Serotonin-1A antagonists attenuate the effects of nicotine withdrawal on the auditory startle response

Synapse

Volumn 27, Issue 2, 1997, Pages 145-152

  Rasmussen, Kurt ^a   Kallman, Mary Jeanne ^a   Helton, David R ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

5 HT; Dependence; Sensorimotor reactivity

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NICOTINE TARTRATE; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; AUDITORY STIMULATION; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SEROTONIN RELEASE; SMOKING CESSATION; STARTLE REFLEX; WITHDRAWAL SYNDROME;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; AUDITORY PERCEPTION; MALE; NICOTINE; PIPERAZINES; PYRIDINES; RATS; SEROTONIN ANTAGONISTS; STARTLE REACTION; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0030838547     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199710)27:2<145::AID-SYN5>3.0.CO;2-E     Document Type: Article

References (54)

1. Alkondon, M., and Albuquerque, E.X. (1993) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J. Pharmacol. Exp. Ther., 265:1455-1473.
2. Benwell, M.E.M., and Balfour, D.J.K. (1979) Effects of nicotine administration and its withdrawal on plasma corticosterone and brain 5-hydroxyindoles. Psychopharmacology (Berlin), 63:7-11.
3. Benwell, M.E.M., and Balfour, D.J.K. (1982) Effects of chronic nicotine administration on the response and adaptation to stress. Psychopharmacology (Berlin), 76:160-162.
4. Benwell, M.E.M., Balfour, D.J.K., and Anderson, J.M. (1990) Smoking-associated changes in the serotonergic systems of discrete regions of human brain. Psychopharmacology (Berlin), 102:68-72.
5. Chalmers, D.T., and Watson, S.J. (1991) Comparative anatomical distribution of 5-HT-1A receptor mRNA and 5-HT-1A binding in rat brain - A combined in situ hybridisation/in vitro autoradiographic study. Brain Res., 561:51-60.
6. Clarke, P.B.S., Schwartz, R.D., Paul, S.M., Pert, C.B., and Pert, A. (1985) Nicotine binding in rat brain: Autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-α-bungarotoxin. J. Neurosci., 5:1307-1315.
7. Claustre, Y., Rouquier, L., Serrano, A., Benavides, J., and Scatton, B. (1991) Effect of the putative 5-HT-1A antagonist NAN-190 on rat brain serotonergic transmission. Eur. J. Pharmacol., 204:71-77.
8. Corrigal, W.A., and Coen, K.M. (1994) Nicotine self-administration and locomotor activity are not modified by the 5-HT-3 antagonists ICS 205-930 and MDL 72222. Pharmacol. Biochem. Behav., 49:67-71.
9. Corrigal, W.A., Franklin, K.B.J., Coen, K.M., and Clarke, P.B.S. (1992) The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology (Berlin), 107:285-289.
10. Court, J., and Clementi, F. (1995) Distribution of nicotine subtypes in human brain. Alz. Dis. Assoc. Dis., 9:6-14.
11. Costall, B., Jones, B.J., Kelly, M.E., Naylor, R.J., Onaivi, E.S., and Tyers, M.B. (1990) The potential of GR38032F to inhibit the behavioral consequences of withdrawing from chronic treatment with drugs of abuse. Pharmacol. Biochem. Behav., 36:97-104.
12. Cross, K., Foreman, R.C., and Chad, J.E. (1995) Enhancement by 5-hydroxytryptamine and analogs of desensitization of neuronal and muscle nicotinic receptors expressed in Xenopus oocytes. Br. J. Pharmacol., 114:1636-1640.
13. Damaj, M.I., Glennon, R.A., and Martin, B.R. (1994) Involvement of the serotonergic system in the hypoactive and antinociceptive effects of nicotine in mice. Brain Res. Bull., 33:199-203.
14. Davis, M. (1980) Neurochemical modulation of sensory-motor reactivity: Acoustic and tactile startle reflexes. Neurosci. Biobehav. Rev., 4:241-263.
15. Davis, M. (1992) The role of the amygdala in fear-potentiated startle: Implications for animal models of anxiety. Trends Pharmacol. Sci., 13:35-41.
16. Engleman, E.A., Robertson, D.W., Thompson, D.C., Perry, K.W., and Wong, D.T. (1996) Antagonism of serotonin 5-htla receptors potentiates the increases in extracellular monoamines induced by duloxetine in rat hypothalamus. J. Neurochem., 66:599-603.
