메뉴 건너뛰기




Volumn 29, Issue 2, 2000, Pages 73-84

New treatment possibilities in rheumatoid arthritis

Author keywords

Anti cytokines; Cytokines; Enbrel; Gene therapy; Monoklonal antibodies; Remicade; Stem cell transplantation

Indexed keywords

ANTIRHEUMATIC AGENT; CD4 ANTIGEN; CD5 ANTIGEN; CD52 ANTIGEN; CD7 ANTIGEN; CYCLOSPORIN; INTERLEUKIN 2 RECEPTOR; LEFLUNOMIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN; METHOTREXATE; MONOCLONAL ANTIBODY; RAPAMYCIN; RECOMBINANT TUMOR NECROSIS FACTOR; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 0033947306     PISSN: 03009742     EISSN: None     Source Type: Journal    
DOI: 10.1080/030097400750001860     Document Type: Review
Times cited : (17)

References (113)
  • 1
    • 0029985217 scopus 로고    scopus 로고
    • Guidelines for the management of rheumatoid arthritis
    • 1. American College of Rheumatology Ad Hoc Committee on Clinical Guidelines. Guidelines for the management of rheumatoid arthritis. Arthritis Rheum 1996;39:712-22.
    • (1996) Arthritis Rheum , vol.39 , pp. 712-722
  • 2
    • 0019995714 scopus 로고
    • In situ characterization of mononuclear cells in rheumatoid tissues using monoclonal antibodies. No reduction in T8-positive cells or augmentation in T4 positive cells
    • 2. Førre Ø, Thoen J, Lea T, Dobloug JH, Mellbye OJ, Solheim BG, et al. In situ characterization of mononuclear cells in rheumatoid tissues using monoclonal antibodies. No reduction in T8-positive Cells or Augmentation in T4 positive cells. Scand J Immunol 1982;16:315-9.
    • (1982) Scand J Immunol , vol.16 , pp. 315-319
    • Førre, Ø.1    Thoen, J.2    Lea, T.3    Dobloug, J.H.4    Mellbye, O.J.5    Solheim, B.G.6
  • 3
    • 0027963256 scopus 로고
    • Seronegative and weakly seropositive rheumatoid arthritis differ from clearly seropositive rheumatoid arthritis in HLA class II associations
    • 3. Ploski R, Mellbye OJ, Skjold Rønningen K, Førre Ø, Thorsby E. Seronegative and weakly seropositive rheumatoid arthritis differ from clearly seropositive rheumatoid arthritis in HLA class II associations. J Rheumatol 1994;28:1397-402.
    • (1994) J Rheumatol , vol.28 , pp. 1397-1402
    • Ploski, R.1    Mellbye, O.J.2    Skjold Rønningen, K.3    Førre, Ø.4    Thorsby, E.5
  • 4
    • 0023272665 scopus 로고
    • Human rheumatoid synovial and normal blood dendritic cells as antigen presenting cells - Comparison with autologous monocytes
    • 4. Waalen K, Førre Ø, Teigland J, Natvig JB. Human rheumatoid synovial and normal blood dendritic cells as antigen presenting cells - comparison with autologous monocytes. Clin Exp Immunol 1987;70:1-9.
    • (1987) Clin Exp Immunol , vol.70 , pp. 1-9
    • Waalen, K.1    Førre, Ø.2    Teigland, J.3    Natvig, J.B.4
  • 5
    • 0024386014 scopus 로고
    • Leukocyte-endothelial cell interaction and the control of leukocyte migration into inflamed synovium
    • 5. Jalkanen S. Leukocyte-endothelial cell interaction and the control of leukocyte migration into inflamed synovium. Springer Semin Immunopathol 1989;11:187-98.
    • (1989) Springer Semin Immunopathol , vol.11 , pp. 187-198
    • Jalkanen, S.1
  • 6
    • 0033152142 scopus 로고    scopus 로고
    • The chemokine system: Redundancy for robust outputs
    • 6. Mantovani A. The chemokine system: redundancy for robust outputs. Immunol Today 1999;6:S254.
    • (1999) Immunol Today , vol.6
    • Mantovani, A.1
  • 7
    • 0024401263 scopus 로고
    • Leukocyte function-associated antigen I is an activation molecule for human T cells
    • 7. Wacholtz MC, Patel SS, Lipsky PE. Leukocyte function-associated antigen I is an activation molecule for human T cells. J Exp Med 1989;170:431-8.
    • (1989) J Exp Med , vol.170 , pp. 431-438
    • Wacholtz, M.C.1    Patel, S.S.2    Lipsky, P.E.3
  • 8
    • 0031809547 scopus 로고    scopus 로고
    • The role of nitric oxide in inflammation and immunity
    • 8. Clancy RM, Amin AR, Abramson SB. The role of nitric oxide in inflammation and immunity. Arthritis Rheum 1998;7: 1141-51.
    • (1998) Arthritis Rheum , vol.7 , pp. 1141-1151
    • Clancy, R.M.1    Amin, A.R.2    Abramson, S.B.3
  • 9
    • 0008586681 scopus 로고
    • Connective tissue, small blood vessels and capillaries
    • Kelley WN, ed. Philadelphia: WB Saunders
    • 9. Folkman J, Ausprunk D, Langer R. Connective tissue, small blood vessels and capillaries. In: Kelley WN, ed. Textbook of Rheumatology edn. 2. Philadelphia: WB Saunders 1985:197-210.
    • (1985) Textbook of Rheumatology Edn. 2 , pp. 197-210
    • Folkman, J.1    Ausprunk, D.2    Langer, R.3
  • 10
    • 0023157363 scopus 로고
    • Angiogenic factors
    • 10. Folkman J, Klagsbrun M. Angiogenic factors. Science 1987;235:44-7.
    • (1987) Science , vol.235 , pp. 44-47
    • Folkman, J.1    Klagsbrun, M.2
  • 11
    • 0028865183 scopus 로고
    • The pathophysiology of angiogenesis
    • 11. Polverinin PJ. The pathophysiology of angiogenesis Crit Rev Oral Biol Med 1995;6:230-47.
