메뉴 건너뛰기




Volumn 24, Issue 42130, 1997, Pages 449-461

CDKN2 (MTS1/p16INK4A) Gene Alterations in Hematological Malignancies

Author keywords

CDKN2 (MTS1 p16INK4A) gene; cell cycle regulator; homozygous deletion; lymphoid malignancy; point mutation

Indexed keywords

CARRIER PROTEIN; PROTEIN P16INK4A; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR;

EID: 0030610476     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428199709055583     Document Type: Article
Times cited : (16)

References (71)
  • 1
    • 0007212497 scopus 로고
    • Oncogenes and tumor suppressor genes
    • M. D. Abeloff, J. O. Armitage, A. S. Lichter, J. E. Niederhuber., Churchill Livingstone, New York
    • Fearon E. R. Oncogenes and tumor suppressor genes. Clinical Oncology, M. D. Abeloff, J. O. Armitage, A. S. Lichter, J. E. Niederhuber. Churchill Livingstone, New York 1995; 11 – 40
    • (1995) Clinical Oncology , pp. 11-40
    • Fearon, E.R.1
  • 3
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T., Miura K., Wu D. J., Lois A., Takabayashi K., Carson D. A. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994; 368: 753 – 756
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 4
    • 0029134016 scopus 로고
    • Role of the cyclin-dependent kinase inhibitors in the development of cancer
    • Hirama T., Koeffler H. P. Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood 1995; 86: 841 – 854
    • (1995) Blood , vol.86 , pp. 841-854
    • Hirama, T.1    Koeffler, H.P.2
  • 5
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr C. J., Roberts J. M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 1995; 9275: 1149 – 1163
    • (1995) Genes Dev. , vol.9275 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 7
    • 0028176483 scopus 로고
    • Cloning of p27kp1 a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K., Lee M. H., Erdjument-Bromage H., Koff A., Roberts J. M., Tempst P., Massague J. Cloning of p27kp1 a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994; 78: 59
    • (1994) Cell , vol.78 , pp. 59
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massague, J.7
  • 8
    • 0028988158 scopus 로고
    • Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
    • Lee M. H., Reynisdottir I., Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes & Dev. 1995; 9: 639 – 649
    • (1995) Genes & Dev. , vol.9 , pp. 639-649
    • Lee, M.H.1    Reynisdottir, I.2    Massague, J.3
  • 9
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M., Hannon G. J., Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366: 704 – 707
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 10
    • 0028168242 scopus 로고
    • p15INK4B is a potential effector of TGF-β-induced cell cycle arrest
    • Hannon G. J., Beach D. p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 1994; 371: 257 – 261
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 11
    • 0028582034 scopus 로고
    • Growth suppression by p18, a p16INK4A/MST1- and p14INK4 B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
    • Guan K. L., Jenkins C. W., Li Y., Nichols M. A., Wu X., O'Keefe C. L., Materw A. G., Xiong Y. Growth suppression by p18, a p16INK4A/MST1- and p14INK4 B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes & Dev. 1994; 8: 2939 – 2952
    • (1994) Genes & Dev. , vol.8 , pp. 2939-2952
    • Guan, K.L.1    Jenkins, C.W.2    Li, Y.3    Nichols, M.A.4    Wu, X.5    O'Keefe, C.L.6    Materw, A.G.7    Xiong, Y.8
  • 12
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai H., Roussel M. F., Kato J., Ashmun R. A., Sherr C. J. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell Biol. 1995; 15: 2672 – 2681
    • (1995) Mol. Cell Biol. , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.3    Ashmun, R.A.4    Sherr, C.J.5
  • 13
    • 0028181760 scopus 로고
    • Identification of G1 kinase activity for cdk6, a novel cyclin D partner
    • Meyerson M., Harlow E. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell Biol. 1994; 14: 2077 – 2086
