The impact of genetic modification of human foods in the 21st century: A review

Biotechnology Advances

Volumn 18, Issue 3, 2000, Pages 179-206

  Uzogara, Stella G ^a  

^a ALKERMES INC   (United States)

Author keywords

Agricultural biotechnology; Controversy; Environment; Genetically modified foods; Health; Risks and benefits

Indexed keywords

ANIMAL BREEDING; ENVIRONMENTAL IMPACT ASSESSMENT; ENVIRONMENTAL PROTECTION; FOOD QUALITY; FOOD SAFETY; GENETIC IMPROVEMENT; GENETIC MANIPULATION; GENETICALLY MODIFIED FOOD; PLANT BREEDING; RISK ASSESSMENT; TRANSGENIC ANIMAL; UNITED STATES;

CROPS; FOOD PRODUCTS; HEALTH RISKS; NUTRITION; SEED; TOXICITY;

AGRICULTURAL BIOTECHNOLOGY; ALLERGENICITY; ANTIBIOTIC RESISTANCE; CARCINOGENICITY; GENETIC MODIFICATION;

GENETIC ENGINEERING;

ENVIRONMENTAL ISSUE; FOOD INDUSTRY; GENETICALLY MODIFIED ORGANISM;

ANIMALIA; INSECTA;

EID: 0033921234     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0734-9750(00)00033-1     Document Type: Article

References (118)