    • (1995) Crit Rev Oral Biol Med , vol.6 , pp. 230-247
    • Polverinin, P.J.1
  • 12
    • 0027503243 scopus 로고
    • Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis
    • 12. Moreland LW, Bucy RP, Tilden A, Pratt PW, LoBuglio AF, Khazaeli M, et al. Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis. Arthritis Rheum 1993;36:307-18.
    • (1993) Arthritis Rheum , vol.36 , pp. 307-318
    • Moreland, L.W.1    Bucy, R.P.2    Tilden, A.3    Pratt, P.W.4    LoBuglio, A.F.5    Khazaeli, M.6
  • 14
    • 0030063898 scopus 로고    scopus 로고
    • Percentage of anti-CD4 monoclonal antibody-coated lymphocytes in the rheumatoid joints is associated with clinical improvement: Implications for the development of immunotheraputic dosing regiments
    • 14. Choy EHS, Pitzalis C, Cauli A, Bijl JA, Schantz A, Woody J, et al. Percentage of anti-CD4 monoclonal antibody-coated lymphocytes in the rheumatoid joints is associated with clinical improvement: Implications for the development of immunotheraputic dosing regiments. Arthritis Rheum 1996;39:52-6.
    • (1996) Arthritis Rheum , vol.39 , pp. 52-56
    • Choy, E.H.S.1    Pitzalis, C.2    Cauli, A.3    Bijl, J.A.4    Schantz, A.5    Woody, J.6
  • 15
    • 0028882681 scopus 로고
    • Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate
    • 15. Moreland LW, Pratt PW, Mayes MD, Postlethwaite A, Weisman MH, Schnitzer T, et al. Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate. Arthritis Rheum 1995;38:1581-8.
    • (1995) Arthritis Rheum , vol.38 , pp. 1581-1588
    • Moreland, L.W.1    Pratt, P.W.2    Mayes, M.D.3    Postlethwaite, A.4    Weisman, M.H.5    Schnitzer, T.6
  • 16
    • 0029115051 scopus 로고
    • A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis
    • 16. Van der Lubbe PA, Dijkmans BAC, Markusse HM, Nässander U, Breedveld FC. A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis. Arthritis Rheum 1995;38:1097-106.
    • (1995) Arthritis Rheum , vol.38 , pp. 1097-1106
    • Van Der Lubbe, P.A.1    Dijkmans, B.A.C.2    Markusse, H.M.3    Nässander, U.4    Breedveld, F.C.5
  • 17
    • 0028238428 scopus 로고
    • Treatment of refractory rheumatoid arthritis with a chimeric anti-CD4 monoclonal antibody: Long-term followup of CD4 + T cell counts
    • 17. Moreland LW, Pratt PW, Bucy RP, Jackson BS, Feldman JW, Koopman WJ. Treatment of refractory rheumatoid arthritis with a chimeric anti-CD4 monoclonal antibody: long-term followup of CD4 + T cell counts. Arthritis Rheum 1994;37:834-8.
    • (1994) Arthritis Rheum , vol.37 , pp. 834-838
    • Moreland, L.W.1    Pratt, P.W.2    Bucy, R.P.3    Jackson, B.S.4    Feldman, J.W.5    Koopman, W.J.6
  • 19
    • 0000056486 scopus 로고    scopus 로고
    • T cell hypothesis in rheumatoid arthritis tested by humanized non-depleting anti-CD4 monoclonal antibody treatment I: Suppression of disease activity and acute phase response
    • 19. Panayi GS, Choy EHS, Connolly DJA, Regan T, Manna VK, Rapson N, et al., T cell hypothesis in rheumatoid arthritis tested by humanized non-depleting anti-CD4 monoclonal antibody treatment I: suppression of disease activity and acute phase response. Arthritis Rheum 1996;39 Suppl 9:S244.
    • (1996) Arthritis Rheum , vol.39 , Issue.SUPPL. 9
    • Panayi, G.S.1    Choy, E.H.S.2    Connolly, D.J.A.3    Regan, T.4    Manna, V.K.5    Rapson, N.6
  • 22
    • 0029143898 scopus 로고
    • Treatment of active refractory rheumatoid arthritis with humanized monocolonal antibody CAMPATH-1H administered by daily subcutaneous injection
    • 22. Matteson EL, Yocum DE, Clair EW. St, Achkar AA, Thakor MS, Jacobs MR, et al. Treatment of active refractory rheumatoid arthritis with humanized monocolonal antibody CAMPATH-1H administered by daily subcutaneous injection. Arthritis Rheum 1995;38:1187-93.
    • (1995) Arthritis Rheum , vol.38 , pp. 1187-1193
    • Matteson, E.L.1    Yocum, D.E.2    St. Clair, E.W.3    Achkar, A.A.4    Thakor, M.S.5    Jacobs, M.R.6
  • 23
    • 0028862268 scopus 로고
    • CAMPATH-H1, a humanized monoclonal antibody, in refractory rheumatoid arthritis: An intravenous dose-escalation study
    • 23. Weinblatt ME, Maddison PJ, Bulpitt KJ, Hazleman BL, Urowitz, Sturrock RD, et al. CAMPATH-H1, a humanized monoclonal antibody, in refractory rheumatoid arthritis: an intravenous dose-escalation study. Arthritis Rheum 1995;38:1589-94.
    • (1995) Arthritis Rheum , vol.38 , pp. 1589-1594
    • Weinblatt, M.E.1    Maddison, P.J.2    Bulpitt, K.J.3    Hazleman, B.L.4    Urowitz5    Sturrock, R.D.6
  • 24
    • 0028785678 scopus 로고
    • T cell regulation
    • Brooks PM Furst DE, eds. Innovative Treatment Approaches for Rheumatoid Arthritis. London: Baillière's
    • 24. Choy EH, Kingsley GH, Panayi GS. T cell regulation. In: Brooks PM Furst DE, eds. Innovative Treatment Approaches for Rheumatoid Arthritis. London: Baillière's. Clin Rheumatol ; 1995:653-71.
