Peptide fragments of β-amyloid precursor protein: Effects on parallel Fiber-Purkinje cell synaptic transmission in rat cerebellum

Journal of Neurochemistry

Volumn 74, Issue 3, 2000, Pages 1112-1121

  Hartell, Nick A ^a   Suh, Y H ^b  

^a ASTON UNIVERSITY   (United Kingdom)

^b Seoul National University   (South Korea)

Author keywords

Alzheimer's disease; Calcium; Carboxy terminal fragment (CT105); Cerebellum; Purkinje cell; Amyloid precursor protein

Indexed keywords

AMPA RECEPTOR; AMYLOID PRECURSOR PROTEIN; CALCIUM; NITRIC OXIDE SYNTHASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CEREBELLUM; ENZYME INHIBITION; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT; SYNAPTIC TRANSMISSION;

ANIMALIA;

EID: 0033962593     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.741112.x     Document Type: Article

References (64)

1. Beeson J. G., Shelton E. R., Chan H. W., and Gage F. H. (1994) Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using 5 different antibodies. J. Comp. Neurol. 342, 78-96.
2. Benowitz L. I., Rodriguez W., Paskevich P., Mufson E. J., Schenk D., and Neve R. L. (1989) The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp. Neurol. 106, 237-250.
3. Bhakdi S. and Tranumjensen J. (1987) Damage to mammalian cells by proteins that form transmembrane pores. Rev. Physiol. Biochem. Pharmacol. 107, 147-223.
4. Blond O., Daniel H., Otani S., Jaillard D., and Crepel F. (1997) Presynaptic and postsynaptic effects of nitric oxide donors at synapses between parallel fibres and Purkinje cells: involvement in cerebellar long-term depression. Neuroscience 77, 945-954.
5. Caputo C. B., Sobel I. E., Scott C. W., Brunner W. F., Barth P. T., and Blowers D. P. (1992) Association of the carboxy-terminus of beta-amyloid protein precursor with Alzheimer paired helical filaments. Biochem. Biophys. Res. Commun. 185, 1034-1040.
6. Cataldo A. M., Barnett J. L., Mann D. A., and Nixon R. A. (1996) Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome. J. Neuropathol. Exp. Neurol. 55, 704-715.
7. Checler F. (1995) Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65, 1431-1444.
8. Chong Y. H., Jung J. M., Choi W., Park C. W., Choi K. S., and Suh Y. H. (1994) Bacterial expression, purification of full-length and carboxyl-terminal fragment of Alzheimer amyloid precursor protein and their proteolytic processing by thrombin. Life Sci. 54, 1259-1268.
9. Clemens J. A. and Stephenson D. T. (1992) Implants containing beta-amyloid protein are not neurotoxic to young and old rat brain. Neurobiol. Aging 13, 581-586.
10. Cullen W. K., Suh Y. H., Anwyl R., and Rowan M. J. (1997) Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments. Neuroreport 8, 3213-3217.
11. Denk W., Sugimori M., and Llinas R. (1995) Two types of calcium response limited to single spines in cerebellar Purkinje cells. Proc. Natl. Acad. Sci. USA 92, 8279-8282.
12. Drake L., Korchev Y., Bashford L., Djamgoz M., Wakelin D., Ashall F., and Bundy D. (1994) The major secreted product of the whipworm, trichuris, is a pore-forming protein. Proc. R. Soc. Land. [B.] 257, 255-261.
13. 2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons. Nature 373, 155-158.
14. Esch F. S., Keim P. S., Beattie E. C., Blacher R. W., Culwell A. R., Oltersdorf T., McClure D., and Ward P. J. (1990) Cleavage of amyloid-beta peptide during constitutive processing of its precursor. Science 248, 1122-1124.
15. Estus S., Golde T. E., Kunishita T., Blades D., Lowery D., Eisen M., Usiak M., Qu X. M., Tabira T., Greenberg B. D., and Younkin S. G. (1992) Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science 255, 726-728.
16. Fraser S. P., Suh Y. H., Chong Y. H., and Djamgoz M. B. A. (1996) Membrane currents induced in Xenopus oocytes by the C-terminal fragment of the β-amyloid precursor protein. J. Neurochem. 66, 2034-2040.
17. Fraser S. P., Suh Y. H., and Djamgoz M. A. (1997) Ionic effects of the Alzheimer's disease beta-amyloid precursor protein and its metabolic fragments. Trends Neurosci. 20, 67-72.
18. Fukuchi K., Kamino K., Deeb S. S., Furlong C. E., Sundstrom J. A., Smith A. C., and Martin G. M. (1992a) Expression of carboxy-terminal region of the beta-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells - evidence for altered processing and selective neurotoxicity. Mol. Brain Res. 16, 37-46.
