Engineered zinc finger proteins that respond to DNA modification by HaeIII and HhaI methyltransferase enzymes

Journal of Molecular Biology

Volumn 295, Issue 3, 2000, Pages 471-477

  Isalan, Mark ^a   Choo, Yen ^a,b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b Gendaq Ltd   (United Kingdom)

Author keywords

DNA methylation; DNA modification; Gene regulation; Methyltransferase; Zinc finger

Indexed keywords

5 METHYLCYTOSINE; DNA METHYLTRANSFERASE; ZINC FINGER PROTEIN;

ARTICLE; DNA METHYLATION; DNA MODIFICATION; ENZYME ANALYSIS; ENZYME REGULATION; GENE CONTROL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING;

PROKARYOTA;

EID: 0034695430     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3366     Document Type: Article

References (18)

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5. Designing DNA-binding proteins on the surface of filamentous phage
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7. Zif268 protein-DNA complex refined at 1.6 Å: A model system for understanding zinc finger interactions
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10. Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated
11. Synergy between adjacent zinc fingers in sequence-specific DNA recognition
12. Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers
13. In vitro selection of zinc fingers with altered DNA-binding specificity
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17. Building zinc fingers by selection: Toward a therapeutic application