Analysis of the mechanism by which glucose inhibits maltose induction of MAL gene expression in Saccharomyces

Genetics

Volumn 154, Issue 1, 2000, Pages 121-132

  Hu, Zhen ^a   Yue, Yingzi ^a   Jiang, Hua ^a   Zhang, Bin ^a   Sherwood, Peter W ^b   Michels, Corinne A ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; MALTOSE;

ARTICLE; ENZYME SYNTHESIS; GENE EXPRESSION REGULATION; GENE INDUCTION; PRIORITY JOURNAL; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE;

BASE SEQUENCE; DNA PRIMERS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GLUCOSE; MALTOSE; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; MONOSACCHARIDE TRANSPORT PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0033958127     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. AUSUBEL, F. M., R. BRENT, R. E. KINGSTON, D. D. MOORE, J. G. SEIDMAN et al., 1999 Current Protocols in Molecular Biology. Green Publishing Associates/John Wiley & Sons, New York.
2. BLANK, T. E., M. P. WOODS, C. M. LEBO, P. XIN and J. E. HOPPER, 1997 Novel Gal3 proteins showing altered Gal80p binding cause constitutive transcription of Gal4-activated genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 17: 2566-2575.
3. BOEKE, J. D., F. LACROUTE and G. R. FINK, 1984 A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet. 197: 345-346.
4. CARLSON, M., 1999 Glucose repression in yeast. Curr. Opin. Microbiol. 2: 202-207.
5. CELENZA, J. L., and M. CARLSON, 1986 A yeast gene that is essential for release from glucose repression encodes a protein kinase. Science 233: 1175-1180.
6. CHARRON, M. J., and C. A. MICHELS, 1987 The constitutive, glucose repression-insensitive mutation of the yeast MAL4 locus is an alteration of the MAL43 gene. Genetics 116: 23-31.
7. CHARRON, M. J., R. A. DUBIN and C. A. MICHELS, 1986 Structural and functional analysis of the MAL1 locus of Saccharomyces cerevisiae. Mol. Cell. Biol. 6: 3891-3899.
8. CHENG, Q., and C. A. MICHELS, 1991 MAL11 and MAL61 encode the inducible high-affinity maltose transporter of Saccharomyces cerevisiae. J. Bacteriol. 173: 1817-1820.
9. DE WINDE, J. H., M. CRAUWELS, S. HOHMANN, J. M. THEVELEIN and J. WINDERICKX, 1996 Differential requirement of the yeast sugar kinases for sugar sensing in the establishment of the catabolite-repressed state. Eur. J. Biochem. 241: 633-643.
10. DEJUAN, C., and R. LAGUNAS, 1986 Inactivation of the galactose transport system in Saccharomyces cerevisiae. FEBS Lett. 207: 258-261.
11. DEVIT, M. J., J. A. WADDLE and M. JOHNSTON, 1997 Regulated nuclear translocation of the MigI glucose repressor. Mol. Biol. Cell 8: 1603-1618.
12. DUBIN, R. A., 1987 Molecular organization of the MAL6 locus of Saccharomyces carlsbergensis. Ph.D. Thesis, The City University of New York.
13. DUBIN, R. A., M. J. CHARRON, S. R. HAUT, R. B. NEEDLEMAN and C. A. MICHELS, 1988 Constitutive expression of the maltose fermentative enzymes in Saccharomyces cerevisiae is dependent upon the mutational activation of a nonessential homolog of MAL63. Mol. Cell. Biol. 8: 1027-1035.
14. ELLEDGE, S. J., and R. DAVIS, 1988 A family of versatile centrometric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae. Gene 70: 303-312.
15. ENTIAN, K.-D., E. KOPETZKI, K. U. FROHLICH and D. MECKE, 1984 Cloning of hexokinase isoenzyme PI from Saccharomyces cerevisiae: PI transformants confirm the unique role of hexokinase isoenzyme PII for glucose repression in yeasts. Mol. Gen. Genet. 198: 50-54.
16. FREDERICK, D. L., and K. TATCHELL, 1996 The REG2 gene of Saccharomyces cerevisiae encodes a type-I protein phosphatase-binding protein that functions with Reg1p and the Snfl protein kinase to regulate growth. Mol. Cell. Biol. 16: 2922-2931.
