Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6

Journal of Virology

Volumn 74, Issue 17, 2000, Pages 8053-8064

  Winkler, M ^a   Siepen, T A D ^a   Stamminger, T ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; COMPLEMENTARY DNA; HISTONE; PHOSPHOPROTEIN; REGULATOR PROTEIN; TRANSACTIVATOR PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; B LYMPHOCYTE; CHROMATIN; CHROMATIN STRUCTURE; DNA LIBRARY; GENE DELETION; GENE EXPRESSION; GENE SEQUENCE; HUMAN CYTOMEGALOVIRUS; IMMUNOPRECIPITATION; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; TRANSACTIVATION; YEAST;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELL LINE; CHROMATIN; CONSERVED SEQUENCE; COS CELLS; CYTOMEGALOVIRUS; FIBROBLASTS; GENE EXPRESSION REGULATION, VIRAL; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PRECIPITIN TESTS; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0033881828     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.17.8053-8064.2000     Document Type: Article

References (67)

1. Primary structure of the herpesvirus saimiri genome
2. Cytomegalovirus
3. A rapid microneutralization assay for the measurement of neutralizing antibody reactive with human cytomegalovirus
4. Identification of binding sites for the 86-kilodalton IE2 protein of human cytomegalovirus within an IE2-responsive viral early promoter
5. DNA sequence and expression of the B96-8 Epstein-Barr virus genome
6. Human cytomegalovirus tegument protein pp71 (ppUL82) enhances the infectivity of viral DNA and accelerates the infectious cycle
7. The CBP co-activator is a histone acetyltransferase
8. Pseudorabies virus and equine herpesvirus l share a nonessential gene which is absent in other herpesviruses and located adjacent to a highly conserved gene cluster
9. Evidence that Spt6p controls chromatin structure by a direct interaction with histones
10. Regulation of the yeast HO gene
11. The Epstein-Barr virus (EBV) early protein EB2 is a posttranscriptional activator expressed under the control of EBV transcription factors EB1 and R
12. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169
13. Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h
14. The SPT6 gene is essential for growth and is required for delta-mediated transcription in Saccharomyces cerevisiae
15. The complete DNA sequence of varicella-zoster virus
16. Human cytomegalovirus DNA: Restriction enzyme cleavage maps and map locations for immediate-early, early, and late RNAs
17. The helix-hairpin-helix DNA-binding motif: A structural basis for non-sequence-specific recognition of DNA
18. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit
19. Immediate-early transcription over covalently joined genome ends of bovine herpesvirus 1: The circ gene
20. The UL84 protein of human cytomegalovirus acts as a transdominant inhibitor of immediate-early-mediated transactivation that is able to prevent viral replication
21. Two versatile eukaryotic vectors permitting epitope tagging, radiolabelling and nuclear localisation of expressed proteins
22. The DNA sequence of human herpesvirus-6: Structure, coding content, and genome evolution
23. Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast
24. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae
25. A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli
26. A histone octamer-like structure within TFIID
27. Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b
28. Differential regulation by varicellazoster virus (VZV) and herpes simplex virus type-1 trans-activating genes
29. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations
30. Functional interaction between the human cytomegalovirus 86-kilodalton IE2 protein and the cellular transcription factor CREB
31. The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE1/2 enhancer-promoter
32. 1 phase of the cell cycle
33. Genetic content and preliminary transcriptional analysis of a representative region of murine gammaherpesvirus 68
34. A yeast SH2 domain
35. Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169
36. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2
37. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1
38. DIALIGN 2: Improvement of the segment-to-segment approach to multiple sequence alignment
39. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1
40. Determination and analysis of the complete nucleotide sequence of human herpesvirus
41. Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: General conservation of genetic organization between HVS and Epstein-Barr virus
42. emb-5, A gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6
43. A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution
44. Posttranscriptional regulation in herpes simplex virus
45. Analysis of proteins encoded by IE regions 1 and 2 of human cytomegalo-virus using monoclonal antibodies generated against recombinant antigens
46. An inducible promoter mediates abundant expression from the immediate-early 2 gene region of human cytomegalovirus at late times after infection
47. Analysis of the complete DNA sequence of murine cytomegalovirus
48. Functional analysis of histones H2A and H2B in transcriptional repression in Saccharomyces cerevisiae
49. Identification and characterization of Marek's disease virus genes homologous to ICP27 and glycoprotein K of herpes simplex virus-1
50. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone
51. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)
52. Herpes simplex virus type 1 ICP27 is an essential regulatory protein
53. The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for the redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not sufficient to inhibit host cell splicing
54. A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing
55. Evidence that the UL84 gene product of human cytomegalovirus is essential for promoting oriLyt-dependent DNA replication and formation of replication compartments in cotransfection assays
56. SPT4, SPT5 and SPT6 interactions: Effects on transcription and viability in Saccharomyces cerevisiae
57. The DNA sequence of equine herpesvirus 2
58. The DNA sequence of equine herpesvirus-1
59. Cloning and mapping of EcoRI, HindIII, and PstI fragments of bovine herpesvirus 4 (DN-599) genome
60. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs
61. Temporal patterns of human cytomegalovirus transcription: Mapping the viral RNAs synthesized at immediate early, early, and late times after infection
62. Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection
63. UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression
64. UL69 of HCMV, a homolog of the HSV ICP27, is contained within the tegument of virions and activates the major IE enhancer of HCMV in synergy with the tegument protein pp71
65. A specific subform of the human cytomegalovirus transactivator protein pUL69 is contained within the tegument of virus particles
66. Hanging on to histones: Chromatin