메뉴 건너뛰기




Volumn 14, Issue 1, 2000, Pages 145-156

Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice

Author keywords

Aging; Biomarker; Glucose; Maillard reaction; Oxidation

Indexed keywords

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; COLLAGEN SYNTHESIS; DIABETES MELLITUS; GLYCATION; GLYCOGEN METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0033963077     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.1.145     Document Type: Article
Times cited : (88)

References (58)
  • 1
    • 0000353211 scopus 로고
    • Aging of long-lived proteins: Extracellular matrix (collagens, elastins, proteoglycans) and lens crystallins
    • (Masoro, E. J., ed) Oxford University Press, New York
    • Sell, D. R., and Monnier, V. M. (1995) Aging of long-lived proteins: extracellular matrix (collagens, elastins, proteoglycans) and lens crystallins. In Physiology of Aging (Masoro, E. J., ed) pp. 235-305, Oxford University Press, New York
    • (1995) Physiology of Aging , pp. 235-305
    • Sell, D.R.1    Monnier, V.M.2
  • 2
    • 0022339852 scopus 로고
    • Hypothesis: Glucose as a mediator of aging
    • Cerami, A. (1985) Hypothesis: glucose as a mediator of aging. J. Am. Geriat. Soc. 33, 624-626
    • (1985) J. Am. Geriat. Soc. , vol.33 , pp. 624-626
    • Cerami, A.1
  • 3
    • 0029842574 scopus 로고    scopus 로고
    • Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats
    • Barzilai, N., and Rossetti, L. (1996) Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats. Am. J. Physiol. 270, E930-E936
    • (1996) Am. J. Physiol. , vol.270
    • Barzilai, N.1    Rossetti, L.2
  • 6
    • 0030965798 scopus 로고    scopus 로고
    • Ageing promotes the increase of early glycation Amadori product as assessed by ε-N-(2-furoylmethyl)-L-lysine (furosine) levels in rodent skin collagen. The relationship to dietary restriction and glycoxidation
    • Sell, D. R. (1997) Ageing promotes the increase of early glycation Amadori product as assessed by ε-N-(2-furoylmethyl)-L-lysine (furosine) levels in rodent skin collagen. The relationship to dietary restriction and glycoxidation. Mech. Ageing Dev. 95, 81-99
    • (1997) Mech. Ageing Dev. , vol.95 , pp. 81-99
    • Sell, D.R.1
  • 7
    • 0030801171 scopus 로고    scopus 로고
    • Age-related association of tail tendon break time with tissue pentosidine in DBA/2 vs. C57BL/6 mice: The effect of dietary restriction
    • Sell, D. R., and Monnier, V. M. (1997) Age-related association of tail tendon break time with tissue pentosidine in DBA/2 vs. C57BL/6 mice: The effect of dietary restriction. J. Gerontol. Biol. Sci. 52A, B277-B284
    • (1997) J. Gerontol. Biol. Sci. , vol.52 A
    • Sell, D.R.1    Monnier, V.M.2
  • 8
    • 0001930917 scopus 로고    scopus 로고
    • Animal models for aging research
    • (Schneider, E. L., and Rowe, J. W., eds) Academic Press, New York
    • Sprott, R., and Austad, S. N. (1996) Animal models for aging research. In Handbook of the Biology of Aging (Schneider, E. L., and Rowe, J. W., eds) pp. 3-23, Academic Press, New York
    • (1996) Handbook of the Biology of Aging , pp. 3-23
