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Volumn 47, Issue 31, 2000, Pages 15-28

Inflammatory bowel disease: Immunologic concepts

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INFLIXIMAB;

EID: 0033952758     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (30)

References (161)
  • 3
    • 0021091510 scopus 로고
    • Quantitative fecal indium 111-labeled leukocyte excretion in the assessment of disease activity in Crohn's disease
    • 3 Saverymuttu SH, Peters AM, Lavender JP, Pepys MB, Hodgson HJ, Chadwick VS: Quantitative fecal indium 111-labeled leukocyte excretion in the assessment of disease activity in Crohn's disease. Gastroenterology 1983; 85:1333-1339.
    • (1983) Gastroenterology , vol.85 , pp. 1333-1339
    • Saverymuttu, S.H.1    Peters, A.M.2    Lavender, J.P.3    Pepys, M.B.4    Hodgson, H.J.5    Chadwick, V.S.6
  • 4
    • 0021799427 scopus 로고
    • In vivo assessment of granulocyte migration to diseased bowel in Crohn's disease
    • 4 Saverymuttu SH, Peters AM, Lavender JP, Chadwick VS, Lavender JP: In vivo assessment of granulocyte migration to diseased bowel in Crohn's disease. Gut 1985; 26:378-383.
    • (1985) Gut , vol.26 , pp. 378-383
    • Saverymuttu, S.H.1    Peters, A.M.2    Lavender, J.P.3    Chadwick, V.S.4    Lavender, J.P.5
  • 5
    • 0023771583 scopus 로고
    • Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m hexamethyl propylene amine oxine as leukocyte label
    • 5 Schölmerich J, Schmidt E, Schumichen C, Billmann P, Schmidt H, Gerok W: Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m hexamethyl propylene amine oxine as leukocyte label. Gastroenterology 1988; 95:1287-1293.
    • (1988) Gastroenterology , vol.95 , pp. 1287-1293
    • Schölmerich, J.1    Schmidt, E.2    Schumichen, C.3    Billmann, P.4    Schmidt, H.5    Gerok, W.6
  • 6
    • 0023900998 scopus 로고
    • Neutrophil mediated mucosal injury. Role of reactive oxygen metabolites
    • 6 Grisham MB, Granger DN: Neutrophil mediated mucosal injury. Role of reactive oxygen metabolites. Dig Dis Sci 1988; 33:6S-15S.
    • (1988) Dig Dis Sci , vol.33
    • Grisham, M.B.1    Granger, D.N.2
  • 7
    • 0022005894 scopus 로고
    • Chemiluminescent response of neutrophils from patients with inflammatory bowel disease
    • 7 Faden H, Rossi TM: Chemiluminescent response of neutrophils from patients with inflammatory bowel disease. Dig Dis Sci 1985; 30:139-142.
    • (1985) Dig Dis Sci , vol.30 , pp. 139-142
    • Faden, H.1    Rossi, T.M.2
  • 8
    • 0024362206 scopus 로고
    • Increased neutrophil receptors for and response to the pro-inflammatory bacterial peptide formyl-methionyl-leucylphenylalanine in Crohn's disease
    • 8 Anton PA, Targan SR, Shanahan F: Increased neutrophil receptors for and response to the pro-inflammatory bacterial peptide formyl-methionyl-leucylphenylalanine in Crohn's disease. Gastroenterology 1989; 97:20-28.
    • (1989) Gastroenterology , vol.97 , pp. 20-28
    • Anton, P.A.1    Targan, S.R.2    Shanahan, F.3
  • 9
    • 0025193627 scopus 로고
    • Chemiluminescence by polymorphonuclear leukocyte subpopulations in chronic inflammatory bowel disease. Influence of the cell separation procedure
    • 9 Kelleher D, Feighery C, Weir DG: Chemiluminescence by polymorphonuclear leukocyte subpopulations in chronic inflammatory bowel disease. Influence of the cell separation procedure. Digestion 1990; 45:158-165.
    • (1990) Digestion , vol.45 , pp. 158-165
    • Kelleher, D.1    Feighery, C.2    Weir, D.G.3
  • 10
    • 0027283582 scopus 로고
    • Monocytes of patients with Crohn's disease are primed for accentuated release of toxic oxygen metabolites: Possible role for endotoxin
    • 10 Baldassano RN, Schreiber S, Johnston RB, Muraki T, MacDermott RP: Monocytes of patients with Crohn's disease are primed for accentuated release of toxic oxygen metabolites: possible role for endotoxin. Gastroenterology 1993; 105:60-66.
    • (1993) Gastroenterology , vol.105 , pp. 60-66
    • Baldassano, R.N.1    Schreiber, S.2    Johnston, R.B.3    Muraki, T.4    MacDermott, R.P.5
  • 11
    • 0029054407 scopus 로고
    • Enhanced superoxide anion release of normal neutrophil granulocytes primed with sera of patients with inactive inflammatory bowel disease
    • 11 Griga T, Tromm A, Schwegler U, May B: Enhanced superoxide anion release of normal neutrophil granulocytes primed with sera of patients with inactive inflammatory bowel disease. Z Gastroentrol 1995; 33:345-348.
    • (1995) Z Gastroentrol , vol.33 , pp. 345-348
    • Griga, T.1    Tromm, A.2    Schwegler, U.3    May, B.4
  • 13
    • 0026529032 scopus 로고
    • Fecal elastase reflects disease activity in active ulcerative colitis
    • 13 Adeyemi EO, Hodgson HJ: Fecal elastase reflects disease activity in active ulcerative colitis. Scand J Gastroenterol 1992; 27:139-142.
    • (1992) Scand J Gastroenterol , vol.27 , pp. 139-142
    • Adeyemi, E.O.1    Hodgson, H.J.2
  • 14
    • 0029586031 scopus 로고
    • Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
    • 14 Duchmann R, Kaiser I, Herrmann E, Mayet W, Ewe K, Meier zum Büschenfelde KH: Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 1995; 102:448-455.
    • (1995) Clin Exp Immunol , vol.102 , pp. 448-455
    • Duchmann, R.1    Kaiser, I.2    Herrmann, E.3    Mayet, W.4    Ewe, K.5    Meier Zum Büschenfelde, K.H.6
  • 16
    • 0024344814 scopus 로고
    • Enhanced production of interleukin 1-β by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn's disease
    • 16 Mahida YR, Wu K, Jewell DP: Enhanced production of interleukin 1-β by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn's disease. Gut 1989; 30:835-838.
    • (1989) Gut , vol.30 , pp. 835-838
    • Mahida, Y.R.1    Wu, K.2    Jewell, D.P.3
  • 17
    • 0025442212 scopus 로고
    • Role of interleukin 1 in inflammatory bowel disease - Enhanced production during active disease
    • 17 Ligumsky M, Simon PL, Karmeli F, Rachmilewitz D: Role of interleukin 1 in inflammatory bowel disease -enhanced production during active disease. Gut 1990; 31:686-689.
    • (1990) Gut , vol.31 , pp. 686-689
    • Ligumsky, M.1    Simon, P.L.2    Karmeli, F.3    Rachmilewitz, D.4
  • 18
    • 0026514203 scopus 로고
    • Increased concentrations of interleukin 1β, interleukin 2, and soluble interleukin-2 receptors in endoscopic mucosal biopsy specimens with active inflammatory bowel disease
    • 18 Brynskov J, Tvede N, Andersen CB, Vilien M: Increased concentrations of interleukin 1β, interleukin 2, and soluble interleukin-2 receptors in endoscopic mucosal biopsy specimens with active inflammatory bowel disease. Gut 1992; 33:55-58.
    • (1992) Gut , vol.33 , pp. 55-58
    • Brynskov, J.1    Tvede, N.2    Andersen, C.B.3    Vilien, M.4
  • 20
    • 0031903013 scopus 로고    scopus 로고
    • Increased secretion of pro-inflammatory cytokines by polymorphonuclear neutrophils and regulation by interleukin 10 in inflammatory bowel disease
    • 20 Nikolaus S, Bauditz J, Gionchetti P, Witt C, Lochs H, Schreiber S: Increased secretion of pro-inflammatory cytokines by polymorphonuclear neutrophils and regulation by Interleukin 10 in inflammatory bowel disease. Gut 1998; 42:470-476.