    • (1994) Mol. Cell Biol. , vol.14 , pp. 2077-2086
    • Meyerson, M.1    Harlow, E.2
  • 14
    • 0028875086 scopus 로고
    • Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins
    • Hall M., Bates S., Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene 1995; 11: 1581 – 1588
    • (1995) Oncogene , vol.11 , pp. 1581-1588
    • Hall, M.1    Bates, S.2    Peters, G.3
  • 15
    • 0028126668 scopus 로고
    • Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16INK4
    • Tam S. W., Shay J. W., Pagano M. Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16INK4. Cancer Res. 1994; 54: 5816 – 5820
    • (1994) Cancer Res. , vol.54 , pp. 5816-5820
    • Tam, S.W.1    Shay, J.W.2    Pagano, M.3
  • 16
    • 0029587551 scopus 로고
    • Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle D. E., Zindy F., Ashmun R. A., Sherr C. J. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995; 83: 993 – 1000
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 20
    • 0029094704 scopus 로고
    • Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector
    • Jin X., Nguyen D., Zhang W. W., Kyritsis A. P., Roth J. A. Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector. Cancer Res. 1995; 55: 3250 – 3253
    • (1995) Cancer Res. , vol.55 , pp. 3250-3253
    • Jin, X.1    Nguyen, D.2    Zhang, W.W.3    Kyritsis, A.P.4    Roth, J.A.5
  • 26
    • 0028172926 scopus 로고
    • Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB
    • Otterson G. A., Kratzke R. A., Coxon A., Kim Y. W., Kaye F. J. Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene 1994; 9: 3375 – 3378
    • (1994) Oncogene , vol.9 , pp. 3375-3378
    • Otterson, G.A.1    Kratzke, R.A.2    Coxon, A.3    Kim, Y.W.4    Kaye, F.J.5
  • 27
    • 0028652269 scopus 로고
    • CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
    • Schmidt E. E., Ichimura K., Reifenberger G., Collins V. P. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res. 1994; 54: 6321 – 6324
    • (1994) Cancer Res. , vol.54 , pp. 6321-6324
    • Schmidt, E.E.1    Ichimura, K.2    Reifenberger, G.3    Collins, V.P.4
  • 28
    • 0028970951 scopus 로고
    • Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control
    • Lukas J., Aagaard L., Strauss M., Bartek J. Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control. Cancer Res. 1995; 55: 4818 – 4823
    • (1995) Cancer Res. , vol.55 , pp. 4818-4823
    • Lukas, J.1    Aagaard, L.2    Strauss, M.3    Bartek, J.4
  • 35
    • 0029560071 scopus 로고
    • Deletion and transfection analysis of the p15/MTS2 gene in malignant gliomas
    • Tenan M., Benedetti S., Finocchiaro G. Deletion and transfection analysis of the p15/MTS2 gene in malignant gliomas. Biochem. Biophys. Res. Commun. 1995; 217: 195 – 202
    • (1995) Biochem. Biophys. Res. Commun. , vol.217 , pp. 195-202
    • Tenan, M.1    Benedetti, S.2    Finocchiaro, G.3
  • 36
    • 0028970766 scopus 로고
    • Homozygous loss of the p15INK4B gene (and not the p16INK4A gene) during tumor progression in sporadic melanoma patient
    • Glendening J. M., Flores J. F., Walker G. J., Stone S., Albino A. P., Fountain J. W. Homozygous loss of the p15INK4B gene (and not the p16INK4A gene) during tumor progression in sporadic melanoma patient. Cancer Res. 1995; 55: 5531 – 5535
    • (1995) Cancer Res. , vol.55 , pp. 5531-5535
    • Glendening, J.M.1    Flores, J.F.2    Walker, G.J.3    Stone, S.4    Albino, A.P.5    Fountain, J.W.6
  • 37
    • 0029664686 scopus 로고    scopus 로고
    • Exclusive” p15INK4B gene deletion in acute lymphocytic leukemia include the E1β exon of the p16INK4A gene, (correspondence)
    • 1657–1658
    • Heyman M., Rasool O., Brandter L. B., Liu Y., Grandér D., Einhorn S. “Exclusive” p15INK4B gene deletion in acute lymphocytic leukemia include the E1β exon of the p16INK4A gene, (correspondence). Blood 1996; 87, 1657–1658
    • (1996) Blood , vol.87
    • Heyman, M.1    Rasool, O.2    Brandter, L.B.3    Liu, Y.4    Grandér, D.5    Einhorn, S.6
