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Volumn 23, Issue 3-4, 1996, Pages 277-285

The biologic function of PML and its role in acute promyelocytic leukemia

Author keywords

Acute promyelocytic leukemia; Pathogenesis; PML growth suppressor; PML oncogenic domain; PML RAR fusion protein

Indexed keywords

HYBRID PROTEIN; PHOSPHOPROTEIN; TRANSCRIPTION FACTOR;

EID: 0030462983     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609054830     Document Type: Review
Times cited : (19)

References (55)
  • 1
    • 0025089467 scopus 로고
    • Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17
    • Borrow, J., Goddard, A. D., Sheer, D. and Solomon, E. (1990) Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science, 249, 1577-1580.
    • (1990) Science , vol.249 , pp. 1577-1580
    • Borrow, J.1    Goddard, A.D.2    Sheer, D.3    Solomon, E.4
  • 2
    • 0025043959 scopus 로고
    • The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor gene to a novel transcribed locus
    • de The, H., Chomienne, C., Lanotte, M., Degos, L. and Dejean, A. (1990) The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor gene to a novel transcribed locus. Nature, 347, 558-561.
    • (1990) Nature , vol.347 , pp. 558-561
    • De The, H.1    Chomienne, C.2    Lanotte, M.3    Degos, L.4    Dejean, A.5
  • 4
    • 0026502780 scopus 로고
    • Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia
    • Chang, K. S., Stass, S A., Chu, D. T., Deaven, L. L , Trujillo, J. M. and Freireich, E. J. (1992) Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia. Mol. Cell. Biol., 12, 800-810.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 800-810
    • Chang, K.S.1    Stass, S.A.2    Chu, D.T.3    Deaven, L.L.4    Trujillo, J.M.5    Freireich, E.J.6
  • 5
    • 0025875679 scopus 로고
    • The PML-RARA fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
    • de The, H., Lavau, C., Marchio, A., Chomienne, C., Degos, L. and Dejean, A. (1991) The PML-RARA fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell, 66, 675-684.
    • (1991) Cell , vol.66 , pp. 675-684
    • De The, H.1    Lavau, C.2    Marchio, A.3    Chomienne, C.4    Degos, L.5    Dejean, A.6
  • 6
    • 0026326963 scopus 로고
    • Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia
    • Goddard, A., Borrow, J., Freemont, P. S. and Solomon, E. (1991) Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science, 24, 1371-1374.
    • (1991) Science , vol.24 , pp. 1371-1374
    • Goddard, A.1    Borrow, J.2    Freemont, P.S.3    Solomon, E.4
  • 7
    • 0025780876 scopus 로고
    • Chromosomal transiocation t(15;17) in human acute promyelocytic leukemia fuses RARA with a novel putative transcription factor, PML
    • Kakizuka, A., Miller, W. H., Umesono, K., Warrell, R. P , Frankel, S R., Murry, V. V. V. S., Dmitrovsky, E. and Evans, R. M. (1991) Chromosomal transiocation t(15;17) in human acute promyelocytic leukemia fuses RARA with a novel putative transcription factor, PML. Cell, 66, 663-674.
    • (1991) Cell , vol.66 , pp. 663-674
    • Kakizuka, A.1    Miller, W.H.2    Umesono, K.3    Warrell, R.P.4    Frankel, S.R.5    Murry, V.V.V.S.6    Dmitrovsky, E.7    Evans, R.M.8
  • 8
    • 0026583943 scopus 로고
    • Structure, localization, and transcriptional properties of two classes of retinoic acid receptor a fusion proteins in acute promyelocytic leukemia (APL): Structural similarities with a new family of oncoproteins
    • Kastner, P., Perez, A., Lutz, Y Rochette-Egly, C., Gaub, M. P., Durand, B., Lanotte, M., Berger, R. and Chambon, P. (1992) Structure, localization, and transcriptional properties of two classes of retinoic acid receptor a fusion proteins in acute promyelocytic leukemia (APL): Structural similarities with a new family of oncoproteins. EMBO J., 11, 629-642.