19. Fukuchi K., Kamino K., Deeb S. S., Smith A. C., Dang T., and Martin G. M. (1992b) Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem. Biophys. Res. Commun. 182, 165-173.
20. Fukutani Y., Cairns N. J., Rossor M. N., and Lantos P. L. (1996) Purkinje cell loss and astrocytosis in the cerebellum in familial and sporadic Alzheimer's disease. Neurosci. Lett. 214, 33-36.
21. + channels and suppression of neuronal activity by secreted beta-amyloid precursor protein. Nature 379, 74-78.
22. Games D., Khan K. M., Soriano F. G., Keim P. S., Davis D. L., Bryant K., and Lieberburg I. (1992) Lack of Alzheimer pathology after beta-amyloid protein injections in rat brain. Neurobiol. Aging 13, 569-576.
23. Gearing M., Wilson R. W., Unger E. R., Shelton E. R., Chan H. W., Masters C. L., Beyreuther K., and Mirra S. S. (1993) Amyloid precursor protein (App) in the striatum in Alzheimer's disease - an immunohistochemical study. J. Neuropathol. Exp. Neurol. 52, 22-30.
24. Glenner G. G. and Wong C. W. (1984) Alzheimer's disease - initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885-890.
25. Golde T. E., Estus S., Younkin L. H., Selkoe D. J., and Younkin S. G. (1992) Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255, 728-730.
26. Haass C., Koo E. H., Mellon A., Hung A. Y., and Selkoe D. J. (1992a) Targeting of cell-surface beta-amyloid precursor protein to lysosomes - alternative processing into amyloid-bearing fragments. Nature 357, 500-503.
27. Haass C., Schlossmacher M. G., Hung A. Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B. L., Lieberburg I., Koo E. H., Schenk D., Teplow D. B., and Selkoe D. J. (1992b) Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-325.
28. Hartell N. A. (1996a) Strong activation of parallel fibers produces localized calcium transients and a form of LTD that spreads to distant synapses. Neuron 16, 601-610.
29. Hartell N. A. (1996b) Two separate pathways for cerebellar LTD: NO-dependent and NO-independent. Behav. Brain Sci. 19, 453.
30. Hayashi Y., Kashiwagi K., and Yoshikawa K. (1992) Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA-transfected glioma cells. Biochem. Biophys. Res. Commun. 187, 1249-1255.
31. Hemart N., Daniel H., Jaillard D., and Crepel F. (1994) Properties of glutamate receptors are modified during long-term depression in rat cerebellar Purkinje cells. Neurosci. Res. 19, 213-221.
32. Howland D. S., Savage M. J., Huntress F. A., Wallace R. E., Schwartz D. A., Loh T., Melloni R. H., Degennaro L. J., Greenberg B. D., Siman R., Swanson M. E., and Scott R. W. (1995) Mutant and native human beta-amyloid precursor proteins in transgenic mouse brain. Neurobiol. Aging 16, 685-699.
33. Joachim C. L., Morris J. H., and Selkoe D. J. (1989) Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am. J. Pathol. 135, 309-319.
34. Kametani F., Tanaka K., Tokuda T., and Ikeda S. (1994) Secretory cleavage site of Alzheimer amyloid precursor protein is heterogeneous in Down's syndrome brain. FEBS Lett. 351, 165-167.
35. Kammesheidt A., Boyce F. M., Spanoyannis A. F., Cummings B. J., Ortegon M., Cotman C., Vaught J. L., and Neve R. L. (1992) Deposition of beta/a4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc. Natl. Acad. Sci. USA 89, 10857-10861.
36. Kang J., Lemaire H. G., Unterbeck A., Salbaum J. M., Masters C. L., Grzeschik K. H., Multhaup G., Beyreuther K., and Mullerhill B. (1987) The precursor of Alzheimer's disease amyloid-a4 protein resembles a cell-surface receptor. Nature 325, 733-736.
37. Kim S.-H. and Suh Y.-H. (1996) Neurotoxicity of a carboxyl-terminal fragment of the Alzheimer's amyloid precursor protein. J. Neurochem. 67, 1172-1182.
38. Koo E. H. and Squazzo S. L. (1994) Evidence that production and release of amyloid beta-protein involve the endocytic pathway. J. Biol. Chem. 269, 17386-17389.
39. Koo E. H., Park L., and Selkoe D. J. (1993) Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. Proc. Natl. Acad. Sci. USA 90, 4748-4752.
40. 2+ transients. Neuron 15, 407-415.
41. 2+ in the induction of cerebellar long-term depression. Neuron 18, 1025-1038.
42. Li Y. T., Woodruffpak D. S., and Trojanowski J. Q. (1994) Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites. Neurobiol. Aging 15, 1-9.
