Interaction of wild-type and mutant adeno-associated virus (AAV) rep proteins on AAV hairpin DNA

Journal of Virology

Volumn 70, Issue 4, 1996, Pages 2440-2448

  Weitzman, Matthew D ^a,b   Kyöstio, Sirkka R M ^a,c   Carter, Barrie J ^a,d   Owens, Roland A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b WISTAR INSTITUTE   (United States)

^c GENZYME CORPORATION   (United States)

^d Targeted Genetics Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; HELICASE; MUTANT PROTEIN; VIRUS DNA; VIRUS PROTEIN;

ADENO ASSOCIATED VIRUS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DELETION MUTANT; DNA REPLICATION; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION;

EID: 0029869445     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.4.2440-2448.1996     Document Type: Article

References (56)

1. Antoni, B. A., A. B. Rabson, I. L. Miller, J. P. Trempe, N. Chejanovsky, and B. J. Carter. 1991. Adeno-associated virus Rep protein inhibits human immunodeficiency virus type 1 production in human cells. J. Virol. 65:396-404
2. Ashktorab, H., and A. Srivastava. 1989. Identification of nuclear proteins that specifically interact with adeno-associated virus type 2 inverted terminal repeat hairpin DNA J Virol. 63:3034-3039
3. Astell, C. R., C. D. Mol, and W. F. Anderson. 1987. Structural and functional homology of parvovirus and papovavirus polypeptides. J. Gen. Virol. 68:885-893
4. Baker, T. A., and K. Mizuuchi. 1992. DNA-promoted assembly of the active tetramer of the Mu transposase. Genes Dev. 6:2221-2232.
5. Bentivoglio, C. M., J. Zhu, and C. N. Cole. 1992 Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 targe T antigen. J. Virol 66:4209-4219.
6. Borowiec, J. A., F. B. Dean, P. A. Bullock, and J. Hurwitz. 1990. Binding and unwinding - how T antigen engages the SV40 origin of DNA replication. Cell 60:181-184.
7. Brendel, V., and S. Karlin. 1989 Association of charge clusters with functional domains of cellular transcription factors. Proc. Natl. Acad. Sci USA 86:5698-5702.
8. Carter, B. J. 1990 Adeno-associated virus helper functions, p 255-282 In P. Tijssen (ed.), Handbook of parvoviruses, vol. 1. CRC Press, Inc., Boca Raton. Fla.
9. Carter, B. J., E. Mendelson, and J. P. Trempe. 1990. AAV DNA replication, integration, and genetics, p. 169-226. In P. Tijssen (ed.), Handbook of parvoviruses, vol. 1. CRC Press, Inc., Boca Raton, Fla.
10. Carter, B. J., J. P. Trempe, and E. Mendelson. 1990 Adeno-associated virus gene expression and regulation, p. 227-254. In P Tijssen (ed.), Handbook of parvoviruses, vol 1 CRC Press, Inc., Boca Raton, Fla.
11. Chejanovsky, N., and B. J. Carter. 1989. Mutagenesis of an AUG codon in the adeno-associated virus rep gene: effects on viral DNA replication. Virology 173:120-128
12. Chejanovsky, N., and B. J. Carter. 1989. Replication of a human parvovirus nonsense mutant in mammalian cells containing an inducible amber suppresso. Virology 171:239-247.
13. Chejanovsky, N., and B. J. Carter. 1990. Mutation of a consensus purine nucleotide binding site in the adeno-associated virus rep gene generates a dominant negative phenotype for DNA replication. J Virol. 64:1764-1770.
14. Doak, T. G., F. P. Doerder, C. L. Jahn, and G. Herrick. 1994. A proposed superfamily of transposase genes: transposon-like elements in ciliated protozoa and a common "D35E" motif. Proc. Natl. Acad. Sci. USA 91:942-946.
15. Engelman, A., and R. Craigie. 1992 Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. J. Virol. 66:6361-6369
16. Farber, J. M., K. W. C. Peden, and D. Nathans. 1987. trans-dominant defective mutants of simian virus 40 T antigen. J. Virol 61:436-445.
17. Graham, F. L., J. Smiley, W. C. Russell, and R. Nairn. 1977 Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol. 36:59-72.
18. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467
19. Hauswirth, W. W., and K. I. Berns. 1977. Origin and termination of adeno-associated virus DNA replication. Virology 78:488-499
20. Henikoff, S. 1984. Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing Gene 28:351-359.
21. Hermonat, P. L., M. A. Labow, R. Wright, K. I. Berns, and N. Muzyczka. 1984. Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants. J. Virol. 51:329-339.
22. Hope, I. A., and K. Struhl. 1987. GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J. 6:2781-2784.
23. Im, D. S., and N. Muzyczka. 1989. Factors that bind to adeno-associated virus terminal repeats. J. Virol. 63:3095-3104.
24. Im, D. S., and N. Muzyczka. 1990. The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity. Cell 61:447-457.
25. Im, D. S., and N. Muzyczka. 1992. Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization J. Virol. 66:1119-1128.
26. Karlin, S., and V. Brendel. 1988. Charge configurations in viral proteins. Proc. Natl. Acad. Sci. USA 85:9396-9400
27. Khan, E., J. P. G. Mack, R. A. Katz, J. Kulkosky, and A. M. Skalka. 1991. Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res. 19:851-860.
