Association and linkage of DRD4 and DRD5 with attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children

Molecular Psychiatry

Volumn 5, Issue 4, 2000, Pages 396-404

  Tahir, E ^a,b   Yazgan, Y ^b   Cirakoglu, B ^c   Ozbay, F ^c   Waldman, I ^d   Asherson, P J ^b  

^a SCIENTIFIC AND TECHNOLOGICAL RESEARCH COUNCIL OF TURKEY   (Turkey)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^d EMORY UNIVERSITY   (United States)

Author keywords

Attention deficit hyperactivity disorder (ADHD); Dopamine D4 receptor gene (DRD4); Dopamine D5 receptor gene (DRD5); Linkage and association

Indexed keywords

DOPAMINE; DOPAMINE 4 RECEPTOR; DOPAMINE 5 RECEPTOR; DOPAMINE RECEPTOR; METHYLPHENIDATE;

ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; DOPAMINERGIC SYSTEM; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC PREDISPOSITION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECEPTOR GENE; SYNAPSE; TURKEY (REPUBLIC);

EID: 0033923995     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000744     Document Type: Article

References (54)

1. Taylor E, Chadwick O, Heptinstall E et al. Hyperactivity and conduct problems as risk factors for adolescent development. J Am Acad Child Adolesc Psychiatry 1996; 35: 1213-1226.
2. Swanson J, Castellanos FX, Murias M et al. Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder. Curr Opin Neurobiol 1998; 8: 263-271.
3. Cantwell DP. Psychiatric illness in families of hyperactive children. Arch Gen Psychiatry 1972; 27: 728-738.
4. Biederman J, Faraone SV, Keenan K et al. Family-genetic and psychosocial risk factors in DSM-III attention deficit disorder. J Am Acad Child Adolesc Psychiatry 1990; 29: 526-533.
5. Biederman J, Faraone SV, Keenan K et al. Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder: patterns of comorbidity in probands and relatives in psychiatrically and pediatrically referred samples. Arch Gen Psychiatry 1992; 49: 728-738.
6. Stevenson J. Evidence for a genetic aetiology in hyperactivity in children. Behav Genet 1992; 22: 337-344.
7. Goodman R, Stevenson J. A twin study of hyperactivity I and II. An examination of hyperactivity scores and categories derived from Rutter teacher and parent questionnaires. J Child Psychol Psychiat 1989; 30: 671-G89.
8. Thapar A, Holmes J, Poulton K et al. Genetic basis of attention deficit and hyperactivity. Br J Psychiatry 1999; 174: 105-111.
9. Levy F, Hay DA, McStephen M et al. Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a largescale twin study. J Am Acad Child Adolesc Psychiatry 1997; 30: 737-744.
10. Eaves LJ, Silberg JL, Meyer JM et al. Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. J Child Psychol Psychiatry Allied Discip 1997; 38: 905-980.
11. Shekim WO, Javaid J, Davis JM et al. Urinary MHPG and HVA excretion in boys with attention deficit disorder and hyperactivity treated with d-amphetamine. Biol Psychiatry 1983; 18: 707-714.
12. Shen YC, Wang YF. 3-methoxy-4-hydroxyphenylglycol sulfate excretion in 73 schoolchildren with minimal brain-dysfunction syndrome. Biol Psychiatry 1984; 19: 861-870.
13. Zametkin AJ, Karoum F, Rapoport JL. Phenylethylamine excretion in attention deficit disorder. J Am Acad Child Psychiatr 1984; 23: 310-314.
14. Arnold LE, Abikoff HB, Cantwell DP et al. National Institute of Mental Health Collaborative Multimodal Treatment Study of Children with ADHD (the MTA): design challenges and choices. Arch Gen Psychiatry 1997; 54: 865-870.
15. Gainetdinov RR, Wetsel WC, Jones SR et al. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 1999; 283: 397-401.
16. Shaywitz BA. CSF amine metabolites in children with minimal brain dysfunction (MBD): evidence of involvement of brain dopamine. J Pediatrics 1977; 90: 67-71.
17. Goldman-Rakic PS. Topography of cognition: parallel distribution networks in primate association cortex. Ann Rev Neurosci 1992; 11: 137-156.
18. Lahoste GJ, Swanson JM, Wigal S et al. Dopamine D4 receptor gene polymorphism is associated with attention-deficit hyperactivity disorder. Mol Psychiatry 1996; 1: 121-124.
19. Swanson JM, Sunohara GA, Kennedy JL et al. Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach. Mot Psychiatry 1998; 3: 38-41.
20. World Health Organisation. International Classification of Diseases: 10th edn. WHO: Geneva, 1999.
21. Rowe DC, Stever C, Giedinghagen LN et al. Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder. Mol Psychiatry 1998; 3: 419-426.
22. Smalley SL, Bailey JN, Palmer CG et al. Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder. Mol Psychiatry 1998; 3: 427-430.
