Protective effect of a single interleukin-12 (IL-12) predose against the toxicity of subsequent chronic IL-12 in mice: Role of cytokines and glucocorticoids

Blood

Volumn 90, Issue 11, 1997, Pages 4473-4479

  Sacco, Silvano ^b   Heremans, Hubertine ^b   Echtenacher, Berndt ^b   Buurman, Wim A ^b   Amraoui, Zoulikha ^b   Goldman, Michel ^b   Ghezzi, Pietro ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; GLUCOCORTICOID; INTERLEUKIN 12; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; BODY WEIGHT; CYTOTOXICITY; DOWN REGULATION; ENCEPHALITIS; FOOD INTAKE; LUNG EDEMA; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; SPLENOMEGALY;

EID: 0030662705     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.11.4473.4473_4473_4479     Document Type: Article

References (35)

1. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G: Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J Exp Med 170:827, 1989
2. Chan SH, Perussia B, Gupta JB, Kobayashi M, Posposil M, Young HA, Wolf SF, Young D, Clark SC, Trinchieri G: Induction of interferon-γ production by natural killer cell stimulation factor: Characterization of the responder cell and synergy with other inducers. J Exp Med 173:869, 1991
3. Hendrzak JA, Brunda MJ: Interleukin-12. Biologic activity, therapeutic utility, and role in disease. Lab Invest 72:619, 1995
4. Lamont AG, Adorini L: IL-12: A key cytokine in immune regulation. Immunol Today 17:214, 1996
5. Nastala CL, Edington HD, McKinney TG, Tahara H, Nalesnik MA, Brunda MJ, Gately MK, Wolf SF, Schreiber RD, Storkus WJ, Lotze MT: Recombinant IL-12 administration induces tumor regression in association with interferon-γ production. J Immunol 153:1697, 1994
6. Leonard JP, Waldburger KE, Goldman SJ: Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J Exp Med 181:381, 1995
7. Williamson E, Garside P, Bradley JA, Mowat AM: IL-12 is a central mediator of acute graft-versus-host disease in mice. J Immunol 157:689, 1996
8. Wysocka M, Kubin M, Vieira LQ, Ozmen L, Garotta G, Scott P, Trinchieri G: Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol 25:672, 1995
9. Ozmen L, Pericin M, Hakimi J, Chizzonite RA, Wysocka M, Trinchieri G, Gately M, Garotta G: Interleukin 12, interferon-γ, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction. J Exp Med 180:907, 1994
10. Car BD, Eng VM, Schnyder B, LeHir M, Shakov AN, Woerly G, Huang S, Aguet M, Anderson TD, Ryffel B: Role of interferonγ in interleukin-12-induced pathology in mice. Am J Pathol 147:1693, 1995
11. Orange JS, Salazar-Mather TP, Opal SM, Spencer RL, Miller AH, McEwen BS, Biron CA: Mechanism of interleukin-12-mediated toxicities during experimental viral infections: Role of tumor necrosis factor and glucocorticoids. J Exp Med 181:901, 1995
12. Cohen J: IL-12 deaths: Explanation and a puzzle. Science 270:908, 1995
13. Kunicka JE, Talle MA, Denhardt GH, Brown M, Prince LA, Goldstein G: Immunosuppression by glucocorticoids: Inhibition of production of multiple lymphokines by in vivo administration of dexamethasone. Cell Immunol 149:39, 1993
14. Fantuzzi G, Ghezzi P: Glucocorticoids as cytokine inhibitors: Role in neuroendocrine control and therapy of inflammatory diseases. Mediat Inflamm 2:263, 1993
15. Gérard C, Bruyns C, Marchant A, Abramowicz D, Vandenabeele P, Delvaux A, Fiers W, Goldman M, Velu T: Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 177:547, 1993
16. Gerosa F, Paganin C, Peritt D, Paiola F, Scupoli MT, Aste-Amezaga M, Frank I, Trinchieri G: Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferonγ and interleukin-10. J Exp Med 183:2559, 1996
