Hypermethylation of a 5' CpG island of p16 is a frequent event in non-Hodgkin's lymphoma

Leukemia

Volumn 11, Issue 3, 1997, Pages 425-428

  Martinez Delgado, B ^a,d   Fernandez Piqueras, J ^b   Garcia, M J ^c   Arranz, E ^a   Gallego, J ^a   Rivas, C ^c   Robledo, M ^a   Benitez, J ^a  

^a PharmaGen   (Spain)

^b Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d SAU   (Spain)

Author keywords

Methylation; Non Hodgkin lymphomas; p16 gene

Indexed keywords

PROTEIN P16;

ARTICLE; B CELL LYMPHOMA; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; HUMAN; HUMAN TISSUE; LYMPHOID TISSUE; MAJOR CLINICAL STUDY; NONHODGKIN LYMPHOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; T CELL LYMPHOMA; TUMOR SUPPRESSOR GENE;

EID: 0030941562     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400579     Document Type: Article

References (25)

1. Weaver-Feldhaus J, Gruis NA, Neuhausen S, Le Paslier D, Stockert E, Skolnick M, Kamb A. Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas. Proc Natl Acad Sci USA 1994; 91: 7563-7567.
2. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366: 704-707.
3. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA. Deletions of the cyclin dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994; 368: 753-756.
4. Kamb A, Gruis N, Weaver-Feldhaus J, Liu Q, Harsman K, Tavtigian SV, Stockert E, Day RS III, Johnson BE, Skolnick MH. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994; 264: 436-440.
5. Hussussian CJ, Struewing JP, Goldstein AM, Higgins PAT, Ally DS, Sheahan MD, Clark WH Jr, Tucker MA, Dracopoli NC. Germline p16 mutations in familial melanoma. Nat Genet 1994; 8: 15-21.
6. Kamb A, Shattuck-Eidens D, Eeles R, Liu Q, Gruis NA, Ding W, Hussey C, Tran T, Miki Y, Weaver-Feldhaus J, McClure M, Aitken JE, Anderson DE, Bergman W, Frants R, Goldgar DE, Green A, MacLennan R, Martin NG, Meyer LJ, Youl P, Zone JJ, Skolnick MH, Cannon-Albright LA. Analysis of the p16 (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Nat Gene 1994; 8: 22-26.
7. Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ, Kern SE. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994; 8: 27-32.
8. Stranks G, Height SE, Mitchell P, Jadayel D, Yuille MAR, De Lord C, Clutterbuck RD, Treleaven JG, Powles RL, Nacheva E, Oscier DG, Karpas A, Lenoir GM, Smith SD, Millar JL, Catovsky D, Dyer MJS. Deletions and rearrangements of CDKN2 in lymphoid malig, nancy. Blood 1995; 85: 893-901.
9. Quesnel B, Preudhomme C, Philippe N, Vanrumbeke M, Dervite I, Lai JL, Bauters F, Wattel E, Fenaux P. P16 homozygous deletions in acute lymphoblastic leukemia. Blood 1995; 85: 657-663.
10. Siebert R, Willers CP, Schramm A, Fossa A, Gana Dresen IM, Uppenkamp M, Nowrousian MR, Seeber S, Opalka B. Homozygous loss of the MTS1/P16 and MTS2/P15 genes in lymphoma and lymphoblastic leukemia cell lines. Br J Haematol 1995; 91: 350-354.
11. Zhou M, Gu L, James CD, He J, Yeager AM, Smith SD, Findley HW. Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia. Leukemia 1995; 9: 1159-1161.
12. Delmer A, Tang R, Senamaud-Beaufort C, Paterlini P, Brechot C, Zittoun R. Alterations of cyclin dependent kinase 4 inhibitor (p16INK4A/MTS1) gene structure and expression in acute lymphoblastic leukemia. Leukemia 1995; 9: 1240-1245.
13. Nakao M, Yokota S, Kaneko H, Seriu T, Koizumi S, Takaue Y, Fujimoto T, Misawa S. Alterations of CDKN2 gene structure in childhood acute lymphoblastic leukemia: mutations of CDKN2 are observed preferentially in T lineage. Leukemia 1996; 10: 249-254.
14. lolascon A, Faienza MF, Coppola B, della Ragione F, Schettini F, Biondi A. Homozygous deletions of cyclin-dependent kinase inhibitors genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias. Leukemia 1996; 10: 255-260.
15. Gombart AF, Morosetti R, Miller CW, Said JW, Koeffler HP. Deletions of the cyclin dependent kinase inhibitor genes p16INK4A and p15INK4B in non-Hodgkin's lymphomas. Blood 1995; 86; 1534-1539.
16. Ogawa S, Hangaishi A, Miyawaki S, Hirosawa S, Miura Y, Takeyama K, Kamada N, Ohtake S, Uike N, Shimazaki C. Loss of the cyclin dependent kinase 4 inhibitor (p16;MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies. Blood 1995; 86: 1548-1556.
17. Uchida T, Watanabe T, Kiroshita T, Murate T, Saito H, Hotta T. Mutational analysis of the CDKN2 (MTS1/p16ink4A) gene in primary B-cell lymphomas. Blood 1995; 86: 2724-2731.
18. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger P, Baylin SB, Sidransky D. 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor P16/CDKN2/MTS1 in human cancers. Nat Med 1995; 1: 686-692.
19. Otterson GA, Khleif SN, Chen W, Coxon AB, Kaye FJ. CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16ink4 protein induction by 5-aza 2′ deoxycytidine. Oncogene 1995; 11: 1211-1216.
20. Herman JG, Merlo A, Mao L, Lapidus RG, Issa JPJ, Davidson NE, Sidransky D, Baylin SB. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995; 55: 4525-4530.
21. Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM, Jones PA. Methylation of the 5′CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 1995; 55: 4531-4535.
22. Fernandez-Piqueras J, Santos J, Perez de Castro I, Melendez B, Martinez B, Robledo M, Rivas C, Benitez J. Frequent allelic losses of 9p21 markers and low incidence of mutations at p16(CDKN2) gene in non-Hodgkin's lymphomas of B-cell lineage. Cancer Genet Cytogenet (in press).
23. Ritter M, de Kant E, Huhn D, Neubauer A. Detection of DNA methylation in the calcitonin gene in human leukemias using differential polymerase chain reaction. Leukemia 1995; 9: 915-921.
24. Lo KW, Cheung ST, Leung SF, van Hasselt A, Tsang YS, Mak KF, Chung YF, Woo JKS, Lee JCK, Huang DP. Hypermethylation of the p16 gene in nasopharyngeal carcinoma. Cancer Res 1996; 56: 2721-2725.
25. Jamal R, Thomas NS, Gale RE, Linch DC. Variable expression of p16 protein in patients with acute myeloid leukemia without rearrangements at the DNA level. Leukemia 1996; 10: 629-636.