23. Faraone SV, Biederman J, Weiffenbach B et al. Dopamine D4 gene 7-repcat allele and attention deficit hyperactivity disorder. Am J Psychiatry 1999; 156: 708-770.
24. Asherson P, Virdee V, Curran S et al. Association study of DSM-IV attention deficit hyperactivity disorder (ADHD) and monoamine pathway genes. Neuropsychiatrie Genet 1998; 81: 549.
25. Gill M. Unpublished data, 1999.
26. Castellanos FX, Lau E, Tayebi N et al. Lack of an association between a dopamine-4 receptor polymorphism and attentiondeficit/hyperactivity disorder: genetic and brain morphometric analyses. Mol Psychiatry 1998; 3: 431-434.
27. Ebstein RP, Novick O, Umansky R et al. Dopamine D4 receptor (D4DR) exon HI polymorphism associated with the human personality trait of Novelty Seeking. Nature Genet 1996; 12: 78-80.
28. Benjamin J, Li L, Patterson C et al. Population and familial association between (he D4 dopamine receptor gene and measures of Novelty Seeking. Nature Genet 1996; 12: 81-84.
29. Paterson AD, Sunohara GA, Kennedy JL. Dopamine D4 receptor gene: novelty or nonsense? Neuropsychopharmacohgy 1999; 21: 3-16.
30. Daly G, Hawi Z, Fitzgerald M et al. Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry 1999; 4: 192-196.
31. Cook JE, Stein MA, Krasowski MD et al. Association of attentiondeficit disorder and the dopamine transporter gene. Am J Hum Genet 1995; 50: 993-998.
32. Gill M, Daly G, Heron S et al. Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 1997; 2: 311-313.
33. Waldman ID, Robinson BF, Feigon SA. Linkage disequilibrium between the dopamine transporter gene (DATl) and bipolar disorder: Extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity. Genet Epidemiol 1997; 14: 699-704.
34. Bailey JN. DRD4 gene susceptibility to attention deficit hyperactivity disorder: differences in familial and sporadic cases. Am J Med Gen (Neuropsych Gen) 1997; 74: 623 (abstract).
35. Tahir E. No association between ADHD and polymorphisms in DATl and DBH. Unpublished data, 1999.
36. Sunohara RK, Guan HC, O'Dowd BF, Seeman P, Laurier LG et al. Cloning of the gene for a human dopamine Do-receptor with higher affinity for dopamine than Dl. Nature 1991; 350: 614-619.
37. Asghari V, Sanyal S, Buchwaldt S et al. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995; G5: 1157-1165.
38. Asghari V, Schools O, Van Kats S et al. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol 1994; 46: 364-373.
39. Kaufman J, Birmaher B, Brent D et al. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997; 36: 980-988.
40. Conners CK, Barkley RA. Rating scales and checklists for child psychopharmacology. Psychopharmacol Bull 1985; 21: 809-843
41. Achenbach TM. Manual for the Child Behaviour Checklist. 1991. Department of Psychiatry, University of Vermont, Burlington.
42. Greenhill LL, Abikoff HB, Arnold LE, Cantwell DP, Conners CK, Elliott G et al. Medication treatment strategies in the MTA Study: relevance to clinicians and researchers. J Am Acad Child Adolesc Psychiatry 1996; 35: 1304-1313.
43. Lichter JB, Barr CL, Kennedy JL et al. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 1993; 2: 767-773.
44. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506-516.
45. Schaid DJ, Sommer SS. Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet 1993; 53: 1114-1126.
46. Sham PC, Curtis D. An extended transmission/disequilibrium test (TDT) for multiallele marker loci. Ann Hum Genet 1993; 59: 323-336.
47. Waldman ID, Robinson BF, Rhec SH. A logistic regression extension of the transmission disequilibrium test for continuous traits: application to linkage disequilibrium between alcoholism and the candidate genes DRD2 and ADH3. Genet Epideiniol 1999; 17 Suppl 1: S379-S384.
48. Curtis D, Sham PC. Population stratifications can cause false positive linkage results if founders are untyped. Annal Hum Genet 1996; GO: 261-203.
49. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996; 273: 1516-1517.
50. Eaves IA, Bennett ST, Forster P, Ferber KM, Ehrmann D, Wilson AJ et al. Transmission ratio distortion at the INS-IGF2 VNTR. Nature Genet 1999; 22: 324-325.
51. O'Donovan MC, Owen MJ. Candidate-gene association studies of schizophrenia, Am J Hum Genet 1999; 05: 587-592.
52. Pliszka SR. Comorbidity of attention-deficit/hyperactivity disorder with psychiatric disorder: an overview. J Clin Psychiatry 1998; 59 Suppl 7: 50-58.
53. Sobell JL, Lind TJ, Sigurdson DC et al. The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. Hum Mol Genet 1995; 4: 507-514.
54. Asherson P, Mant R, Williams N et al. A study of chromosome 4p markers and dopamine Do receptor gene in schizophrenia and bipolar disorder. Mol Psychiatry 1998; 3: 310-320.