    • (1998) Gut , vol.42 , pp. 470-476
    • Nikolaus, S.1    Bauditz, J.2    Gionchetti, P.3    Witt, C.4    Lochs, H.5    Schreiber, S.6
  • 21
    • 0027451455 scopus 로고
    • Enhanced secretion of tumor necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
    • 21 Reinecker H-C, Steffen M, Witthoeft T, Pflueger I, Schreiber S, MacDermott RP, Raedler A: Enhanced secretion of tumor necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 1993; 94:174-181.
    • (1993) Clin Exp Immunol , vol.94 , pp. 174-181
    • Reinecker, H.-C.1    Steffen, M.2    Witthoeft, T.3    Pflueger, I.4    Schreiber, S.5    MacDermott, R.P.6    Raedler, A.7
  • 24
    • 0026709751 scopus 로고
    • Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification
    • 24 Isaacs KL, Sartor RB, Haskill S: Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification. Gastroenterology 1992; 103:1587-1595.
    • (1992) Gastroenterology , vol.103 , pp. 1587-1595
    • Isaacs, K.L.1    Sartor, R.B.2    Haskill, S.3
  • 25
    • 0027998678 scopus 로고
    • Cytokine expression in intestinal mucosal biopsies. In situ hybridisation of the mRNA for interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha in inflammatory bowel disease
    • 25 Woywodt A, Neustock P, Kruse A, Schwarting K, Ludwig D, Stange EF, Kirchner H: Cytokine expression in intestinal mucosal biopsies. In situ hybridisation of the mRNA for interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha in inflammatory bowel disease. Eur-Cytokine-Newt 1994; 5:387-395.
    • (1994) Eur-Cytokine-Newt , vol.5 , pp. 387-395
    • Woywodt, A.1    Neustock, P.2    Kruse, A.3    Schwarting, K.4    Ludwig, D.5    Stange, E.F.6    Kirchner, H.7
  • 27
    • 0023906367 scopus 로고
    • Dexamethasone inhibition of interleukin-1-beta production by human monocytes
    • 27 Kern JA, Lamb RJ, Reed JC, et al: Dexamethasone inhibition of interleukin-1-beta production by human monocytes. J Clin Invest 1988; 81:237-244.
    • (1988) J Clin Invest , vol.81 , pp. 237-244
    • Kern, J.A.1    Lamb, R.J.2    Reed, J.C.3
  • 30
    • 0033021497 scopus 로고    scopus 로고
    • Anti-TNF strategies in Crohn's disease: Mechanisms, clinical effects, indications
    • 30 Baert FJ, Rutgeerts PR: Anti-TNF strategies in Crohn's disease: mechanisms, clinical effects, indications. Int J Colorectal Dis 1999; 14(1):47-51.
    • (1999) Int J Colorectal Dis , vol.14 , Issue.1 , pp. 47-51
    • Baert, F.J.1    Rutgeerts, P.R.2
  • 31
    • 0023816306 scopus 로고
    • Interferon gamma production by human intestinal mucosa mononuclear cells. Decreased levels in inflammatory bowel disease
    • 31 Lieberman BY, Fiocchi C, Youngman KR, Sapatnekar WK, Proffitt MR: Interferon gamma production by human intestinal mucosa mononuclear cells. Decreased levels in inflammatory bowel disease. Dig Dis Sci 1988; 33:1297-1304.
    • (1988) Dig Dis Sci , vol.33 , pp. 1297-1304
    • Lieberman, B.Y.1    Fiocchi, C.2    Youngman, K.R.3    Sapatnekar, W.K.4    Proffitt, M.R.5
  • 33
    • 0032983031 scopus 로고    scopus 로고
    • IgG, albumin, and sCD44 in whole-gut lavage fluid are useful clinical markers for assessing the presence and activity of pouchitis
    • 33 Stallmach A, van Look M, Scheiffele F, Ecker KW, Feifel G, Duchmann R, Zeitz M: IgG, albumin, and sCD44 in whole-gut lavage fluid are useful clinical markers for assessing the presence and activity of pouchitis. Int J Colorectal Dis 1999; 14:35-40.
    • (1999) Int J Colorectal Dis , vol.14 , pp. 35-40
    • Stallmach, A.1    Van Look, M.2    Scheiffele, F.3    Ecker, K.W.4    Feifel, G.5    Duchmann, R.6    Zeitz, M.7
  • 34
    • 0031790311 scopus 로고    scopus 로고
    • The interferon-gamma gene as a positive and functional candidate gene for inflammatory bowel disease
    • 34 Hampe J, Hermann B, Bridger S, MacPherson AJ, Mathews CG, Schreiber S: The interferon-gamma gene as a positive and functional candidate gene for inflammatory bowel disease. Int J Colorectal Dis 1998; 13(5-6):260-263.
    • (1998) Int J Colorectal Dis , vol.13 , Issue.5-6 , pp. 260-263
    • Hampe, J.1    Hermann, B.2    Bridger, S.3    MacPherson, A.J.4    Mathews, C.G.5    Schreiber, S.6
  • 36
    • 0025076370 scopus 로고
    • Differential regulation of IL-1 production in human monocytes by IFN-g and IL-4
    • 36 Donnelly RP, Fenton MJ, Finbloom DS, Gerrard TL: Differential regulation of IL-1 production in human monocytes by IFN-g and IL-4. J Immunol 1990; 145:569-575.
    • (1990) J Immunol , vol.145 , pp. 569-575
    • Donnelly, R.P.1    Fenton, M.J.2    Finbloom, D.S.3    Gerrard, T.L.4
  • 37
    • 0026503448 scopus 로고
    • Coordinated antiinflammatory effects of interleukin 4: Interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist
    • 37 Vannier E, Miller LC, Dinarello CA: Coordinated antiinflammatory effects of interleukin 4: Interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. Proc Natl Acad Sci USA 1992; 89:4076-4080.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4076-4080
    • Vannier, E.1    Miller, L.C.2    Dinarello, C.A.3
  • 41
    • 0026004931 scopus 로고
    • Regulation of immune responses by T cells with different cytokine secretion profiles: Role of a new cytokine, cytokine synthesis inhibitory factor (IL-10)
    • 41 Mosmann TR: Regulation of immune responses by T cells with different cytokine secretion profiles: Role of a new cytokine, cytokine synthesis inhibitory factor (IL-10). Int Arch Allergy Appl Immunol 1991; 94:110-115.
    • (1991) Int Arch Allergy Appl Immunol , vol.94 , pp. 110-115
    • Mosmann, T.R.1
  • 44
    • 0026530464 scopus 로고
    • IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor
    • 44 Ralph P, Nakoinz I, Sampson-Johannes A, Fong S, Lowe D, Min H-Y, Lin L: IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor. J Immunol 1992; 148:808-814.
    • (1992) J Immunol , vol.148 , pp. 808-814
    • Ralph, P.1    Nakoinz, I.2    Sampson-Johannes, A.3    Fong, S.4    Lowe, D.5    Min, H.-Y.6    Lin, L.7
  • 45
    • 0026559756 scopus 로고
    • IL-10 synergizes with IL-4 and transforming growth factor-β to inhibit macrophage cytotoxic activity
    • 45 Oswald IP, Gazzinelli RT, Sher A, James SL: IL-10 synergizes with IL-4 and transforming growth factor-β to inhibit macrophage cytotoxic activity. J Immunol 1992; 148:3578-3582.
    • (1992) J Immunol , vol.148 , pp. 3578-3582
    • Oswald, I.P.1    Gazzinelli, R.T.2    Sher, A.3    James, S.L.4
  • 47
    • 0026094306 scopus 로고
    • Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • 47 de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE: Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174:1209-1220.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    De Vries, J.E.5
  • 48
    • 0024408824 scopus 로고
    • Two types of mouse T helper cells. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • 48 Fiorentino DF, Bond MW, Mosmann TR: Two types of mouse T helper cells. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170:2081-2085.
    • (1989) J Exp Med , vol.170 , pp. 2081-2085
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 49
    • 0028907439 scopus 로고
    • Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease
    • 49 Schreiber S, Heinig T, Thiele HG, Raedler A: Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995; 108:1434-1444.