1. Alliance for Better Foods. Improving Agriculture through Biotechnology: Health and Nutritional Benefits of Food Biotechnology. 1999 Website: www.betterfoods.org/ .
2. Allen S. Labeling rules prohibit food makers from telling what isn't in their products. The Boston Globe, July 12, 1999a, E4.
3. Allen S. Revolution on the farm: tinkering with the DNA on your dinner plate. The Boston Sunday Globe, July 12, 1999b, E1, E4.
4. Ames B.N. Micronutrients prevent cancer and delay aging. Toxicology Letters. 103:1998;5-18.
5. Annas J. Cloning: Crossing nature's boundaries. The Boston Sunday Globe, March 2, 1997, D1, D2.
6. Anon. Success of edible vaccines may depend on picking the right fruit. The Scientist August 18, 1998, 4-5.
7. Anon Vegetable vaccines. Vegetarian Times, Feb. 221:1996;20. a.
8. Anon Agriculture. Humble crop goes high-tech! Science News. 150(5):1996;73. b.
9. Bettelheim A. Drug resistant bacteria. Can scientists find a way to control 'superbugs'? CQ Researcher. 9(21):1999 June 4;473-496.
10. Bevan M.W., Flavell R.B., Chilton M.D. A chimaeric antibiotic resistant gene as a selectable marker for plant cell transformation. Nature. 304:1983;184-187.
11. Billings PR. Modified foods are like drugs. The Boston Globe, August 28, 1999.
12. BIO. Member survey. Biotechnology Industry Organization. 1998. Web site: www.BIO.org .
13. Bishop JE. Technology and health: sheep cloning methods hold promise of fast introduction of livestock traits. The Wall Street Journal, Thursday March 7, 1996, B6.
14. Block G., Langseth L. Anti-oxidant vitamins and health prevention. Food Technol. 46(7):1994;80-85.
15. Brown K.S. Prescription. one plant please Bioscience. 46(2):1996;82.
16. Campbell P.O.Q. Super foods. agricultural products and genetic engineering Biology Digest. 1(23):1996;10-17.
17. Clinton S.K. Lycopene. chemistry, biology, and implications for human health and disease Nutr Rev. 56:1998;35-51.
18. Coleman A. Production of proteins in the milk of transgenic livestock. problems, solutions and success Am J Clin Nutr. 63:1996;5639-5645.
19. Contreras A., Molin S., Ramos J.L. Conditional suicide containment system for bacteria which mineralize aromatics. Appl Environ Microbiol. 57:1991;1504-1508.
20. Crist W.E. Waiter, there's a flounder in my fruit. (Bio-engineered fruits and vegetables with animal genetic materials are not so labeled). Vegetarian Times. 231:1996;22.
21. Cummins R. US plans to define bio-engineered foods as 'organic.'. Earth Island J. 12(4):1997;18.
22. Daie J., Belanger F. Plant factories. production of industrial proteins and non-food products in transgenic plants Agro Food Industry Hi-Tech. January-February:1993;7.
23. Dalrymple M.A. Genetically modified livestock for the production of human proteins. Biotechnol and Genet Eng Rev. 15:1998;33-49.
24. Day P.R. Genetic modification of plants. significant issues and huddles to success. Genetic engineering-opportunities and challenges in infant nutrition Amer J Clin Nutr. 63(4):1996;6315.
25. De Lumen B.O., Krenz D.C., Jamela M. Molecular strategies to improve the protein quality of legumes. Food Technol. 51(5):1997;67-70.
26. Del Vechio A.J. High laurate canola. how Calgene's program began, where it is headed Inform. 7:1996;230-240.
27. Dickson D. Proceed with caution, says UK report on ethics of GM foods. Nature. 399(6735):1999 June 3;396.
28. Dyer O. Sheep cloned by nuclear transfer. Br Med J. 312(7032):1996;658.
29. Elliot J.G. Application of antioxidant vitamins in foods and beverages. Food Technology. 53(2):1999;46-48.
30. Enserink M. Ag biotech moves to mollify critics. Science. 286:1999;1666-1668. a.
31. Enserink M. Transgenic food debate. The Lancet scolded over the Pusztai paper. Science. Oct 22; 286(5440):1999;656. b.
32. Ewen S.W., Pusztai A. Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. Lancet. Oct 16;354(9187):1999;1353-1354.
33. Federal Register. US FDA's Statement of Policy: Foods derived from new plant varieties. 57:22984-23005 (29 May 1992).