    • Sprott, R.1    Austad, S.N.2
  • 9
    • 0024242627 scopus 로고
    • Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats
    • Kalant, N., Stewart, J., and Kaplan, R. (1988) Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats. Mech. Ageing Dev. 46, 89-104
    • (1988) Mech. Ageing Dev. , vol.46 , pp. 89-104
    • Kalant, N.1    Stewart, J.2    Kaplan, R.3
  • 12
    • 0029143129 scopus 로고
    • Long-term dietary restriction in older-aged rhesus monkeys: Effects on insulin resistance
    • Bodkin, N. L., Ortmeyer, H. K., and Hansen, B. C. (1995) Long-term dietary restriction in older-aged rhesus monkeys: effects on insulin resistance. J. Gerontol. Biol. Sci. 50A, B142-B147
    • (1995) J. Gerontol. Biol. Sci. , vol.50 A
    • Bodkin, N.L.1    Ortmeyer, H.K.2    Hansen, B.C.3
  • 13
    • 0029108666 scopus 로고
    • Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points
    • Lane, M. A., Ball, S. S, Ingram, D. K., Cutler, R. G., Engel, J., Read, V., and Roth, G. S. (1995) Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points. Am. J. Physiol. 268, E941-E948
    • (1995) Am. J. Physiol. , vol.268
    • Lane, M.A.1    Ball, S.S.2    Ingram, D.K.3    Cutler, R.G.4    Engel, J.5    Read, V.6    Roth, G.S.7
  • 15
    • 0031692758 scopus 로고    scopus 로고
    • Long-term fructose consumption accelerates glycation and several age-related variables in male rats
    • Levi, B., and Werman, M. J. (1998) Long-term fructose consumption accelerates glycation and several age-related variables in male rats. J. Nutr. 128, 1442-1449
    • (1998) J. Nutr. , vol.128 , pp. 1442-1449
    • Levi, B.1    Werman, M.J.2
  • 16
    • 0029080591 scopus 로고
    • Source of dietary carbohydrate affects life span of Fischer 344 rats independent of caloric restriction
    • Murtagh-Mark, C. M., Reiser, K. M., Harris, R., and McDonald, B. B. (1995) Source of dietary carbohydrate affects life span of Fischer 344 rats independent of caloric restriction. J. Gerontol. Biol. Sci. 50A, B148-B154
    • (1995) J. Gerontol. Biol. Sci. , vol.50 A
    • Murtagh-Mark, C.M.1    Reiser, K.M.2    Harris, R.3    McDonald, B.B.4
  • 19
    • 0030948134 scopus 로고    scopus 로고
    • Biomarkers of age and aging
    • McClearn, G. G. (1997) Biomarkers of age and aging. Exp. Gerontol. 32, 87-94
    • (1997) Exp. Gerontol. , vol.32 , pp. 87-94
    • McClearn, G.G.1
  • 20
    • 0031031497 scopus 로고    scopus 로고
    • Candidate biomarkers of aging: Age-sensitive indices of immune and muscle function covary in genetically heterogeneous mice
    • Miller, R. A., Bookstein, F., Van der Meulen, J., Engle, S., Kim, J., Mullins, L., and Faulkner, J. (1997) Candidate biomarkers of aging: age-sensitive indices of immune and muscle function covary in genetically heterogeneous mice. J. Gerontol. Biol. Sci. 52A, B39-B47
    • (1997) J. Gerontol. Biol. Sci. , vol.52 A
    • Miller, R.A.1    Bookstein, F.2    Van Der Meulen, J.3    Engle, S.4    Kim, J.5    Mullins, L.6    Faulkner, J.7
  • 21
    • 0025223406 scopus 로고
    • Biomarkers of aging: Do we know what to look for?