    • (1995) Gastroenterology , vol.108 , pp. 1434-1444
    • Schreiber, S.1    Heinig, T.2    Thiele, H.G.3    Raedler, A.4
  • 50
    • 0033527549 scopus 로고    scopus 로고
    • Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding
    • 50 Schottelius AJG, Mayo MW, Sartor RB, Baldwin AS: Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding. J Biol Chem 1999; 274:31868-31874.
    • (1999) J Biol Chem , vol.274 , pp. 31868-31874
    • Schottelius, A.J.G.1    Mayo, M.W.2    Sartor, R.B.3    Baldwin, A.S.4
  • 51
    • 0028207511 scopus 로고
    • Production of interleukin-1 receptor antagonist, inflammatory chemotactic proteins, and prostaglandin E by rheumatoid and osteoarthritic synoviocytes-regulation by IFN-gamma and IL-4
    • 51 Seitz M, Loetscher P, Dewald B, Towbin H, Ceska M, Baggiolini M: Production of interleukin-1 receptor antagonist, inflammatory chemotactic proteins, and prostaglandin E by rheumatoid and osteoarthritic synoviocytes-regulation by IFN-gamma and IL-4. J Immunol 1994; 152:2060-2065.
    • (1994) J Immunol , vol.152 , pp. 2060-2065
    • Seitz, M.1    Loetscher, P.2    Dewald, B.3    Towbin, H.4    Ceska, M.5    Baggiolini, M.6
  • 52
    • 0024581767 scopus 로고
    • Effects of IL-4 on macrophage functions: Increased uptake and killing of a protozoan parasite (Trypanosoma cruzi)
    • 52 Wirth JJ, Kierszenbaum F, Zlotnik A: Effects of IL-4 on macrophage functions: increased uptake and killing of a protozoan parasite (Trypanosoma cruzi). Immunology 1989; 66:296-301.
    • (1989) Immunology , vol.66 , pp. 296-301
    • Wirth, J.J.1    Kierszenbaum, F.2    Zlotnik, A.3
  • 53
    • 0028519015 scopus 로고
    • Inhibition of TH1 responses prevents inflammatory bowel disease in SCID mice reconstituted with CD45RB (high) CD4 T cells
    • 53 Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffmann RL: Inhibition of TH1 responses prevents inflammatory bowel disease in SCID mice reconstituted with CD45RB (high) CD4 T cells. Immunity 1994; 1:553-562.
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Menon, S.4    Caddle, L.B.5    Coffmann, R.L.6
  • 54
    • 0028877556 scopus 로고
    • Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease
    • 54 Schreiber S, Heinig T, Panzer U, Reinking R, Bouchard A, Stahl PD, et al: Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease. Gastroenterology 1995; 108:21-33.
    • (1995) Gastroenterology , vol.108 , pp. 21-33
    • Schreiber, S.1    Heinig, T.2    Panzer, U.3    Reinking, R.4    Bouchard, A.5    Stahl, P.D.6
  • 55
    • 0008918555 scopus 로고    scopus 로고
    • Comparison of the suppressive effects of interleukin-13, interleukin-10, and interleukin-4 on blood monocytes from patients with IBD
    • Abstract
    • 55 Kucharzik T, Lügering N, Weigelt H, Adolf M, Domschke W, Stoll R: Comparison of the suppressive effects of interleukin-13, interleukin-10, and interleukin-4 on blood monocytes from patients with IBD. Gastroenterology, 1996; 110:A943. (Abstract)
    • (1996) Gastroenterology , vol.110
    • Kucharzik, T.1    Lügering, N.2    Weigelt, H.3    Adolf, M.4    Domschke, W.5    Stoll, R.6
  • 56
    • 0001704488 scopus 로고
    • Opposite modulatory activity of IL-10 and IL-4 on lamina propria mononuclear cells (LpMC) is stimulus-dependent
    • Abstract
    • 56 Fukushima K, West GA, Klein JS, Levine AD, Fiocchi C: Opposite modulatory activity of IL-10 and IL-4 on lamina propria mononuclear cells (LpMC) is stimulus-dependent. Gastroenterology 1993; 104:A702. (Abstract)
    • (1993) Gastroenterology , vol.104
    • Fukushima, K.1    West, G.A.2    Klein, J.S.3    Levine, A.D.4    Fiocchi, C.5
  • 58
    • 0024475227 scopus 로고
    • NF-kappa B: A pleiotropic mediator of inducible and tissue-specific gene control
    • 58 Lenardo MJ, Baltimore D: NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989; 58:227-229.
    • (1989) Cell , vol.58 , pp. 227-229
    • Lenardo, M.J.1    Baltimore, D.2
  • 59
    • 0029874138 scopus 로고    scopus 로고
    • The NF-KB and I-KB proteins: New discoveries and insights
    • 59 Baldwin AS: The NF-KB and I-KB proteins: New discoveries and insights. Ann Rev Immunol 1996; 14:649-681.
    • (1996) Ann Rev Immunol , vol.14 , pp. 649-681
    • Baldwin, A.S.1
  • 60
    • 0033022837 scopus 로고    scopus 로고
    • A role for transcription factor NF-κB in intestinal inflammation
    • 60 Schottelius AJG, Baldwin AS: A role for transcription factor NF-κB in intestinal inflammation. Int J Colorectal Dis 1999; 14:18-28.
    • (1999) Int J Colorectal Dis , vol.14 , pp. 18-28
    • Schottelius, A.J.G.1    Baldwin, A.S.2
  • 61
    • 0028986075 scopus 로고
    • Control of IkB-a proteolysis by site-specific signal induced phosphorylation
    • 61 Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U: Control of IkB-a proteolysis by site-specific signal induced phosphorylation. Science 1995; 267:1485-1487.
    • (1995) Science , vol.267 , pp. 1485-1487
    • Brown, K.1    Gerstberger, S.2    Carlson, L.3    Franzoso, G.4    Siebenlist, U.5
  • 62
    • 0029836444 scopus 로고    scopus 로고
    • Local administration of antisense phosphothiocate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice
    • 62 Neurath MF, Petterson S, Meger zum Büschenfelde KH, Strober W: Local administration of antisense phosphothiocate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice. Nature Medicine 1996; 2:998-1004.
    • (1996) Nature Medicine , vol.2 , pp. 998-1004
    • Neurath, M.F.1    Petterson, S.2    Meger Zum Büschenfelde, K.H.3    Strober, W.4
  • 63
    • 0031925362 scopus 로고    scopus 로고
    • Activation of nuclear factor kappa B in inflammatory bowel disease
    • 63 Schreiber S, Nikolaus S, Hampe J: Activation of Nuclear Factor kappa B in Inflammatory Bowel Disease. Gut 1998, 42:477-485.
    • (1998) Gut , vol.42 , pp. 477-485
    • Schreiber, S.1    Nikolaus, S.2    Hampe, J.3
  • 64
    • 0016173190 scopus 로고
    • Peripheral blood T and B cells in chronic inflammatory bowel disease
    • 64 Strickland RG, Korsmeyer S, Soltis RD, et al: Peripheral blood T and B cells in chronic inflammatory bowel disease. Gastroenterology 1974; 67:569-577.
    • (1974) Gastroenterology , vol.67 , pp. 569-577
    • Strickland, R.G.1    Korsmeyer, S.2    Soltis, R.D.3
  • 65
    • 0016998079 scopus 로고
    • The subpopulations of circulating white blood cells in inflammatory bowel disease
    • 65 Thayer WR, Charland C, Field CE: The subpopulations of circulating white blood cells in inflammatory bowel disease. Gastroenterology 1976; 71:379-384.
    • (1976) Gastroenterology , vol.71 , pp. 379-384
    • Thayer, W.R.1    Charland, C.2    Field, C.E.3
  • 66
    • 0018183169 scopus 로고
    • Immune status in Crohn's disease, I. Leukocyte and lymphocyte subpopulations in peripheral blood
    • 66 Auer IO, Wechsler W, Ziemer E, et al: Immune status in Crohn's disease, I. Leukocyte and lymphocyte subpopulations in peripheral blood. Scan J Gastroenterol 1978; 13:561-571.