34. Ferber D. GM crops in the cross hairs. Science. Nov 26;286:1999;1662-1666.
35. FAO/WHO. Strategies for assessing the safety of foods produced by biotechnology. Geneva: WHO, 1991.
36. Fraley R.T., Rogers S.G., Horsch R.B., Sanders P.R., Rick J.S., Adams S.P., Bittner M.L., Brand L.A., Fink C.L., Fry J.S., Gallupi G.R., Goldberg S.B., Hoffman N.L., Woo S.C. Expression of bacterial genes in plant cells. Proc Natl Acad Sci USA. 80:1983;4803-4807.
37. Gaskell G., Bauer M.W., Durant J., Allum N.C. Worlds apart? The reception of genetically modified foods in Europe and the US. Science. 285(5426):1999;384-387.
38. Gavaghan H. Britain struggles to turn anti GM tide. Science. 284:1999;1442-1444.
39. Goddijn O.J.M., Pen J. Plants as bio-reactors. Tibtech. 13:1995;379-387.
40. Gray S.N. Fungi as potential bioremediation agents in soil contaminated with heavy or radioactive metals. Biochem Soc Trans. 26(4):1998;666-670.
41. Hadfield P. An enzyme for surviving in the desert. New Scientist. 149(2013):1996;21.
42. Hauman B.F. Bio-engineered oilseed acreage escalating. Inform. 8:1997;804-811.
43. Henkel J. Genetic engineering, fast-forwarding to the future foods. FDA Consumer. 29(3):1995;6.
44. Hercberg S., Galan P., Preziosi P., Alvarez M., Vasquez C. The potential role of anti-oxidant vitamins in preventing cardiovascular diseases and cancers. Nutrition. 14:1998;513-520.
45. Herrera-Estrella L., Depicker A., Van Montagu M.L., Schell J. Expression of chimaeric genes transferred into plant cells using a Ti-plasmid-derived vector. Nature. 303:1983;209-213.
46. Hileman B. UK moratorium on biotech crops. Chemical & Eng News May 24, 1999a, p. 7.
47. Hileman B. Bt corn pollen kills monarch butterflies. Chemical & Eng News, May 24, 1999b, p. 7.
48. Hileman B. Prescription for a global biotechnology dialogue. Chemical & Eng News. 77;(29):1999;42. c.
49. Hinchee M.A.W., Connor-Ward D.V., Newell C.A., McDonnel R.E., Sato S.J., Gasser C.S., Fischhoff D.A., Re D.B., Fraley R.T., Horsch R.B. Production of transgenic soybean plants during Agrobacterium-mediated DNA transfer. Bio/Technology. 53(5):1988;50-53.
50. Hoban T.J. Consumer acceptance of biotechnology in the United States and Japan. Food Technology. 53(5):1999;50-53.
51. Hoef A.M., Kok E.J., Bowo E., Kuiper H.A., Keijer J. Development and application of a selective detection method for genetically modified soy and soy derived products. Food Add Contamin. Oct;15(7):1998;767-774.
52. Howe PJ. Plants doing the dirty work in clean up of toxic waste. The Boston Globe, March 8, 1997, P.C1, C2.
53. Hsu K. The future of foods is now: surprisingly genetically altered ingredients are already a staple of the American diet. The Boston Globe, July 12, 1999a, E1, E4.
54. Hsu K. Future foods may cure what ails you. The Boston Globe, July 12, 1999b, E4.
55. Jackson W. Development of perennial grains. Paper presented at the 18th International conference on the Unity of the Sciences. Aug 23-26, 1991, Seoul Korea.
56. Jacoby M. Botanists design plants with a taste for salt. Chemical & Eng News. 23(77):1999;9.
57. Kaiser J. Pests overwhelm Bt cotton crop. Science. 273(5274):1996;423.
58. Kaiser J. Animal rights. activists ransack Minnesota labs Science. 284:1999;410-411.
59. Kessler D.A. "Are genetically engineered foods safe? ... Yes" Commissioner of US Food and Drug Administration, Testimony before the House Appropriations Sub-Committee (Agriculture, Rural Development, FDA and Related Issues). April. 4(29):1993;689.
60. Kessler D.A., Taylor M.R., Maryanski J.H., Flamm E.L., Kahl L.S. The safety of foods developed by biotechnology. Science. 256:1992;1747.
61. Kiernan V. Yes, we have vaccinating bananas. New Scientist. 151(2048):1996;6.
62. Kitamura K. Genetic improvement of nutritional and food processing quality in soybean. Japan Agric Research Quarterly. 29:1995;1-8.
63. Koch K. Food safety battle. organic vs. biotech Congressional Quarterly Researcher. 9(33):1998;761-784.
64. Koenig R. European researchers grapple with animal rights. Science. 284:1999;1604-1606.