    • (1995) Clin Rheumatol , pp. 653-671
    • Choy, E.H.1    Kingsley, G.H.2    Panayi, G.S.3
  • 26
    • 0027299097 scopus 로고
    • Effects of administration of an anti-CD5 plus immunoconjugate in rheumatoid arthritis: Results of two phase II studies
    • 26. Strand V, Lipsky PE, Cannon GW, Calabrese LH, Wiesenhutter C, Cohen SB, et al. Effects of administration of an anti-CD5 plus immunoconjugate in rheumatoid arthritis: results of two phase II studies. Arthritis Rheum 1993;36:620-30.
    • (1993) Arthritis Rheum , vol.36 , pp. 620-630
    • Strand, V.1    Lipsky, P.E.2    Cannon, G.W.3    Calabrese, L.H.4    Wiesenhutter, C.5    Cohen, S.B.6
  • 27
    • 8944229691 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of anti-CD5 immunoconjugate in patients with rheumatoid arthritis
    • 27. Olsen NJ, Brooks RH, Cush JJ, Lipsky PE, Clair EW. St, Mattesen EL, et al. A double-blind, placebo-controlled study of anti-CD5 immunoconjugate in patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1102-8.
    • (1996) Arthritis Rheum , vol.39 , pp. 1102-1108
    • Olsen, N.J.1    Brooks, R.H.2    Cush, J.J.3    Lipsky, P.E.4    St. Clair, E.W.5    Mattesen, E.L.6
  • 29
    • 0023612203 scopus 로고
    • Evidence of an activated T cell system with augmented turnover of interleukin-2 in rheumatoid arthritis - Stimulation of human T lymphocytes by dendritic cells as a model for rheumatoid T cell activation
    • 29. Waalen K, Førre Ø, Linker-Israeli M, Thoen J. Evidence of an activated T cell system with augmented turnover of interleukin-2 in rheumatoid arthritis - stimulation of human T lymphocytes by dendritic cells as a model for rheumatoid T cell activation. Scand J Immunol 1987;25:367-73.
    • (1987) Scand J Immunol , vol.25 , pp. 367-373
    • Waalen, K.1    Førre, Ø.2    Linker-Israeli, M.3    Thoen, J.4
  • 30
    • 0024512227 scopus 로고
    • Beneficial effects of monoclonal antibody to interleukin-2 receptor on activated T cells in rheumatoid arthritis
    • 30. Kyle V, Coughlan RJ, Tighe H, Waldmann H, Hazleman BL. Beneficial effects of monoclonal antibody to interleukin-2 receptor on activated T cells in rheumatoid arthritis. Ann Rheum Dis 1989;48:428-9.
    • (1989) Ann Rheum Dis , vol.48 , pp. 428-429
    • Kyle, V.1    Coughlan, R.J.2    Tighe, H.3    Waldmann, H.4    Hazleman, B.L.5
  • 32
    • 0029164940 scopus 로고
    • Interleukin-2 diphtheria fusion protein (DAB486IL-2) in refractory rheumatoid arthritis: A double-blind placebo-controlled trial with open-label extension
    • 32. Moreland LW, Sewell KL, Trentham DE, Bucy RP, Sullivan WF, Schrohenloher RE, et al. Interleukin-2 diphtheria fusion protein (DAB486IL-2) in refractory rheumatoid arthritis: a double-blind placebo-controlled trial with open-label extension. Arthritis Rheum 1995;38:1177-86.
    • (1995) Arthritis Rheum , vol.38 , pp. 1177-1186
    • Moreland, L.W.1    Sewell, K.L.2    Trentham, D.E.3    Bucy, R.P.4    Sullivan, W.F.5    Schrohenloher, R.E.6
  • 34
  • 35
    • 0024368659 scopus 로고
    • Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis
    • 35. Myers LK, Stuart JM, Seyer JM, Kang AH. Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis. J Exp Med 1989;170:1999-2010.
    • (1989) J Exp Med , vol.170 , pp. 1999-2010
    • Myers, L.K.1    Stuart, J.M.2    Seyer, J.M.3    Kang, A.H.4
  • 36
    • 0017304047 scopus 로고
    • Biochemical characteristics and biological significance of the genetically distinct collagens
    • 36. Miller EJ. Biochemical characteristics and biological significance of the genetically distinct collagens. Mol Cell Biochem 1976;13:165-92.
    • (1976) Mol Cell Biochem , vol.13 , pp. 165-192
    • Miller, E.J.1
  • 37
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • 37. Weiner HL. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today 1997;19:335 43.
    • (1997) Immunol Today , vol.19 , pp. 33543
    • Weiner, H.L.1
  • 39
    • 0030042970 scopus 로고    scopus 로고
    • Oral type II collagen treatment in early RA: A double-blind, placebo-controlled, randomized trial
    • 39. Sieper J, Kary S, Sörensen H, Alten R, Eggens U, Huge W, et al. Oral type II collagen treatment in early RA: a double-blind, placebo-controlled, randomized trial. Arthritis Rheum 1996;39:41-51.
    • (1996) Arthritis Rheum , vol.39 , pp. 41-51
    • Sieper, J.1    Kary, S.2    Sörensen, H.3    Alten, R.4    Eggens, U.5    Huge, W.6
  • 41
    • 0028172613 scopus 로고
    • Increased frequency of Vβ17 -positive T cells in patients with rheumatoid arthritis
    • 41. Zagon G, Tumang JR, Li Y, Friedman SM, Crow MK. Increased frequency of Vβ17 -positive T cells in patients with rheumatoid arthritis. Arthritis Rheum 1994:1431-40.