    • Mooradian, A. D. (1990) Biomarkers of aging: do we know what to look for? J. Gerontol. Biol. Sci. 45, B183-B186
    • (1990) J. Gerontol. Biol. Sci. , vol.45
    • Mooradian, A.D.1
  • 23
    • 0001787362 scopus 로고
    • Pathological endpoints in dietary restricted rodents - Fischer 344 rats and B6C3F1 mice
    • (Fishbein, L., ed) Springer-Verlag, New York
    • Witt, W. M., Sheldon, W. G. and Thurman, J. D. (1991) Pathological endpoints in dietary restricted rodents - Fischer 344 rats and B6C3F1 mice. In Biological Effects of Dietary Restriction (Fishbein, L., ed) pp. 73-86, Springer-Verlag, New York
    • (1991) Biological Effects of Dietary Restriction , pp. 73-86
    • Witt, W.M.1    Sheldon, W.G.2    Thurman, J.D.3
  • 24
    • 3643102573 scopus 로고    scopus 로고
    • The use of nutrition to implement refinement in animal bioassays
    • March Issue
    • Hart, R. W., Hass, B. S., Turturro, A., and Lewis, S. M. (1996) The use of nutrition to implement refinement in animal bioassays. Lab Animal (March Issue) 29-34
    • (1996) Lab Animal , pp. 29-34
    • Hart, R.W.1    Hass, B.S.2    Turturro, A.3    Lewis, S.M.4
  • 26
    • 0028934990 scopus 로고
    • Mechanism of protein modification by glyoxal and glycolaldehyde, reactive intermediates of the Maillard reaction
    • Glomb, M. A., and Monnier, V. M. (1995) Mechanism of protein modification by glyoxal and glycolaldehyde, reactive intermediates of the Maillard reaction. J. Biol. Chem. 270, 10017-10026
    • (1995) J. Biol. Chem. , vol.270 , pp. 10017-10026
    • Glomb, M.A.1    Monnier, V.M.2
  • 27
    • 0025939381 scopus 로고
    • Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus
    • Lyons, T. J., Bailie, K. E., Dyer, D. G., Dunn, J. A., and Baynes, J. W. (1991) Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus. J. Clin. Invest. 87, 1910-1915
    • (1991) J. Clin. Invest. , vol.87 , pp. 1910-1915
    • Lyons, T.J.1    Bailie, K.E.2    Dyer, D.G.3    Dunn, J.A.4    Baynes, J.W.5
  • 28
    • 0030941484 scopus 로고    scopus 로고
    • Diet and calorie restriction
    • Sprott, R. L. (1997) Diet and calorie restriction. Exp. Gerontol. 32, 205-214
    • (1997) Exp. Gerontol. , vol.32 , pp. 205-214
    • Sprott, R.L.1
  • 29
    • 0030866161 scopus 로고    scopus 로고
    • Age-dependent increase in orthotyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes
    • Wells-Knecht, M. C., Lyons, T. J., McCance, D. R., Thorpe, S. R., and Baynes, J. W. (1997) Age-dependent increase in orthotyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. J. Clin. Invest. 100, 839-856
    • (1997) J. Clin. Invest. , vol.100 , pp. 839-856
    • Wells-Knecht, M.C.1    Lyons, T.J.2    McCance, D.R.3    Thorpe, S.R.4    Baynes, J.W.5
  • 30
    • 0020044308 scopus 로고
    • Dietary restriction in mice beginning at one year of age: Effect on life-span and spontaneous cancer incidence
    • Weindruch, R., and Walford, R. L. (1982) Dietary restriction in mice beginning at one year of age: effect on life-span and spontaneous cancer incidence. Science 215, 1415-1418
    • (1982) Science , vol.215 , pp. 1415-1418
    • Weindruch, R.1    Walford, R.L.2
  • 31
    • 0025841730 scopus 로고
    • Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice
    • Bronson, R. T., and Lipman, R. D. (1991) Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice. Growth Dev. Aging 55, 169-184
    • (1991) Growth Dev. Aging , vol.55 , pp. 169-184
    • Bronson, R.T.1    Lipman, R.D.2