65. Krauthammer C. A special report on cloning. Time. 149(10):1997 March 10;60.
66. Kridl J.C., Shewmaker C.K. Food for thought. improvement of food quality and composition through genetic engineering Collins G.B., Shepherd R.J. Engineering Plants for Commercial Products and Applications. 1996;Annals New York Academy of Sciences, New York. 1-12.pp.
67. Laane C, Willis BJ. Biotechnology in food production. In: Encyclopedia of Food Sciences: Food Technology and Nutrition, vol. 1. Acad Press, New York, 1993. pp. 392-95.
68. Lesney M.S. The Garden of Dr. Moreau. plant biotechnology as a chemical enterprise. Genetically modified foods are the fore-runners of designer chemical plants Todays Chemist at Work. 8(6):1999;28-33.
69. Liu K. Biotech crops. products, properties and prospects Food Technology. 53(5):1999;42-49.
70. Liu K.S., Brown E.A. Enhancing vegetable oil quality through plant breeding and genetic engineering. Food Technol. 50(11):1996;67-71.
71. Longman JP. The curse of Frankenfood. Genetically modified crops stir up controversy at home and abroad. US News and World Report July 26, 1999, 38-41.
72. Losey J.E., Rayor L.S., Carter M.E. Transgenic pollen harms monarch larvae. Nature. 399:1999;214.
73. Lustgarden S. Gene cuisine: When genetically engineered foods come to your local supermarket, will you be able to identify them by their labels? Vegetarian Times 1994a(200):62.
74. Lustgarden S. Patently out of control: biotechnology. Vegetarian Times 1994b(208):14.
75. Maryanski JH. FDA's policy for foods developed by biotechnology. In: Engel, Takeoka, Teranishi, editors. Genetically Modified Foods: Safety Issues, American Chemical Society, Symposium Series No 605, chap 2. Washington, DC: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 1995. pp. 12-22 ( http://vm.cfsan.fda.gov/-lrd/biopolicy.html ).
76. Masci D. The cloning controversy. Should the US ban human cloning research? CQ Researcher. 7(18):1997;409-432.
77. Mason H.S., Amtzen C.J. Transgenic plants and animals as vaccine production systems. Tibtechnology. 13:1995;388-392.
78. McMillan M., Thompson J.C. An outbreak of suspected solanine poisoning in school boys. examinations of criteria of solanine poisoning Q J Med. 48:1979;227-243.
79. Moffat AS. High tech plants promise a bumper crop of new products. Science May 8, 1992, p. 770.
80. Nguyen M.L., Schwartz S.J. Lycopene. chemical and biological properties Food Technol. 53:1999;38-45.
81. Nordlee J.A., Taylor S.L., Townsend J.A., Thomas L.A., Bush R.K. Identification of Brazil nut allergen in transgenic soybeans. N Engl J Med. 334:1996;668-692.
82. Organization for Economic Cooperation & Development (OECD). Safety evaluation of foods derived from modern biotechnology, 1993, Paris.
83. Oldham J. Harvesting medicine (Biosource Technologies Inc. genetically modifies tobacco to synthesize drugs.) The Los Angeles Times, June 10, 1996, vol. 115, D1.
84. Palevitz B.A. Green genes. chloroplast studies point to crop enhancements The Scientist. 13(8):1999;6. a.
85. Palevitz BA. Bt or no Bt. Transgenic corn vs. Monarch butterflies. The Scientist June 7, 1999b:5-7.
86. Paoletti M.G., Pimental D. Genetic engineering in agriculture and the environment. assessing risks and potential benefits Bioscience. 46(9):1996;665.
87. Patterson W.J., Painter M.J. Bovine spongiform encephalopathy (BSE) and new variant Creutzfeldt-Jakob Disease. an overview Commun Dis Public Health. 2(1):1999;5-13.
88. Phillips S.C. Genetically engineered foods. do they pose health and environmental hazards? CQ Researcher. 4(29):1994;673-696.
89. Redenbaugh K., Berner T., Emlay D., Frankos B., Haitt W., Houck C., Kramer M., Malyj L., Martineau B., Rachmann N., Rudenko L., Sanders R., Sheey R., Wixtrom R. Regulatory issues for commercialization of tomatoes with anti-sense polygalaturonase gene. In vitro Cell Dev Biol. 29:1993;17-26.
90. Rhodes J.M. Genetically modified foods and the Pusztai affair. BMJ. May 8;318(7193):1999;1284.