    • (1992) EMBO J. , vol.11 , pp. 629-642
    • Kastner, P.1    Perez, A.2    Lutz, Y.3    Rochette-Egly, C.4    Gaub, M.P.5    Durand, B.6    Lanotte, M.7    Berger, R.8    Chambon, P.9
  • 9
    • 0025917413 scopus 로고
    • Structure and origin of the acute promyelocytic leukemia myl/RARA cDNA and characterization of its retinoic-binding and transactivation properties
    • Pandolfi, P. P , Grignani, F., Alcalay, M., Mencarelli, A., Biondi, A., LoCoco, F. and Pelicci, P. G. (1991) Structure and origin of the acute promyelocytic leukemia myl/RARA cDNA and characterization of its retinoic-binding and transactivation properties. Oncogene., 6, 1285-1292.
    • (1991) Oncogene. , vol.6 , pp. 1285-1292
    • Pandolfi, P.P.1    Grignani, F.2    Alcalay, M.3    Mencarelli, A.4    Biondi, A.5    LoCoco, F.6    Pelicci, P.G.7
  • 11
    • 0023752982 scopus 로고
    • Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
    • Huang, M., Ye, Y. C., Chen, B. R., Chai, J. R., Lu, J. X., Zhoa, L., Gu, L. J. and Wang, Z. Y. (1988) Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood, 72, 567-572.
    • (1988) Blood , vol.72 , pp. 567-572
    • Huang, M.1    Ye, Y.C.2    Chen, B.R.3    Chai, J.R.4    Lu, J.X.5    Zhoa, L.6    Gu, L.J.7    Wang, Z.Y.8
  • 12
    • 0025201879 scopus 로고
    • All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results
    • Castaigne, S , Chomienne, C., Daniel, M. T., Ballerini, P., Berger, R., Fenaux, P and Degos, L. (1990) All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood, 76, 1704-1709.
    • (1990) Blood , vol.76 , pp. 1704-1709
    • Castaigne, S.1    Chomienne, C.2    Daniel, M.T.3    Ballerini, P.4    Berger, R.5    Fenaux, P.6    Degos, L.7
  • 13
    • 0025241453 scopus 로고
    • All-trans retinoic acid in acute promyelocytic leukemias. II. in vitro studies: Structure-function relationship
    • Chomienne, C., Ballerini, P., Balitrand, N., Daniel, M. T., Fenaux, P., Castaigne, S. and Degos, L. (1990) All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship. Blood, 76, 1710-1717.
    • (1990) Blood , vol.76 , pp. 1710-1717
    • Chomienne, C.1    Ballerini, P.2    Balitrand, N.3    Daniel, M.T.4    Fenaux, P.5    Castaigne, S.6    Degos, L.7
  • 15
    • 0025724079 scopus 로고
    • Rearrangement in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular markers for retinoic acid-induced leukemia cell differentiation
    • Chen, S., Zhu, Y., Tong, J., Dong, S., Huang, W., Chen, Y., Ziang, W., Zhang, L , Li, X., Qian, G., Wang, Z., Chen, Z., Larsen, C. and Berger, R. (1991) Rearrangement in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular markers for retinoic acid-induced leukemia cell differentiation. Blood, 79, 2696-2701.
    • (1991) Blood , vol.79 , pp. 2696-2701
    • Chen, S.1    Zhu, Y.2    Tong, J.3    Dong, S.4    Huang, W.5    Chen, Y.6    Ziang, W.7    Zhang, L.8    Li, X.9    Qian, G.10    Wang, Z.11    Chen, Z.12    Larsen, C.13    Berger, R.14
  • 16
    • 0028179010 scopus 로고
    • A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
    • Dyck, J. A., Maul, G. G , Miller, W. H., Chen, J. D., Kakizuka, A. and Evans, R. M. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. (1994) Cell, 76, 333-343.
    • (1994) Cell , vol.76 , pp. 333-343
    • Dyck, J.A.1    Maul, G.G.2    Miller, W.H.3    Chen, J.D.4    Kakizuka, A.5    Evans, R.M.6
  • 17
    • 0028158682 scopus 로고
    • Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells
    • Weis, K., Ramboud, S., Lavau, C., Jansen, J., Carvalho, T., Carmo-Fonseca, M., Lamond, A. and Dejean, A. (1994) Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells. Cell, 76, 345-356.
    • (1994) Cell , vol.76 , pp. 345-356
    • Weis, K.1    Ramboud, S.2    Lavau, C.3    Jansen, J.4    Carvalho, T.5    Carmo-Fonseca, M.6    Lamond, A.7    Dejean, A.8
  • 18
    • 0027328057 scopus 로고
    • PML-RAR homodimers: Distinct DNA binding properties and heteromeric interaction with RXR
    • Perez, A., Kastner, P., Sethi S , Lutz, Y., Reibel, C. and Chambon, P. (1993) PML-RAR homodimers: distinct DNA binding properties and heteromeric interaction with RXR. EMBO J., 12, 3171-3182.