  • 32
    • 0026673110 scopus 로고
    • Dietary alteration in the rates of cancer and aging
    • Turturro, A., and Hart, R. (1992) Dietary alteration in the rates of cancer and aging. Exp. Gerontol. 27, 583-592
    • (1992) Exp. Gerontol. , vol.27 , pp. 583-592
    • Turturro, A.1    Hart, R.2
  • 33
    • 0027282957 scopus 로고
    • Dietary restriction and aging
    • Masoro, E. J. (1993) Dietary restriction and aging. J. Am. Geriatr. Soc. 41, 994-999
    • (1993) J. Am. Geriatr. Soc. , vol.41 , pp. 994-999
    • Masoro, E.J.1
  • 34
    • 0023203008 scopus 로고
    • Factors associated with glucose tolerance in adults in the United States
    • Harlan, Y. C., Harlan, W. R., Landis, J. R., and Goldstein, N. G. (1987) Factors associated with glucose tolerance in adults in the United States. Am. J. Epidemiol. 126, 674-684
    • (1987) Am. J. Epidemiol. , vol.126 , pp. 674-684
    • Harlan, Y.C.1    Harlan, W.R.2    Landis, J.R.3    Goldstein, N.G.4
  • 35
    • 0028969233 scopus 로고
    • Subgroup analyses of the major clinical endpoints in the program on the surgical control of the hyperlipidemias (POSCH): Overall mortality, atherosclerotic coronary heart disease (ACHD), and ACHD mortality or myocardial infarction
    • Matts, J. P., Buchwald, H., Fitch, L. L., Campos, C. T., Varco, R. L., Campbell, G. S., Pearce, M. B., Yellin, A. E., Smink, R. D., Jr., Sawin, H. S., Jr., and Long, J. M. (1995) Subgroup analyses of the major clinical endpoints in the program on the surgical control of the hyperlipidemias (POSCH): Overall mortality, atherosclerotic coronary heart disease (ACHD), and ACHD mortality or myocardial infarction. J. Clin. Epidermiol. 48, 389-405
    • (1995) J. Clin. Epidermiol. , vol.48 , pp. 389-405
    • Matts, J.P.1    Buchwald, H.2    Fitch, L.L.3    Campos, C.T.4    Varco, R.L.5    Campbell, G.S.6    Pearce, M.B.7    Yellin, A.E.8    Smink R.D., Jr.9    Sawin H.S., Jr.10    Long, J.M.11
  • 36
    • 0033101684 scopus 로고    scopus 로고
    • Relationship of glucose and insulin levels to the risk of myocardial infarction: A case-control study
    • Gerstein, H. C., Pais, P., Pogue, J., and Yusuf, S. (1999) Relationship of glucose and insulin levels to the risk of myocardial infarction: A case-control study. J. Am. Coll. Cardiol. 33, 612-619
    • (1999) J. Am. Coll. Cardiol. , vol.33 , pp. 612-619
    • Gerstein, H.C.1    Pais, P.2    Pogue, J.3    Yusuf, S.4
  • 37
    • 0002695343 scopus 로고
    • Nonenzymatic glycosylation and browning of proteins in vivo
    • Monnier, V. M., and Cerami, A. (1983) Nonenzymatic glycosylation and browning of proteins in vivo. Am. Chem. Soc. 215, 431-449
    • (1983) Am. Chem. Soc. , vol.215 , pp. 431-449
    • Monnier, V.M.1    Cerami, A.2
  • 38
    • 0024376778 scopus 로고
    • Toward a Maillard reaction theory of aging
    • (Baynes, J. W., and Monnier, V. M., eds) Alan R. Liss, New York
    • Monnier, V. M. (1989) Toward a Maillard reaction theory of aging. In The Maillard Reaction in Aging, Diabetes, and Nutrition (Baynes, J. W., and Monnier, V. M., eds) pp. 1-22, Alan R. Liss, New York
    • (1989) The Maillard Reaction in Aging, Diabetes, and Nutrition , pp. 1-22
    • Monnier, V.M.1
  • 39
    • 0027174144 scopus 로고
    • Relationship between glycemic control and collagen-linked advanced glycosylation end products in Type I diabetes