    • (1994) Arthritis Rheum , pp. 1431-1440
    • Zagon, G.1    Tumang, J.R.2    Li, Y.3    Friedman, S.M.4    Crow, M.K.5
  • 43
    • 0025840491 scopus 로고
    • Limited T-cell receptor B-chain heterogenity among interleukin-2 receptor-positive synovial T cell suggests a role for superantigen in rheumatoid arthritis
    • 43. Howell MD, Diveley JP, Lundeen KA, Esty A, Winters ST, Carlo DJ, et al. Limited T-cell receptor B-chain heterogenity among interleukin-2 receptor-positive synovial T cell suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci USA 1991;88:10921-5.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10921-10925
    • Howell, M.D.1    Diveley, J.P.2    Lundeen, K.A.3    Esty, A.4    Winters, S.T.5    Carlo, D.J.6
  • 45
    • 0025788357 scopus 로고
    • Immune responses to 18.6 and 30-kDa mycobacterial antigens in rheumatoid patients and Vβ usage by specific synovial T cell lines and fresh T cells
    • 45. Sioud M, Kjeldsen-Kragh J, Quayle A, Wiker HG, Sörskaar D, Natvig JB, et al. Immune responses to 18.6 and 30-kDa mycobacterial antigens in rheumatoid patients and Vβ usage by specific synovial T cell lines and fresh T cells. Scand J Immunol 1991;34:803-12.
    • (1991) Scand J Immunol , vol.34 , pp. 803-812
    • Sioud, M.1    Kjeldsen-Kragh, J.2    Quayle, A.3    Wiker, H.G.4    Sörskaar, D.5    Natvig, J.B.6
  • 49
    • 0027450770 scopus 로고
    • Induction of an anti-vaccine response by T-cell vaccination in non-human primates and humans
    • 49. Lohse AW, Bakker NPM, Hermann E, Poralla T, Jonker M, Meyer ZUM, et al. Induction of an anti-vaccine response by T-cell vaccination in non-human primates and humans. J Autoimmun 1993 1993;1 121:30.
    • (1993) J Autoimmun , vol.1 , pp. 121
    • Lohse, A.W.1    Bakker, N.P.M.2    Hermann, E.3    Poralla, T.4    Jonker, M.5    Meyer, Z.U.M.6
  • 50
    • 0021855053 scopus 로고
    • Human placenta-eluted gammaglobulins in immunomodulating treatment of rheumatoid arthritis
    • 50. Combe B, Cosso B, Clot J, Bonneau M, Sany J. Human placenta-eluted gammaglobulins in immunomodulating treatment of rheumatoid arthritis. Am J Med 1985;78:920-8.
    • (1985) Am J Med , vol.78 , pp. 920-928
    • Combe, B.1    Cosso, B.2    Clot, J.3    Bonneau, M.4    Sany, J.5
  • 51
    • 0023216719 scopus 로고
    • Identification of class II HLA alloantibodies in placenta-eluted gammaglobulins used for treating rheumatoid arthritis
    • 51. Moynier M, Cosso B, Brochier J, Clot J. Identification of class II HLA alloantibodies in placenta-eluted gammaglobulins used for treating rheumatoid arthritis. Arthritis Rheum 1987;30:375-81.
    • (1987) Arthritis Rheum , vol.30 , pp. 375-381
    • Moynier, M.1    Cosso, B.2    Brochier, J.3    Clot, J.4
  • 52
    • 0000413349 scopus 로고
    • Safety and immunogenicity of a single intramuscular injection of a synthetic HLA-DR4/1-peptide vaccine with alum adjuvant in rheumatoid arthritis patients
    • 52. Pratt W, Heck L, Moreland L, Koopman W, Parkhill T, Pratt G, et al., Safety and immunogenicity of a single intramuscular injection of a synthetic HLA-DR4/1-peptide vaccine with alum adjuvant in rheumatoid arthritis patients. Arthritis Rheum 1995;38 Suppl 9:S281.
    • (1995) Arthritis Rheum , vol.38 , Issue.SUPPL. 9
    • Pratt, W.1    Heck, L.2    Moreland, L.3    Koopman, W.4    Parkhill, T.5    Pratt, G.6
  • 53
    • 0030940187 scopus 로고    scopus 로고
    • Pathogenesis and immunotherapy of autoimmune diseases
    • 53. Adorini L, Sinigaglia F. Pathogenesis and immunotherapy of autoimmune diseases. Immunol Today 1997;18:209-11.
    • (1997) Immunol Today , vol.18 , pp. 209-211
    • Adorini, L.1    Sinigaglia, F.2
  • 54
    • 0030991059 scopus 로고    scopus 로고
    • Biologic agents for treating rheumatoid arthritis
    • 54. Moreland LW, Heck LW, Koopman WJ. Biologic agents for treating rheumatoid arthritis. Arthritis Rheum 1997;40:397-409.
    • (1997) Arthritis Rheum , vol.40 , pp. 397-409
    • Moreland, L.W.1    Heck, L.W.2    Koopman, W.J.3
  • 55
    • 0023712236 scopus 로고
    • Detection of tumor necrosis factor alpha, but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum
    • 55. Saxne T, Palladino MA jr. , Heinegrad D. Detection of tumor necrosis factor alpha, but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum. Arthritis Rheum 1988;31:1041-5.
    • (1988) Arthritis Rheum , vol.31 , pp. 1041-1045
    • Saxne, T.1    Palladino M.A., Jr.2    Heinegrad, D.3
  • 56
    • 0029916803 scopus 로고    scopus 로고
    • The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers
    • 56. Häuselmann HJ, Flechtenmacher J, Michal L, Thonar EJ-MA, Shinmei M, Kuettner KE, et al. The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers. Arthritis Rheum 1996;39:478-88.
    • (1996) Arthritis Rheum , vol.39 , pp. 478-488
    • Häuselmann, H.J.1    Flechtenmacher, J.2    Michal, L.3    Thonar, E.J.-M.A.4    Shinmei, M.5    Kuettner, K.E.6
  • 57
    • 0029554533 scopus 로고    scopus 로고
    • Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis
    • 57. Douni E, Akassoglou K, Alexopoulou L, Georgopoulos S, Haralambous S, Hill S, et al. Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. J Inflamm 1996;47:27-38.
    • (1996) J Inflamm , vol.47 , pp. 27-38
    • Douni, E.1    Akassoglou, K.2    Alexopoulou, L.3    Georgopoulos, S.4    Haralambous, S.5    Hill, S.6
  • 58
    • 0028226982 scopus 로고
    • Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis
    • 58. Williams RO, Mason LJ, Feldmann M, Maini RN. Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis. Proc Natl Acad Sci USA 1994:2762-6.
