Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation

Gut

Volumn 42, Issue 4, 1998, Pages 470-476

  Nikolaus, S ^a   Bauditz, J ^a   Gionchetti, P ^b   Witt, C ^a   Lochs, H ^a   Schreiber, S ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Granulocytes; Inflammation; Inflammatory bowel disease; Interleukin 10; Interleukin 1 ; Intestinal immunity; Neutrophils; Tumour necrosis factor

Indexed keywords

CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; FEMALE; HUMAN; HUMAN CELL; IMMUNOREGULATION; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN SECRETION; ULCERATIVE COLITIS;

EID: 0031903013     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.42.4.470     Document Type: Article

References (56)

1. Saverymuttu SH, Peters AM, Lavender JP, et al. In vivo assessment of granulocyte migration to diseased bowel in Crohn's disease. Gut 1985;26:378 83.
2. Saverymuttu SH, Chadwick VS, Hodgson HJ. Granulocyte migration in ulcerative colitis. Eur J Clin Invest 1985;15:60-8.
3. Saverymuttu SH, Peters AM, Lavender JP, et al. Quantitative fecal indium 111-labeled leucocyte excretion in the assessment of disease activity in Crohn's disease. Gastroenterology 1983;85:1333-9.
4. Schoelmerich J, Schmidt E, Schumichen C, et al. Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m hexamethyl propylene amine oxine as leukocyte label. Gastroenterlogy 1988;95:1287-93.
5. Malizia G, Calabrese A, Cottone M, et al. Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease. Gastroenterology 1991;100:150-9.
6. Koizumi M, King N, Lobb R, et al. Expression of vascular adhesion molecules in inflammatory bowel disease. Gastro-enterology 1992;103:840-7.
7. Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J 1994;8:504-12.
8. Guthrie LA, McPhail LC, Henson PM, et al. Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide, evidence for increased activity of the superoxide-producing enzyme. J Exp Med 1984;160: 1656-71.
9. Schreiber S, Raedler A, Stenson WF, et al. The immunology of inflammatory bowel disease. Gastroenterol Clin North Am 1992;21:451-502.
10. Mahida YR, Wu K, Jewell DP. Enhanced production of interleukin 1-β by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn's disease, Gut 1989; 30:815 8.
11. Ligumsky M, Simon PL, Karmeli F, et al. Role of interleukin 1 in inflammatory bowel disease - enhanced production during active disease. Gut 1990;31:686 9.
12. MacDonald TT, Hutchings P, Choy MY, et al Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol 1990;81:301 5.
13. Brynskov J, Tvede N, Andersen CB, et al. Increased concentrations of interleukin 1β, interleukin 2, and soluble interleukin-2 receptors in endoscopic mucosal biopsy specimens with active inflammatory bowel disease. Gut 1992;33:55 8.
14. Pullman WE, Elsbury S, Masanobu K, et al. Enhanced mucosal cytokine production in inflammatory bowel disease. Gastroenterology 1992;102:529 17.
15. Schreiber S, Raedler A, Conn AF, et al. Increased release of soluble interleukin-2 receptor by colonic lamina propria mononuclear cells in inflammatory bowel disease. Gut 1992;32:236 9.
16. Stevens C, Walz G, Singaram C, et al. Tumor necrosis factor-α, interleukin-1β and interleukin 6 expression in inflammatory bowel disease. Dig Dis Sci 1992;37:818 26.
17. Isaacs KL, Sartor RB, Haskill S. Cytokine messenger RNA profiles in inflammatory bowel diseuse mucosa detected by polymerase chain reaction amplification. Gastroenterology 1992;103:1587 95.
18. Reinecker H-C, Steffen M, Witthoeft T, et al. Enhanced secretion of tumor necrosis factor-alpha, IL-6, and IL-I beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 1993;94:174 81.
19. Dinarello CA, Wolff SM. The role of interleukin 1 in disease. N Engl J Med 1993;328:106 13.
20. Nicholls S, Stephens S, Braegger CP, et al. Cytokines in stools of children with inflammatory bowel disease or infective diarrhoea. J Clin Pathol 1993;46:757-60.
21. Grisham MB, Granger DN. Neutrophil mediated mucosal injury. Role of reactive oxygen metabolites. Dig Dis Sci 1988;33:6S-15S.
22. Faden H, Rossi TM. Chemiluminescent response of neutrophils from patients with inflammatory bowel disease. Dig Dis Sci 1985;30:139 42.
23. Anton PA, Targan SR, Shanahan F. Increased neutrophil receptors for and response to the pro-inflammatory bacterial peptide formyl-methionyl-leucyl-phenylalanine in Crohn's disease. Gastroenterology 1989;97:20-8.
24. Kelleher D, Feighery C, Weir DG. Chemiluminescence by polymorphonuclear leucocyte subpopulations in chronic inflammatory bowel disease. Influence of the cell separation procedure. Digesion 1990;45:158-65.