    • (1978) Scan J Gastroenterol , vol.13 , pp. 561-571
    • Auer, I.O.1    Wechsler, W.2    Ziemer, E.3
  • 67
    • 0018425040 scopus 로고
    • Immune status in Crohn's disease, 3. Peripheral blood lymphocytes, enumerated by means of F(ab)2-antibody fragments, null and T lymphocytes
    • 67 Auer IO, Gotz S, Ziemer E, et al: Immune status in Crohn's disease, 3. Peripheral blood lymphocytes, enumerated by means of F(ab)2-antibody fragments, null and T lymphocytes. Gut 1979; 20:261-268.
    • (1979) Gut , vol.20 , pp. 261-268
    • Auer, I.O.1    Gotz, S.2    Ziemer, E.3
  • 68
    • 0020677329 scopus 로고
    • T lymphocyte subsets in inflammatory bowel disease: Peripheral blood
    • 68 Selby WS, Jewell DP: T lymphocyte subsets in inflammatory bowel disease: peripheral blood. Gut 1983; 24:99-105.
    • (1983) Gut , vol.24 , pp. 99-105
    • Selby, W.S.1    Jewell, D.P.2
  • 69
    • 0021074696 scopus 로고
    • Circulating lymphocyte subpopulations in Crohn's disease
    • 69 Yuan SZ, Hanauer SB, Kluskens LF, et al: Circulating lymphocyte subpopulations in Crohn's disease. Gastroenterology 1983; 85:1313-1318.
    • (1983) Gastroenterology , vol.85 , pp. 1313-1318
    • Yuan, S.Z.1    Hanauer, S.B.2    Kluskens, L.F.3
  • 70
    • 0022001881 scopus 로고
    • Involvement of the immune system in the pathogenesis of Crohn's disease. Expression of the T9 antigen on peripheral immunocytes correlated with the severity of the disease
    • 70 Raedler A, Fraenkel S, Klose G, et al: Involvement of the immune system in the pathogenesis of Crohn's disease. Expression of the T9 antigen on peripheral immunocytes correlated with the severity of the disease. Gastroenterology 1985; 88:978-983.
    • (1985) Gastroenterology , vol.88 , pp. 978-983
    • Raedler, A.1    Fraenkel, S.2    Klose, G.3
  • 71
    • 0021881695 scopus 로고
    • Elevated numbers of peripheral T cells in inflammatory bowel diseases displaying T9 antigen and Fc alpha receptors
    • 71 Raedler A, Fraenkel S, Klose G, et al: Elevated numbers of peripheral T cells in inflammatory bowel diseases displaying T9 antigen and Fc alpha receptors. Clin Exp Immunol 1985; 60:518-524.
    • (1985) Clin Exp Immunol , vol.60 , pp. 518-524
    • Raedler, A.1    Fraenkel, S.2    Klose, G.3
  • 72
    • 0002555731 scopus 로고
    • Human lamina propria mononuclear cells are activated in inflammatory bowel disease
    • Tsuchiya M, Nagura H, Hibi T, Moro I, (Eds.). Amsterdam: Elsevier
    • 72 Schreiber S, Nash GS, Raedler A, et al: Human lamina propria mononuclear cells are activated in inflammatory bowel disease. In: Tsuchiya M, Nagura H, Hibi T, Moro I, (Eds.). Frontiers of mucosal immunology. Amsterdam: Elsevier, 1991; pp. 749-753.
    • (1991) Frontiers of Mucosal Immunology , pp. 749-753
    • Schreiber, S.1    Nash, G.S.2    Raedler, A.3
  • 73
    • 0024201856 scopus 로고
    • Activated Fc-alpha T-cells in Crohn's disease are involved in regulation of IgA
    • 73 Raedler A, Schreiber S, Schulz KH, et al: Activated Fc-alpha T-cells in Crohn's disease are involved in regulation of IgA. Adv Exp Med Biol 1988; 237:665-673.
    • (1988) Adv Exp Med Biol , vol.237 , pp. 665-673
    • Raedler, A.1    Schreiber, S.2    Schulz, K.H.3
  • 74
    • 0022655024 scopus 로고
    • In vivo activated T cells in autoimmune disease
    • 74 Raedler A, Bredow G, Kirch W, et al: In vivo activated T cells in autoimmune disease. J Clin Lab Immunol 1986; 19:181-186.
    • (1986) J Clin Lab Immunol , vol.19 , pp. 181-186
    • Raedler, A.1    Bredow, G.2    Kirch, W.3
  • 75
    • 0023219626 scopus 로고
    • Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens
    • 75 Pallone F, Fais S, Squarcia O, et al: Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens. Gut 1987; 28:745-753.
    • (1987) Gut , vol.28 , pp. 745-753
    • Pallone, F.1    Fais, S.2    Squarcia, O.3
  • 76
    • 0021959839 scopus 로고
    • T cell early activation antigens expressed by peripheral lymphocytes in Crohn's disease
    • 76 Fais S, Pallone F, Squarcia O, Boirivant M, Pozzilli P: T cell early activation antigens expressed by peripheral lymphocytes in Crohn's disease. J Clin Lab Immunol 1985; 16:75-76.
    • (1985) J Clin Lab Immunol , vol.16 , pp. 75-76
    • Fais, S.1    Pallone, F.2    Squarcia, O.3    Boirivant, M.4    Pozzilli, P.5
  • 78
    • 0023240740 scopus 로고
    • HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers
    • 78 Fais S, Pallone F, Sqarcia O, Biancone L, Ricci F, Paoluzzi P, Boivirant M: HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers. Clin Exp Immunol 1987; 68:605-612.
    • (1987) Clin Exp Immunol , vol.68 , pp. 605-612
    • Fais, S.1    Pallone, F.2    Sqarcia, O.3    Biancone, L.4    Ricci, F.5    Paoluzzi, P.6    Boivirant, M.7
  • 79
    • 0008935530 scopus 로고
    • Activated T cells and macrophages in the intestinal mucosa of children with inflammatory bowel disease
    • MacDonald TT, Chalacombe SJ, Bland PW, Stokes CR, Heatley RC, Movat AM (Eds.). Boston: Kluwer
    • 79 MacDonald TT, Choy MY, Hutchings P, Cooke A: Activated T cells and macrophages in the intestinal mucosa of children with inflammatory bowel disease. In: MacDonald TT, Chalacombe SJ, Bland PW, Stokes CR, Heatley RC, Movat AM (Eds.). Advances in mucosal immunology. Boston: Kluwer, 1990; pp. 683-690.
    • (1990) Advances in Mucosal Immunology , pp. 683-690
    • MacDonald, T.T.1    Choy, M.Y.2    Hutchings, P.3    Cooke, A.4
  • 80
    • 0025330941 scopus 로고
    • Immunohistochemical studies of surface antigen on colonic lymphoid cells in normal and inflamed mucosa
    • 80 Allison CM, Poulter LW, Dhillon AP, Pounder RE: Immunohistochemical studies of surface antigen on colonic lymphoid cells in normal and inflamed mucosa. Gastroenterology 1990; 99:421-430.
    • (1990) Gastroenterology , vol.99 , pp. 421-430
    • Allison, C.M.1    Poulter, L.W.2    Dhillon, A.P.3    Pounder, R.E.4
  • 81
    • 0021276878 scopus 로고
    • Intestinal lymphocyte subpopulations in inflammatory bowel disease: An analysis by immunohistochemical and cell isolation techniques
    • 81 Selby WS, Janossy G, Bofill M, Jewell DP: Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistochemical and cell isolation techniques. Gut 1984; 25:32-40.
    • (1984) Gut , vol.25 , pp. 32-40
    • Selby, W.S.1    Janossy, G.2    Bofill, M.3    Jewell, D.P.4
  • 82
    • 0024374428 scopus 로고
    • Ability of human colonic epithelium to express the 4F2 antigen, the common acute lymphoblastic leukemia antigen and the transferrin receptor
    • 82 Fais S, Pallone F: Ability of human colonic epithelium to express the 4F2 Antigen, the common acute lymphoblastic leukemia antigen and the transferrin receptor. Gastroenterology 1989; 97:1435-1441.
