The putative benzene metabolite 2,3,5-tris(glutathion-S-yl)hydroquinone depletes glutathione, stimulates sphingomyelin turnover, and induces apoptosis in HL-60 cells

Chemical Research in Toxicology

Volumn 13, Issue 7, 2000, Pages 550-556

  Bratton, Shawn B ^a,b   Lau, Serrine S ^a   Monks, Terrence J ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE DERIVATIVE; CASPASE; CASPASE 3; CASPASE 7; CATALASE; CERAMIDE; GLUTATHIONE PEROXIDASE; HYDROQUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; PROTEIN METABOLISM; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION;

APOPTOSIS; BENZENE; BIOLOGICAL TRANSPORT; CASPASES; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HL-60 CELLS; HUMANS; HYDROQUINONES; PHOSPHATIDYLSERINES; REACTIVE OXYGEN SPECIES; SPHINGOMYELINS;

EID: 0033931806     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0000015     Document Type: Article

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