECEPTOR; BACLOFEN; BUCLADESINE; CALCIUM ION; CARBACHOL; COBALT 57; CYCLIC AMP; CYCLOTHIAZIDE; FORSKOLIN; GLUTAMATE RECEPTOR; KAINIC ACID; METABOTROPIC RECEPTOR; PERTUSSIS TOXIN; PHOSPHOSERINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; GRANULE CELL; ION TRANSPORT; ISOMER; LIGAND BINDING; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; AMINOBUTYRIC ACIDS; ANIMALS; CELLS, CULTURED; CEREBELLUM; COBALT; DOSE-RESPONSE RELATIONSHIP, DRUG; PHOSPHOSERINE; RATS; RATS, WISTAR; RECEPTORS, AMPA; SERINE;

EID: 0030986688     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00012-9     Document Type: Article

References (62)

1. 2+ signal transduction. J. Biol. Chem. 267:1992;13361-13368.
2. Aleppo G., Pisani A., Copani A., Bruno V., Aronica E., D'Agata V., Canonico P.L. and Nicoletti F. (1992) Metabotropic glutamate receptors and neuronal toxicity. In: Neurobiology of Essential Fatty Acids (Bazan N.G., Murphy M.G. and Toffano G. Eds), pp. 137-145. Plenum Press, New York.
3. Aramori I., Nakanishi S. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron. 8:1992;757-765.
4. Bettler B., Mulle C. Review: Neurotransmitter receptors. II. AMPA and kainate receptors Neuropharmacology. 34:1995;123-139.
5. Bleakman D., Rusin K.I., Chard P.S., Glaum S.R., Miller S.R. Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn. Mol. Pharmacol. 42:1992;192-196.
6. Bond A., Lodge D. Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo. Neuropharmacology. 34:1995;1015-1023.
7. Boulter J., Hollmann M., O'Shea-Greenfield A., Hartley M., Deneris E.S., Heinemann S. Molecular cloning and functional expression of glutamate receptor subunit genes. Science. 249:1990;1033-1037.
8. Brorson J.R., Bleakman D., Chard P.S., Miller R.J. Calcium directly permeates kainate/α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in cultured cerebellar Purkinje neurons. Mol. Pharmacol. 41:1992;603-608.
9. Brown B.L., Ekins R.P., Albano J.D.M. A highly sensitive adenylate cyclase assay. Adv. Cyclic Nucl. Res. 2:1972;25-40.
10. Burnashev N., Khodorova A., Jonas P., Helm P.J., Wisden W., Monyer H., Seeburg P.H., Sakmann B. Calcium permeable AMPA-kainate receptors in fusiform cerebellar glial cells. Science. 256:1992;1566-1570.
11. Burnashev N., Monyer H., Seeburg P.H., Sakmann B. Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron. 8:1992;189-198.
12. 2+ uptake in brain neurons. Eur. J. Pharmacol. 290:1995;105-115.
13. Cerne R., Randic M. Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-1-aminocyclopentane-1,3-dicarboxylic acid. Neurosci. Lett. 144:1992;180-184.
14. Condorelli D.F., Dell'Albani P., Aronica E., Genazzani A.A., Casabona G., Corsaro M., Balázs R., Nicoletti F. Growth conditions differentially regulate the expression of α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunits in cultured neurons. J. Neurochem. 61:1993;2133-2139.
15. Courtney M.J., Nicholls D.G. Interactions between phospholipase C-coupled and N-methyl-D-aspartate receptors in cultured cerebellar granule cells: protein kinase C mediated inhibition of N-methyl-D-aspartate responses. J. Neurochem. 59:1992;983-992.
16. Duvoisin R.M., Zhang C., Ramonell K. A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J. Neurosci. 15:1995;3075-3083.
17. 2+ influx into astrocytes. Proc. natn. Acad. Sci. U.S.A. 87:1990;3454-3458.
18. Glaum S.R., Sunter D.C., Udvarhelyi P.M., Watkins J.C., Miller R.J. The actions of phenylglycine derived metabotropic glutamate receptor antagonists on multiple (1S,3R)-ACPD responses in the rat nucleus of the tractus solitarius. Neuropharmacology. 32:1993;1419-1425.