    • (1989) Gastroenterology , vol.97 , pp. 1435-1441
    • Fais, S.1    Pallone, F.2
  • 84
    • 0024431475 scopus 로고
    • Colonic mucosal T lymphocytes in ulcerative colitis: Expression of CD7 antigen in relation to MHC class II (HLA-D) antigens
    • 84 Trejdosiewicz LK, Badr-el-Din S, Smart CJ, Malizia G, Oakes DJ, Heatley RV, Losowsky MS: Colonic mucosal T Lymphocytes in ulcerative colitis: expression of CD7 antigen in relation to MHC class II (HLA-D) antigens. Dig Dis Sci 1989; 34(9): 1449-1456.
    • (1989) Dig Dis Sci , vol.34 , Issue.9 , pp. 1449-1456
    • Trejdosiewicz, L.K.1    Badr-el-Din, S.2    Smart, C.J.3    Malizia, G.4    Oakes, D.J.5    Heatley, R.V.6    Losowsky, M.S.7
  • 85
    • 0025321970 scopus 로고
    • Plasma interleukin-2 and a soluble/shed interleukin-2 receptor in serum of patients with Crohn's disease. Effect of cyclosporin
    • 85 Brynskov J, Tvede N: Plasma interleukin-2 and a soluble/shed interleukin-2 receptor in serum of patients with Crohn's disease. Effect of cyclosporin. Gut 1990; 31:795-799.
    • (1990) Gut , vol.31 , pp. 795-799
    • Brynskov, J.1    Tvede, N.2
  • 86
    • 0025173926 scopus 로고
    • T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells
    • 86 Müller C, Knoflach P, Zielinski CC: T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells. Gastroenterology 1990; 98:639-646.
    • (1990) Gastroenterology , vol.98 , pp. 639-646
    • Müller, C.1    Knoflach, P.2    Zielinski, C.C.3
  • 87
    • 0026095732 scopus 로고
    • Soluble interleukin-2 receptor as a marker of lymphocyte activation in childhood Crohn's disease
    • 87 Proujansky R, Carpenter AB: Soluble interleukin-2 receptor as a marker of lymphocyte activation in childhood Crohn's disease. J Pediatr Gastroenterol Nutr 1991; 13:277-284.
    • (1991) J Pediatr Gastroenterol Nutr , vol.13 , pp. 277-284
    • Proujansky, R.1    Carpenter, A.B.2
  • 88
    • 0028978458 scopus 로고
    • Circulating soluble interleukin-2 receptor alpha and beta chain in inflammatory bowel disease
    • 88 Nielsen OH, Ciardelli T, Wu Z, Langholz E, Kirman I: Circulating soluble interleukin-2 receptor alpha and beta chain in inflammatory bowel disease. Am J Gastroenterol 1995; 90:1301-1306.
    • (1995) Am J Gastroenterol , vol.90 , pp. 1301-1306
    • Nielsen, O.H.1    Ciardelli, T.2    Wu, Z.3    Langholz, E.4    Kirman, I.5
  • 89
    • 0026736026 scopus 로고
    • Soluble interleukin-2 receptor, interleukin-6 and interleukin-1 beta in patients with Crohn's disease and ulcerative colitis: Preoperative levels and postoperative changes of serum concentrations
    • 89 Schurmann G, Betzler M, Post S, Herfarth C, Meuer S: Soluble interleukin-2 receptor, interleukin-6 and interleukin-1 beta in patients with Crohn's disease and ulcerative colitis: preoperative levels and postoperative changes of serum concentrations. Digestion 1992; 51:51-59.
    • (1992) Digestion , vol.51 , pp. 51-59
    • Schurmann, G.1    Betzler, M.2    Post, S.3    Herfarth, C.4    Meuer, S.5
  • 90
    • 0027299767 scopus 로고
    • Soluble interleukin-2 receptors, antineutrophil cytoplasmic antibodies, and other autoantibodies in patients with ulcerative colitis
    • 90 Dalekos GN, Manoussakis MN, Goussia AC, Tsianos EV, Moutsopoulos HM: Soluble interleukin-2 receptors, antineutrophil cytoplasmic antibodies, and other autoantibodies in patients with ulcerative colitis. Gut 1993; 34:658-664.
    • (1993) Gut , vol.34 , pp. 658-664
    • Dalekos, G.N.1    Manoussakis, M.N.2    Goussia, A.C.3    Tsianos, E.V.4    Moutsopoulos, H.M.5
  • 91
    • 0025041111 scopus 로고
    • Soluble interleutkin-2 receptor in Crohn's disease: Relation of serum concentrations to disease activity
    • 91 Crabtree JE, Juby LD, Heatley RV, Lobo AJ, Bullimore DW, Axon AT: Soluble interleutkin-2 receptor in Crohn's disease: relation of serum concentrations to disease activity. Gut 1990; 31:1033-1036.
    • (1990) Gut , vol.31 , pp. 1033-1036
    • Crabtree, J.E.1    Juby, L.D.2    Heatley, R.V.3    Lobo, A.J.4    Bullimore, D.W.5    Axon, A.T.6
  • 92
    • 0029081017 scopus 로고
    • Soluble interleukin-2 receptor in Crohn's disease. Assessment of disease activity and predicition of relapse
    • 92 Louis E, Belaiche J, Van-Kemseke C, Schaaf N, Mahieu P, Mary JY: Soluble interleukin-2 receptor in Crohn's disease. Assessment of disease activity and predicition of relapse. Dig Dis Sci 1995; 40:1750-1756.
    • (1995) Dig Dis Sci , vol.40 , pp. 1750-1756
    • Louis, E.1    Belaiche, J.2    Van-Kemseke, C.3    Schaaf, N.4    Mahieu, P.5    Mary, J.Y.6
  • 93
    • 0026518208 scopus 로고
    • Soluble interleukin-2 receptor and disease activity in Crohn's disease
    • 93 Williams AJ, Symons JA, Watchet K, Duff GW: Soluble interleukin-2 receptor and disease activity in Crohn's disease. J Autoimmun 1992; 5:251-259.
    • (1992) J Autoimmun , vol.5 , pp. 251-259
    • Williams, A.J.1    Symons, J.A.2    Watchet, K.3    Duff, G.W.4
  • 94
    • 0025037449 scopus 로고
    • Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease
    • 94 Mahida YR, Gallagher A, Kurlak L, Hawkey CJ: Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease. Clin Exp Immunol 1990; 82:75-80.
    • (1990) Clin Exp Immunol , vol.82 , pp. 75-80
    • Mahida, Y.R.1    Gallagher, A.2    Kurlak, L.3    Hawkey, C.J.4
  • 95
    • 0026502409 scopus 로고
    • Increased release of soluble interleukin-2 receptor by colonic lamina propria mononuclear cells in inflammatory bowel disease
    • 95 Schreiber S, Raedler A, Conn AF, Rombeau JL, MacDermott RP: Increased release of soluble interleukin-2 receptor by colonic lamina propria mononuclear cells in inflammatory bowel disease. Gut 1992; 32: 236-241.
    • (1992) Gut , vol.32 , pp. 236-241
    • Schreiber, S.1    Raedler, A.2    Conn, A.F.3    Rombeau, J.L.4    MacDermott, R.P.5
  • 96
    • 0026095235 scopus 로고
    • Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease
    • 96 Schreiber S, MacDermott RP, Raedler A, Pinnau R, Bertovich M, Nash GS: Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease. Gastroenterology 1991; 101:1020-1030.
    • (1991) Gastroenterology , vol.101 , pp. 1020-1030
    • Schreiber, S.1    MacDermott, R.P.2    Raedler, A.3    Pinnau, R.4    Bertovich, M.5    Nash, G.S.6
  • 98
    • 0023690334 scopus 로고
    • Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease
    • 98 Kaulfersch W, Fiocchi C, Waldmann TH: Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease. Gastroenterology 1988; 95:364-370.
    • (1988) Gastroenterology , vol.95 , pp. 364-370
    • Kaulfersch, W.1    Fiocchi, C.2    Waldmann, T.H.3
  • 99
    • 0027270344 scopus 로고
    • Human intestinal intraepithelial lymphocytes are derived from a limited number of T cells clones that utilize multiple V beta T cell receptor genes
    • 99 Blumberg RS, Yockey CE, Gross GG, Ebert EC, Balk SP: Human intestinal intraepithelial lymphocytes are derived from a limited number of T cells clones that utilize multiple V beta T cell receptor genes. J Immunol 1993; 1:5144-5153.
