메뉴 건너뛰기




Volumn 83, Issue 1-2, 1997, Pages 15-23

Cognitive enhancers in theory and practice: Studies of the cholinergic hypothesis of cognitive deficits in Alzheimer's disease

Author keywords

acetylcholine; Alzheimer's disease; anticholinesterase; attention; dementia; dopamine; hippocampus; memory; noradrenaline; nucleus basalis magnocellularis

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CHOLINERGIC RECEPTOR STIMULATING AGENT; NICOTINE; NOOTROPIC AGENT; PHYSOSTIGMINE; TACRINE;

EID: 0031081092     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(97)86040-8     Document Type: Conference Paper
Times cited : (86)

References (34)
  • 2
    • 0030045515 scopus 로고    scopus 로고
    • The alpha-2 antagonist, idazoxan, remediates certain attenional and executive dysfunction in patients with dementia of frontal type
    • [2] Coull J.T., Sahakian B.J. and Hodges, J.R., The alpha-2 antagonist, idazoxan, remediates certain attenional and executive dysfunction in patients with dementia of frontal type, Psychopharmacology, 123 (1996) 239-249.
    • (1996) Psychopharmacology , vol.123 , pp. 239-249
    • Coull, J.T.1    Sahakian, B.J.2    Hodges, J.R.3
  • 3
    • 0022384940 scopus 로고
    • Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats
    • [3] Dunnett, S.B., Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats, Psychopharmacology, 87 (1985) 357-363.
    • (1985) Psychopharmacology , vol.87 , pp. 357-363
    • Dunnett, S.B.1
  • 4
    • 0025938569 scopus 로고
    • The basal forebrain-cortical cholinergic system. Interpreting the functional consequences of excitotoxic lesions
    • [4] Dunnett, S.B., Everitt, B.J. and Robbins, T.W., The basal forebrain-cortical cholinergic system. Interpreting the functional consequences of excitotoxic lesions, Trends Neurosci., 14 (1991) 494-501.
    • (1991) Trends Neurosci. , vol.14 , pp. 494-501
    • Dunnett, S.B.1    Everitt, B.J.2    Robbins, T.W.3
  • 5
    • 0023628134 scopus 로고
    • Comparative effects of nucleus basalis and fimbria-fornix lesions on delayed matching and alternation tests of memory
    • [5] Etherington, R.E., Mittleman, G. and Robbins T.W., Comparative effects of nucleus basalis and fimbria-fornix lesions on delayed matching and alternation tests of memory, Neurosci. Res. Commun., 1 (1987) 135-143.
    • (1987) Neurosci. Res. Commun. , vol.1 , pp. 135-143
    • Etherington, R.E.1    Mittleman, G.2    Robbins, T.W.3
  • 6
    • 0023241491 scopus 로고
    • The effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on the acquisition and retention of a conditional viual discrimination: Implications for cholinergic hypotheses of learning and memory
    • [6] Everitt, B.J., Robbins, T.W., Evenden, J.L., Marston, H.M., Jones, G.H. and Sirkia, T.E., The effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on the acquisition and retention of a conditional viual discrimination: implications for cholinergic hypotheses of learning and memory, Neurosciece, 22 (1987) 441-469.
    • (1987) Neurosciece , vol.22 , pp. 441-469
    • Everitt, B.J.1    Robbins, T.W.2    Evenden, J.L.3    Marston, H.M.4    Jones, G.H.5    Sirkia, T.E.6
  • 7
    • 0025782928 scopus 로고
    • Cholinergic mechanisms in learning, memory and dementia: A review of recent evidence
    • [7] Fibiger, H.C., Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence, Trends Neurosci, 14 (1991) 973-981.
    • (1991) Trends Neurosci , vol.14 , pp. 973-981
    • Fibiger, H.C.1
  • 8
    • 0026605217 scopus 로고
    • Monkeys (macaco fascicularis) with rhinal cortex ablations succeed in object discrimination learning despite 24 hour intertrial intervals and fail at matching to sample despite double sample presentation
    • [8] Gaffan, D. and Murray, E.A., Monkeys (macaco fascicularis) with rhinal cortex ablations succeed in object discrimination learning despite 24 hour intertrial intervals and fail at matching to sample despite double sample presentation, Behav. Neurosci., 106 (1992) 30-38.
    • (1992) Behav. Neurosci. , vol.106 , pp. 30-38
    • Gaffan, D.1    Murray, E.A.2
  • 9
    • 0001842285 scopus 로고
    • Memory impairment in Alzheimer"s disease: An anatomical perspective