19. Graham M.E., Burgoyne R.D. Activation of metabotropic glutamate receptors by L-AP4 stimulates survival of rat cerebellar granule cells in culture. Eur. J. Pharmacol. Molec. Pharmacol. 288:1994;115-123.
20. 2+ influx studies. J. Neurochem. 65:1995;1077-1084.
21. 3H]-5-fluorowillardiine binding in rat brain. Br. J. Pharmacol. 116:1995;2033-2039.
22. 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science. 252:1991;851-853.
23. Hollmann M., O'Shea-Greenfield A., Rogers S.W., Heinemann S. Cloning by functional expression of a member of the glutamate receptor family. Nature. 342:1989;643-648.
24. Holzwarth J.A., Gibbons S.J., Brorson J.R., Philipson L.H., Miller R.J. Glutamate receptor agonists stimulate calcium responses in different types of cultured rat cortical glial cells. J. Neurosci. 14:1994;1879-1891.
25. Hume R.I., Dingledine R., Heinemann S. Identification of a site in glutamate receptor subunits that controls calcium permeability. Science. 253:1991;1028-1031.
26. Huston E., Cullen G., Sweeney M.I., Pearson H., Fazeli M.S., Dolphin A.C. Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons. Neuroscience. 52:1993;787-798.
27. Iino M., Ozawa S., Tsuzuki K. Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurons. J. Physiol. 424:1990;151-165.
28. Jensen A.M., Chiu S.Y. Differential intracellular calcium responses to glutamate in type 1 and type 2 cultured brain astrocytes. J. Neurosci. 11:1991;1674-1684.
29. 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron. 12:1994;1281-1289.
30. Jones M.W., Headley P.M. Interactions between metabotropic and ionotropic glutamate receptor agonists in the rat spinal cord in vivo. Neuropharmacology. 34:1995;1025-1031.
31. Keinänen K., Wisden W., Sommer B., Werner P., Herb A., Verdoorn T.A., Sakmann B., Seeburg P.H. A family of AMPA-selective glutamate receptors. Science. 249:1990;556-560.
32. Kristensen P., Suzdak P.D., Thomsen C. Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor. Neurosci. Lett. 155:1993;159-162.
33. Mayer M.L., Westbrook G.L. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurons. J. Physiol. 394:1987;501-527.
34. McGurk J.F., Roginski R.S., Zukin R.S., Bennett M.V.L. Divalent ion permeability and pharmacology of cloned kainate/AMPA receptors expressed in oocytes. Soc. Neurosci. Abst. 17:1991;139.4.
35. Moriokamoto J., Okamoto K., Tatsuno J. Intracellular mechanisms underlying the suppression of AMPA responses by trans-ACPD in cultured chick Purkinje neurons. Mol. Cell. Neurosci. 4:1993;375-386.
36. ++ influx into striatal neurons by kainic acid. J. Pharmacol. Exp. Ther. 249:1989;184-193.
37. Nakajima Y., Iwakabe H., Akazawa C., Nawa H., Shigemoto R., Mizuno N., Nakanishi S. Molecular characterization of a novel retinal metabotropic glutamate mGluR6 with a high agonist selectivity for L-2-amino-4-phosphobutyrate. J. Biol. Chem. 268:1993;11868-11873.
38. Nicoletti F., Wroblewski J.T., Fadda E., Costa E. Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells. Neuropharmacology. 27:1988;551-556.
39. Okamoto N., Hori S., Akazawa C., Hayashi Y., Shigemoto R., Mizuno N., Nakanishi S. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to an inhibitory cyclic AMP signal transduction. J. Biol. Chem. 269:1994;1231-1236.
40. Patneau D.K., Mayer M.L., Jane D.E., Watkins J.C. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J. Neurosci. 12:1992;595-606.
41. Pin J.-P., Duvoisin R. Review: Neurotransmitter receptors. I. The metabotropic glutamate receptors: structure and functions Neuropharmacology. 34:1995;1-26.
42. Pizzi M., Fallacara C., Arrighi V., Memo M., Spano P.F. Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells. J. Neurochem. 61:1993;683-689.