17. GIBSON, W. A., L. A. WOJCIECHOWICZ, S. DANZI, B. ZHANG, J. H. KIM et al., 1997 Constitutive mutations of the Saccharomyces cerevisiae MAL-activator genes MAL23, MAL43, MAL63, and mal64. Genetics 146: 1287-1298.
18. HARDIE, D. G., and D. CARLING, 1997 The AMP-activated protein kinase: fuel gauge of the mammalian cell? Eur. J. Biochem. 246: 259-273.
19. HERRERO, P., J. GALINDEZ, N. RUIZ, C. MARTINEZ-CAMPA and F. MORENO, 1995 Transcriptional regulation of the Saccharomyces cerevisiae HXK1, HXK2 and GLK1 genes. Yeast 11: 137-144.
20. HORAK, J., and D. H. WOLF, 1997 Catabolite inactivation of the galactose transporter in the yeast Saccharomyces cerevisiae: ubiquitination, endocytosis, and degradation in the vacuole. J. Bacteriol. 179: 1541-1549.
21. HU, Z., J. O. NEHLIN, H. RONNE and C. A. MICHELS, 1995 MIG1-dependent and MIG1-independent glucose regulation of MAL gene expression in Saccharomyces cerevisiae. Curr. Genet. 28: 258-266.
22. HU, Z., A. W. GIBSON, J. H. KIM, B. ZHANG, L. A. WOJCIECHOWICZ et al., 1999 Functional domain analysis of the Saccharomyces MAL-activator. Curr. Genet. 36: 1-12.
23. JIANG, H., I. MEDINTZ and C. A. MICHELS, 1997 Two glucose sensing/ signaling pathways stimulate glucose-induced inactivation of maltose permease in Saccharomyces. Mol. Biol. Cell 8: 1293-1304.
24. JIANG, H., I. MEDINTZ, B. ZHANG and C. A. MICHELS, 2000a Metabolic signals trigger glucose-induced inactivation of maltose permease in Saccharomyces. J. Bacteriol. (in press).
25. JIANG, H., K. TATCHELL and C. A. MICHELS, 2000b Protein phosphatase type-1 regulatory subunits Reg1p and Reg2p are signal transducers in the glucose-induced proteolysis of maltose permease in Saccharomyces. Mol. Gen. Genet. (in press).
26. JOHNSTON, M., 1999 Feasting, fasting and fermenting: glucose sensing in yeast and other cells. Trends Genet. 15: 29-33.
27. JOHNSTON, M., J. S. FLICK and T. PEXTON, 1994 Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 3834-3841.
28. LAMPHIER, M. S., and M. PTASHNE, 1992 Multiple mechanisms mediate glucose repression of the yeast GAL1 gene. Proc. Natl. Acad. Sci. USA 89: 5922-5926.
29. LOBO, Z., and P. K. MAITRA, 1977 Genetics of yeast hexokinase. Genetics 86: 727-744.
30. LOHR, D., P. VFNKOV and J. ZLATANOVA, 1995 Transcriptional regulation in the yeast GAL gene family: a complex genetic network. FASEB J. 9: 777-787.
31. LUDIN, K., R. JIANG and M. CARLSON, 1998 Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snfl protein kinase in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 95: 6245-6250.
32. LUTFIYYA, L. L., and M. JOHNSTON, 1996 Two zinc-finger-containing repressors are responsible for glucose repression of SUC2 expression. Mol. Cell. Biol. 16: 4790-4797.
33. LUTFIYYA, L. L., V. R. IVER, J. DERISI, M. J. DEVIT, P. O. BROWN et al., 1998 Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae. Genetics 150: 1377-1391.
34. MA, H., and D. BOTSTEIN, 1986 Effects of null mutations in the hexokinase genes of Saccharomyces cerevisiae on catabolite repression. Mol. Cell. Biol. 6: 4046-4052.
35. MATERN, H., and H. HOLZER, 1977 Catabolite inactivation of the galactose uptake system in yeast. J. Biol. Chem. 252: 6399-6402.
36. MEDINTZ, I., H. JIANG, E.-K. HAN, W. CUI and C. A. MICHELS, 1996 Characterization of the glucose-induced inactivation of maltose permease in Saccharomyces cerevisiae. J. Bacteriol. 178: 2245-2254.
37. NEEDLEMAN, R. B., 1991 Control of maltase synthesis in yeast. Mol. Microbiol. 5: 2079-2084.