    • (1994) Proc Natl Acad Sci USA , pp. 2762-2766
    • Williams, R.O.1    Mason, L.J.2    Feldmann, M.3    Maini, R.N.4
  • 59
    • 0027438710 scopus 로고
    • Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α
    • 59. Elliot MJ, Maini RN, Feldmann M, Long-Fox A, Charles P, Katsikis P, et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum 1993;36:1681-90.
    • (1993) Arthritis Rheum , vol.36 , pp. 1681-1690
    • Elliot, M.J.1    Maini, R.N.2    Feldmann, M.3    Long-Fox, A.4    Charles, P.5    Katsikis, P.6
  • 60
    • 0028143211 scopus 로고
    • Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
    • 60. Elliot MJ, Maini RN, Feldman M, Kalden JR. , Antoni C, Smolen JS, et al. Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 1994;344:1105-10.
    • (1994) Lancet , vol.344 , pp. 1105-1110
    • Elliot, M.J.1    Maini, R.N.2    Feldman, M.3    Kalden, J.R.4    Antoni, C.5    Smolen, J.S.6
  • 61
    • 0030992610 scopus 로고    scopus 로고
    • Adhesion molecules: A rheumatologic perspective
    • 61. Mojcik CF, Shevach EM. Adhesion molecules: a rheumatologic perspective. Arthritis Rheum 1997;40:991-1004.
    • (1997) Arthritis Rheum , vol.40 , pp. 991-1004
    • Mojcik, C.F.1    Shevach, E.M.2
  • 62
    • 0031660364 scopus 로고    scopus 로고
    • Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor a monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
    • 62. Maini RN, Breedeveld FC, Kalden JR, Smolen JS, Davis D, et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor a monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 1998;41:1552-63.
    • (1998) Arthritis Rheum , vol.41 , pp. 1552-1563
    • Maini, R.N.1    Breedeveld, F.C.2    Kalden, J.R.3    Smolen, J.S.4    Davis, D.5
  • 63
    • 0008615547 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled trial of tumor necrosis factor receptor fusion protein (TNFR:Fcc) in active rheumatoid arthritis
    • 63. Baumgartner S, Moreland LW, Schiff MH, Tindall E, Fleischmann RM, Weaver A, et al. Double-blind, placebo-controlled trial of tumor necrosis factor receptor fusion protein (TNFR:Fcc) in active rheumatoid arthritis. J Invest Med 1996;44:235A.
    • (1996) J Invest Med , vol.44
    • Baumgartner, S.1    Moreland, L.W.2    Schiff, M.H.3    Tindall, E.4    Fleischmann, R.M.5    Weaver, A.6
  • 64
    • 0001668155 scopus 로고    scopus 로고
    • Loading/maintenance doses approach to neutralization of TNF by lenercept (TNFR55-IgG1, ro-45-2081) in patients with rheumatoid arthritis treated for 3 months: Results of a double-blind placebo-controlled phase II trial
    • 64. Cutolo M, Kirkham B, Bologna C, Sany J, Scott D, Brooks P, et al. Loading/maintenance doses approach to neutralization of TNF by lenercept (TNFR55-IgG1, Ro-45-2081) in patients with rheumatoid arthritis treated for 3 months: results of a double-blind placebo-controlled phase II trial. Arthritis Rheum 1996;39 Suppl:S243.
    • (1996) Arthritis Rheum , vol.39 , Issue.SUPPL.
    • Cutolo, M.1    Kirkham, B.2    Bologna, C.3    Sany, J.4    Scott, D.5    Brooks, P.6
  • 65
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • 65. Weinblatt ME, Kremer JM, Bankhurst AD, Bulpitt KJ, Fleischmann RM, et al. A trial of Etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999;340:253-8.
    • (1999) N Engl J Med , vol.340 , pp. 253-258
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3    Bulpitt, K.J.4    Fleischmann, R.M.5
  • 66
    • 0026513691 scopus 로고
    • Preformed ribozyme destroys tumor necrosis factor mRNA in human cells
    • 66. Sioud M, Natvig JB, Förre Ö. Preformed ribozyme destroys tumor necrosis factor mRNA in human cells. J Mol Biol 1992;223:831-5.
    • (1992) J Mol Biol , vol.223 , pp. 831-835
    • Sioud, M.1    Natvig, J.B.2    Förre, Ö.3
  • 67
    • 0023952058 scopus 로고
    • Cytokines in synovial fluid I: The presence of biologically active and immunoreactive IL-1
    • 67. Hopkins SJ, Humphreys M, Jayson MIV. Cytokines in synovial fluid I: the presence of biologically active and immunoreactive IL-1. Clin Exp Immunol 1988;72:422-7.
    • (1988) Clin Exp Immunol , vol.72 , pp. 422-427
    • Hopkins, S.J.1    Humphreys, M.2    Jayson, M.I.V.3
  • 68
    • 0027968721 scopus 로고
    • Interleukin-1 beta, hand and foot bone mineral content and the development of joint erosions in rheumatoid arthritis
    • 68. North J, Situnayake RD, Tikley M. Interleukin-1 beta, hand and foot bone mineral content and the development of joint erosions in rheumatoid arthritis. Ann Rheum Dis 1994;53:543-6.
    • (1994) Ann Rheum Dis , vol.53 , pp. 543-546
    • North, J.1    Situnayake, R.D.2    Tikley, M.3
  • 69
    • 0026058710 scopus 로고
    • Soluble cytokine receptors: Their role in immunoregulation
    • 69. Fernandez-Botran R. Soluble cytokine receptors: their role in immunoregulation. FASEB J 1991;5:2567-74.