43. Matsumoto A. (1994) Altered processing characteristics of beta-amyloid-containing peptides in cytosol and in media of familial Alzheimer's disease cells. Biochim. Biophys. Acta 1225, 304-310.
44. Nakanishi H., Amano T., Sastradipura D. F., Yoshimine Y., Tsukuba T., Tanabe K., Hirotsu I., Ohono T., and Yamamoto K. (1997) Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein. J. Neurochem. 68, 739-749.
45. Nalbantoglu J., Tirado Santiago G., Lahsaini A., Poirier J., Goncalves O., Verge A., Momoli F., Welner S. A., Massicotte G., Julien J. P., and Shapiro M. L. (1997) Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387, 500-505.
46. Neve R. L., Kammesheidt A., and Hohmann C. F. (1992) Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo. Proc. Natl. Acad. Sci. USA 89, 3448-3452.
47. Ostergranite M. L., McPhie D. L., Greenan J., and Neve R. L. (1996) Age-dependent neuronal and synaplic degeneration in mice transgenic for the c-terminus of the amyloid precursor protein. J. Neurosci. 16, 6732-6741.
48. Podlisny M. B., Stephenson D. T., Frosch M. P., Tolan D. R., Lieberburg I., Clemens J. A., and Selkoe D. J. (1993) Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity. Am. J. Pathol. 142, 17-24.
49. Selkoe D. J. (1994) Amyloid β-protein precursors; new clues to the genesis of Alzheimer's disease. Curr. Opin. Neurobiol. 4, 708-716.
50. Selkoe D. J., Podlisny M. B., Joachim C. L., Vickers E. A., Lee G., Fritz L. C., and Oltersdorf T. (1988) Beta-amyloid precursor protein of Alzheimer disease occurs as 110-kilodalton to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc. Natl. Acad. Sci. USA 85, 7341-7345.
51. Shoji M., Golde T. E., Ghiso J., Cheung T. T., Estus S., Shaffer L. M., Cai X. D., McKay D. M., Tintner R., Frangione B., and Younkin S. G. (1992) Production of the Alzheimer amyloid-beta protein by normal proteolytic processing. Science 258, 126-129.
52. Sisodia S. S., Koo E. H., Beyreuther K., Unterbeck A., and Price D. L. (1990) Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248, 492-495.
53. Song D.-K., Won M.-H., Jung J.-S., Lee J.-C., Kang T.-C., Suh H.-W., Huh S.-O., Paek S.-H., Kim Y.-H., Kim S.-H., and Suh Y.-H. (1998) Behavioral and neuropathologic changes induced by central injection of carboxyl-terminal fragment of β-amyloid precursor protein in mice. J. Neurochem. 71, 875-878.
54. Sopher B. L., Fukuchi K., Smith A. C., Leppig K. A., Furlong C. E., and Martin G. M. (1994) Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein. Mol. Brain Res. 26, 207-217.
55. Steinbehrens B., Adams K., Yeh M., and Sapolsky R. (1992) Failure of beta-amyloid protein fragment 25-35 to cause hippocampal damage in the rat. Neurobiol. Aging 13, 577-579.
56. Takahashi M., Kovalchuk Y., and Attwell D. (1995) Pre- and postsynaptic determinants of epsc waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses. J. Neurosci. 15, 5693-5702.
57. Tamaoka A., Kalaria R. N., Lieberburg I., and Selkoe D. J. (1992) Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels. Proc. Natl. Acad. Sci. USA 89, 1345-1349.
58. Tokuda T., Tanaka K., Kametani F., Ikeda S., and Yanagisawa N. (1995) Secretory cleavage of beta-amyloid precursor protein in the cerebral white matter produces amyloidogenic carboxyl-terminal fragments. Neurosci. Lett. 186, 149-152.
59. Usowicz M. M., Sugimori M., Chersky B., and Llinas R. (1992) P-type calcium channels in the somata and dendrites of adult cerebellar Purkinje cells. Neuron 9, 1185-1199.
60. Wegiel J., Wisniewski H. M., Dziewiatkowski J., Badmajew E., Tarnawski M., Reisberg B., Mlodzik B., Deleon M. J., and Miller D. C. (1999) Cerebellar atrophy in Alzheimer's disease - clinico-pathological correlations. Brain Res. 818, 41-50.
61. Yankner B. A., Dawes L. R., Fisher S., Villakomaroff L., Ostergranite M. L., and Neve R. L. (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245, 417-420.
62. Yankner B. A., Duffy L. K., and Kirschner D. A. (1990) Neurotrophic and neurotoxic effects of amyloid beta-protein - reversal by tachykinin neuropeptides. Science 250, 279-282.
63. Yoshikawa K., Aizawa T., and Hayashi Y. (1992) Degeneration in vitro of postmitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359, 64-67.
64. Young J. D., Peterson C. B., Venge P., and Cohn Z. A. (1986) Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature 321, 613-616.