Differentiation of 5-HT (1A) receptor ligands by drug discrimination

European Journal of Pharmacology

Volumn 333, Issue 2-3, 1997, Pages 113-122

  Wolff, Mary C ^a   Leander, J David ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

5 HT(1A) receptor; Drug discrimination; Efficacy; Pigeon

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; BUSPIRONE; IDAZOXAN; LY 206130; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PINDOLOL; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; 4 (2' METHOXYPHENYL) 1 (2' (N (2'' PYRIDINYL) 4 IODOBENZAMIDO)ETHYL)PIPERAZINE; 4-(2'-METHOXYPHENYL)-1-(2'-(N-(2''-PYRIDINYL)-4-IODOBENZAMIDO)ETHYL)PIPERAZINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMINOPYRIDINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLOHEXYLAMINE DERIVATIVE; LIGAND; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DISCRIMINATION; DRUG DOSE; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PIGEON; PRIORITY JOURNAL; TRAINING; ANIMAL; ANIMAL BEHAVIOR; COMPARATIVE STUDY; DISCRIMINATION LEARNING; DOSE RESPONSE; DRUG EFFECT; PIGEONS AND DOVES;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; AMINOPYRIDINES; ANIMALS; BEHAVIOR, ANIMAL; BUSPIRONE; COLUMBIDAE; CYCLOHEXYLAMINES; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; IDAZOXAN; LIGANDS; MALE; PINDOLOL; PIPERAZINES; PYRIDINES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030608867     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01125-4     Document Type: Article

References (47)

