Potential use of lipoxygenase inhibitors for cancer chemoprevention

Expert Opinion on Investigational Drugs

Volumn 9, Issue 9, 2000, Pages 2121-2138

  Steele, V E ^a   Holmes, C A ^a   Hawk, E T ^a   Kopelovich, L ^a   Lubet, R A ^a   Crowell, J A ^a   Sigman, C C ^a   Kelloff, G J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer; Chemopreventive agents; Lipoxygenase; Mechanisms

Indexed keywords

1 [3 [5 (4 FLUOROPHENOXY) 2 FURYL] 1 METHYL 2 PROPYNYL] 1 HYDROXYUREA; 2 CYCLOPENTYL 2 [4 (2 QUINOLINYLMETHOXY)PHENYL]ACETIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 (2 QUINOLINYLMETHOXY) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 1 METHYL 2 QUINOLONE; 7 [3 (4 ACETYL 3 METHOXY 2 PROPYLPHENOXY)PROPOXY] 3,4 DIHYDRO 8 PROPYL 2H 1 BENZOPYRAN 2 CARBOXYLIC ACID; 7 [3 [2 (CYCLOPROPYLMETHYL) 3 METHOXY 4 (4 THIAZOLYL)PHENOXY]PROPOXY] 3,4 DIHYDRO 8 PROPYL 2H 1 BENZOPYRAN 2 CARBOXYLIC ACID; 7 [3 [2 CYCLOPROPYLMETHYL 3 METHOXY 4 [(METHYLAMINO)CARBONYL]PHENOXY]PROPOXY] 3,4 DIHYDRO 8 PROPYL 2H 1 BENZOPYRAN 2 PROPANOIC ACID; ATRELEUTON; BAICALEIN; BENZO[A]PYRENE; DOCEBENONE; ESCULETIN; GROWTH FACTOR; HYDROXAMIC ACID; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; METHYLNITROSOUREA; PRANLUKAST; TRANSCRIPTION FACTOR; XIAO CHAI HU TANG; ZAFIRLUKAST; ZILEUTON;

ACUTE LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTHRITIS; ASTHMA; BREAST CANCER; BREAST TUMOR; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER PREVENTION; CATALYSIS; CHRONIC LEUKEMIA; COLON CANCER; DNA SYNTHESIS; DRUG ACTIVITY; ENZYME ACTIVITY; GENE INDUCTION; GENETIC DAMAGE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG TUMOR; METABOLIC ACTIVATION; METABOLITE; NONHUMAN; ONCOGENE; PROSTATE CANCER; PROSTATE TUMOR; PSORIASIS; REVIEW; SIGNAL TRANSDUCTION; SKIN CANCER;

EID: 0033850048     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.9.9.2121     Document Type: Review

References (143)

