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A decade of work has served to characterize the regulation of this gene as deeply as any. The authors go beyond listing the effects of the individual sites, attempting to lay out what is, in essence, the decision algorithm encoded in the DNA for responding to the more than 15 transcription factors controlling the regulation of this gene
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Heinemeyer T., Chen X., Karas H., Kel A.E., Kel O.V., Liebich I., Meinhardt T., Reuter I., Schacherer F., Wingender E. Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res. 27:1999;318-322. The largest existing collection of known transcription factor binding specificities.
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Clusters of genes derived from expression data are shown to correlate with functional groupings. Transcription factor binding specificities, some old and some new, are derived and shown to be specific to the clusters and near translation starts. This paper also provides an overview of other similar analyses
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Lopez, L.L., Wasserman, W.W., Fickett, J.W.: Muscle-specific regulation of transcription: a catalog of regulatory elements. http://www.cbil.upenn.edu/MTIR/HomePage.html No longer up to date, but still one of the best available collections of data about the regulation of genes in one particular context.
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