1. Andrade R., Nicoll R.A. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn Schmiedebergs Arch. Pharmacol. 336:1987;5-10.
2. 3 Antagonists and Benzodiazepines: Their Comparative Behavioral Pharmacology. John Wiley and Sons, New York, pp. 59-105.
3. 1A receptor antagonists BMY7378 and NAN-190. Eur. J. Pharmacol. 217:1992;163-171.
4. Cunningham K., Callahan P., Appel J. Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT): Implications for understanding the actions of novel anxiolytics. Eur. J. Pharmacol. 138:1987;29-36.
5. 1A receptor agonists: Recent developments and controversial issues. Psychopharmacology. 121:1995;1-26.
6. 1A agonists in anxiety and depression. J. Psychopharmacol. 7:1993;283-289.
7. Dourish C., Hutson P., Curzon G. Para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Psychopharmacology. 89:1986;467-471.
8. 1A receptors potentiates the increases in extracellular monoamines induced by duloxetine in rat hypothalamus. J. Neurochem. 66:1996;599-603.
9. 1A receptor antagonists: Utility as research tools and therapeutic agents. Trends Pharmacol. Sci. 14:1993;441-448.
10. 1A receptor antagonist. Behav. Brain Res. 73:1996;337-353.
11. 1A agonist. J. Pharmacol. Exp. Ther. 267:1993;58-71.
12. Fozard J.R., Kidd E.J., Neill J., Tricklebank M. Further characterization of the discriminative cue induced by 8-hydroxy-2-(di-n-propylamino)tetralin in rats. Br. J. Pharmacol. 88:1986;371P.
13. Glaser T., Rath M., Traber J., Zilles K., Schleicher A. Autoradiographic identification and topographical analyses of high affinity serotonin receptor subtypes as a target for the putative anxiolytic TVX Q7812. Brain Res. 358:1985;129-136.
14. Gleeson S., Barrett J.E. Discriminative stimulus effects of anxiolytics in the hippocampus. Soc. Neurosci. Abstr. 15:1989;252.7.
15. 1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur. J. Pharmacol. 154:1988;339-341.
16. Gommans J., Hijzen T.H., Maes R.A., Mos J., Olivier B. Discriminative stimulus properties of flesinoxan: Effects of enantiomers, (s)-UH301 and WAY-100635. Eur. J. Pharmacol. 284:1995;135-140.
17. 1A receptor agonist, in treatment-resistant depression. Int. Clin. Psychopharm. 8:1993;167-172.
18. Hjorth S., Carlsson A. (-)-pindolol stereospecifically inhibits rat brain serotonin (5-HT) synthesis. Neuropharmacology. 24:1985;1143-1146.
19. 1C sites. Neurosci. Lett. 85:1988;357-362.
20. Hoyer D., Schoeffter P. 5-HT receptors: Subtypes and second messengers. J. Receptor Res. 11:1991;197-214.
21. Kalkman H.O. Discriminative stimulus properties of 8-OH-DPAT are not altered by pretreatment with para-chloro-phenylaline. Psychopharmacology. 101:1990;39-42.
22. Koek W., Woods J.H. Partial generalization in pigeons trained to discriminate morphine from saline: Applications of receptor theory. Drug Dev. Res. 16:1989;169-181.
23. 1A receptor antagonist: p-MPPI. Life Sci. 55:1994;1459-1462.
24. 1A autoreceptors modulating serotonin synthesis in the rat brain in vivo. Neurosc. Lett. 218:1996;111-114.
25. Lucki I., Wieland S., Andrews R. Differential modulation of the stimulus properties of 5-HT agonists by 5-HT neurons. Soc. Neurosci. Abstr. 15:1989;94.17.
26. Meltzer H.Y., Maes M. Effect of pindolol on hormone secretion and body temperature: Partial agonist effects. J. Neural. Transm. 103:1996;77-88.
27. 1A mediated lower lip retraction: Effects of 5-HT1A agonists and antagonists. Pharmacol. Biochem. Behav. 46:1993;141-143.
28. 1A receptor antagonist (s)-UH-301 in rodents and monkeys. Brain Res. Bull. 29:1992;901-904.
29. Papp M., Willner P. 8-OH-DPAT-induced place preference and place aversion: Effects of PCPA and dopamine antagonists. Psychopharmacology. 103:1991;99-102.
30. Pazos A., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. Serotonin-1 receptors. Brain Res. 346:1985;205-230.
31. Rijnders H.J., Slangen J.L. Discriminative stimulus properties of buspirone involve dopamine-2 receptor antagonist activity. Psychopharmacol. 111:1993;55-61.
32. Sanger D.J. Discriminative stimulus effects of the α2-adrenoceptor antagonist idazoxan. Psychopharmacology. 99:1989;117-121.
33. 1A receptors. Psychopharmacology. 108:1992;85-92.
34. Schipper J., Tulp M., Berkelmans B., Mos J., Van Der Heijden J., Olivier B. Preclinical pharmacology of flesinoxan: A potential anxiolytic and antidepressant drug. Human Psychopharmacol. 6:1991;S53-61.
35. 1A receptor ligands in animal models of anxiety, impulsivity and depression: Multiple mechanisms of action? Pro. Neuro-Psychopharmacol. Biol. Psychiatry. 17:1993;87-104.
36. 1A receptor agonists in the rat. J. Pharmacol. Exp. Ther. 265:1993;572-579.
37. 1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin. J. Pharmacol. Exp. Ther. 275:1995;822-831.
38. 1A receptor activation by flesinoxan in humans: Body temperature and neuroendocrine responses. Neuropsychopharmocology. 13:1995;93-104.
39. 1 receptor and of catecholamine systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin. Eur. J. Pharmacol. 106:1984;271-282.
40. 1A receptor. Eur. J. Pharmacol. 133:1987;47-56.
41. 1A agonists measured with the forced swim assay. Psychopharmacology. 101:1990;497-504.
42. 1A agonists in the pigeon. Pharmacol. Biochem. Behav. 49:1994;385-391.
43. 3 antagonists in the pigeon. Pharmacol. Biochem. Behav. 52:1995;571-575.
44. 1A agonist. Drug Dev. Res. 40:1997;17-34.
45. 1A receptor. Soc. Neurosc. Abstr. 20:1994;1542.
46. Ybema C.E., Slangen J.L., Olivier B., Mos J. Dose-dependent discriminative stimulus properties of 8-OH-DPAT. Behav. Pharmacol. 4:1993;610-624.
47. 1A antagonists and PCPA. Pharmacol. Biochem. Behav. 47:1994;957-962.