1. 12-Lipoxygenases and 12(S)-HETE: Role in cancer metastasis
2. Endogenous 12(S)-HETE production by tumor cells and its role in metastasis
3. Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer
4. 12-Lipoxygenase, 12(S)-HETE and cancer metastasis
5. Multiple use of a signal transduction pathway in tumor cell invasion
6. Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C
7. A lipoxygenase metabolite, 12(S)-HETE, stimulates protein kinase C-mediated release of cathepsin B from malignant cells
8. 3 integrins on endothelial cells
9. Arachidonic acid stimulates prostate cancer cell growth: Critical role of 5-lipoxygenase. Biochem
10. Arachidonic acid metabolism
11. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases
12. Leukotrienes: Potent mediators of airway constriction
13. Prostanoid and leukotriene receptors: A progress report from the IUPHAR working parties on classification and nomenclature
14. Exercise-induced bronchoconstriction: Elucidating the roles of leukotrienes and prostaglandins
15. Leukotrienes and airway responses
16. The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice
17. Arachidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes
18. On the nature of the 5-lipoxygenase reaction in human leukocytes: Enzyme purification and requirement for multiple stimulatory factors
19. Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187
20. 5-Lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes
21. Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation
22. Interactions of 5-lipoxygenase with membranes: Studies on the association of soluble enzyme with membranes and alterations in enzyme activity
23. Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages
24. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation
25. Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation
26. Epidermal growth factor enhances a microsomal 12-lipoxygenase activity in A431 cells
27. Calcium induces membrane translocation of 12-lipoxygenase in rat platelets
28. 2+-dependent translocation to membranes
29. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes and airway cells
30. Arachidonic acid 15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes
31. Mammalian lipoxygenases: Molecular structures and functions
32. Characterization of human 12-lipoxygenase genes
33. Two immunologically and catalytically distinct arachidonate 12-lipoxygenases of bovine platelets and leukocytes
34. Demonstration of a 12-lipoxygenase activity in bovine polymorphonu-clear leukocytes
35. Molecular cloning, primary structure and expression of the human platelet/erythroleukemia cell 12-lipoxygenase
36. Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins
37. Cloning and expression of an airway epithelial 12-lipoxygenase
38. Molecular cloning of a 12-lipoxygenase cDNA from rat brain
39. Arachidonate 12-lipoxygenases
40. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation
41. Eicosanoid synthesis in 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in Sprague-Dawley rats fed primrose oil, menhaden oil or corn oil diet
42. Effects of D,L-2-difluoro-methylornithine and indomethacin on mammary tumor promotion in rats fed high n-3 and/or n-6 fat diets
43. Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumors
44. Effect of ω-3 fatty acids on growth of a rat mammary tumor
45. Eicosanoids in breast cancer patients before and after mastectomy
46. Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by epidermal growth factor
47. Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line
48. Barrett's esophagus: Metaplastic cells with loss of heterozygosity at the APC gene locus are clonal precursors to invasive adenocarcinoma
49. Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: Stimulation of 13-HODE formation by TGF-α/EGF
50. Neu(c-erbB-2/HER2) and the epidermal growth factor receptor (EGFR) in breast cancer
51. The epidermal growth factor receptor as a prognostic marker: Results of 370 patients and review of 3009 patients
52. Nordihydroguaiaretic acid suppression of rat mammary carcinogenesis induced by N-methyl-N-nitrosourea
53. Comparative effects of piroxicam and esculetin on incidence, proliferation and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets
54. Inhibitory effects of nabumetone, a cyclooxygenase-2 inhibitor and esculetin, a lipoxygenase inhibitor, on N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats
55. The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells
56. Inhibition of tumour growth by lipoxygenase inhibitors
57. The 5-lipoxygenase pathway in cultured human intestinal epithelial cells
58. 4
59. Modulation of cellular phospholipid fatty acids and leukotriene B4 synthesis in the human intestinal cell (CaCo-2)
60. Profiles of eicosanoid production by superficial and proliferative colonic epithelial cells and sub-epithelial colonic tissue
61. Biological properties of 12(S)-HETE in cancer metastasis
62. Lipoxygenase inhibition in prostate cancer
63. 5-Lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death
64. Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells
65. The selective 5-lipoxygenase inhibitor A63162 reduces PC3 proliferation and initiates morphologic changes consistent with secretion
66. Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth
67. Inhibitors of lipoxygenase: A new class of cancer chemopreventive agents
68. Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling
69. 12-Lipoxygenase isoenzymes in mouse skin tumor development
70. Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells
71. Overexpression of Ha-ras enhances the transcription of human arachidonate 12-lipoxygenase promoter in A431 cells
72. Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase
73. Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid
74. Lipoxygenase metabolites activate protein kinase C
75. Epidermal growth factor enhances transcription of human arachidonate 12-lipoxygenase in A431 cells
76. Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-α-mediated apoptosis: Role for lipoxygenase pathway but not mitochondrial respiratory chain
77. Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid
78. 12(S)-HETE enhancement of prostate tumor cell invasion: Selective role of PKCα
