Systemically derived large intestinal CD4+ Th2 cells play a central role in STAT6-mediated allergic diarrhea

Journal of Clinical Investigation

Volumn 106, Issue 2, 2000, Pages 199-206

  Kweon, Mi Na ^a   Yamamoto, Masafumi ^a,b   Kajiki, Masahiro ^c   Takahashi, Ichiro ^a   Kiyono, Hiroshi ^a,d  

^a OSAKA UNIVERSITY   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c ASAHI CHEMICAL INDUSTRY CO   (Japan)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 3; INTERLEUKIN 4; OVALBUMIN; STAT6 PROTEIN;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CYTOKINE RELEASE; DIARRHEA; HISTOPATHOLOGY; IMMUNOPATHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH2 CELL;

EID: 0033925799     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8490     Document Type: Article

References (42)

1. Romagnani, S. 1995. Atopic allergy and other hypersensitivities editorial overview: technological advances and new insights into pathogenesis prelude novel therapeutic strategies. Curr. Opin. Immunol. 7:745-750.
2. Sampson, H.A. 1997. Food allergy. JAMA. 278:1888-1894.
3. Gall, D.G., and Perdue, M.H. 1986. Experimental models of intestinal allergy. Front. Gastrointest. Res. 13:45-54.
4. + T cell responses by oral or parenteral immunization with ISCOMS. Eur. J. Immunol. 25:2835-2841.
5. Layton, G.T., Stanworth, D.R., and Amos, H.K. 1986. Factors influencing the immunogenicity of the haptenic drug chlorhexidine in mice. II. The role of the carrier and adjuvants in the induction of IgE and IgG anti-hapten responses. Immunology. 59:459-465.
6. Snider, D.P., Marshall, J.S., Perdue, M.H., and Liang, H. 1994. Production ot IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. J. Immunol. 153:647-657.
7. Ohtsuka, Y., et al. 1998. Chronic oral antigen exposure induces lymphocyte migration in anaphylactic mouse intestine. Pediatr. Res. 44:791-797.
8. Takeda, K., et al. 1996. Essential role of Stat6 in IL-4 signalling. Nature. 380:627-630.
9. Shimoda, K., et al. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 380:630-633.
10. Takeda, K., Kamanaka, M., Tanaka, T., Kishimoto, T., and Akira, S. 1996. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J. Immunol. 157:3220-3222.
11. Kuperman, D., Schofield, B., Wills-Karp, M., and Grusby, M.J. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J. Exp. Med. 187:939-948.
12. Akimoto, T., et al. 1998. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT) 6 deficient mice. J. Exp. Med. 187:1537-1542.
13. Okabe, M., Ikawa, M., Kminami, K., Nakanishi, T., and Nishimune, Y. 1997. 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 407:313-319.
14. Iijima, H., et al. 1999. Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice. J. Exp. Med. 190:607-615.
15. Yamamoto, S., et al. 1997. Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity. J. Exp. Med. 185:1203-1210.
16. Jackson, R.J., Fujihashi, K., Kiyono, H., and McGhee, J.R. 1996. Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses. J. Immunol. Methods. 190:189-197.
17. Kweon, M.N., et al. 1998. Lack of orally induced systemic unresponsiveness in IFN-γ knockout mice. J. Immunol. 160:1687-1693.
18. Fujihashi, K., et al. 1996. γ/δ T cell-deficient mice have impaired mucosal immunoglobulin A responses. J. Exp. Med. 183:1929-1935.
19. Jackson, R.J.,et al. 1993. Optimising oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect. Immun. 61:4272-4279.
20. + Th2 cells producing IL-6 and IL-10 are associated with mucosal IgA responses. Infect. Immun. 64:1516-1525.
21. Yamamoto, M., Fujihashi, K., Kawabata, K., McGhee, J.R., and Kiyono, H. 1998. A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J. Immunol. 160:2188-2196.
22. Wittwer, C.T., et al. 1997. The LightCycler: a microvolume multisample fluorimeter with rapid temperature control. Biotechniques. 22:176-181.
23. Openshaw, P., et al. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182:1357-1367.
24. Crowe, S.E., and Perdue, M.H. 1992. Gastrointestinal food hypersensitivity: basic mechanisms of pathophysiology. Gastroenterology. 103:1075-1095.
25. Robinson, D.S., et al. 1992. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298-304.
26. DelPrete, G.F., et al. 1993. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur. J. Immunol. 23:1445-1449.
27. Kuhn, R., Rajewsky, K. and Muller, W. 1991. Generation and analysis of interleukin-4 deficient nice. Science. 254:707-710.
28. Kopf, M., et al. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature. 362:245-248.
29. Morawetz, R.A., et al. 1996. Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse. J. Exp. Med. 184:1651-1661.
30. Hogan, S.P., Mould, A., Kikutani, H., Ramsay, A.J., and Foster, P.S. 1997. Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins. J. Clin. Invest. 99:1329-1339.
31. Wills-Karp, M., et al. 1998. Interleukin-13: central mediator of allergic asthma. Science. 282:2258-2261.
32. McKenzie, G.J., et al. 1998. Impaired development of Th2 cells in IL-13-deficient mice. Immunity. 9:423-432.
33. Levy, F., Kristofic, C., Heusser, C., and Brinkmann, V. 1997. Role of IL-13 in CD4 T cell-dependent IgE production in atopy. Int. Arch. Allergy Immunol. 112:49-58.
34. Huang, S.K., et al. 1995. IL-13 expression at the sites of allergen challenge in patients with asthma. J. Immunol. 155:2688-2694.
35. Navarro-Garcia, F., et al. 1997. Intragastric immunization of rats with Entamoeba histolytica trophozoites induces cecal mucosal IgE, eosinophilic infiltration, and type I hypersensitivity. Clin. Immunol. Immunopathol. 82:221-229.
36. Venge, P., Hakansson, L., and Peterson, C.G. 1987. Eosinophil activation in allergic disease. Int. Arch. Allergy Appl. Immunol. 82:333-337.
37. Lopez, A.F., et al. 1988. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J. Exp. Med. 167:219-224.
38. Wang, J.M., et al. 1989. Recombinant human interleukin 5 is a selective eosinophil chemoattractant. Eur. J. Immunol. 19:701-705.
39. Ehrhardt, R.O., Ludviksson, B.R., Gray, B., Neurath, M., and Strober, W. 1997. Induction and prevention of colonic inflammation in IL-2-deficient mice. J. Immunol. 158:566-573.
40. Beagley, K.W., et al. 1995. Differences in intraepithelial lymphocyte T cell subsets isolated from marine small versus large intestine. J. Immunol. 154:5611-5619.
41. high T cells to SCID recipients. J. Immunol. 158:3464-3473.
42. + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179:589-600.