    • (1993) J Immunol , vol.1 , pp. 5144-5153
    • Blumberg, R.S.1    Yockey, C.E.2    Gross, G.G.3    Ebert, E.C.4    Balk, S.P.5
  • 101
    • 0028582009 scopus 로고
    • Oligoclonality and skewed T cell receptor V beta gene segment expression in in vivo activated human intestinal intraepithelial T lymphocytes
    • 101 Pluschke G, Taube H, Krawinkel U, Pfeffer K, Wagner H, Glassen M, Deusch K: Oligoclonality and skewed T cell receptor V beta gene segment expression in in vivo activated human intestinal intraepithelial T lymphocytes. Immunobiology 1994; 192:77-93.
    • (1994) Immunobiology , vol.192 , pp. 77-93
    • Pluschke, G.1    Taube, H.2    Krawinkel, U.3    Pfeffer, K.4    Wagner, H.5    Glassen, M.6    Deusch, K.7
  • 102
    • 0027164431 scopus 로고
    • Activated CA19+ B cell lamina propria lymphocytes in ulcerative colitis
    • 102 Yacyshyn BR: Activated CA19+ B cell lamina propria lymphocytes in ulcerative colitis. Immunol Cell Biol 1993; 71:265-274.
    • (1993) Immunol Cell Biol , vol.71 , pp. 265-274
    • Yacyshyn, B.R.1
  • 103
    • 0028878346 scopus 로고
    • CD45RO expression on circulating CD19+ b cells in Crohn's disease correlates with intestinal permeability
    • 103 Yacyshyn BR, Meddings JB: CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability. Gastroenterology 1995; 108:132-137.
    • (1995) Gastroenterology , vol.108 , pp. 132-137
    • Yacyshyn, B.R.1    Meddings, J.B.2
  • 104
    • 0029180514 scopus 로고
    • Anders Jahre Prize for young researches 1994. Chronic intestinal inflammation studies with multicolored immunohistochemistry
    • 104 Halstensen TS: Anders Jahre Prize for young researches 1994. Chronic intestinal inflammation studies with multicolored immunohistochemistry. Nord Med 1995; 110:56-59.
    • (1995) Nord Med , vol.110 , pp. 56-59
    • Halstensen, T.S.1
  • 105
    • 0024413527 scopus 로고
    • T lymphocytes in human gut epithelium preferentially express the alpha/beta antigen receptor and are often CD45/UCHL1-positive
    • 105 Brandtzaeg P, Bosnes V, Halstensen TS, Scott H, Sollid LM, Valnes KN: T lymphocytes in human gut epithelium preferentially express the alpha/beta antigen receptor and are often CD45/UCHL1 -positive. Scand J Immunol 1989; 30:123-128.
    • (1989) Scand J Immunol , vol.30 , pp. 123-128
    • Brandtzaeg, P.1    Bosnes, V.2    Halstensen, T.S.3    Scott, H.4    Sollid, L.M.5    Valnes, K.N.6
  • 107
    • 0029085294 scopus 로고
    • T cells in inflammatory bowel disease: Protective and pathogenic roles
    • 107 Powrie F: T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 1995; 3:171-174.
    • (1995) Immunity , vol.3 , pp. 171-174
    • Powrie, F.1
  • 109
    • 0023871935 scopus 로고
    • Lymphocytes isolated from the intestinal lamina propria of normal nonhuman primates have increased expression of genes associated with T cell activation
    • 109 Zeitz M, Greene WC, Pfeffer NJ, James SP: Lymphocytes isolated from the intestinal lamina propria of normal nonhuman primates have increased expression of genes associated with T cell activation. Gastroenterology 1988; 94:647-655.
    • (1988) Gastroenterology , vol.94 , pp. 647-655
    • Zeitz, M.1    Greene, W.C.2    Pfeffer, N.J.3    James, S.P.4
  • 110
    • 0019781638 scopus 로고
    • Alterations of IgA IgM, and IgG by peripheral blood mononuclear cells, and by human bone marrow mononuclear cells from patients with ulcerative colitis and Crohn's disease
    • 110 MacDermott RP, Nash GS, Bertovich MJ, et al: Alterations of IgA IgM, and IgG by peripheral blood mononuclear cells, and by human bone marrow mononuclear cells from patients with ulcerative colitis and Crohn's disease. Gastroenterology 1981; 81:844-852.
    • (1981) Gastroenterology , vol.81 , pp. 844-852
    • MacDermott, R.P.1    Nash, G.S.2    Bertovich, M.J.3
  • 111
    • 0022655716 scopus 로고
    • Evidence for the migration of B cells secreting monomeric IgA and IgA subclass 1 (IgA1) from peripheral compartments into the intestine in inflammatory bowel disease
    • 111 MacDermott RP, Delacroix DL, Nash GS, et al: Evidence for the migration of B cells secreting monomeric IgA and IgA subclass 1 (IgA1) from peripheral compartments into the intestine in inflammatory bowel disease. Gastroenterology 1986; 91:379-385.
    • (1986) Gastroenterology , vol.91 , pp. 379-385
    • MacDermott, R.P.1    Delacroix, D.L.2    Nash, G.S.3
  • 112
    • 0002246421 scopus 로고
    • Role of intestinal T-cells and intestinal lymphokine production in inflammatory bowel disease
    • Tsuchiya M, Nagura H, Hibi T, Moro I (Eds.). Amsterdam: Elsevier
    • 112 James SP, Murakawa Y, Kanof ME, et al: Role of intestinal T-cells and intestinal lymphokine production in inflammatory bowel disease. In: Tsuchiya M, Nagura H, Hibi T, Moro I (Eds.). Frontiers of mucosal immunology. Amsterdam: Elsevier, 1991; pp. 727-731.
    • (1991) Frontiers of Mucosal Immunology , pp. 727-731
    • James, S.P.1    Murakawa, Y.2    Kanof, M.E.3
  • 113
    • 0022262308 scopus 로고
    • Functional characterization of human T-lymphocyte subsets distinguished by monoclonal anti-leu-8
    • 113 Kansas GS, Wood GS, Fishwild DM, et al: Functional characterization of human T-lymphocyte subsets distinguished by monoclonal anti-leu-8. J Immunol 1985; 134:2995-3000.
    • (1985) J Immunol , vol.134 , pp. 2995-3000
    • Kansas, G.S.1    Wood, G.S.2    Fishwild, D.M.3
  • 114
    • 0023024787 scopus 로고
    • Phenotypic analysis of lamina propria lymphocytes: Predominance of helper-inducer and cytolytic T-cell phenotypes and deficiency of supressor-inducer phenotypes in Crohn's disease and control patients
    • 114 James SP, Fiocchi C, Graeff AS, et al: Phenotypic analysis of lamina propria lymphocytes: predominance of helper-inducer and cytolytic T-cell phenotypes and deficiency of supressor-inducer phenotypes in Crohn's disease and control patients. Gastroenterology 1986; 91:1483-1492.
    • (1986) Gastroenterology , vol.91 , pp. 1483-1492
    • James, S.P.1    Fiocchi, C.2    Graeff, A.S.3
  • 115
    • 0023696551 scopus 로고
    • CD4 positive leu-8 negative helper-inducer T cells predominate in the human intesinal lamina propria
    • 115 Kanof ME, Strober W, Fiocchi C, et al: CD4 positive leu-8 negative helper-inducer T cells predominate in the human intesinal lamina propria. J Immunol 1988, 141:3036-3041.
    • (1988) J Immunol , vol.141 , pp. 3036-3041
    • Kanof, M.E.1    Strober, W.2    Fiocchi, C.3
  • 116
    • 0022545059 scopus 로고
    • Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: Differences between ulcerative colitis, Crohn's disease and controls
    • 116 Scott MG, Nahm MH, Macke K, et al: Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease and controls. Clin Exp Immunol 1986; 66:209-215.