    • (1991) FASEB J , vol.5 , pp. 2567-2574
    • Fernandez-Botran, R.1
  • 70
    • 0001925856 scopus 로고
    • Phase I study of recombinant human interleukin-1 receptor (rhu IL-IR) administrered intra-articularly in active rheumatoid arthritis
    • 70. Drevlow B, Capezio J, Lovis R, Jacobs C, Landay A, Pope RM. Phase I study of recombinant human interleukin-1 receptor (rhu IL-IR) administrered intra-articularly in active rheumatoid arthritis. Arthritis Rheum 1993;36 Suppl 9:S39.
    • (1993) Arthritis Rheum , vol.36 , Issue.SUPPL. 9
    • Drevlow, B.1    Capezio, J.2    Lovis, R.3    Jacobs, C.4    Landay, A.5    Pope, R.M.6
  • 71
    • 0030039524 scopus 로고    scopus 로고
    • Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis
    • 71. Drevlow BE, Lovis R, Haag MA. Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis. Arthritis Rheum 1996;39:257-65.
    • (1996) Arthritis Rheum , vol.39 , pp. 257-265
    • Drevlow, B.E.1    Lovis, R.2    Haag, M.A.3
  • 72
    • 0027501020 scopus 로고
    • Interleukin-1 receptor antagonists
    • 72. Arend WP. Interleukin-1 receptor antagonists. Adv Immunol 1993;54:167-227.
    • (1993) Adv Immunol , vol.54 , pp. 167-227
    • Arend, W.P.1
  • 74
    • 0029943271 scopus 로고    scopus 로고
    • Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis
    • 74. Champion GV, Lebsack ME, Lookabaugh J, Gordon G, Catalano M, The IL-IRa Arthritis Study Group. Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1092-101.
    • (1996) Arthritis Rheum , vol.39 , pp. 1092-1101
    • Champion, G.V.1    Lebsack, M.E.2    Lookabaugh, J.3    Gordon, G.4    Catalano, M.5
  • 75
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-I receptor antagonist
    • 75. Bresnihan B, Alvaro-Gracia JM, Cobby M, Doherty M, Domljan Z, et al. Treatment of rheumatoid arthritis with recombinant human interleukin-I receptor antagonist. Arthritis Rheum 1998;41:2196-204.
    • (1998) Arthritis Rheum , vol.41 , pp. 2196-2204
    • Bresnihan, B.1    Alvaro-Gracia, J.M.2    Cobby, M.3    Doherty, M.4    Domljan, Z.5
  • 77
    • 0029951421 scopus 로고    scopus 로고
    • 2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclooxygenase II, but not of cyclo-oxygenase I
    • 2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclooxygenase II, but not of cyclo-oxygenase I. Ann Rheum Dis 1996;55:375-82.
    • (1996) Ann Rheum Dis , vol.55 , pp. 375-382
    • Sugiyama, F.1    Taki, H.2    Kuroda, A.3    Mino, T.4    Yamashita, N.5    Kobayashi, M.6
  • 78
    • 0029740959 scopus 로고    scopus 로고
    • The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis
    • 78. Isomäki P, Luukkainen R, Toivanen P, Punnonen J. The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1693-702.
    • (1996) Arthritis Rheum , vol.39 , pp. 1693-1702
    • Isomäki, P.1    Luukkainen, R.2    Toivanen, P.3    Punnonen, J.4
  • 79
    • 0029797868 scopus 로고    scopus 로고
    • Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13
    • 79. Bessis N, Boissier MC, Ferrara P, Blankenstein T, Fradelizi D, Fournier C. Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13. Eur J Immunol 1996;26:2399-403.
    • (1996) Eur J Immunol , vol.26 , pp. 2399-2403
    • Bessis, N.1    Boissier, M.C.2    Ferrara, P.3    Blankenstein, T.4    Fradelizi, D.5    Fournier, C.6
  • 80
    • 0024421582 scopus 로고
    • Double-blind trial of recombinant γ-interferon versus placebo in the treatment of rheumatoid arthritis
    • 80. Cannon GW, Pincus SH, Emkey RD, Denes A, Cohen SA, Wolfe F, et al. Double-blind trial of recombinant γ-interferon versus placebo in the treatment of rheumatoid arthritis. Arthritis Rheum 1989;32:964-73.
    • (1989) Arthritis Rheum , vol.32 , pp. 964-973
    • Cannon, G.W.1    Pincus, S.H.2    Emkey, R.D.3    Denes, A.4    Cohen, S.A.5    Wolfe, F.6
  • 81
    • 0026348703 scopus 로고
    • Multicenter double-blind trial of inlerferon-γ versus placebo in the treatment of rheumatoid arthritis
    • 81. Lemmel EM, Gaus W, Hofschneider PH. Multicenter double-blind trial of inlerferon-γ versus placebo in the treatment of rheumatoid arthritis. Arthritis Rheum 1991;34:1621-2.
    • (1991) Arthritis Rheum , vol.34 , pp. 1621-1622
    • Lemmel, E.M.1    Gaus, W.2    Hofschneider, P.H.3
  • 82
    • 0023911879 scopus 로고
    • Interferon gamma in RA: A double-blind study comparing human recombinant interferon gamma with placebo
    • 82. Veys EM, Mielants H, Verbruggen G, Grosclande JP, Meyer W, Galazka A, et al. Interferon gamma in RA: a double-blind study comparing human recombinant interferon gamma with placebo. J Rheumatol 1988;15:570-4.
    • (1988) J Rheumatol , vol.15 , pp. 570-574
    • Veys, E.M.1    Mielants, H.2    Verbruggen, G.3    Grosclande, J.P.4    Meyer, W.5    Galazka, A.6
  • 83
    • 0026767264 scopus 로고
    • Recombinant human interferon gamma in the treatment of rheumatoid arthritis: Double blind placebo-controlled study
    • 83. Machold KP, Neumann K, Smolen JS. Recombinant human interferon gamma in the treatment of rheumatoid arthritis: double blind placebo-controlled study. Ann Rheum Dis 1992;51:1039-43.
