Population stratifications can cause false positive linkage results if founders are untyped

Annals of Human Genetics

Volumn 60, Issue 3, 1996, Pages 261-263

  Curtis, D ^a   Sham, P C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELISM; ARTICLE; DIAGNOSTIC VALUE; GENE FREQUENCY; GENETIC LINKAGE; GENOTYPE; HUMAN; HUMAN CELL; LABORATORY DIAGNOSIS; POPULATION GENETICS; POPULATION RISK; PRIORITY JOURNAL;

EID: 0029783754     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-1809.1996.tb00430.x     Document Type: Article

References (9)

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2. LANGE, K. (1986). A test statistic for the affected-sib-set method. Ann. Hum. Genet. 50, 283-290.
3. LATHROP, G. M., LALOUEL, J. M., JULIER, C. & OTT, J. (1984). Strategics for multilocus linkage analysis in humans. Proc. Natl Acad. Sci. USA 81, 3443-3446.
4. MALIARIK, M. J., KOST, J. A., HARRIXGTOX, D. W., POPOVICH, J. JUNIOR, MAJOR, M. L., RYBICKI, B. A. & IASNUZZI, M. C. (1995). Chromosome Cp microsatellite polymorphisms in African-Americans. Hum. Ilered. 45, 90-97.
5. MILLER, M. B., Gu, C. & REICH, T. (1995). Sensitivity of Lange's (1980) identity-by-state method of linkage analysis to population stratification. Psychiat. Genet. 5, S104.
6. OTT, J. (1989). Computer-simulation methods in human linkage analysis. Prof,. Nail. Acad. Sci. USA 86, 4175-4178.
7. OTT, J. (1992). Strategies for characterizing highly polymorphic markers in human gene mapping. Am. J. Hum. Genet. 51, 283-290.
8. WEEKS, D. E. & LANGE, K. (1988). The affected-pedigreemember method of linkage analysis. A m. J. Hum. Genet. 42, 315-326.
9. WEEKS, D. E., OTT, J. & LATHROP, G. M. (1990). SLINK: a general simulation program for linkage analysis. Am. J. Hum. Genet. 47, A204.