The novel 5-hydroxytryptamine(1A) antagonist LY426965: Effects on nicotine withdrawal and interactions with fluoxetine

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 2, 2000, Pages 688-700

  Rasmussen, Kurt ^a   Calligaro, David O ^a   Czachura, Janet F ^a   Dreshfield Ahmad, Laura J ^a   Evans, David C ^a   Hemrick Luecke, Susan K ^a   Kallman, Mary Jeanne ^a   Kendrick, William T ^a   Leander, J David ^a   Nelson, David L ^a   Overshiner, Carl D ^a   Wainscott, David B ^a   Wolff, Mary C ^a   Wong, David T ^a   Branchek, Theresa A ^b   Zgombick, John M ^a,b   Xu, Yao Chang ^a  

^a ELI LILLY AND COMPANY   (United States)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 CYCLOHEXYL 4 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 METHYL 2 PHENYL 1 BUTANONE; 1 CYCLOHEXYL 4 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]2 METHYL 2 PHENYL 1 BUTANONE MONOHYDROCHLORIDE; FLUOXETINE; NICOTINE; RECEPTOR SUBTYPE; SEROTONIN 1A ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DISCRIMINATIVE STIMULUS; DORSAL RAPHE NUCLEUS; DRUG EFFECT; DRUG WITHDRAWAL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SEROTONIN RELEASE; STARTLE REFLEX;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ACOUSTIC STIMULATION; ANIMALS; BODY TEMPERATURE; COLUMBIDAE; CORTICOSTERONE; DEPRESSION; DISCRIMINATION LEARNING; DRUG INTERACTIONS; FLUOXETINE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LIP; MALE; MICRODIALYSIS; NEURONS; NICOTINE; PIPERIDINES; POSTURE; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SMOKING CESSATION; STARTLE REACTION; SUBSTANCE WITHDRAWAL SYNDROME; SULFUR RADIOISOTOPES;

EID: 0033942238     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Artigas F, Perez V and Alverez E (1994) Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch Gen Psychiatry 51:248-251.
2. Berman RM, Darnell AM, Miller HL, Anand A and Charney DS (1997) Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: A double-blind, placebo-controlled trial. Am J Psychiatry 154:37-43.
3. 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum. Life Sci 35:1885-1893.
4. Blier P and de Montigney C (1983) Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat. J Neurosci 3:1270-1278.
5. 3H]idazoxan in rat brain. J Pharmacol Exp Ther 241:1092-1098.
6. 3H]diazepam binding. Proc Natl Acad Sci USA 74:3805-3809.
7. Bylund DB and Snyder SH (1976) Beta adrenergic receptor binding in membrane preparations form mammalian brain. Mol Pharmacol 12:568-580.
8. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
9. Chopin P, Moret C and Briley M (1994) Neuropharmacology of 5-hydroxytryptamine 1B/1D receptor ligands. Pharmacol Ther 62:385-405.
10. Czachura JF and Rasmussen K (2000) Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat. Naunyn-Schmiedeberg's Arch Pharmacol, in press.
11. Dreshfield LJ, Rocco VP and Wong DT (1997a) Greater effects of fluoxetine and its combination with (-)-pindolol in elevating hypothalamic serotonin in rats during dark hours. Chin J Physiol 40:57-61.
12. 1A receptors. Neurochem Res 21:557-562.
13. 1A receptor antagonist, WAY-100635. Eur J Pharmacol 281:81-88.
14. 1A antagonist, increases serotonergic neuronal activity in behaving cats: Comparison with (S)-WAY-100135. J Pharmacol Exp Ther 278:752-762.
15. 3H-prazosin to rat brain alpha-adrenergic receptors. Eur J Pharmacol 55:323-326.
16. 2 receptors. Prog Neuro-Psychopharmacol Biol Psychiatry 12:559-568.
17. Helton DR, Modlin DL, Tizzano JP and Rasmussen K (1993) Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity. Psychopharmacology 113:205-210.
18. Helton DR, Tizzano JP, Monn JA, Schoepp DD and Kallman MJ (1997) LY354740: A metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats. Neuropharmacology 36:1511-1516.
19. 1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: A microdialysis study. J Neurochem 60:776-779.
20. Hughes JR and Hatsukami D (1986) Signs and symptoms of tobacco withdrawal. Arch Gen Psychiatry 43:289-294.
21. 2B receptor. Mol Pharmacol 46: 227-234.
22. Maes M, Libbrecht I, van Hunsel F, Campens D and Meltzer HY (1999) Pindolol and mianserin augment antidepressant activity of fluoxetine in hospitalized major depressed patients, including those with treatment resistance. J Clin Psychopharmacol 19:177-182.
23. Munson PJ and Rodbard D (1980) Ligand: A versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239.
24. Perez V, Soler J, Puigdemont D, Alverez E and Artigas F (1999) A double-blind, randomized, placebo-controlled trial of pindolol augmentation in depressive patients resistant to serotonin reuptake inhibitors. Arch Gen Psychiatry 56:375-379.
25. 1A agonist 8-OH-DPAT. Psychopharmacology 133:343-346.
26. Rasmussen K, Czachura JF, Kallman MJ and Helton DR (1996) The CCK-B antagonist LY288513 blocks the effects of nicotine withdrawal on auditory startle. Neuroreport 7:1050-1052.
27. 1A antagonists attenuate the effects of nicotine withdrawal on the auditory startle response. Synapse 27: 145-152.
28. 1A receptor modulators, in Annual Reports in Medicinal Chemistry (Bristol JA ed) vol 30, pp 1-9, Academic Press, New York.
29. 1A receptor antagonist. Soc Neurosci Abstr 23.
30. 1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. Br J Pharmacol 121:941-946.
31. 1B agonists. Synapse 1:3-9.
32. 3H]mepyramine. Proc Natl Acad Sci USA 75:6290-6294.
33. VanderMaelen CP, Matheson GK, Wilderman RC and Patterson LA (1986) Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administratioon of buspirone, a non-benzodiazepine anxiolytic drug. Eur J Pharmacol 129:123-130.
34. 35S]GTPγS binding: Correlation with inhibition of guinea pig durai plasma protein extravasation. Eur J Pharmacol 352:117-124.
35. 3H]muscimol, a potent γ-aminobutyric acid agonist, to rat brain synaptosomal membranes using a filtration assay. J Neurochem 32:713-718.
36. Wolff MC, Benvenga MJ, Calligaro DO, Fuller RW, Gidda JS, Hemrick-Luecke S, Lucot JB, Nelson DL, Overshiner CD and Leander JD (1997) Pharmcological profile of LY301317, a potent and selective 5-HT1a agonist. Drug Dev Res 40:17-34.
37. 1A receptor ligands by drug discrimination. Eur J Pharmacol 333:113-122.
38. Yamamura HI and Snyder SH (1974) Muscarinic cholinergic binding in rat brain. Proc Natl Acad Sci USA 71:1725-1729.
39. 1D receptor subtype. Mol Pharmacol 40:1036-1042.