    • Beisswenger, P. J., Moore, L. L., and Curphey, T. J. (1993) Relationship between glycemic control and collagen-linked advanced glycosylation end products in Type I diabetes. Diabetes Care. 16, 689-694
    • (1993) Diabetes Care , vol.16 , pp. 689-694
    • Beisswenger, P.J.1    Moore, L.L.2    Curphey, T.J.3
  • 42
    • 0024246725 scopus 로고
    • Methods for assaying nonenzymatic glycosylation
    • Furth, A. J. (1988) Methods for assaying nonenzymatic glycosylation. Anal. Biochem. 175, 347-360
    • (1988) Anal. Biochem. , vol.175 , pp. 347-360
    • Furth, A.J.1
  • 43
    • 0028223128 scopus 로고
    • Glycation, glycoxidation and crosslinking of collagen by glucose: Kinetics, mechanisms and inhibition of late stages of the Maillard reaction
    • Fu, M.-X., Wells-Knecht, K. J., Blackledge, J. A., Lyons, T. J., Thorpe, S. R., and Baynes, J. W. (1994) Glycation, glycoxidation and crosslinking of collagen by glucose: kinetics, mechanisms and inhibition of late stages of the Maillard reaction. Diabetes 43, 676-683
    • (1994) Diabetes , vol.43 , pp. 676-683
    • Fu, M.-X.1    Wells-Knecht, K.J.2    Blackledge, J.A.3    Lyons, T.J.4    Thorpe, S.R.5    Baynes, J.W.6
  • 44
    • 0030854261 scopus 로고    scopus 로고
    • Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha, beta-unsaturated aldehydes by phagocytes at sites of inflammation
    • Anderson, M. M., Hazen, S. L., Hsu, F. F., and Heinecke, J. W. (1997) Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha, beta-unsaturated aldehydes by phagocytes at sites of inflammation. J. Clin. Invest. 99, 424-432
    • (1997) J. Clin. Invest. , vol.99 , pp. 424-432
    • Anderson, M.M.1    Hazen, S.L.2    Hsu, F.F.3    Heinecke, J.W.4
  • 47
    • 0029901345 scopus 로고    scopus 로고
    • Insulin exposure controls the rate of mammalian aging
    • Parr, T. (1996) Insulin exposure controls the rate of mammalian aging. Mech. Ageing Dev. 88, 75-82
    • (1996) Mech. Ageing Dev. , vol.88 , pp. 75-82
    • Parr, T.1
  • 48
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans
    • Kimura, K. D., Tissenbaum, H. A., Liu, Y., and Ruvkun, G. (1997) Daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans. Science 277, 942-946
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 49
    • 0032573178 scopus 로고    scopus 로고
    • The genetics of caloric restriction in C. elegans
    • Lakowski, B., and Hekimi, S. (1998) The genetics of caloric restriction in C. elegans. Proc. Natl. Acad. Sci. USA 95, 13091-13096
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13091-13096
    • Lakowski, B.1    Hekimi, S.2
  • 50
    • 0015953733 scopus 로고
    • Enlarged seminal vesicles of senescent C57BL/6J mice
    • Finch, C. E., and Girgis, F. G. (1974) Enlarged seminal vesicles of senescent C57BL/6J mice. J. Gerontol. Biol. Sci. 29, 134-138
    • (1974) J. Gerontol. Biol. Sci. , vol.29 , pp. 134-138
    • Finch, C.E.1    Girgis, F.G.2
  • 51
    • 0023920877 scopus 로고
    • Paternal age and its effects on reproduction in C57BL/6NNia mice
    • Parkening, T. A., Collins, T. J., and Au, W. W. (1988) Paternal age and its effects on reproduction in C57BL/6NNia mice. J. Gerontol. Biol Sci. 43, B79-B84
    • (1988) J. Gerontol. Biol Sci. , vol.43
    • Parkening, T.A.1    Collins, T.J.2    Au, W.W.3
  • 52
    • 0343666995 scopus 로고
    • An idiopathic dermatitis in C57BL/6N mice effectively modulated by dietary restriction
    • Witt, W. M. (1989) An idiopathic dermatitis in C57BL/6N mice effectively modulated by dietary restriction. Lab Anim. Sci. 39, 470