    • (1992) Ann Rheum Dis , vol.51 , pp. 1039-1043
    • Machold, K.P.1    Neumann, K.2    Smolen, J.S.3
  • 84
    • 0029739255 scopus 로고    scopus 로고
    • A phase I/II open label study of the safety and efficacy of an anti-ICAM-1 (intercelluar adhesion molecule-1; CD54) monoclonal antibody in early rheumatoid arthritis
    • 84. Kavanaugh AR, Davis LS, Jain RI, Nicholos LA, Norris SH, Pe L. A phase I/II open label study of the safety and efficacy of an anti-ICAM-1 (intercelluar adhesion molecule-1; CD54) monoclonal antibody in early rheumatoid arthritis. J Rheumatol 1996;23 1338:44.
    • (1996) J Rheumatol , vol.23 , pp. 1338
    • Kavanaugh, A.R.1    Davis, L.S.2    Jain, R.I.3    Nicholos, L.A.4    Norris, S.H.5    Pe, L.6
  • 85
    • 0030953117 scopus 로고    scopus 로고
    • Autologous hemopoietic stem cell transplantation: A possible cure for rheumatoid arthritis?
    • 85. Wicks I, Cooley H, Szer J. Autologous hemopoietic stem cell transplantation: a possible cure for rheumatoid arthritis? Arthritis Rheum 1997;40:1005-11.
    • (1997) Arthritis Rheum , vol.40 , pp. 1005-1011
    • Wicks, I.1    Cooley, H.2    Szer, J.3
  • 86
    • 0030855070 scopus 로고    scopus 로고
    • Bone marrow transplantation in the treatment of autoimmune diseases
    • 86. Tyndall A, Grathwohl A. Bone marrow transplantation in the treatment of autoimmune diseases. Br J Rheumatol 1997;36:1-5.
    • (1997) Br J Rheumatol , vol.36 , pp. 1-5
    • Tyndall, A.1    Grathwohl, A.2
  • 89
    • 0030015151 scopus 로고    scopus 로고
    • Potential of tetracyclines to modify cartilage breakdown in osteoarthritis
    • 89. Ryan ME, Greenwald RA, Golub LM. Potential of tetracyclines to modify cartilage breakdown in osteoarthritis. Curr Opin Rheumatol 1996;8:238-47.
    • (1996) Curr Opin Rheumatol , vol.8 , pp. 238-247
    • Ryan, M.E.1    Greenwald, R.A.2    Golub, L.M.3
  • 91
    • 0021953757 scopus 로고
    • Further evidence that tetracyclines inhibit collagenase activity in human crevicular lung and from other mammalian sources
    • 91. Golub LM, Wolff M, Lee HM, McNamara TF, Ramamurthy NS, Zambon J, et al. Further evidence that tetracyclines inhibit collagenase activity in human crevicular lung and from other mammalian sources. J Periodontal Res 1985;20:12-23.
    • (1985) J Periodontal Res , vol.20 , pp. 12-23
    • Golub, L.M.1    Wolff, M.2    Lee, H.M.3    McNamara, T.F.4    Ramamurthy, N.S.5    Zambon, J.6
  • 92
    • 0026683930 scopus 로고
    • Tetracycline administration increases collagen synthesis in osteoblasts of streptozotocin-induced diabetic rats: A quantitative autoradio-graphic study
    • 92. Sasaki T, Ramamurthy NS, Golub LM. Tetracycline administration increases collagen synthesis in osteoblasts of streptozotocin-induced diabetic rats: a quantitative autoradio-graphic study. Calcif Tissue Int 1992;50:411-9.
    • (1992) Calcif Tissue Int , vol.50 , pp. 411-419
    • Sasaki, T.1    Ramamurthy, N.S.2    Golub, L.M.3
  • 93
    • 0025099325 scopus 로고
    • Minocycline treatment for rheumatoid arthritis: An open dose finding study
    • 93. Breedveld FC, Dijkmans BAC, Mattie H. Minocycline treatment for rheumatoid arthritis: an open dose finding study. J Rheumatol 1990;7:43-6.
    • (1990) J Rheumatol , vol.7 , pp. 43-46
    • Breedveld, F.C.1    Dijkmans, B.A.C.2    Mattie, H.3
  • 96
    • 0028483990 scopus 로고
    • Treatment of murine lupus with CTLA4Ig
    • 96. Finck BK, Linsley PS, Wofsy D. Treatment of murine lupus with CTLA4Ig. Science 1994;265:1225-7.
    • (1994) Science , vol.265 , pp. 1225-1227
    • Finck, B.K.1    Linsley, P.S.2    Wofsy, D.3
  • 97
    • 0029162499 scopus 로고
    • Collagen induced arthritis in the BB rat: Prevention of disease by treatment with CTLA-4-Ig
    • 97. Knoerzer DB, Karr RW, Schwartz BD, Mengle-Gaw LJ. Collagen induced arthritis in the BB rat: prevention of disease by treatment with CTLA-4-Ig. J Clin Invest 1995;96:987-93.
    • (1995) J Clin Invest , vol.96 , pp. 987-993
    • Knoerzer, D.B.1    Karr, R.W.2    Schwartz, B.D.3    Mengle-Gaw, L.J.4
  • 98
    • 0027493906 scopus 로고
    • In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40-gp39
    • 98. Foy TM, Shepherd DM, Durie FH, Aruffo A, Ledbetter JA, Noelle RJ . In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40-gp39. J Exp Med 1993;178:1567-75.
    • (1993) J Exp Med , vol.178 , pp. 1567-1575
    • Foy, T.M.1    Shepherd, D.M.2    Durie, F.H.3    Aruffo, A.4    Ledbetter, J.A.5    Noelle, R.J.6
  • 99
    • 0027816953 scopus 로고
    • Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40
    • 99. Durie FH, Fava RA, Foy TM, Aruffo A, Ledbetter JA, Noelle RJ. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 1993;261: 1328-30.
    • (1993) Science , vol.261 , pp. 1328-1330
    • Durie, F.H.1    Fava, R.A.2    Foy, T.M.3    Aruffo, A.4    Ledbetter, J.A.5    Noelle, R.J.6
  • 100
    • 0031744967 scopus 로고    scopus 로고
    • Analysis of the NF-KB p65 subunit, fas antigen, fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA
    • 100. Sioud M, Mellbye O, Förre Ö. Analysis of the NF-KB p65 subunit, fas antigen, fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA. Clin Fxp Rheumatol 1998;16:125-34.