38. NEHLIN, J. O., and H. RONNE, 1990 Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumor finger proteins. EMBO J. 9: 2891-2898.
39. NEHLIN, J. O., M. CARLBERG and H. RONNE, 1991 Control of yeast GAL genes by MIG1 repressor: a transcriptional cascade in the glucose response. EMBO J. 10: 3373-3377.
40. NG, R., and J. ABELSON, 1980 Isolation and sequence of the gene for actin in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 77: 3912-3916.
41. OZCAN, S., and M. JOHNSTON, 1995 Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Mol. Cell. Biol. 15: 1564-1572.
42. OZCAN, S., F. SCHULTE, K. FREIDEL, A. WEBER and M. CIRIACY, 1994 Glucose uptake and metabolism in grr1/cal80mutants of Saccharomyces cerevisiae. Eur. J. Biochem. 224: 605-611.
43. OZCAN, S., J. DOVER, A. G. ROSENWALD, D. WOLFL and M. JOHNSTON, 1996a Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc. Natl. Acad. Sci. USA 93: 12428-12432.
44. OZCAN, S., T. LEONG and M. JOHNSTON, 1996b Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Mol. Cell. Biol. 16: 6419-6426.
45. PLATT, A., and R. J. REECE, 1998 The yeast galactose genetic switch is mediated by the formation of a Gal4p-Gal80p-Gal3p complex. EMBO J. 17: 4086-4091.
46. RONNE, H., 1995 Glucose repression in fungi. Trends Genet. II: 12-17.
47. ROSE, M., W. ALBIG and K. D. ENTIAN, 1991 Glucose repression in Saccharomyces cerevisiae is directly associated with hexose phosphorylation by hexokinase-PI and hexokinase-PII. Eur. J. Biochem. 199: 511-518.
48. ROSE, M. D., F. WINSTON and P. HIETER, 1990 Methods in Yeast Genetics: A Laboratory Manual. Gold Spring Harbor Laboratory Press, Gold Spring Harbor, NY.
49. SHERWOOD, P. W., and M. CARLSON, 1997 Mutations in GSF1 and GSF2 alter glucose signaling in Saccharomyces cerevisiae. Genetics 147: 557-566.
50. SUZUKI-FUJIMOTO, T., M. FUKUMA, K.-I. YANO, H. SAKUKAI, A. VONIKA et al., 1996 Analysis of the galactose signal transduction pathway in Saccharomyces cerevisiae: interaction between Gal3p and Gal80p. Mol. Cell. Biol. 16: 2504-2508.
51. TU, J., and M. CARLSON, 1994 The GLC7 type 1 protein phosphatase is required for glucose repression in Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 6789-6796.
52. TU, J., and M. CARLSON, 1995 REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J. 14: 5939-5946.
53. VALLIER, L. G., and M. CARLSON, 1994 Synergistic release from glucose repression by mig1 and ssn mutations in Saccharomyces cerevisiae. Genetics 137: 49-54.
54. VALLIER, L. G., D. COONS, L. F. BISSON and M. CARLSON, 1994 Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Genetics 136: 1279-1285.
55. VINCENT, O., and M. CARLSON, 1998 Sip4, a Snfl kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes. EMBO J. 17: 7002-7008.
56. WANG, J., O. SIRENKO and R. NEEDLEMAN, 1997 Genomic foot-printing of Mig1p in the MAL62 promoter: binding is dependent upon carbon source and competitive with Mal63p activator. J. Biol. Chem. 272: 4613-4622.
57. WILSON, W. A., S. A. HAWLEY and D. G. HARDIE, 1996 Glucose repression/derepression in budding yeast: Snfl protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio. Curr. Biol. 6: 1426-1434.
58. WOODS, A., M. R. MUNDAY, J. SCOTT, X. YANG, M. CARLSON et al., 1994 Yeast Snfl is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J. Biol. Chem. 269: 19509-19515.
59. YANO, K.-I., and T. FUKASAWA, 1997 Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 94: 1721-1726.
60. ZENKE, F. T., R. ENGELS, V. VOLLENBROICH, J. MEYER, C. P. HOLLEBERG et al., 1996 Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p. Science 272: 1662-1665.