  • 38
    • 0026337295 scopus 로고
    • Tumor suppressor gene
    • Weinberg R. A. Tumor suppressor gene. Science 1991; 254: 1138
    • (1991) Science , vol.254 , pp. 1138
    • Weinberg, R.A.1
  • 39
    • 0023239517 scopus 로고
    • Functional inactivation of genes by dominant negative mutations
    • Herskowitz I. Functional inactivation of genes by dominant negative mutations. Nature 1987; 329: 219 – 222
    • (1987) Nature , vol.329 , pp. 219-222
    • Herskowitz, I.1
  • 40
    • 0039712065 scopus 로고
    • Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma
    • Kundson A. G., Hethcote H. W., Brown B. W. Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. Proc. Natl. Acad. Sci. USA 1975; 72: 5116 – 5120
    • (1975) Proc. Natl. Acad. Sci. USA , vol.72 , pp. 5116-5120
    • Kundson, A.G.1    Hethcote, H.W.2    Brown, B.W.3
  • 43
    • 0029011539 scopus 로고
    • 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo A., Herman J. G., Mao L., Lee D. J., Gabrielson E., Burger P. C., Baylin S. B., Sidransky D. 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nature Med. 1995; 1: 686 – 692
    • (1995) Nature Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 44
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common cancers
    • Herman J. G., Merlo A., Mao L., Lapidus R. G., Issa J. P. J., Davidson N. E., Sidransky D., Baylin S. B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common cancers. Cancer Res. 1995; 55: 4525 – 4530
    • (1995) Cancer Res. , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.P.J.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 45
    • 0028338514 scopus 로고
    • Frequent somatic mutation of the MTS1/CDK4I (Multiple Tumor Suppressor/Cylin-dependent Kinase 4 Inhibitor) gene in esophageal squamous cell carcinoma
    • Mori T., Miura K., Aoki T., Nishihara T., Mori S., Nakamura Y. Frequent somatic mutation of the MTS1/CDK4I (Multiple Tumor Suppressor/Cylin-dependent Kinase 4 Inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res. 1994; 54: 3396 – 3397
    • (1994) Cancer Res. , vol.54 , pp. 3396-3397
    • Mori, T.1    Miura, K.2    Aoki, T.3    Nishihara, T.4    Mori, S.5    Nakamura, Y.6
  • 47
    • 0021799508 scopus 로고
    • Lymphoblastic leukemia with lymphomatous features associated with abnormalities of the short arm of chromosome 9
    • Chilcote R. R., Brown E., Rowley J. D. Lymphoblastic leukemia with lymphomatous features associated with abnormalities of the short arm of chromosome 9. N. Engl. J. Med. 1985; 313: 286
    • (1985) N. Engl. J. Med. , vol.313 , pp. 286
    • Chilcote, R.R.1    Brown, E.2    Rowley, J.D.3
  • 49
    • 0029915461 scopus 로고    scopus 로고
    • Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia
    • Cayuela J. M., Madani A., Sanhes L., Stern M. H., Sigaux F. Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. Blood 1996; 87: 2180 – 2186
    • (1996) Blood , vol.87 , pp. 2180-2186
    • Cayuela, J.M.1    Madani, A.2    Sanhes, L.3    Stern, M.H.4    Sigaux, F.5
  • 51
    • 0029121279 scopus 로고
    • Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia
    • Ohnishi H., Kawamura M., Ida K., Sheng X. M., Hanada R., Nobori T., Yamamori S., Hayashi Y. Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia. Blood 1995; 86: 1269 – 1275
    • (1995) Blood , vol.86 , pp. 1269-1275
    • Ohnishi, H.1    Kawamura, M.2    Ida, K.3    Sheng, X.M.4    Hanada, R.5    Nobori, T.6    Yamamori, S.7    Hayashi, Y.8
  • 52
    • 0029029358 scopus 로고
    • Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features
    • Fizzotti M., Cimino G., Pisegna S., Alimena G., Quartarone C., Mandelli F., Pelicci P. G., Lo Coco F. Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features. Blood 1995; 85: 2685 – 2690
    • (1995) Blood , vol.85 , pp. 2685-2690
    • Fizzotti, M.1    Cimino, G.2    Pisegna, S.3    Alimena, G.4    Quartarone, C.5    Mandelli, F.6    Pelicci, P.G.7    Lo Coco, F.8
  • 53
    • 0029073477 scopus 로고