    • (1998) Clin Fxp Rheumatol , vol.16 , pp. 125-134
    • Sioud, M.1    Mellbye, O.2    Förre, Ö.3
  • 101
    • 9344241398 scopus 로고    scopus 로고
    • Therapeutic effect of the anti-fas antibody on arthritis in HTLV-1 tax transgenic mice
    • 101. Fujisawa Y, Asahara H, Okamoto K, Aono H, Hasunuma T, Kobata T, et al. Therapeutic effect of the anti-fas antibody on arthritis in HTLV-1 tax transgenic mice. J Clin Invest 1996;98:271-8.
    • (1996) J Clin Invest , vol.98 , pp. 271-278
    • Fujisawa, Y.1    Asahara, H.2    Okamoto, K.3    Aono, H.4    Hasunuma, T.5    Kobata, T.6
  • 102
    • 0029093391 scopus 로고
    • Cyclosporine in rheumatoid arthritis: An overview
    • 102. Förre Ö. Cyclosporine in rheumatoid arthritis: an overview. Clin Rheumatol 1995;14 Suppl 2:33-6.
    • (1995) Clin Rheumatol , vol.14 , Issue.SUPPL. 2 , pp. 33-36
    • Förre, Ö.1
  • 103
    • 0027987025 scopus 로고
    • Radiological evidence of disease modification in rheumatoid arthritis patients treated with cyclosporine. Results of a 48-week multicenter study comparing low-dose cyclosporine with placebo
    • 103. Förre Ö. The Norwegian Arthritis Study Group. Radiological evidence of disease modification in rheumatoid arthritis patients treated with cyclosporine. Results of a 48-week multicenter study comparing low-dose cyclosporine with placebo. Arthritis Rheum 1994;37:1506-12.
    • (1994) Arthritis Rheum , vol.37 , pp. 1506-1512
    • Förre, Ö.1
  • 104
    • 0031851205 scopus 로고    scopus 로고
    • Progression of joint damage in early active severe rheumatoid arthritis during 18 months of treatment: Comparison of low-dose cyclosporine and parenteral gold
    • 104. Zeidler HK, Kvien TK, Hannonen P, Wollheim FA, Förre Ö, Geidel H, et al. Progression of joint damage in early active severe rheumatoid arthritis during 18 months of treatment: comparison of low-dose cyclosporine and parenteral gold. Br J Rheumatol 1998;37:874-82.
    • (1998) Br J Rheumatol , vol.37 , pp. 874-882
    • Zeidler, H.K.1    Kvien, T.K.2    Hannonen, P.3    Wollheim, F.A.4    Förre, Ö.5    Geidel, H.6
  • 105
    • 8944256867 scopus 로고    scopus 로고
    • Slow progression of joint damage in early rheumatoid arthritis treated with cyclosporine A
    • 105. Pasero G, Priolo F, Marubini E, et al. Slow progression of joint damage in early rheumatoid arthritis treated with cyclosporine A. Arthritis Rheum 1996;39 6:1006-15.
    • (1996) Arthritis Rheum , vol.396 , pp. 1006-1015
    • Pasero, G.1    Priolo, F.2    Marubini, E.3
  • 106
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporin A and FK506
    • 106. Schreiber SL, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Immunol Today 1992;13:136-42.
    • (1992) Immunol Today , vol.13 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, G.R.2
  • 107
    • 0025735273 scopus 로고
    • Rapamycin: FK506's fraternal twin or distant cousin?
    • 107. Randall EM. Rapamycin: FK506's fraternal twin or distant cousin? Immunol Today 1991;12:137-40.
    • (1991) Immunol Today , vol.12 , pp. 137-140
    • Randall, E.M.1
  • 108
    • 0001811314 scopus 로고    scopus 로고
    • Effects of leflunomide on early T cell signaling and cell cycle commitment
    • 108. Herrmann M, Frangou GC, Kirschbaum B. Effects of Leflunomide on early T cell signaling and cell cycle commitment. Rheumatol Europe 1997;26 Suppl:16.
    • (1997) Rheumatol Europe , vol.26 , Issue.SUPPL. , pp. 16
    • Herrmann, M.1    Frangou, G.C.2    Kirschbaum, B.3
  • 109
    • 0033053835 scopus 로고    scopus 로고
    • Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomised, multicentre trial
    • 109. Smolen JS, Kalden JR, Scott DL, Rozman B, Kvien TK, Larsen A, et al. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. Lancet 1999;353:259-66.
    • (1999) Lancet , vol.353 , pp. 259-266
    • Smolen, J.S.1    Kalden, J.R.2    Scott, D.L.3    Rozman, B.4    Kvien, T.K.5    Larsen, A.6
  • 110
    • 0027786826 scopus 로고
    • Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate Mofetil
    • 110. Allison AC, Eugui EM. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate Mofetil. Immunol Rev 1993;136:5-28.
    • (1993) Immunol Rev , vol.136 , pp. 5-28
    • Allison, A.C.1    Eugui, E.M.2
  • 111
    • 0030730162 scopus 로고    scopus 로고
    • Thalidomide and derivatives: Immunological investigations of tumor necrosis factor-alpha (TNF-α) inhibition suggest drugs capable of selective gene regulation
    • 111. McHugh SM, Rowland TL. Thalidomide and derivatives: Immunological investigations of tumor necrosis factor-alpha (TNF-α) inhibition suggest drugs capable of selective gene regulation. Clin Exp Immunol 1997;110:151-4.
    • (1997) Clin Exp Immunol , vol.110 , pp. 151-154
    • McHugh, S.M.1    Rowland, T.L.2
  • 113
    • 0033031331 scopus 로고    scopus 로고
    • COX-2 inhibitors
    • 113. Hawkey CJ. COX-2 inhibitors. Lancet 1999;353:307-14.
    • (1999) Lancet , vol.353 , pp. 307-314
    • Hawkey, C.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.