LY354740: A metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats

Neuropharmacology

Volumn 36, Issue 11-12, 1997, Pages 1511-1516

  Helton, D R ^a,b   Tizzano, J P ^a   Monn, J A ^a   Schoepp, D D ^a   Kallman, M J ^a  

^a ELI LILLY AND COMPANY   (United States)

^b IQVIA   (United States)

Author keywords

Metabotropic glutamate receptors (mGluRs); Nicotine; Sensorimotor reactivity; Startle; Withdrawal

Indexed keywords

EGLUMETAD; GLUTAMATE RECEPTOR AGONIST; METABOTROPIC RECEPTOR; NICOTINE; UNCLASSIFIED DRUG;

ANXIETY; ARTICLE; DOSE RESPONSE; DRUG EFFECT; DRUG WITHDRAWAL; ENANTIOMER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; STARTLE REFLEX; SYMPTOM; SYNAPTIC TRANSMISSION;

EID: 0031406508     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00170-6     Document Type: Article

References (41)

1. Aizenman E., Tang L.-H. and Reynolds I. J. (1991) Effects of nicotinic agonists on the NMDA receptor. Brain Research 551: 355-357.
2. Akaike A., Tamura Y., Yokota T., Shimohama S. and Kimura J. (1994) Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity. Brain Research 644: 181-187.
3. Baskys, A. (1994) Metabotropic Glutamate Receptors, pp. 1-83. R. G. Landes Co., Austin.
4. Battaglia G., Monn J. A. and Schoepp D. D. (1997) In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats. Neuroscience Letters 229: 161-164.
5. Bruno V., Battaglia G., Copani A., Giffard R. G., Raciti G., Raffaele R., Shinozaki H. and Nicoletti F. (1995) Activation of class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration. European Journal of Neuroscience 7: 1906-1913.
6. Buisson A., Yu S. P. and Choi D. W. (1996) DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons. European Journal of Neuroscience 8: 138-143.
7. Clarke P. B. S. (1987) Nicotine and smoking: a perspective from animal studies (Berlin). Psychopharmacology 92: 135-143.
8. Davis M., Gendelman D. S., Tischler M. D., and Gendelman P. M. (1982) A primary acoustic startle circuit: lesion and stimulation studies. Journal of Neuroscience 2: 791-805.
9. Davis, M. (1987) The mammalian startle response. In Neural Mechanisms of Startle Behavior, ed. R. C. Saton, p. 287. Plenum Press, New York.
10. Di Iorio P., Battaglia G., Ciccarelli R., Ballerini P., Giuliani P., Poli A., Nicoletti F. and Caciagli F. (1996) Interaction between Al adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices. Journal of Neurochemistry 67: 302-309.
11. East S. J., Hill M. P. and Brotchie J. M. (1995) Metabotropic glutamate receptor agonists inhibit endogenous glutamate release from rat striatal synaptosomes. European Journal of Pharmacology 277: 117-121.
12. Emmett-Oglesby M. W., Mathis D. A., Moon R. T. Y. and Lal H. (1990) Animal models of drug withdrawal. Psychopharmacology 101: 292-309.
13. Gray R., Rajan A. S., Radcliffe K. A., Yakehiro M. and Dani J. A. (1996) Hippocampal synaptic transmission enhanced by low concentration of nicotine. Nature 383: 713-716.
14. Helton D. R., Modlin D. L., Tizzano J. P. and Rasmussen K. (1993) Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity. Psychopharmacology 113: 205-212.
15. Helton D. R., Tizzano J. P., Monn J. A., Schoepp D. D. and Kallman M. J. (1997) Anxiolytic and side-effect profile of LY354740: A potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. Journal of Pharmacology and Experimental Therapeutics, in press.
16. Henningneid, J. E., Schuh, L. M. and Jarvik, M. E. (1995) Pathophysiology of tobacco dependence. In Psychopharmacology: Fourth Generation of Progress, ed. F. E. Bloom and D. J. Kupfer, pp. 1715-1729. Raven Press, New York.
17. Honore T., Davies S. N., Drejer J., Fletcher E. J., Jacobsen P., Lodge D. and Nielsen F. E. (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241: 701-703.
18. Hughes J. R. and Hatsukami D. K. (1992) The nicotine withdrawal syndrome: a brief review and update. International Journal of Smoking Cessation 1: 21-26.
19. Johnson J. W. and Ascher P. (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325: 629-631.