    • (1993) EMBO J. , vol.12 , pp. 3171-3182
    • Perez, A.1    Kastner, P.2    Sethi, S.3    Lutz, Y.4    Reibel, C.5    Chambon, P.6
  • 20
    • 0025977953 scopus 로고
    • A novel cysteine-rich sequence motif
    • Freemom, P. S., Hanson, I. M. and Trowsdale, J. (1991) A novel cysteine-rich sequence motif. Cell, 64, 483-484.
    • (1991) Cell , vol.64 , pp. 483-484
    • Freemom, P.S.1    Hanson, I.M.2    Trowsdale, J.3
  • 21
    • 0026782376 scopus 로고
    • A novel finger coiled-coil domain in a family of nuclear proteins
    • Reddy, B. A., Etkin, L. D. and Freemont, P. S. (1992) A novel finger coiled-coil domain in a family of nuclear proteins. TIBS, 17, 344-345.
    • (1992) TIBS , vol.17 , pp. 344-345
    • Reddy, B.A.1    Etkin, L.D.2    Freemont, P.S.3
  • 22
    • 85086607500 scopus 로고
    • The solution structure of the RING finger domain from the acute promyelocytic leukemia proto-oncogene PML
    • Borden, K. L. B., Boddy, M. N., Lally, J., O'Reilly, N. J. and Freemont, P. S (1995) The solution structure of the RING finger domain from the acute promyelocytic leukemia proto-oncogene PML EMBO J., 14, 461-472.
    • (1995) EMBO J. , vol.14 , pp. 461-472
    • Borden, K.L.B.1    Boddy, M.N.2    Lally, J.3    O'Reilly, N.J.4    Freemont, P.S.5
  • 23
    • 0028095410 scopus 로고
    • PML, a growth suppressor disrupted in acute promyelocytic leukemia
    • Mu, Z-M., Chin, K-V., Liu, J-H., Lozano, G. and Chang, K. S. PML, a growth suppressor disrupted in acute promyelocytic leukemia. (1994) Mol. Cell Biol., 14, 6858-6867.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 6858-6867
    • Mu, Z.-M.1    Chin, K.-V.2    Liu, J.-H.3    Lozano, G.4    Chang, K.S.5
  • 24
    • 0029053743 scopus 로고
    • PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu
    • Liu, J. H., Mu, Z. M. and Chang, K. S. (1995) PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu. J. Exp. Med. 181, 1965-1973.
    • (1995) J. Exp. Med. , vol.181 , pp. 1965-1973
    • Liu, J.H.1    Mu, Z.M.2    Chang, K.S.3
  • 26
    • 0029030246 scopus 로고
    • Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RARα or PML
    • Ahn, M. J , Nason-Burchenal, K., Moasser, M. M. and Dmitrovsky, E. (1995) Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RARα or PML. Oncogene, 10, 2307-2314.
    • (1995) Oncogene , vol.10 , pp. 2307-2314
    • Ahn, M.J.1    Nason-Burchenal, K.2    Moasser, M.M.3    Dmitrovsky, E.4
  • 27
    • 0027520499 scopus 로고
    • Nuclear dot antigens may specify transcriptional domains in the nucleus
    • Xie, K., Lambie, E J. and Snyder, M. (1993) Nuclear dot antigens may specify transcriptional domains in the nucleus. Mol. Cell. Biol , 13, 6170-6179.
    • (1993) Mol. Cell. Biol , vol.13 , pp. 6170-6179
    • Xie, K.1    Lambie, E.J.2    Snyder, M.3
  • 28
    • 0027239790 scopus 로고
    • Sluyser, M., Geent, A. B., Brinkmann, A. O. and Blankenstein, R. A., (eds.). The New York Academy of Sciences: New York
    • Freemont, P. S. (1993) Zinc-finger proteins in oncogenesis. Sluyser, M., Geent, A. B., Brinkmann, A. O. and Blankenstein, R. A., (eds.). The New York Academy of Sciences: New York, pp. 174-192.