25. Baldassano RN, Schreiber S, Johnston RB, et al. Monocytes of patients with Crohn's disease are primed for accentuated release of toxic oxygen metabolites: possible role for endotoxin. Gastroenterology 1909;105:60 6.
26. Griga T, Tromm A, Schwegler U, et al. Enhanced Superoxide anion release of normal neutrophil granulocytes primed with sera of patients with inactive inflammatory bowel disease. Z Gastroentrol 1995;33:345 8.
27. Andus T, Gross V, Caesar I, et al. PMN-elastase in assessment of patients with inflammatory bowel disease. Dig Dis Sci 1993;38:1638-44.
28. Adeyemi EO, Hodgson HJ. Faecal elastase reflects disease activity in active ulcerative colitis. Scand J Gastroenterol 1992;27:139-42.
29. Bazzoni F, Cassatella MA, Laudanna C, et al. Phagocytosis of opsonized yeast induces tumor necrosis factor alpha mRNA accumulation and protein release by human polymorphonuclear leukocytes. J Leukocyte Biol 1991;50: 223 8.
30. Cassatella MA, Meda L, Bonora S, et al. Interleukin 10 (IL-10) inhibits the release of pro-inflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopolysaccharide. J Exp Med 1993;178:2207 11.
31. Cassatella MA. The production of cytokines by polymorphonuclear neutrophils. Immunol Today 1995;16:21 6.
32. Vieira P, de Waal-Malefyt R, Dang M, et al. Isolation and expression of human cytokine synthesis inhibitory factor (CSIF/IL-10) c-DNA clones homology to Epstein-Barr virus open reading frame BCREI. Proc Natl Acad Sci USA 1991;88:1172 7.
33. de Waal Malefyt R, Yssel H, Roncarolo M-G, et al. Interleukin 10. Curr Opin Immunol 1992;4:314 22.
34. Fiorentino DF, Zlotnik A, Mosmann TR, et al. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991;147:3815 22.
35. Ralph P, Nakoinz I, Sampson-Johannes A, et al IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor. J Immunol 1992;148:808 14.
36. de Waal Malefyt R, Abrams J, Bennett ,B, et al. Interleukin 10 (IL-10) inhibits cytokine synthesis by human munocytcs: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:1209 20.
37. Schreiber S, Heinig T, Thiele HG, et al. Immunoregulatory role of interleukin 10 in inflammatory bowel disease in vitro and in vivo. Gastroenterology 1992;108:1434-44.
38. Cassatella MA, Meda L, Gasperini S, et al. Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leucocytes by delaying mRNA degradation. J Exp Med 1994;179:1695-9.
39. van Deventer SJH, Elson CO, Fedorak RN for the Crohn's disease study group. Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Gastroenterology 1997;113:383-90.
40. Best WR, Becktel JM, Singleton JW, et al. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterololgy 1976;70:439 44.
41. Rachmilewitz D. Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomized trial. BMJ 1989;298:82-6.
42. Gasperini S, Donini M, Dusi S, et al. Interleukin-10 decreases tyrosine phosphorylation of discrete lipopolysaccharide-induced phosphorylation in human granulocytes. Biochem Biophys Res Commun 1995;209:87 94.
43. Metcalf JA, Gallini JI, Nauseef WN, et al Laboratory manual of neutrophil function. New York: Raven Press, 1989:109.
44. Yam LT, Li CY, Crosby WH. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol 1971;55: 283-90.
45. Bienvenu J, Coulon L, Doche C et al Analytical performance of commercial ELISA-kits for IL-2, IL-6 and TNF-α. A WHO study. Eur Cytokine New 1993;4:447 51.
46. Chromczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156 9.
47. Wang AM, Doyle MV, Mark DE Quantitation of mRNA by the polymerase chain reaction. Proc Natl Acad Sci USA 1989;86:9717 21.
48. Lilliefors HW. On the Kolmogorov-Smirnov test for normality with mean and variance unknown. J Am Stat Assoc 1967;64:399-402.
49. Sachs L. Angewandra Statistik. 7th edn. Heidelberg, New York, Tokyo: Springer, 1992.
50. Mann HB, Whitney DR. On a test of whether one of two random variables is stochastically larger than the other. Ann Math Statistics 1947;18:50 60.
51. Raah Y, Gerdin R, Ahlstedt S, et al. Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis. Gut 1993;34:1203 6.
52. Monajemi H, Meenan J, Lamping R, et al. Inflammatory bowel disease is associated with increased mucosal levels of bactericidal permeability-increasing protein, Gastroenterology 1996;110:733-9.
53. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood 1991;77:1627 52.
54. Lenardo MJ, Baltimore D. NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989;58:227-9.
55. Baldwin AS. The NF-κB and I-κB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-81.
56. Colotta F, Re F, Polentarutti N, et al Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Biol 1992;80:2012-20.