28. Kleinschmidt, J. A., M. Mohler, F. W. Weindler, and R. Ileilbronn. 1995. Sequence elements of the adeno-associated virus rep gene required for suppression of herpes-simplex-virus-induced DNA amplification Virology 206:254-262.
29. Kulkosky, J., K. S. Jones, R. A. Katz, J. P. G. Mack, and A. M. Skalka. 1992. Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases. Mol. Cell. Biol. 12:2331-2338.
30. Kulkosky, J., R. A. Katz, G. Merkel, and A. M. Skalka. 1995. Activities and substrate specificity of the evolutionarily conserved central domain of retroviral integrase. Virology 206:448-456.
31. 5 Rep binding site and the consensus ATP-binding motif of the AAV Rep68 protein. J. Virol. 69:6787-6796.
32. Li, J. J., and T. J. Kelly. 1984. Simian virus 40 DNA replication in vitro. Proc. Natl. Acad. Sci. USA 81:6973-6977.
33. Manen, D., L. C. Upegui-Gonzalez, and L. Caro. 1992. Monomers and dimers of the RepA protein in plasmid pSC101 replication: domains in RepA Proc Natl Acad Sci. USA 89:8923-8927.
34. Mastrangelo, I. A., P. V. C. Hough, J. S. Wall, M. Dodson, F. B. Dean, and J. Hurwitz. 1989 ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication. Nature (London) 338:658-662.
35. McCarty, D. M., T. H. Ni, and N. Muzyczka. 1992. Analysis of mutations in adeno-associated virus Rep protein in vivo and in vitro. J Virol. 66:4050-4057
36. McCarty, D. M., J. H. Ryan, S. Zolotukhin, X. Zhou, and N. Muzyczka. 1994 Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat J. Virol. 68:4998-5006.
37. Mendelson, E., J. P. Trempe, and B. J. Carter. 1986 Identification of the trans-acting Rep proteins of adeno-associated virus by antibodies to a synthetic oligopeptide. J. Virol. 60:823-832.
38. Nilsson, S. V., and G. Magnusson. 1984. Activities of polyomavirus large-T-antigen proteins expressed by mutant genes. J. Virol. 51:768-775.
39. Owens, R. A., and B. J. Carter. 1992. In vitro resolution of adeno-associated virus DNA hairpin termini by wild-type Rep protein is inhibited by a dominant-negative mutant of Rep. J. Virol 66:1236-1240.
40. Owens, R. A., J. P. Trempe, N. Chejanovsky, and B. J. Carter. 1991. Adeno-associated virus Rep proteins produced in insect and mammalian expression systems: wild-type and dominant-negative mutant proteins bind to the viral replication origin. Virology 184:14-22.
41. Owens, R. A., M. D. Weitzman, S. R. M. Kyöstiö, and B. J. Carter. 1993. Identification of a DNA-binding domain in the amino terminus of adeno-associated virus Rep proteins. J. Virol 67:997-1005
42. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors Proc. Natl. Acad. Sci USA 74:5463-5467.
43. - mutant and correction of terminal palindrome deletions. J. Mol. Biol. 179:1-20
44. Snyder, R. O., D. S. Im, and N. Muzyczka. 1990. Evidence for covalent attachment of the adeno-associated virus (AAV) Rep protein to the ends of the AAV genome. J Virol. 64:6204-6213.
45. Snyder, R. O., R. J. Samulski, and N. Muzyczka. 1990. In vitro resolution of covalently joined AAV chromosome ends. Cell 60:105-113
46. Srivastava, A., E. W. Lusby, and K. I. Berns. 1983. Nucleotide sequence and organization of the adeno-associated virus 2 genome. J. Virol. 45:555-564.
47. Stillman, B., R. D. Gerard, R. A. Guggenheimer, and Y. Gluzman. 1985. T antigen and template requirements for SV40 DNA replication in vitro. EMBO J 4:2933-2939.
48. Straus, S. E., E. D. Sebring, and J. A. Rose. 1976. Concatemers of alternating plus and minus strands are intermediates in adenovirus-associated virus DNA synthesis. Proc. Natl. Acad. Sci. USA 73:742-746.
49. Tratschin, J. D., I. L. Miller, and B. J. Carter. 1984. Genetic analysis of adeno-associated virus: properties of deletion mutants constructed in vitro and evidence for an adeno-associated virus replication function. J. Virol. 51:611-619
50. Trempe, J. P., E. Mendelson, and B. J. Carter. 1987. Characterization of adeno-associated virus rep proteins in human cells by antibodies raised against rep expressed in Escherichia coli. Virology 161:18-28.
51. Weitzman, M. D., S. R. M. Kyöstiö, R. M. Kotin, and R. A. Owens. 1994. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA Proc Natl. Acad. Sci. USA 91:5808-5812.
52. Wong, I., K. L. Chao, W. Bujalowski, and T. M. Lohman. 1992. DNA-induced dimerization of the Escherichia coli Rep helicase. J Biol. Chem. 267:7596-7610.
53. Wong, I., and T. M. Lohman. 1992. Allosteric effects of nucleotide cofactors on Escherichia coli Rep helicase-DNA binding. Science 256:350-355.
54. Yang, Q., A. Kadam, and J. P. Trempe. 1992. Mutational analysis of the adeno-associated virus rep gene. J. Virol. 66:6058-6069.
55. Yang, Q., and J. P. Trempe. 1993. Analysis of the terminal repeat binding abilities of mutant adeno-associated virus replication proteins J. Virol. 61: 4442-4447.
56. Zhu, J., and C. N. Cole. 1989 Linker insertion mutants of simian virus 40 large T antigen that show trans-dominant interference with wild-type large T antigen map to multiple sites within the T-antigen gene. J. Virol. 63:4777-4786.