    • R.W. Park,, R.F. Zec and R.P. Wilson (Eds.). Oxford University Press, New York
    • [9] Hyman, B.T., Arriagada, P.V., Van Hoesen, G. and Damasio, A., Memory impairment in Alzheimer"s disease: an anatomical perspective. In R.W. Park,, R.F. Zec and R.P. Wilson (Eds.) Neuropsychology of Alzheimer's Disease and Other Dementias. Oxford University Press, New York, 1993, pp. 138-150.
    • (1993) Neuropsychology of Alzheimer's Disease and Other Dementias , pp. 138-150
    • Hyman, B.T.1    Arriagada, P.V.2    Van Hoesen, G.3    Damasio, A.4
  • 10
    • 0026534848 scopus 로고
    • L-Dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction
    • [10] Lange, K.W., Robbins, T.W., Marsden, C.D., James, M., Owen, A.M. and Paul, G.M., L-Dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction, Psychopharmacology, 107 (1992) 394-404.
    • (1992) Psychopharmacology , vol.107 , pp. 394-404
    • Lange, K.W.1    Robbins, T.W.2    Marsden, C.D.3    James, M.4    Owen, A.M.5    Paul, G.M.6
  • 11
    • 0023740951 scopus 로고    scopus 로고
    • Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats
    • [11] Mandel, R.J. and Thal, L.J., Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats, Psychopharmacology, 96 (1998) 421-425.
    • (1998) Psychopharmacology , vol.96 , pp. 421-425
    • Mandel, R.J.1    Thal, L.J.2
  • 12
    • 0028809331 scopus 로고
    • The effects of AMPA-induced lesions of the septo-hippocampal cholinergic projection on aversive conditioning to explicit and contextual cues and spatial learning in the water maze
    • [12] McAlonan, G.M., Wilkinson, L.S., Robbins, T.W. and Everitt, B.J., The effects of AMPA-induced lesions of the septo-hippocampal cholinergic projection on aversive conditioning to explicit and contextual cues and spatial learning in the water maze, Eur. J. Neurosci., 7 (1995) 281-292.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 281-292
    • McAlonan, G.M.1    Wilkinson, L.S.2    Robbins, T.W.3    Everitt, B.J.4
  • 13
    • 0029023752 scopus 로고
    • The effects of AMPA-induced lesions of the medial septum and vertical limb nucleus of the diagonal band of Broca on spatial delayed matching to sample and spatial learning in the water-maze
    • [13] McAlonan, G.M., Dawson, G.R., Wilkinson, L.O., Robbins, T.W. and Everitt, B.J., The effects of AMPA-induced lesions of the medial septum and vertical limb nucleus of the diagonal band of Broca on spatial delayed matching to sample and spatial learning in the water-maze, Eur. J. Neurosci., 7 (1995) 1034-1049.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1034-1049
    • McAlonan, G.M.1    Dawson, G.R.2    Wilkinson, L.O.3    Robbins, T.W.4    Everitt, B.J.5
  • 14
    • 0026724263 scopus 로고
    • Attentional functions of the forebrain cholinergic systems: Effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task
    • [14] Muir, J.L., Dunnett, S.B., Robbins, T.W. and Everitt, B.J., Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task, Exp. Brain. Res., 89 (1992) 611-622.
    • (1992) Exp. Brain. Res. , vol.89 , pp. 611-622
    • Muir, J.L.1    Dunnett, S.B.2    Robbins, T.W.3    Everitt, B.J.4
  • 15
    • 0028316603 scopus 로고
    • AMPA-induced lesions of the basal forebrain: A significant role for the cortical cholinergic system in attentional function
    • [15] Muir, J.L., Everitt, B.J. and Robbins, T.W., AMPA-induced lesions of the basal forebrain: a significant role for the cortical cholinergic system in attentional function, J. Neurosci., 14 (1994) 2313-2326.
    • (1994) J. Neurosci. , vol.14 , pp. 2313-2326
    • Muir, J.L.1    Everitt, B.J.2    Robbins, T.W.3
  • 16
    • 0029898666 scopus 로고    scopus 로고
    • The cerebral cortex of the rat and visual attentional function: Dissociable effects of mediofrontal, cingulate, anterior dorsolateral and parietal cortex lesions on a 5-choice serial reaction time task
    • [16] Muir, J.L., Everitt, B.J. and Robbins, T.W., The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral and parietal cortex lesions on a 5-choice serial reaction time task, Cerebral Cortex, 6 (1996) 470-481.
    • (1996) Cerebral Cortex , vol.6 , pp. 470-481
    • Muir, J.L.1    Everitt, B.J.2    Robbins, T.W.3