    • (1993) Zinc-finger Proteins in Oncogenesis , pp. 174-192
    • Freemont, P.S.1
  • 30
    • 0023022998 scopus 로고
    • Characterization of the IE110 gene of herpes simplex virus type I
    • Perry, L. J., Rixon, F., Everett, R. D., Frame, M. C. and Mcgeoch, D. J. (1986) Characterization of the IE110 gene of herpes simplex virus type I. J. Gen. Virol., 67, 2365-2380.
    • (1986) J. Gen. Virol. , vol.67 , pp. 2365-2380
    • Perry, L.J.1    Rixon, F.2    Everett, R.D.3    Frame, M.C.4    Mcgeoch, D.J.5
  • 31
    • 0023886635 scopus 로고
    • A 52K protein is a novel component of the SS-A/Ro antigenic particle
    • Ben-Chetrit, E., Chan, E., Sullivan, K. and Tan, E. (1988) A 52K protein is a novel component of the SS-A/Ro antigenic particle. J. Exp. Med., 167, 1560-1571.
    • (1988) J. Exp. Med. , vol.167 , pp. 1560-1571
    • Ben-Chetrit, E.1    Chan, E.2    Sullivan, K.3    Tan, E.4
  • 32
    • 0025773264 scopus 로고
    • Sequence similarity between the mammalian bmi-1 proto-oncoaene and the Drosophila regulatory genes Psc and Su(z)2
    • Van Lohuizen, M., Frasch, M., Wientjens, E. and Berns, A. (1991) Sequence similarity between the mammalian bmi-1 proto-oncoaene and the Drosophila regulatory genes Psc and Su(z)2. Nature, 353, 353-356.
    • (1991) Nature , vol.353 , pp. 353-356
    • Van Lohuizen, M.1    Frasch, M.2    Wientjens, E.3    Berns, A.4
  • 33
    • 0000968858 scopus 로고
    • Nuclear bodies as functional indicators in the target cells of sex steroid hormones
    • Padykula, H. A. and Clark, J. H. (1981) Nuclear bodies as functional indicators in the target cells of sex steroid hormones. Cell Nucleus, 9, 309-339.
    • (1981) Cell Nucleus , vol.9 , pp. 309-339
    • Padykula, H.A.1    Clark, J.H.2
  • 34
    • 0026778573 scopus 로고
    • Nuclear bodies (NBs): A newly "rediscovered" organelle
    • Brasch, K. and Ochs, R. L. (1992) Nuclear bodies (NBs): a newly "rediscovered" organelle Exp. Cell. Res., 202, 211-223.
    • (1992) Exp. Cell. Res. , vol.202 , pp. 211-223
    • Brasch, K.1    Ochs, R.L.2
  • 35
    • 0030027449 scopus 로고    scopus 로고
    • Analysis of the growth and transformation suppressor domains of PML
    • Le, X. F., Yang, P. and Chang, K. S. (1996) Analysis of the growth and transformation suppressor domains of PML. J. Biol. Chem., 271, 130-135.
    • (1996) J. Biol. Chem. , vol.271 , pp. 130-135
    • Le, X.F.1    Yang, P.2    Chang, K.S.3
  • 36
    • 0029010740 scopus 로고
    • The PML gene encodes a phosphoprotein associated with the nuclear matrix
    • Chang, K. S., Fan, Y. H., Andreeff, M., Liu, J. and Mu, Z. M. (1995) The PML gene encodes a phosphoprotein associated with the nuclear matrix. Blood, 85, 3646-3653.
    • (1995) Blood , vol.85 , pp. 3646-3653
    • Chang, K.S.1    Fan, Y.H.2    Andreeff, M.3    Liu, J.4    Mu, Z.M.5
  • 37
    • 0027769358 scopus 로고
    • Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICPO)
    • Maul, G. G., Gulder, H. H. and Spivack, J. G. (1993) Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICPO). J, Gen. Virol., 74, 2679-2690.
    • (1993) J, Gen. Virol. , vol.74 , pp. 2679-2690
    • Maul, G.G.1    Gulder, H.H.2    Spivack, J.G.3
  • 38
    • 0028039189 scopus 로고
    • HSV-1 IE protein Vmw 110 causes redistribution of PML
    • Everett, R. D. and Maul, G. G. (1994) HSV-1 IE protein Vmw 110 causes redistribution of PML. EMBO J., 13, 502-5069.