79. Lipoxygenase products as common intermediates in cyclic AMP-dependent and -independent adrenal steroido-genesis in rats
80. Cell proliferation status, cytokine action and protein tyrosine phosphorylation modulate leukotriene biosynthesis in a basophil leukaemia and a mastocytoma cell line
81. Lipoxygenase inhibitors suppress formation of tumor necrosis factor in vitro and in vivo
82. Arachidonic acid metabolites in bFGF-, PDGF- and serum-stimulated vascular cell growth
83. Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase-mediated leukotriene C4 production
84. Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells
85. Growth factors and oncogenes in prostate cancer
86. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis
87. Oxidative stress as a mediator of apoptosis
88. Morphologic changes of apoptosis induced in human chronic myelogenous leukemia 'blast' cells by SC41661A (Searle), a selective inhibitor of 5-lipoxygenase
89. Modulators of leukotriene biosynthesis and receptor activation
90. Rat pulmonary lipoxygenase: Dioxygenase activity and role in xenobiotic metabolism
91. Arachidonic acid-dependent activation of benzo[a]pyrene to bind to proteins with cytosolic and microsomal fractions from rat liver and lung
92. Regulation of melanoma-cell motility by the lipoxygenase metabolite 12-(S)-HETE
93. Leukotriene B, a potent chemokinetic and aggregating substance released from polymor-phonuclear leukocytes
94. Inhibition of leukotriene B4 formation in human neutrophils after oral nafazatrom (Bay g 6575)
95. Excessive production of reactive oxygen metabolites by inflamed colon: Analysis by chemiluminescence probe
96. Lipoxygenase inhibitors counteract protein kinase C mediated events in human T lymphocyte proliferation
97. 5-Lipoxygenase
98. Free radicals as targets for cancer chemoprevention: Prospects and Problems
99. Eicosanoid regulation of angiogenesis: Role of endothelial arachidonate 12-lipoxygenase
100. 12(S)-HETE is a mitogenic factor for microvascular endothelial cells: Its potential role in angiogenesis
101. The mitogenic effect of 15- and 12-hydroxyeicosatetraenoic acid on endothelial cells may be mediated via deacylglycerol kinase inhibition
102. Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth
103. Cloning of the cDNA for human 12-lipoxygenase
104. Inflammation and cancer: Role of phagocyte-generated oxidants in carcinogenesis
105. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer
106. 5-Lipoxygenase inhibitory activity of zileuton
107. (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]- 2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor
108. 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA861), a selective inhibitor of the 5-lipoxygenase reaction and the biosynthesis of slow-reacting substance of anaphylaxis
109. Inhibition of mouse epidermal 12-lipoxygenase by 2,3,4-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1, 4-benzoquinone (AA861)
110. The design of therapeutically effective 5-lipoxygenase
111. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t- butylthio-5-isopropylindol-2-yl]-2,2-dimethyl propanoic acid), a novel, orally active leukotriene biosynthesis inhibitor
112. Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5- (quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor
113. BAYX1005, a new selective inhibitor of leukotriene synthesis: Pharmacology and pharmacokinetics
114. 7-[3-(4-Acetyl-3-methoxy-2-propylphenoxy)pro-poxy]-3,4-dihydro- 8-propyl-2H-1-benzopyran-2-carboxylic acid: An orally active selective leukotriene B4 receptor antagonist
115. The in vitro pharmacology of SC-51146: A potent antagonist of leukotriene B4 receptors
116. The preclinical pharmacology of ICI 204,219. A peptide leukotriene antagonist
117. Selective inhibition of platelet lipoxygenase by esculetin
118. Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins
119. Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis
120. Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells
121. Antiproliferative effect of esculetin on vascular smooth muscle cells. Possible roles of signal transduction pathways
122. Effects of eicosanoid synthesis inhibitors on the in vitro growth and prostaglandin E and leukotriene B secretion of a human breast cancer cell line
123. Influence of esculetin on incidence, proliferation and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets
124. Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells
125. Selective inhibition of platelet lipoxygenase by baicalein
126. Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from scutellaria baicalensis Georgy roots
127. Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines
128. Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen
129. Arachidonic acid metabolism of cytosolic fractions of Lewis lung carcinoma cells
130. Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis
131. Direct observation of iron-induced conformational changes of mitochondrial DNA by high-resolution field-emission in-lens scanning electron microscopy
132. A-78773: A selective, potent 5-lipoxygenase inhibitor
133. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects
134. Arachidonate 5-lipoxygenase inhibitors show potent antiproliferative effects on human leukemia cell lines
135. An in vivo inhibitor of 5-lipoxygenase, MK886, at micromolar concentration induces apoptosis in U937 and CML cells
136. A new class of leukotriene biosynthesis inhibitor: The development of MK-0591
137. Mode of action of the new selective leukotriene synthesis inhibitor BAY X-1005 ((R)-2-[4-(quinolin-2-yl-methoxy) phenyl]-2-cyclopentyl acetic acid) and structurally related compounds
138. SC-41930: An inhibitor of leukotriene B4-stimulated human neutrophil functions
139. Second-generation leukotriene B4 receptor antagonists related to SC-41930: Heterocyclic replacement of the methyl ketone pharmacophore
140. Cell death induced by baicalein in hepatocellular carcinoma cell lines
141. Requirement for epidermal growth factor receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid carcinoma cells
142. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit
143. Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: Methods and results from the NCI chemoprevention drug development program