  • 18
    • 0027732875 scopus 로고
    • Excitotoxic lesions of basal forebrain cholinergic neurons: Effects on learning, memory and attention
    • [18] Muir, J.L., Page, K.J. Siranthsinghji, D.J.S., Robbins, T.W. and Everitt, B.J., Excitotoxic lesions of basal forebrain cholinergic neurons: effects on learning, memory and attention, Behav. Brain Res., 57 (1993) 123-131.
    • (1993) Behav. Brain Res. , vol.57 , pp. 123-131
    • Muir, J.L.1    Page, K.J.2    Siranthsinghji, D.J.S.3    Robbins, T.W.4    Everitt, B.J.5
  • 19
    • 0026560355 scopus 로고
    • Disruptive effects of muscimol infused into the basal forebrain on conditional discrimination and visual attention: Differential interactions with cholinergic mechanisms
    • [19] Muir, J.L., Robbins, T.W. and Everitt B.J., Disruptive effects of muscimol infused into the basal forebrain on conditional discrimination and visual attention: differential interactions with cholinergic mechanisms, Psychopharmacology, 107 (1992) 541-550.
    • (1992) Psychopharmacology , vol.107 , pp. 541-550
    • Muir, J.L.1    Robbins, T.W.2    Everitt, B.J.3
  • 20
    • 0002083998 scopus 로고
    • Dementia: Animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system
    • H.Y. Meltzer (Ed.), Raven Press, New York
    • [20] Olton, D.S. and Wenk, G.L., Dementia: animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system. In H.Y. Meltzer (Ed.), Psychopharmacology: The Third Generation of Progress, Raven Press, New York, 1987, pp. 941-953.
    • (1987) Psychopharmacology: The Third Generation of Progress , pp. 941-953
    • Olton, D.S.1    Wenk, G.L.2
  • 22
    • 0025822891 scopus 로고
    • Dissociable effects on spatial water maze and passive avoidance acqusition and retention following AMPA- and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats: Differential dependence on cholinergic neuronal loss
    • [22] Page K.J., Everitt, B.J., Robbins, T.W., Marston, H.M. and Wilkinson, L.S., Dissociable effects on spatial water maze and passive avoidance acqusition and retention following AMPA- and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats: differential dependence on cholinergic neuronal loss, Neuroscience, 43 (1991) 457-472.
    • (1991) Neuroscience , vol.43 , pp. 457-472
    • Page, K.J.1    Everitt, B.J.2    Robbins, T.W.3    Marston, H.M.4    Wilkinson, L.S.5
  • 23
    • 0029022890 scopus 로고
    • The distribution of neurons coexpressing immunoreactivity to AMPA sensitive glutamate receptor subtypes (Glur 1-4) and nerve growth factor receptor in the rat basal forebrain
    • [23] Page, K.J. and Everitt, B.J., The distribution of neurons coexpressing immunoreactivity to AMPA sensitive glutamate receptor subtypes (GluR 1-4) and nerve growth factor receptor in the rat basal forebrain, Eur. J. Neurosci., 7 (1995) 1022-1033.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1022-1033
    • Page, K.J.1    Everitt, B.J.2
  • 24
    • 0029068472 scopus 로고
    • AMPA-induced lesions of the basal forebrain differentially affect cholinergic and non-cholinergic neurons: Lesion assessment using quantitative in situ hybridization histochemistry
    • [24] Page, K.J., Sirinathsinghji, D.J.S. and Everitt, B.J., AMPA-induced lesions of the basal forebrain differentially affect cholinergic and non-cholinergic neurons: lesion assessment using quantitative in situ hybridization histochemistry, Eur. J. Neurosci., 7 (1995) 1012-1021.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1012-1021
    • Page, K.J.1    Sirinathsinghji, D.J.S.2    Everitt, B.J.3
  • 25
    • 0022645755 scopus 로고
    • The cholinergic hypothesis-ten years on
    • [25] Perry E.K., The cholinergic hypothesis-ten years on, Br. Med. Bull., 42 (1986) 63-69.
    • (1986) Br. Med. Bull. , vol.42 , pp. 63-69
    • Perry, E.K.1
  • 26
    • 0001167474 scopus 로고
    • Arousal systems and attention
    • M. Gazzaniga (Ed.), MIT Press, Cambridge, MA
    • [26] Robbins, T.W. and Everitt, B.J., Arousal systems and attention. In M. Gazzaniga (Ed.), The Cognitive Neurosciences, MIT Press, Cambridge, MA, 1995, pp. 903-925.
    • (1995) The Cognitive Neurosciences , pp. 903-925