    • (1986) Clin Exp Immunol , vol.66 , pp. 209-215
    • Scott, M.G.1    Nahm, M.H.2    Macke, K.3
  • 117
    • 0023446035 scopus 로고
    • Expression of human immunoglobulin G subclassed in inflammatory bowel disease
    • 117 MacDermott RP, Nahm MH: Expression of human immunoglobulin G subclassed in inflammatory bowel disease. Gastroenterology 1987; 93:1127.
    • (1987) Gastroenterology , vol.93 , pp. 1127
    • MacDermott, R.P.1    Nahm, M.H.2
  • 118
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • 118 Neurath MF, Fuss I, Kelsall BL, Stuber E, Stober W: Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995; 182:1281-1290.
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Stober, W.5
  • 121
    • 0026552488 scopus 로고
    • Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis
    • 121 Mullin GE, Lazenby AJ, Harris ML, Bayless TM, James SP: Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992; 102:1620-1627.
    • (1992) Gastroenterology , vol.102 , pp. 1620-1627
    • Mullin, G.E.1    Lazenby, A.J.2    Harris, M.L.3    Bayless, T.M.4    James, S.P.5
  • 122
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • 122 Fuss IJ, Neurath M, Boirivant M, Klein JS, de la Motte C, Strong SA, Fiocchi C, Strober W: Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996; 157:1261-1270.
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    De La Motte, C.5    Strong, S.A.6    Fiocchi, C.7    Strober, W.8
  • 123
  • 124
    • 4244172803 scopus 로고    scopus 로고
    • Human host defence against helicobacter pylori: Role of pro-inflammatory cytokines IL-12, TNF-α, IL-1β, IL-6 and IL-8
    • 124 Bauditz J, Ortner M, Bierbaum M, Niedobitek M, Lochs H, Schreiber S: Human host defence against helicobacter pylori: role of pro-inflammatory cytokines IL-12, TNF-α, IL-1β, IL-6 and IL-8. Gastroenterology 1997; 112:A67.
    • (1997) Gastroenterology , vol.112
    • Bauditz, J.1    Ortner, M.2    Bierbaum, M.3    Niedobitek, M.4    Lochs, H.5    Schreiber, S.6
  • 125
    • 0022399257 scopus 로고
    • Macrophage endosomes contain proteases which degrade endocytosed protein ligands
    • 125 Diment S, Stahl P: Macrophage endosomes contain proteases which degrade endocytosed protein ligands. J Biol Chem 1985; 260:15311-15315.
    • (1985) J Biol Chem , vol.260 , pp. 15311-15315
    • Diment, S.1    Stahl, P.2
  • 126
    • 0023347690 scopus 로고
    • The basis for the immunoregulatory role of macrophages and other accessory cells
    • 126 Unanue ER, Allen PM: The basis for the immunoregulatory role of macrophages and other accessory cells. Science 1987; 236:551-554.
    • (1987) Science , vol.236 , pp. 551-554
    • Unanue, E.R.1    Allen, P.M.2
  • 127
    • 0021360513 scopus 로고
    • Differential requirement for antigen processing by macrophages for lysozyme-specific T-cell hybridomas
    • 127 Allen PM, Unanue ER: Differential requirement for antigen processing by macrophages for lysozyme-specific T-cell hybridomas. J Immunol 1984; 132:1077-1082.
    • (1984) J Immunol , vol.132 , pp. 1077-1082
    • Allen, P.M.1    Unanue, E.R.2
  • 128
    • 0023678901 scopus 로고
    • In vivo competition between self peptides and foreign antigens in T cell activation
    • 128 Adorini LS, Muller S, Cardinaux F, Lehmann PV, Falcioni F, Nagy ZA: In vivo competition between self peptides and foreign antigens in T cell activation. Nature 1988; 334:623-625.
    • (1988) Nature , vol.334 , pp. 623-625
    • Adorini, L.S.1    Muller, S.2    Cardinaux, F.3    Lehmann, P.V.4    Falcioni, F.5    Nagy, Z.A.6
  • 129
    • 0025338180 scopus 로고
    • Constitutive competition by self proteins for antigen presentation can be overcome by receptor-enhanced uptake
    • 129 Lorenz RG, Blum JS, Allen PM: Constitutive competition by self proteins for antigen presentation can be overcome by receptor-enhanced uptake. J Immunol 1990; 144:1600-1606.
    • (1990) J Immunol , vol.144 , pp. 1600-1606
    • Lorenz, R.G.1    Blum, J.S.2    Allen, P.M.3
  • 130
    • 0025741821 scopus 로고
    • Aggregated bovine IgG inhibits mannose receptor expression of murine bone marrow derived macrophages via activation
    • 130 Schreiber S, Stenson WF, MacDermott RP, Chappel JC, Teitelbaum SL, Perkins SL: Aggregated bovine IgG inhibits mannose receptor expression of murine bone marrow derived macrophages via activation. J Immunol 1991; 147:1377-1382.
    • (1991) J Immunol , vol.147 , pp. 1377-1382
    • Schreiber, S.1    Stenson, W.F.2    MacDermott, R.P.3    Chappel, J.C.4    Teitelbaum, S.L.5    Perkins, S.L.6
  • 131
    • 0027311319 scopus 로고
    • Enhancement of macrophage candidacidal activity by interferon-γ: Increased phagocytosis killing and calcium signal mediated by a decreased number of mannose receptors
    • 131 Marodi L, Schreiber S, Anderson DC, MacDermott RP, Korchak HM, Johnston RB: Enhancement of macrophage candidacidal activity by interferon-γ: increased phagocytosis killing and calcium signal mediated by a decreased number of mannose receptors. J Clin Invest, 1993; 91:2596-2601.
    • (1993) J Clin Invest , vol.91 , pp. 2596-2601
    • Marodi, L.1    Schreiber, S.2    Anderson, D.C.3    MacDermott, R.P.4    Korchak, H.M.5    Johnston, R.B.6
  • 134
    • 0029146381 scopus 로고
    • Respiratory burst of intestinal macrophages in inflammatory bowel disease is mainly caused by CD14(+)L14(+) monocyte derived cells
    • 134 Rugveit J, Haraldsen G, Hogasen AK, Bakka A, Brandtzaeg P, Scott H: Respiratory burst of intestinal macrophages in inflammatory bowel disease is mainly caused by CD14(+)L14(+) monocyte derived cells. Gut 1995; 37:367-373.
    • (1995) Gut , vol.37 , pp. 367-373
    • Rugveit, J.1    Haraldsen, G.2    Hogasen, A.K.3    Bakka, A.4    Brandtzaeg, P.5    Scott, H.6
  • 135
    • 0025146261 scopus 로고
    • The alpha 1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin 1
    • 135 Karp DR, Teletski CL, Scholl P, Geha R, Long EO: The alpha 1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin 1. Nature 1990; 346:474-476.
    • (1990) Nature , vol.346 , pp. 474-476
    • Karp, D.R.1    Teletski, C.L.2    Scholl, P.3    Geha, R.4    Long, E.O.5
  • 136
    • 0027428733 scopus 로고
    • T-cell activation in human intestinal mucosa: The role of superantigens
    • 136 Aisenberg J, Ebert EC, Mayer L: T-cell activation in human intestinal mucosa: the role of superantigens. Gastroenterology 1993; 105:1421-30.
    • (1993) Gastroenterology , vol.105 , pp. 1421-1430
    • Aisenberg, J.1    Ebert, E.C.2    Mayer, L.3
  • 138
    • 0028987074 scopus 로고
    • Cytotoxic activity of V beta 8+ T cells in Crohn's disease: The role of bacterial superantigens
    • 138 Baca-Estrada ME, Wong DK, Croitoru K: Cytotoxic activity of V beta 8+ T cells in Crohn's disease: the role of bacterial superantigens. Clin Exp Immunol 1995; 99:398-403.
    • (1995) Clin Exp Immunol , vol.99 , pp. 398-403
    • Baca-Estrada, M.E.1    Wong, D.K.2    Croitoru, K.3
  • 139
    • 0029144848 scopus 로고
    • The delta T cell receptor repertoire in human colon and peripheral blood in oligoclonal irrespective of V region usage
    • 139 Holtmeier W, Chowers Y, Lumeng A, Morzycka-Woblenska E, Kagnoff MF: The delta T cell receptor repertoire in human colon and peripheral blood in oligoclonal irrespective of V region usage. J Clin Invest 1995; 96:1108-1117.