    • (1994) EMBO J. , vol.13 , pp. 502-5069
    • Everett, R.D.1    Maul, G.G.2
  • 41
    • 0028966628 scopus 로고
    • Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: Immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia
    • Flenghi, L., Fagioli, M., Tomassoni, L., Pileri, S., Gambacorta, M., Pacini, R., Grignani, F., Casini, T., Ferrucci, P. F., Martelli, M. F., Pelicci, P. G. and Fatini, B. (1995) Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia. Blood, 85, 1871-1880.
    • (1995) Blood , vol.85 , pp. 1871-1880
    • Flenghi, L.1    Fagioli, M.2    Tomassoni, L.3    Pileri, S.4    Gambacorta, M.5    Pacini, R.6    Grignani, F.7    Casini, T.8    Ferrucci, P.F.9    Martelli, M.F.10    Pelicci, P.G.11    Fatini, B.12
  • 42
    • 0026019835 scopus 로고
    • Identification of a novel nuclear domain
    • Ascoli, C. A. and Maul, G. G. (1991) Identification of a novel nuclear domain. J. Cell Biol., 112, 785-795.
    • (1991) J. Cell Biol. , vol.112 , pp. 785-795
    • Ascoli, C.A.1    Maul, G.G.2
  • 44
    • 0028009849 scopus 로고
    • The cell cycle and the retinoblastoma protein family
    • Ewen, M. E. (1994) The cell cycle and the retinoblastoma protein family. Cancer Metastasis Rev., 13, 45-66.
    • (1994) Cancer Metastasis Rev. , vol.13 , pp. 45-66
    • Ewen, M.E.1
  • 45
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. (1995) The retinoblastoma protein and cell cycle control. Cell, 81, 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 48
    • 0028951531 scopus 로고
    • PML nuclear bodies are general targets for inflammation and cell proliferation
    • Terris, B., Baldin, V., Dubois, S., Degatt, C., Flejou, J. F. and Henin, D. (1995) PML nuclear bodies are general targets for inflammation and cell proliferation. Cancer Res., 55, 1590-1597.
    • (1995) Cancer Res. , vol.55 , pp. 1590-1597
    • Terris, B.1    Baldin, V.2    Dubois, S.3    Degatt, C.4    Flejou, J.F.5    Henin, D.6
  • 49
    • 0028894265 scopus 로고
    • Promyelocytic leukemia-specific PML-retinoic acid-α receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells
    • Grignani, F., Testa, U., Fagioli, M., Barberi, T., Masciulli, R., Mariani, G., Cesare, P. and Pelicci, P G. (1995) Promyelocytic leukemia-specific PML-retinoic acid-α receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells. Cancer Res., 55, 440-443.
    • (1995) Cancer Res. , vol.55 , pp. 440-443
    • Grignani, F.1    Testa, U.2    Fagioli, M.3    Barberi, T.4    Masciulli, R.5    Mariani, G.6    Cesare, P.7    Pelicci, P.G.8
  • 51
    • 0026074818 scopus 로고
    • Cooperation between oncogenes
    • Hunter, T. (1991) Cooperation between oncogenes. Cell, 64, 249-257.
    • (1991) Cell , vol.64 , pp. 249-257
    • Hunter, T.1
  • 52
    • 0009613058 scopus 로고
    • Oncogenes and multistep carcinogenesis
    • edited by R. Weinberg, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory press
    • Weinberg, R. A. (1989) Oncogenes and multistep carcinogenesis, In Oncogenes and the Molecular Origins of Cancer, edited by R. Weinberg, pp. 307-326, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory press
    • (1989) Oncogenes and the Molecular Origins of Cancer , pp. 307-326
    • Weinberg, R.A.1
  • 54
    • 0026776822 scopus 로고
    • Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia
    • Yamamoto, K., Hirosawa, S., Sakamaki, H. and Aoki, N. (1992) Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia Am. J. Hematol., 40, 252-258.
    • (1992) Am. J. Hematol. , vol.40 , pp. 252-258
    • Yamamoto, K.1    Hirosawa, S.2    Sakamaki, H.3    Aoki, N.4
  • 55
    • 0027297095 scopus 로고
    • A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocytic stage
    • Tsai, S. and Collins, S. J. (1993) A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocytic stage. Proc. Natl. Acad. Sci. USA, 90, 7153-7157.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7153-7157
    • Tsai, S.1    Collins, S.J.2


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