    • (1989) Lab Anim. Sci. , vol.39 , pp. 470
    • Witt, W.M.1
  • 53
    • 0028432736 scopus 로고
    • Immune complex vasculitis with secondary ulcerative dermatitis in aged C57BL/ 6NNia mice
    • Andrews, A. G., Dysko, R. C., Spilman, S. C., Kunkel, R. G., Brammer, D. W., and Johnson, K. J. (1994) Immune complex vasculitis with secondary ulcerative dermatitis in aged C57BL/ 6NNia mice. Vet. Pathol. 31, 293-300
    • (1994) Vet. Pathol. , vol.31 , pp. 293-300
    • Andrews, A.G.1    Dysko, R.C.2    Spilman, S.C.3    Kunkel, R.G.4    Brammer, D.W.5    Johnson, K.J.6
  • 54
    • 0031926761 scopus 로고    scopus 로고
    • Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice
    • Perkins, S. N., Hursting, S. D., Phang, J. M., and Haines, D. C. (1998) Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice. J. Invest. Dermatol. 111, 292-296
    • (1998) J. Invest. Dermatol. , vol.111 , pp. 292-296
    • Perkins, S.N.1    Hursting, S.D.2    Phang, J.M.3    Haines, D.C.4
  • 55
    • 0025978339 scopus 로고
    • The effects of alternating dietary restriction and ad libitum feeding of mice on the development of diethylnitrosamine-induced liver tumors and its correlation to insulinaemia
    • Lagopoulos, L., Sunahara, G. I., Würzner, H., Dombrowsky, I., and Stalder, R. (1991) The effects of alternating dietary restriction and ad libitum feeding of mice on the development of diethylnitrosamine-induced liver tumors and its correlation to insulinaemia. Carcinogenesis 12, 311-315
    • (1991) Carcinogenesis , vol.12 , pp. 311-315
    • Lagopoulos, L.1    Sunahara, G.I.2    Würzner, H.3    Dombrowsky, I.4    Stalder, R.5
  • 56
    • 0025323817 scopus 로고
    • Expression of the trk proto- oncogene is restricted to the sensory-cranial and spinal ganglia of neural crest origin in mouse development
    • Martin-Zanca, D., Barbacid, M., and Parada, L. T. (1990) Expression of the trk proto- oncogene is restricted to the sensory-cranial and spinal ganglia of neural crest origin in mouse development. Genes Dev. 4, 683-694
    • (1990) Genes Dev. , vol.4 , pp. 683-694
    • Martin-Zanca, D.1    Barbacid, M.2    Parada, L.T.3
  • 57
    • 0029811059 scopus 로고    scopus 로고
    • Alterations in enzymatic functions in hepatocytes and hepatocellular carcinomas from Ras-transduced livers resemble the effects of insulin
    • Pearline, R. V., Lin, Y.-Z., Shen, K. J., Brunt, E. M., Bowling, W. M., Hafenrichter, D. G., Kennedy, S., Flye, M. W., and Ponder, K. P. (1996) Alterations in enzymatic functions in hepatocytes and hepatocellular carcinomas from Ras-transduced livers resemble the effects of insulin. Hepatology 24, 838-848
    • (1996) Hepatology , vol.24 , pp. 838-848
    • Pearline, R.V.1    Lin, Y.-Z.2    Shen, K.J.3    Brunt, E.M.4    Bowling, W.M.5    Hafenrichter, D.G.6    Kennedy, S.7    Flye, M.W.8    Ponder, K.P.9
  • 58
    • 0031008896 scopus 로고    scopus 로고
    • ALK, the chromosome 2 gene locus altered by the t(2;5)in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
    • Morris, S. W., Naeve, C., Mathew, P., James, P. L., Kirstein, M. N., Cui, X., and Witte, D. P. (1997) ALK, the chromosome 2 gene locus altered by the t(2;5)in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14, 2175-2188
    • (1997) Oncogene , vol.14 , pp. 2175-2188
    • Morris, S.W.1    Naeve, C.2    Mathew, P.3    James, P.L.4    Kirstein, M.N.5    Cui, X.6    Witte, D.P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.