91. Rissler J., Mellon M. The ecological risks of engineered crops. Union of Concerned Scientists. 1996;The MIT Press, Cambridge, MA.
92. Rissler J, Mellon M. Perils amid the promise: ecological risks of transgenic crops in a global market. Union of Concerned Scientists, Washington D.C., Dec. 1993.
93. Robinson C. Genetically modified foods and consumer choice. Trends in Food Science and Technol. 8:1997;84-88.
94. Rohricht P. Transgenic protein production. Part 2. Process economics. BioPharm. ;12:1999;52-54. Sept.
95. Ronk R.J., Maryanski J.H., Thompson P. Government regulatory issues. reducing uncertainties in food safety Hort Science. 25:1990;1482-1484.
96. Roller SR, Hallander S. Genetic modification in the food industry: A strategy for food quality improvement. Aspen Publishers, Frederick, Maryland, USA, 1998.
97. Rudnitsky H. Another agricultural revolution. genetically altered seeds hold great promise for seed companies and for the fast growing world population Forbes Magazine. 157(10):1996;159.
98. Ryan A.M. Functional foods hit supermarket shelves. Nutraceuticals arrive in form of two cholesterol-lowering margarines. Todays Chemist at Work September. 8:1999;59-64.
99. Schardt D. Brave new foods (genetically engineered foods). Amer Health. Jan-Feb;13(1):1994;60.
100. Share K. Has mother nature been outsmarted by genetically engineered food? Muscle & Fitness. 55(8):1994;36.
101. Sinha G. Organ cowboy. organs from animals Popular Science. 255(4):1999;68-73.
102. Sloan A.E. The new market. foods for the not-so-healthy Food Technol. 53(2):1999;54-60.
103. Smaglik P. Food as medicine. nutritionists, clinicians disagree on role of chemo-preventive supplements The Scientist. 13(11):1999;14.
104. Starke D.M., Barry G.F., Kishore G.M. Improvement of food quality traits through enhancement of starch biosynthesis. Collins G.B., Shepherd R.J. Engineering Plants for Commercial Products and Applications, vol. 792. 1996;Annals of New York Academy of Sciences, New York. 26-36.pp.
105. Thayer A.M. Transforming agriculture. transgenic crops and the application of discovery technologies are altering the agrochemical and agriculture businesses Chemical & Eng News. 77(16):1999;21-35.
106. Thayer A.M. FDA gives go-ahead to bio-engineered tomato. Chemical & Eng News. May 23;72:1994;7-8.
107. Thompson P.B. Food biotechnology's challenge to cultural integrity and individual consent. Hastings Center Report. 27(4):1997;34-38.
108. Walters DKH. First genetically altered food approved by the FDA. (Food and Drug Administration approves Calgene's "Flavr Savr" tomato). The Los Angeles Times, May 19, 1994. Vol. 113, A1.
109. Wambugu F. Why Africa needs agricultural biotech. Nature. 400:1999 July 1;15-16.
110. Weihl C.C., Roos R.P. Creutzfeldt-Jakob Disease, new variant Creutzfeldt-Jakob Disease and Bovine Spongiform Encephalopathy. Neurol Clin. Nov;17(4):1999;835-859.
111. Weiss R. Organic label ruled out for biotech irradiated foods. The Washington Post, May 1, 1998, A2.
112. Wilkinson J.Q. Biotech plants. from lab bench to supermarket shelf Food Technol. 51(12):1997;37-42.
113. Wilmut I., Schnleke A.E., McWhir J., Kind A.J., Campbell K.H.S. Viable offspring derived from fetal and adult mammalian cells. Nature. Feb 27;385(6619):1997;810-813.
114. Wise J. Sheep cloned from mammary gland cells. Brit Med J. 314:1997;623-625.
115. Wood M. Boosting plant's virus resistance. genetic engineering research could yield a safe way to produce hardy new plants Agricultural Res. 43:1995;18-20.
116. Woodard K.L., Underwood A. Today the sheep,...tomorrow the shepherd? Before scientists get there, ethicists want some hard questions asked and answered. Newsweek. 129(10):1997;60.
117. Young A.L., Lewis C.G. Biotechnology and potential nutritional implications for children. Pediatr Clin North Am. 42(4):1995;917-930.
118. Zambrynski P., Joos H., Genetello C., Leemans J., Van Montagu M., Schell J. Ti-plasmid vector for the introduction of DNA into plant cells without alteration of their normal regeneration capacity. Embo J. 2:1983;2143-2150.