17. Tripp CS, Wolf SF, Unanue ER: Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci USA 90:3725, 1993
18. Faggioni R, Gatti S, Demitri MT, Delgado R, Echtenacher B, Gnocchi P, Heremans H, Ghezzi P: Role of xanthine oxidase and reactive oxygen intermediates in LPS- and TNF-induced pulmonary edema. J Lab Clin Med 123:394, 1994
19. D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste M, Chan SH, Kobayashi M, Young D, Nickbarg E, Chizzonite R, Wolf SF, Trinchieri G: Production of natural killer cell stimulatory factor (interleukin-12) by human peripheral blood mononuclear cells. J Exp Med 176:1387, 1992
20. Delvaux A, Donckier V, Bruyns C, Florquin S, Gérard C, Amraoui Z, Abramowicz D, Goldman M, Velu T: Effect of systemic administration of rIL-10 in an in vivo model of alloreactivity. Transplantation 58:973, 1994
21. Heremans H, Van Damme J, Dillen C, Dijkmans R, Billiau A: Interferon gamma, a mediator of lethal lipopolysaccharide-induced Schwartzman-like shock reactions in mice. J Exp Med 171:1853, 1990
22. Di Santo E, Sironi M, Pozzi P, Gnocchi P, Isetta AM, Delvaux A, Goldman M, Marchant A, Ghezzi P: Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin-1 β production in the brain without affecting the activation of the hypothalamus-pituitary adrenal axis. Neuroimmunomodulation 2:149, 1995
23. Aggarwal BB, Khor WJ, Hass PE, Moffat B, Spencer SA, Henzel J, Bringman S, Nedwin GE, Goeddel DV, Harkins RN: Human tumor necrosis factor. Production, purification and characterization. J Biol Chem 260:2345, 1985
24. Sironi M, Breviario F, Proserpio P, Biondi A, Vecchi A, Van Damme J, Dejana E, Mantovani A: IL-1 stimulates IL-6 production in endothelial cells. J Immunol 142:549, 1989
25. Heremans H, Dillen C, Put W, Van Damme J, Billiau A: Protective effect of anti-interleukin (IL)-6 antibody against endotoxin, associated with paradoxically increased IL-6 levels. Eur J Immunol 22:2395, 1992
26. Bemelmans MHA, Gouma DJ, Buurman WA: LPS-induced sTNF-receptor release in vivo in a murine model. Investigation of the role of tumor necrosis factor, IL-1, leukemia inhibiting factor, and IFN-γ. J Immunol 151:5554, 1993
27. Orange JS, Wolf S, Biron CA: Effects of IL-12 on the response and susceptibility to experimental viral infections. J Immunol 152:1253, 1994
28. Van Zee KJ, Kohno T, Fisher E, Rock CS, Moldawer LL, Lowry SF: Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor-α in vitro and in vivo. Proc Natl Acad Sci USA 89:4845, 1992
29. Heinzel FP: The role of IFN-γ in the pathology of experimental endotoxemia. J Immunol 145:2920, 1990
30. Car BD, Eng VM, Schnyder B, Gallay P, Heumann D, Ozmen L, Aguet M, Huang S, Ryffel B: Increased resistance to endotoxic shock in interferon-γ receptor deficient mice. J Exp Med 179:1437, 1994
31. Chrousos GP: The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351, 1995
32. Morris SC, Madden KB, Adamovicz JI, Cause WC, Hubbard BR, Gately MK, Finkelman FD: Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol 152:1047, 1994
33. Caspi RR, Chan C-C, Grubbs BG, Silver PB, Wiggert B, Parsa CF, Bahmanyar S, Billiau A, Heremans H: Endogenous systemic IFN-γ has a protective role against ocular autoimmunity in mice. J Immunol 152:890, 1994
34. Wahl SM, Allen JB, Ohura K, Chenoweth DE, Hand AR: IFN-gamma inhibits inflammatory cells recruitment and the evolution of bacterial cell wall-induced arthritis. J Immunol 146:95, 1991
35. Durez P, Abramowicz D, Gérard C, Van Mechelen M, Amraoui Z, Dubois C, Oberdan L, Velu T, Goldman M: In vivo induction of interleukin 10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide: Differential modulation by cyclosporin A. J Exp Med 177:551, 1993