Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers

Pharmaceutical Research

Volumn 15, Issue 2, 1998, Pages 239-245

  Annaert, P ^a   Gosselin, G ^b   Pompon, A ^b   Benzaria, S ^b   Valette, G ^b   Imbach, J L ^b   Naesens, L ^c   Hatse, S ^c   De Clercq, E ^c   Van Den Mooter, G ^a   Kinget, R ^a   Augustijns, P ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIV MONTPELLIER   (France)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral; Caco 2; Drug transport; Intestinal metabolism; Intestinal permeability; PMEA; Prodrugs

Indexed keywords

ADEFOVIR; ANTIVIRUS AGENT; ESTER DERIVATIVE; PRODRUG;

ARTICLE; CELL STRAIN CACO 2; DRUG ABSORPTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; MONOLAYER CULTURE; PARTITION COEFFICIENT; PRIORITY JOURNAL;

ADENINE; ANTIVIRAL AGENTS; CACO-2 CELLS; CHROMATOGRAPHY, ION EXCHANGE; ESTERS; HUMANS; PHOSPHONIC ACIDS; PRODRUGS;

EID: 15444344061     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011914618109     Document Type: Article

References (25)

1. L. Naesens, J. Balzarini, N. Bischofberger, and E. De Clercq. Antimicrob. Agents Chemother. 40:22-28 (1996).
2. L. Naesens, R. Snoeck, G. Andrei, J. Balzarini, J. Neyts, and E. de Clercq. Antiviral Chem. Chemother. 8:1-23 (1997).
3. K. C. Cundy, J. A. Fishback, J.-P. Shaw, M. L. Lee, K. F. Soike, G. C. Visor, and W. A. Lee. Pharm. Res. 11:839-843 (1994).
4. J. Balzarini, L. Naesens, J. Slachmuylders, H. Niphuis, I. Rosenberg, A. Holy, H. Schellekens, and E. De Clercq. AIDS 5:21-28 (1991).
5. K. C. Cundy and W. A. Lee. Antimicrobs. Agents Chemother. 38:365-368 (1994).
6. J. E. Starrett, Jr., D. R. Tortolani, J. Russell, M. J. M. Hitchcock, V. Whiterock, J. C. Martin, and M. M. Mansuri. J. Med. Chem. 37:1857-1864 (1994).
7. J.-P. Shaw and K. C. Cundy. Pharm. Res. 10(Suppl.):S294 (1993).
8. P. Artursson. J. Pharm. Sci. 79(6):476-482 (1990).
9. K. L. Audus, R. L. Bartel, I. J. Hildago, and R. T. Borchardt. Pharm. Res. 7:435-451 (1990).
10. A. R. Hilgers, R. A. Conradi, and P. S. Burton. Pharm. Res. 7:902-910 (1990).
11. L. S. Gan, C. Eads, T. Niederer, A. Bridgers, S. Yanni, P.-H. Hsyu, F. J. Pritchard, and D. Thakker. Drug Develop. Ind. Pharm. 20:615-631 (1994).
12. P. Annaert, R. Kinget, L. Naesens, E. De Clercq, and P. Augustijns. Pharm. Res. 14:492-496 (1997).
13. P. A. Barditch-Crovo, K. C. Cundy, M. Wachsman, J. Toole, H. Burgee, and D. Ebeling. Antiviral Res. 26(3, suppl.):A229, abstract nr. 9 (1995).
14. S. Benzaria, H. Pélicano, R. Johnson, G. Maury, J.-L. Imbach, A.-M. Aubertin, G. Obert, and G. Gosselin. J. Med. Chem. 39: 4958-4965 (1996).
15. G. Valette, A. Pompon, J.-L. Girardet, L. Cappellacci, P. Franchetti, M. Grifantini, P. La Colla, A.-G. Loi, C. Périgaud, G. Gosselin, and J.-L. Imbach. J. Med. Chem. 39:1981-1990 (1996).
16. S. Hatse, E. De Clercq, and J. Balzarini. Mol. Pharmacol. 50:1231-1242 (1996).
17. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall. J. Biol. Chem. 193:265-275 (1951).
18. A. Pompon I. Lefebvre, J.-L. Imbach, S. Kahn, and D. Farquhar. Antiviral Chem. Chemother. 5:91-98 (1994).
19. D. Farquhar, S. Khan, D. N. Srivasta, and P. P. Saunders. J. Med. Chem. 37:3902-3909 (1994).
20. I. Lefebvre, C. Périgaud, A. Pompon, A.-M. Aubertin, J.-L. Girardet, A. Kirn, G. Gosselin, and J.-L. Imbach. J. Med. Chem. 38:3941-3950 (1995).
21. N. M. Nielsen and H. Bundgaard. Int. J. Pharm. 39:75-85 (1987).
22. A. Durrer, B. Walther, A. Racciatti, G. Boss, and B. Testa. Pharm. Res. 8:832-839 (1991).
23. I. J. Hildago, T. J. Raub, and R. T. Borchardt. Gastroenterology 96:736-49 (1989).
24. A. Merta, I. Votruba, J. Jindrich, A. Holy, T. Cihlar, I. Rosenberg, M. Otmar, and T. Y. Herve. Biochem. Pharmacol. 44:2067-2077 (1992).
25. J. Balzarini and E. De Clercq. J. Biol. Chem. 266:8686-8689 (1991).