20. Kamiya H., Shinozaki H. and Yamamoto C. (1996) Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses. Joournal of Physiology 493: 447-455.
21. Lodge, D. and Collingridge, G. (1991) The pharmacology of excitatory amino acids Trends in Pharmacological Sciences.
22. Marin P., Maus M., Desagher S., Glowinski J. and Premont J. (1994) Nicotine protects cultured striatal neurones against N-methyl-D-aspartate receptor-mediated neurotoxicity. Neuro Report 5: 1977-1980.
23. McGehee D. S., Heat M. J., Gelber S., Devay P. and Role L. W. (1995) Nicotinic enhancement of fast excitatory synaptic transmission in the CNS by presynaptic receptors. Science 269: 1692-1696.
24. Miyamoto M., Ishida M. and Shinozaki H. (1997) Anticonvulsant and neuroprotectant actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat. Neuroscience 77: 131-140.
25. Monn J. A., Valu M. J., Massey S. M., Wright R. A., Salhoff C. R., Johnson B. G., Howe T., Alt C. A., Rhodes G. A., Robey R. L., Griffey K. R., Tizzano J. P., Kallman M. J., Helton D. R. and Schoepp D. D. (1997) Design, synthesis and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: a potent, selective, systemically active Group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. Journal of Medicinal Chemistry 40: 528-537.
26. Nakanishi S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603.
27. Pin J.-P. and Duvoisin R. (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34: 1-26.
28. Rasmussen K., Czachura J. F., Kallman M. J. and Helton D. R. (1996) The CCK-B antagonist LY288513 blocks the effects of nicotine withdrawal on auditory startle. Neuroreport 7: 1050-1052.
29. Rasmussen K., Kallman M. J. and Heiton D. R. (1997) Serotonin-lA antagonists attenuate the effects of nicotine withdrawal on the auditory startle response. Synapse 27: 145-152.
30. Schachter S. (1979) Regulation, withdrawal and nicotine addiction. National Institute of Drug Abuse Research Monograph Series 23: 123-133.
31. Schoepp D. D. (1994) Novel functions for subtypes of metabotropic glutamate receptors. Neurochemistry International 24: 439-449.
32. Schoepp D. D., Johnson B. G., Wright R. A., Salhoff C. R., Mayne N. G., Wu S., Cockerham S. L., Burnett J. P., Belagaje R., Bleakman D. and Monn J. A. (1997) LY354740 is a potent and highly selective Group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology 36: 1-11.
33. Shiffman S. M. and Phil C. (1979) The tobacco withdrawal syndrome. National Institiute of Drug Abuse Research Monograph Series 23: 158-184.
34. Shoaib M., Benwell M. E. M., Akbar M. T., Stolerman I. P. and Balfour D. J. K. (1994) Behavioral and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists. British Journal of Pharmacology 111: 1073-1080.
35. Shoaib M. and Stolerman I. P. (1996) The NMDA antagonist dizocilpine (MK801) attenuates tolerance to nicotine in rats. Journal of Psychopharmacology 10: 214-218.
36. Shytle, R. D., Borlongan, C. V., Cahill, D. W. and Sanberg, P. R. (1996) Evidence for the neuroprotective actions of nicotine in an in vivo model of excitotoxicity. Medical Chemical Research, 555-561. (Birkhauser, Boston).
37. Stolerman I. P., Mirza N. R. and Shoaib M. (1995) Nicotine psychopharmacology: addiction, cognition, and neuroadaption. Medicinal Research Reviews 15: 47-72.
38. Toth E. (1996) Effect of nicotine on the level of extracellular amino acids in the hippocampus of rat. Neurochemical Research 21: 903-907.
39. Vidal C. (1994) Nicotine potentiation of glutamatergic synapses in the prefrontal cortex: new insight into the analysis of the role of nicotinic receptors in cognitive functions. Drug Development Research 31: 120-126.
40. Yu Z. J. and Wecker L. (1994) Chronic nicotine administration differentially affects neurotransmitter release from rat striatal slices. Journal of Neurochemistry 63: 186-194.
41. Zhang X., Gong Z.-H. and Nordberg A. (1994) Effects of chronic treatment with (+)-nicotine and (-)-nicotine on nicotinic acetylcholine-receptors and N-methyl-D-aspartate receptors in rat brain. Brain Research 644: 32-39.