17. File, S.E., and Andrews, N. (1994) Anxiolytic-like effects of 5-HT-1A agonists in drug-naive and in benzodiazepine-experienced rats. Behav. Pharmacol., 5:99-102.
18. Fletcher, A., Forster, E.A., Bill, D.J., Brown, G., Cliffe, I.A., Hartley, J.E., Jones, D.E., Mclenachan, A., Stanhope, K.J., Critchley, D., Childs, K.J., Middlefell, V.C., Lanfumey, L., Corradetti, R., Laporte, A.M., Gozlan, H., Hamon, M., and Dourish, C.T. (1996) Electrophysiological, biochemical, neurohormonal and behavioral-studies with WAY-100635, a potent, selective and silent 5-HT-1A receptor antagonist. Behav. Brain Res., 73:337-353.
19. Foreman, M.M., Fuller, R.W., Leander, J.D., Nelson, D.L., Calligaro, D.O., Lucaites, V.L., Wong, D.T., Zhang, L., Barrett, J.E., and Schaus, J.M. (1995) Pharmacological characterization of enantiomers of 8-thiomethyl-2-(di-n-propylamino)tetralin, potent and selective 5-HT-1A receptor agonists. Drug Dev. Res., 34:66-85.
20. Fornal, C.A., Litto, W.J., Metzler, C.W., Marrosu, F., Tada, K., and Jacobs, B.L. (1994) Single-unit responses of serotonergic dorsal raphe neurons to 5-HT-1A agonist and antagonist administration in behaving cats. J. Pharmacol. Exp. Ther., 270:1345-1358.
21. Fornal, C.A., Metzler, C.W., Gallegos, R.A., Veasey, S.C., McCreary, A.W., and Jacobs, B.L. (1996) WAY-100635, a potent and selective 5-hydroxytryptamine-1A antagonist, increases serotonergic neuronal activity in behaving cats: Comparison with (S)-WAY-100135. J. Pharmacol. Exp. Ther., 278:752-762.
22. Fuller, R.W., Perry, K.W., Hemrickluecke, S.K., and Engleman, E. (1996) Serum corticosterone increases reflect enhanced uptake inhibitor-induced elevation of extracellular 5-hydroxytryptamine in rat hypothalamus. J. Pharm. Pharmacol., 48:68-70.
23. Garcia-Colunga, J., and Miledi, R. (1995) Effects of serotonergic agents on neuronal nicotinic acetylcholine-receptors. Proc. Nat. Acad. Sci. USA, 92:2919-2923.
24. Grunberg, N.E., Bowen, D.J., and Winders, S.E. (1986) Effects of nicotine on body weight and food consumption in female rats. Psychopharmacology (Berlin), 90:101-105.
25. Helton, D.R., Modlin, D.L., Tizzano, J.P., and Rasmussen, K. (1993) Nicotine withdrawal: A behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity. Psychopharmacology (Berlin), 113:205-210.
26. Helton, D.R., Berger, J.E., Czachura, J.F., Rasmussen, K., and Kallman, M.J. (1996) Central nervous system characterization of the new cholecyctokinin-B antagonist LY288513. Pharmacol. Biochem. Behav., 53:493-502.
27. Hilleman, D.E., Mohiuddin, S.M., Del Gore, M.G., and Sketch, M.H. (1992) Effect of buspirone on withdrawal symptoms associated with smoking cessation. Arch. Intern. Med., 152:350-355.
28. Hilleman, D.E., Mohiuddin, S.M., and Del Gore, M.G. (1994) Comparison of fixed-dose transdermal nicotine, tapered-dose transdermal nicotine, and buspirone in smoking cessation. J. Clin. Pharmacol., 34:222-224.
29. Hjorth, S., and Sharp, T. (1990) Mixed agonist/antagonist properties of NAN-190 at 5-HT-1A receptors: Behavioral and in vivo brain microdialysis studies. Life Sci., 46:955-963.
30. Hughes, J.R., Gulliver, S.B., Fenwick, J.W., Valliere, W.A., Cruser, K., Pepper, S., Shea, P., Solomon, L.J., and Flynn, B.S. (1992) Smoking cessation among self-quitters. Health Psychol., 11:331-334.
31. Hughes, J.R., and Hatsukami, D. (1986) Signs and symptoms of tobacco withdrawal. Arch. Gen. Psychiatry, 43:289-294.
32. Kia, H.K., Miquel, M.C., Brisorgueil, M.J., Daval, G., Riad, M., Elmestikawy, S., Hamon, M., and Verge, D. (1996) Immunocytochemical localization of serotonin(1a) receptors in the rat central-nervous-system. J. Comp. Neurol., 365:289-305.
33. Malin, D.H., Lake, J.R., Newlin-Maultsby, P., Roberts, L.K., Lanier, J.G., Carter, V.A., Cunningham, J.S., and Wilson, O.B. (1992) Rodent model of nicotine abstinence syndrome. Pharmacol. Biochem. Behav., 43:779-784.