    • Mutational analysis of the CDKN2 (MTS1/p16INK4A) gene in primary B-cell lymphomas
    • Uchida T., Watanabe T., Kinoshita T., Murate T., Saito H., Hotta T. Mutational analysis of the CDKN2 (MTS1/p16INK4A) gene in primary B-cell lymphomas. Blood 1995; 86: 2724 – 2731
    • (1995) Blood , vol.86 , pp. 2724-2731
    • Uchida, T.1    Watanabe, T.2    Kinoshita, T.3    Murate, T.4    Saito, H.5    Hotta, T.6
  • 55
    • 0028846864 scopus 로고
    • Deletion of cyclin-dependent kinase 4 inhibitor genes p15 and p16 in non-Hodgkin's lymphoma
    • Koduru P. R. K., Zariwala M., Soni M., Gong J. Z., Xiong Y., Broome J. D. Deletion of cyclin-dependent kinase 4 inhibitor genes p15 and p16 in non-Hodgkin's lymphoma. Blood 1995; 86: 2900 – 2905
    • (1995) Blood , vol.86 , pp. 2900-2905
    • Koduru, P.R.K.1    Zariwala, M.2    Soni, M.3    Gong, J.Z.4    Xiong, Y.5    Broome, J.D.6
  • 56
    • 0027942844 scopus 로고
    • p53 in hematologic malignancies
    • Imamura J., Miyoshi I., Koeffler H. P. p53 in hematologic malignancies. Blood 1994; 84: 2412 – 2421
    • (1994) Blood , vol.84 , pp. 2412-2421
    • Imamura, J.1    Miyoshi, I.2    Koeffler, H.P.3
  • 57
    • 0029066731 scopus 로고
    • p16 gene alterations in nasopharyngeal carcinoma
    • Lo K. W., Huang D. P., Lau K. M. p16 gene alterations in nasopharyngeal carcinoma. Cancer Res. 1995; 55: 2039 – 2043
    • (1995) Cancer Res. , vol.55 , pp. 2039-2043
    • Lo, K.W.1    Huang, D.P.2    Lau, K.M.3
  • 58
    • 0028787417 scopus 로고
    • Molecular mechanisms of human T-cell leukemia/lymphotrophic virus type 1 infection
    • Franchini G. Molecular mechanisms of human T-cell leukemia/lymphotrophic virus type 1 infection. Blood 1995; 86: 3619 – 3639
    • (1995) Blood , vol.86 , pp. 3619-3639
    • Franchini, G.1
  • 60
    • 0029002249 scopus 로고
    • Homozygous deletions of p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia
    • Hatta Y., Hirama T., Miller C. W., Yamada Y., Tomonaga M., Koeffler H. P. Homozygous deletions of p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. Blood 1995; 85: 2699 – 2704
    • (1995) Blood , vol.85 , pp. 2699-2704
    • Hatta, Y.1    Hirama, T.2    Miller, C.W.3    Yamada, Y.4    Tomonaga, M.5    Koeffler, H.P.6
  • 61
    • 0028900889 scopus 로고
    • Homozygous deletions of p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia
    • Sill H., Goldman J. M., Cross N. C. P. Homozygous deletions of p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood 1995; 85: 2013 – 2016
    • (1995) Blood , vol.85 , pp. 2013-2016
    • Sill, H.1    Goldman, J.M.2    Cross, N.C.P.3
  • 62
    • 0028875498 scopus 로고
    • Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukaemia
    • Serra A., Gottardi E., Ragione F. D., Saglio G., Iolascon A. Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukaemia. Br. J. Haematol. 1995; 91: 625 – 629
    • (1995) Br. J. Haematol. , vol.91 , pp. 625-629
    • Serra, A.1    Gottardi, E.2    Ragione, F.D.3    Saglio, G.4    Iolascon, A.5
  • 63
    • 0028987262 scopus 로고
    • Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas
    • Otsuki T., Clark H. M., Wellmann A., Jaffe E. S., Raffeld M. Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas. Cancer Res. 1995; 55: 1436 – 1440
    • (1995) Cancer Res. , vol.55 , pp. 1436-1440
    • Otsuki, T.1    Clark, H.M.2    Wellmann, A.3    Jaffe, E.S.4    Raffeld, M.5
  • 65
    • 0028886533 scopus 로고
    • Alterations of multiple tumor suppressor genes (p53(17p13), p16INK4A (9p21), and DBM (13q14)) in B-cell chronic lymphocytic leukemia
    • Newcomb E. W., Rao I. S., Giknavorian S. S., Lee S. Y. Alterations of multiple tumor suppressor genes (p53(17p13), p16INK4A (9p21), and DBM (13q14)) in B-cell chronic lymphocytic leukemia. Mol. Carcinogen. 1995; 14: 141 – 146
    • (1995) Mol. Carcinogen. , vol.14 , pp. 141-146
    • Newcomb, E.W.1    Rao, I.S.2    Giknavorian, S.S.3    Lee, S.Y.4
  • 71


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.