    • (1995) J Clin Invest , vol.96 , pp. 1108-1117
    • Holtmeier, W.1    Chowers, Y.2    Lumeng, A.3    Morzycka-Woblenska, E.4    Kagnoff, M.F.5
  • 140
    • 0029586031 scopus 로고
    • Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
    • 140 Duchmann R, Kaiser I, Herrmann E, Mayet W, Ewe K, Meier zum Büschenfelde KH: Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 1995; 102:448-455.
    • (1995) Clin Exp Immunol , vol.102 , pp. 448-455
    • Duchmann, R.1    Kaiser, I.2    Herrmann, E.3    Mayet, W.4    Ewe, K.5    Meier Zum Büschenfelde, K.H.6
  • 141
    • 0023240740 scopus 로고
    • HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers
    • 141 Fais S, Pallone F, Squarcia O, Biancone L, Ricci F, Paoluzi P, Boirivant M: HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers. Clin Exp Immunol 1987; 68:605-612.
    • (1987) Clin Exp Immunol , vol.68 , pp. 605-612
    • Fais, S.1    Pallone, F.2    Squarcia, O.3    Biancone, L.4    Ricci, F.5    Paoluzi, P.6    Boirivant, M.7
  • 142
    • 0022997883 scopus 로고
    • Immunoelectron microscopic localization of HLA-DR antigen in control small intestine and colon and in inflammatory bowel disease
    • 142 Hirata I, Austin LL, Bleckwell WH, Weber JR, Dobbins WO: Immunoelectron microscopic localization of HLA-DR antigen in control small intestine and colon and in inflammatory bowel disease. Dig Dis Sci 1986; 31:1317-3130.
    • (1986) Dig Dis Sci , vol.31 , pp. 1317-3130
    • Hirata, I.1    Austin, L.L.2    Bleckwell, W.H.3    Weber, J.R.4    Dobbins, W.O.5
  • 143
    • 0023158155 scopus 로고
    • Glass II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon
    • 143 McDonald GB, Jewell DP: Glass II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon. J Clin Pathol 1987; 40:312-317.
    • (1987) J Clin Pathol , vol.40 , pp. 312-317
    • McDonald, G.B.1    Jewell, D.P.2
  • 144
    • 0020551753 scopus 로고
    • Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease
    • 144 Selby WS, Janossy G, Mason DY, Jewell DP: Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. Clin Exp Immunol 1983; 53:614-618.
    • (1983) Clin Exp Immunol , vol.53 , pp. 614-618
    • Selby, W.S.1    Janossy, G.2    Mason, D.Y.3    Jewell, D.P.4
  • 146
    • 0023899866 scopus 로고
    • MHC class II expression by the gut epithelium
    • 146 Bland P: MHC class II expression by the gut epithelium. Immunol Today 1988; 9:174-178.
    • (1988) Immunol Today , vol.9 , pp. 174-178
    • Bland, P.1
  • 147
    • 0023612719 scopus 로고
    • Evidence for function of Ia molecules on gut epithelial cells in man
    • 147 Mayer L, Shlien R: Evidence for function of Ia molecules on gut epithelial cells in man. J Exp Med 1987; 166:1471-1483.
    • (1987) J Exp Med , vol.166 , pp. 1471-1483
    • Mayer, L.1    Shlien, R.2
  • 148
    • 0026032886 scopus 로고
    • Expression of class II molecules on intestinal epithelial cells in humans. Differences between normal and inflammatory bowel disease
    • 148 Mayer L, Eisenhardt D, Salomon P, Bauer W, Plous R, Piccinini L: Expression of class II molecules on intestinal epithelial cells in humans. Differences between normal and inflammatory bowel disease. Gastroenterology 1991; 100:3-12.
    • (1991) Gastroenterology , vol.100 , pp. 3-12
    • Mayer, L.1    Eisenhardt, D.2    Salomon, P.3    Bauer, W.4    Plous, R.5    Piccinini, L.6
  • 149
    • 0023641176 scopus 로고
    • Heterogeneous epithelial expression of class II(HLA-DR) determinants and secretory component related to dysplasia in ulcerative colitis
    • 149 Rognum TO, Brandtzaeg P, Elgjo K, Fausa O: Heterogeneous epithelial expression of class II(HLA-DR) determinants and secretory component related to dysplasia in ulcerative colitis. Br J Cancer 1987; 56:419-424.
    • (1987) Br J Cancer , vol.56 , pp. 419-424
    • Rognum, T.O.1    Brandtzaeg, P.2    Elgjo, K.3    Fausa, O.4
  • 150
    • 0028069666 scopus 로고
    • Stimulation of lamina propria lymphocytes by intestinal epithelial cells: Evidence for recognition of non-classical restriction elements
    • 150 Panja A, Barone A, Mayer L: Stimulation of lamina propria lymphocytes by intestinal epithelial cells: evidence for recognition of non-classical restriction elements. J Exp Med 1994; 179:943-950.
    • (1994) J Exp Med , vol.179 , pp. 943-950
    • Panja, A.1    Barone, A.2    Mayer, L.3
  • 151
    • 0027169814 scopus 로고
    • CD1d is involved in T cell-intestinal epithelial cell interactions
    • 151 Panja A, Blumberg RS, Balk SP, Mayer L: CD1d is involved in T cell-intestinal epithelial cell interactions. J Exp Med 1993; 178:1115-1119.
    • (1993) J Exp Med , vol.178 , pp. 1115-1119
    • Panja, A.1    Blumberg, R.S.2    Balk, S.P.3    Mayer, L.4
  • 152
    • 0028179279 scopus 로고
    • Intraepithelial lymphocytes and their recognition of non-classical MHC molcules
    • 152 Blumberg RS, Balk SP: Intraepithelial lymphocytes and their recognition of non-classical MHC molcules. Int Rev Immunol 1994; 11:15-30.
    • (1994) Int Rev Immunol , vol.11 , pp. 15-30
    • Blumberg, R.S.1    Balk, S.P.2
  • 156
    • 0031841110 scopus 로고    scopus 로고
    • Substance P containing nerve fibers in ulcerative colitis
    • 156 Watanabe T, Kubota Y, Muto T: Substance P containing nerve fibers in ulcerative colitis. Int J Colorectal Dis 1998; 13(2):61-67.
    • (1998) Int J Colorectal Dis , vol.13 , Issue.2 , pp. 61-67
    • Watanabe, T.1    Kubota, Y.2    Muto, T.3
  • 158
    • 0033056459 scopus 로고    scopus 로고
    • Genetics in GI disease: How much can we learn from the molecular analysis?
    • 158 Schreiber S, Hampe J: Genetics in GI disease: How much can we learn from the molecular analysis? Int J Colorectal Dis 1999; 14:10-12.
    • (1999) Int J Colorectal Dis , vol.14 , pp. 10-12
    • Schreiber, S.1    Hampe, J.2
  • 159
    • 0002494110 scopus 로고    scopus 로고
    • Morbus Crohn und colitis ulcerosa - Aspekte zur pathophysiologie
    • 159 Schreiber S: Morbus Crohn und Colitis ulcerosa - Aspekte zur Pathophysiologie. Leber Magen Darm 1997; 29 (S3):34-39.
    • (1997) Leber Magen Darm , vol.29 , Issue.S3 , pp. 34-39
    • Schreiber, S.1
  • 160
    • 0033051293 scopus 로고    scopus 로고
    • Inflammatory bowel disease and the genes for the natural resistance-associated macrophage protein-1 and the interferon-gamma receptor 1
    • 160 Stokkers PC, de Heer K, Leegwater AC, Reitsma PH, Tytgat GN, van Deventer SJ: Inflammatory bowel disease and the genes for the natural resistance-associated macrophage protein-1 and the interferon-gamma receptor 1. Int J Colorectal Dis 1999; 14(1):13-17.
    • (1999) Int J Colorectal Dis , vol.14 , Issue.1 , pp. 13-17
    • Stokkers, P.C.1    De Heer, K.2    Leegwater, A.C.3    Reitsma, P.H.4    Tytgat, G.N.5    Van Deventer, S.J.6


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