34. Maurel-Remy, S., Schreiber, R., Dalmus, M., and De Vry, J. (1996) Somatodendritic 5-HT-1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT. Psychopharmacology (Berlin), 125: 89-91.
35. Moore, N.A., Rees, G., Sanger, G., and Perrett, L. (1993) 5-HT-1a-mediated lower lip retraction: Effects of 5-HT-1A agonists and antagonists. Pharmacol. Biochem. Behav., 46:141-143.
36. Nakazawa, K., Akiyama, T., and Inoue, K. (1995) Block by 5-hydroxytryptamine of neuronal acetylcholine-receptor channels expressed in Xenopus oocytes. Cell. Mol. Neurobiol., 15:495-500.
37. Pasqualetti, M., Nardi, I., Ladinsky, H., Marazziti, D., and Cassano, G.B. (1996) Comparative anatomical distribution of serotoin 1A, 1Dα and 2A receptor mRNAs in human brain postmortem. Mol. Brain Res., 39:223-233.
38. Pich, E.M., Pagliusi, S.R., Tessari, M., Talabot-Ayer, D., van Huijsduijnen, R.H., and Chiamulera, C. (1997) Common neural substrates for the addictive properties of nicotine and cocaine. Science, 275:83-86.
39. Rasmussen, K., and Czachura, J.F. (1997) Nicotine withdrawal leads to increased sensitivity of serotonergic neurons to the 5-HT-1A agonist 8-OH-DPAT. Psychopharmacology (Berlin) (in press).
40. Rasmussen, K., Czachura, J.F., Kallman, M.J., and Helton, D.R. (1996) The CCK-B antagonist LY288513 blocks the effects of nicotine withdrawal on auditory startle. Neuroreport, 7:1050-1052.
41. Ribeiro, E.B., Bettiker, R.L., Bodganov, M., and Wurtman, R.J. (1993) Effects of systemic nicotine on serotonin release in rat brain. Brain Res., 621:311-318.
42. Riekkinen, M., Tolonen, R., and Riekkinen, P., Jr. (1994) Interaction between 5-HT-1A and nicotinic cholinergic receptors in the regulation of water maze navigation behavior. Brain Res., 649:174-180.
43. Riekkinen, P., Sirvio, J., and Riekkinen, M. (1994) Serotonin depletion decreases the therapeutic effect of nicotine, but not THA, in medial septal-lesioned rats. Brain Res., 662:95-102.
44. Rydelek-Fitzgerald, L., Teitler, M., Fletcher, P.W., Ismaiel, A.M., and Glennon, R.A. (1990) NAN-190: Agonist and antagonist interactions with brain 5-HT-1A receptors. Brain Res., 532:191-196.
45. Sannerud, C.A., Prada, J., Goldberg, D.M., and Goldberg, S.R. (1994) The effects of sertraline on nicotine self-administration and food-maintained responding in squirrel monkeys. Eur. J. Pharmacol., 271:461-469.
46. Schneider, N.G., Olmstead, R.E., Steinberg, C., Sloan, K., Daims, R.M., and Brown, H.V. (1996) Efficacy of buspirone in smoking cessation: A placebo-controlled trial. Clin. Pharmacol. Ther., 60:568-575.
47. Schwartz, R.D., Lehmann, J., and Kellar, K.J. (1984) Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain. J. Neurochem., 42:1495-1498.
48. Sprouse, J.S., and Aghajanian, G.K. (1987) Electrophysiological responses of serotonergic dorsal raphe neurons to 5-HT-1A and 5-HT-1B agonists. Synapse, 1:3-9.
49. Stanhope, K.J., and Dourish, C.T. (1996) Effects of 5-HT-1A receptor agonists, partial agonists and a silent antagonist on the performance of the conditioned emotional response test in the rat. Psychopharmacology (Berlin), 128:293-303.
50. Summers, K.L., and Giacobini, E. (1995) Effects of local and repeated systemic administration of (-)nicotine on extracellular levels of acetylcholine, norepinehrine, dopamine, and serotonin in rat cortex. Neurochem. Res., 20:753-759.
51. West, R.J., Hajek, P. and Belcher, M. (1989) Severity of withdrawal symptoms as a predictor of outcome of an attempt to quit smoking. Psychological Med. 19:981-985.
52. West, R., Hajek, P., and McNeill, A. (1991) Effect of buspirone on cigarette withdrawal symptoms and short-term abstinence rates in a smoker's clinic. Psychpharmacology (Berlin), 104:91-96.
53. Wong, D.T., Mayle, D.N., Delapp, N.W., Calligaro, D.O., and Robertson, D.W. (1994) LY206130, a cyclohexyl analog of pindolol, an antagonist of 5-HT-1A receptor. Soc. Neurosci. Abstr., 20:1542.
54. Yu, Z.J., and Wecker, L. (1994) Chronic nicotine administration differentially affects neurotransmitter release from rat striatal slices. J. Neurochem., 63:186-194.