43. 2+ concentration and excitoxicity in cultured cerebellar granule cells: pivotal role of protein kinase C. Mol. Pharmacol. 49:1996;586-594.
44. Prézeau L., Carrette J., Helpap B., Curry K., Pin J.-P., Bockaert J. Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures. Mol. Pharmacol. 45:1994;570-577.
45. Pruss R.M., Akeson R.C., Racke M.M., Wilburn J.L. Agonist activated cobalt identifies divalent cation-permeable kainate receptors on neurons and glial cells. Neuron. 7:1991;509-518.
46. Santi M.R., Ikonomovic S., Wroblewski J.T., Grayson D.R. Temporal and depolarization-induced changes in the absolute amounts of mRNAs encoding metabotropic glutamate receptors in cerebellar granule neurones in vitro. J. Neurochem. 63:1994;1207-1217.
47. Saugstad J.A., Kinzie J.M., Mulvihill E.R., Segerson T.P., Westbrook G.L. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. Mol. Pharmacol. 45:1994;367-372.
48. Schoepp D.D., Goldsworthy J., Johnson B.G., Salhoff C.R., Baker S.R. 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat. J. Neurochem. 63:1994;769-772.
49. Sheardown M.J., Nielsen E.Ø, Hansen A.J., Jacobsen P., Honoré T. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline: a neuroprotectant for cerebral ischaemia. Science. 247:1990;571-574.
50. Sorimachi M. Calcium permeability of non-N-methyl-D-aspartate receptor channels in immature cerebellar Purkinje cells: studies using fura-2 microfluorometry. J. Neurochem. 60:1993;1236-1243.
51. Tanabe Y., Nomura A., Masu M., Shigemoto R., Mizuno N., Nakanishi S. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J. Neurosci. 13:1993;1372-1378.
52. Tanabe Y., Nomura A., Masu M., Shigemoto R., Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 8:1992;169-179.
53. Thomas N.K., Jane D.E., Tse H.-W., Watkins J.C. (S)-α-Ethyl-glutamic acid and (RS)-α-cyclopropyl-4-phosphonophenylglycine as antagonists of L-AP4- and (1S,3S)-ACPD-induced depression of monosynpatic excitation of neonatal rat motoneurones. Br. J. Pharmacol. 117:1996;70P.
54. Thomsen C., Kristensen P., Mulvihill E., Haldeman B., Suzdak P.D. L-2-Amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase. Eur. J. Pharmacol. Mol. Pharamacol. 227:1992;361-362.
55. Toms N.J., Jane D.E., Kemp M.C., Bedingfield J.S., Roberts P.J. The effects of (RS)-α-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br. J. Pharmacol. 119:1996;851-854.
56. Toms N.J., Jane D.E., Tse H.-W., Roberts P.J. Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells. Br. J. Pharmacol. 116:1995;2824-2827.
57. Travagli R.A., Ulivi M., Wojcik W.J. γ-Aminobutyric acid-B receptors inhibit glutamate release from cerebellar granule cells: consequences of inhibiting cyclic AMP formation and calcium influx. J. Pharmacol. Exp. Ther. 258:1991;903-909.
58. Turetsky D.M., Buisson A., Choi D.W. The metabotropic glutamate receptor agonist, 4C3HPG, reduces kainate-induced death of cortical neurons expressing calcium-permeable AMPA/kainate receptors. Soc. Neurosci. Abst. 21:1995;529.20.
59. Verdoorn T.A., Burnsahev N., Monyer H., Seeburg P.H., Sakmann B. Structural determinants of ion flow through recombinant glutamate receptor channels. Science. 252:1991;1715-1718.
60. Voss T., Wallner E. An easy cAMP extraction method facilitating adenylyl cyclase assays. Anal. Biochem. 207:1992;40-48.
61. Winegar B.D., Kelly R., Lansman J.B. Block of current through single calcium channels by Fe, Co and Ni. J. Gen. Physiol. 97:1991;351-367.
62. Wong L.A., Mayer M.L., Jane D.E., Watkins J.C. Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. J. Neurosci. 14:1994;3881-3897.