Genomic locus and promoter region of rat Smad7, an important antagonist of TGFβ signaling

Mammalian Genome

Volumn 11, Issue 2, 2000, Pages 169-176

  Stopa, Marcin ^a   Benes, Vladimir ^b   Ansorge, Wilhelm ^b   Gressner, Axel M ^a   Dooley, Steven ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL TRANSFORMATION; GENE LOCUS; INTRON; LIVER FIBROSIS; MYOFIBROBLAST; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; CELLS, CULTURED; DNA-BINDING PROTEINS; EXONS; INTRONS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033955048     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003350010032     Document Type: Article

References (43)

1. Afrakhte M, Moren A, Jossan S, Itoh S, Sampath K et al. (1998) Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members. Biochem Biophys Res Commun 249, 505-511
2. Attisano L, Wrana JL, Lopez-Casillas F, Massague J (1994) TGF-beta receptors and actions. Biochim Biophys Acta 122, 71-80
3. Baker JC, Harland RM (1996) A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev 10, 1880-1889
4. Benes V, Kilger C, Voss H, Paabo S, Ansorge W (1997) Direct primer walking on P1 plasmid DNA. Biotechniques 23, 98-100
5. Blomhoff R, Wake K (1991) Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J 5, 271-277
6. Border WA, Ruoslahti E (1992) Transforming growth factor-beta in disease - the dark side of tissue repair. J Clin Invest 90, 1-7
7. Chen X, Rubock MJ, Whitman M (1996) A transcriptional partner for MAD proteins in TGF-beta signalling. Nature 383, 691-696
8. Cross SH, Clark VH, Bird AP (1999) Isolation of CpG islands from large genomic clones. Nucleic Acids Res 27, 2099-2107
9. Derynck R, Zhang Y, Feng XH (1998) Smads: Transcriptional activators of TGF-beta responses. Cell 95, 737-740
10. Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P et al. (1996) MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86, 543-552
11. Friedman SL, Roll FJ, Boyles J, Bissell DM (1985) Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 82, 8681-8685
12. Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK et al. (1992) Isolated hepatic lipocytes and Kupffer cells from normal human liver: Morphological and functional characteristics in primary culture. Hepatology 15, 234-243
13. Gardiner-Garden M, Frommer M (1987) CpG islands in vertebrate genomes. J Mol Biol 196, 261-282
14. Graff JM, Bansal A, Melton DA (1996) Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily. Cell 85, 479-487
15. Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY et al. (1997) The Mad-related protein Smad7 associates with the TGF-receptor and functions as an antagonist of TGF-signaling. Cell 89, 1165-1173
16. Heils A, Wichems C, Mossner R, Petri S, Glatz K et al. (1998) Functional characterization of the murine serotonin transporter gene promoter in serotonergic raphe neurons. J Neurochem 70, 932-939
17. Hoodless PA, Tsukazaki T, Nishimatsu S, Attisano L, Wrana JL et al. (1999) Dominant-negative smad2 mutants inhibit Activin/Vg1 signaling and disrupt axis formation in xenopus. Dev Biol 207, 364-379
18. Imamura T, Takase M, Nishihara A, Oeda E, Hanai J et al. (1997) Smad6 inhibits signalling by the TGF-beta superfamily. Nature 389, 622-626
19. Itoh S, Landstrom M, Hermansson A, Itoh F, Heldin CH et al. (1998) Transforming growth factor beta 1 induces nuclear export of inhibitory Smad7. J Biol Chem 273, 29195-29201
20. Kim J, Martignetti JA, Shen MR, Brosius J, Deininger P (1994) Rodent BCI RNA gene as a master gene for ID element amplification. Proc Natl Acad Sci USA 91, 3607-3611
21. Kingsley DM (1994) The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8, 133-146
22. Knook DL, DeLeeuw AM (1982) Isolation and characterization of fat storing cells from the rat liver. In Sinusoidal Liver Cells, D.L. Knook, E. Wisse, eds. (Rijswijk, The Netherlands.: Elsevier Biomedical Press), pp 45-52
23. Kretzschmar M, Liu F, Hata A, Doody J, Massague J (1997) The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev 11, 984-995
24. Lagna G, Hata A, Hemmati-Brivanlou A, Massague J (1996) Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature 383, 832-836
25. Liu F, Hata A, Baker JC, Doody J, Carcamo J et al. (1996) A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620-623
26. Macias-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L et al. (1997) MADR2 is a substrate of the TGF-receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215-1224
27. Massague J (1998) TGF-beta signal transduction. Annu Rev Biochem 67, 753-791
28. Moghal N, Sternberg PW (1999) Multiple positive and negative regulators of signaling by the EGF-receptor. Curr Opin Cell Biol II, 190-196
29. Moses HL, Serra R. (1996) Regulation of differentiation by TGF-beta. Curr Opin Genet Dev 6, 581-586
30. Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL et al. (1997) Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 389, 631-635
31. Okada N (1991) SINEs. Curr Opin Genet Dev 1, 498-504
32. Roberts AB, Sporn MB (1993) Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors 8, 1-9
33. Roijer E, Moren A, ten Dijke P, Stenman G (1998) Assignment 1 of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridization. Cytogenet Cell Genet 81, 189-190
34. Savage C, Das P, Finelli AL, Townsend SR, Sun CY et al. (1996) Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components. Proc Natl Acad Sci USA 93, 790-794
35. Schäfer S, Zerbe O, Gressner AM (1987) The synthesis of proteoglycans in fat-storing cells of rat liver. Hepatology 7, 680-687
36. Schmid C, Maraia R (1992) Transcriptional regulation and transpositional selection of active SINE sequences. Curr Opin Genet Dev 2, 874-882
37. Shaw G, Kamen R (1986) A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46, 659-667
38. Thuring RW, Sanders JP, Borst P (1975) A freeze-squeeze method for recovering long DNA from agarose gels. Anal Biochem 66, 213-220
39. Tsuneizumi K, Nakayama T, Kamoshida Y, Kornberg TB, Christian JL et al. (1997) Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature 389, 627-631
40. Ulloa L, Doody J, Massague J (1999) Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 397, 710-713
41. Wahle E, Keller W (1996) The biochemistry of polyadenylation. Trends Biochem Sci 21, 247-250
42. Zhang Y, Feng XH, Wu RY, Derynck R (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383, 168-172
43. Zubiaga AM, Belasco JG, Greenberg ME (1995) The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol Cell Biol 15, 2219-2230