    • Robbins, T.W.1    Everitt, B.J.2
  • 27
    • 0024355945 scopus 로고
    • Comparative effects of ibotenic acid-and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: Further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes
    • [27] Robbins, T.W., Everitt, B.J., Marston, H.M., Wilkinson, J., Jones, G.H. and Page, K.J., Comparative effects of ibotenic acid-and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes, Behav. Brain Res., 35 (1989) 221-240.
    • (1989) Behav. Brain Res. , vol.35 , pp. 221-240
    • Robbins, T.W.1    Everitt, B.J.2    Marston, H.M.3    Wilkinson, J.4    Jones, G.H.5    Page, K.J.6
  • 28
    • 0024385514 scopus 로고
    • The effects of nicotine on attention, information processing and short-term memory in patients with dementia of the Alzheimer type
    • [28] Sahakian, B.J., Jones G., Levy, R., Gray, J. and Warburton, D., The effects of nicotine on attention, information processing and short-term memory in patients with dementia of the Alzheimer type, Br. J. Psychiatry, 154 (1989) 797-800.
    • (1989) Br. J. Psychiatry , vol.154 , pp. 797-800
    • Sahakian, B.J.1    Jones, G.2    Levy, R.3    Gray, J.4    Warburton, D.5
  • 29
    • 0027526076 scopus 로고
    • Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: Assessment of attentional and mnemonic function using the CANTAB battery
    • [29] Sahakian, B.J. Owen, A.M., Morant N.J., Eagger, S.A., Boddington, S., Crayton, L., Crockford, H.A., Crooks, M., Hill, K. and Levy, R., Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using the CANTAB battery, Psychopharmacology, 110 (1993) 395-401.
    • (1993) Psychopharmacology , vol.110 , pp. 395-401
    • Sahakian, B.J.1    Owen, A.M.2    Morant, N.J.3    Eagger, S.A.4    Boddington, S.5    Crayton, L.6    Crockford, H.A.7    Crooks, M.8    Hill, K.9    Levy, R.10
  • 30
    • 0028006141 scopus 로고
    • Selective enhancement of executive function by idazoxan in a patient with dementia of the frontal type
    • [30] Sahakian, B.J., Coull, J. and Hodges, J.R., Selective enhancement of executive function by idazoxan in a patient with dementia of the frontal type, J. Neurol., Neurosurg. Psychiatry, 57 (1994) 120-121.
    • (1994) J. Neurol., Neurosurg. Psychiatry , vol.57 , pp. 120-121
    • Sahakian, B.J.1    Coull, J.2    Hodges, J.R.3
  • 31
    • 0025232365 scopus 로고
    • Activating the damaged basal forebrain cholinergic system: Tonic stimulation versus signal amplification
    • [31] Sarter, M., Bruno, J.P. and Dudchenko, P., Activating the damaged basal forebrain cholinergic system: tonic stimulation versus signal amplification, Psychopharmacology, 101 (1990) 1-17.
    • (1990) Psychopharmacology , vol.101 , pp. 1-17
    • Sarter, M.1    Bruno, J.P.2    Dudchenko, P.3
  • 32
    • 0023025132 scopus 로고
    • Frontal lobe dysfunction in Parkinson's disease
    • [32] Taylor, A.E., Saint-Cyr, J.A. and Lang A.E., Frontal lobe dysfunction in Parkinson's disease, Brain, 109 (1986) 845-883.
    • (1986) Brain , vol.109 , pp. 845-883
    • Taylor, A.E.1    Saint-Cyr, J.A.2    Lang, A.E.3
  • 33
    • 0028069391 scopus 로고
    • Basal forebrain lesions in monkeys disrupt attention but not learning and memory
    • [33] Voytko, M.L., Olton, D.S., Richardson, R.T., Gorman, L.K. and Robin, J.R., Basal forebrain lesions in monkeys disrupt attention but not learning and memory, J. Neurosci., 14 (1994) 167-186.
    • (1994) J. Neurosci. , vol.14 , pp. 167-186
    • Voytko, M.L.1    Olton, D.S.2    Richardson, R.T.3    Gorman, L.K.4    Robin, J.R.5
  • 34
    • 0024803782 scopus 로고
    • Presynaptic modulation of transmitter release by nicotine receptors
    • A. Nordberg, A.K. Fuxe, B. Holmstedt and A. Sundwall (Eds.), Elsevier, Amsterdam
    • [34] Wonnacott, S. Irons, J. Rapier, C., Thorne, B. and Lunt, G.G., Presynaptic modulation of transmitter release by nicotine receptors. In A. Nordberg, A.K. Fuxe, B. Holmstedt and A. Sundwall (Eds.), Progress in Brain Research, Elsevier, Amsterdam, 1989, pp. 157-163.
    • (1989) Progress in Brain Research , pp. 157-163
    • Wonnacott, S.1    Irons, J.2    Rapier, C.3    Thorne, B.4    Lunt, G.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.