Pindolol occupancy of 5-HT(1A) receptors measured in vivo using small animal positron emission tomography with carbon-11 labeled WAY 100635

Synapse

Volumn 36, Issue 4, 2000, Pages 330-341

  Hirani, Ella ^a   Opacka Juffry, Jolanta ^a   Gunn, Roger ^a   Khan, Imtiaz ^a   Sharp, Trevor ^b   Hume, Susan ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

Autoreceptors; PET; Rat brain; Serotonin

Indexed keywords

AUTORECEPTOR; CARBON 11; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PINDOLOL; SEROTONIN; SEROTONIN 1A RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG RECEPTOR BINDING; FRONTAL CORTEX; HIPPOCAMPUS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; RECEPTOR OCCUPANCY; SEROTONIN RELEASE;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; PINDOLOL; PIPERAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034659979     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(20000615)36:4<330::AID-SYN10>3.0.CO;2-H     Document Type: Article

References (47)

1. Artigas F, Pérez V, Alvarez E. 1994. Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch Gen Psychiatry 51:248-251.
2. 1A antagonists. Trends Neurosci 19:378-383.
3. Blier P, Bergeron R. 1995. Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. J Clin Psychopharmacol 15:217-222.
4. Blier P, Bergeron R. 1998. The use of pindolol to potentiate antidepressant medication. J Clin Psychiatry 59(Suppl. 5):16-25.
5. Bloomfield PM, Myers R, Hume SP, Spinks TJ, Lammertsma AA, Jones T. 1996. Three-dimensional performance of a small-diameter positron emission tomography. Phys Med Biol 42:389-400.
6. 1A receptors: variation in intrinsic activity studied in transfected HeLa neurones. Naunyn Schmiedebergs Arch Pharmacol 345:257-263.
7. Bordet R, Thomas P, Dupuis B. 1998. Effect of pindolol on onset of action of paroxetine in the treatment of major depression: intermediate analysis of a double blind placebo-controlled trial. Am J Psychiatry 155:1346-1351.
8. 1A receptors in rat brain. Br J Pharmacol 126:260P.
9. Clark WP, Yocca FD, Maayani S. 1996. Lack of 5-hydroxytryptamine (1A)-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats. J Pharmacol Exp Ther 277:1259-1266.
10. 1A autoreceptor in vivo. Br J Pharmacol 124:206-212.
11. 1A receptors in the rat brain. Br J Pharmacol 123:449-462.
12. Cunningham VJ, Lammertsma AA. 1994. Radioligand studies in brain: kinetic analysis of PET data. Med Chem Res 5:79-96.
13. 1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea-pig and rat hippocampal membranes. J Pharmacol Exp Ther 238:248-253.
14. Farde L, Ginovart N, Ito H, Lundkvist C, Pike VW, McCarron JA, Halldin C. 1997. PET-characterization of [carbonyl-11C]WAY-100635 binding to 5-HT1A receptors in the primate brain. Psychopharmacology 133:196-202.
15. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ. 1997. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 6:279-287.
16. 11C] WAY-100635 for PET. Neuroimage 8:426-440.
17. 1A receptors in rat brain membranes. Eur J Pharmacol 228:173-186.
18. 1A receptors: pharmacological, biochemical, functional and regulatory properties. Ann NY Acad Sci 600:114-129.
19. Hayes PE, Schulz SCh. 1987. Beta-blockers in anxiety disorders. J. Affect Disord 13:119-130.
20. Hjorth S, Carlsson A. 1985. (-)-Pindolol stereospecifically inhibits rat brain serotonin (5-HT) synthesis. Neuropharmacology 24:1143-1146.
21. Hjorth S, Carlsson A. 1986. Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors? Eur J Pharmacol 129:131-138.
22. 1C sites. Neurosci Lett 85:357-362.
23. Hume SP, Jones T. 1998. Positron emission tomography (PET) methodology for small animals and its application in radiopharmaceutical preclinical investigation. Nucl Med Biol 25:729-732.
24. Hume SP, Myers R, Bloomfield PM, Opacka-Juffry J, Cremer J, Ahier RG, Luthra SK, Brooks DJ, Lammertsma AA. 1992. Quantification of carbon-11-labeled raclopride in rat striatum using positron emission tomography. Synapse 12:47-54.
25. 3H]WAY 100635 as an in vivo radioligand for 5-HT1A receptors in rat brain. Eur J Pharmacol 271:515-523.
26. 11C]raclopride binding in rat striatum, quantified using PET. Synapse 21:45-53.
27. Hume SP, Gunn RN, Jones T. 1998. Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals. Eur J Nucl Med 25:173-176.
28. 1A receptor antagonist. Brain Res 673:217-225.
29. 1B, receptors. Eur J Pharmacol 244:77-87.
30. McAskill R, Mir S, Taylor D. 1998. Pindolol augmentation of antidepressant therapy. Br J Psychiatry 173:203-208.
31. 11C-carboxylation of an immobilized Grignard reagent. J Label Comp Radiopharm 48:941-953.
32. 1A agonists and antagonists. Pharmacol Biochem Behav 46:141-143.
33. 2 receptor radioligands in rat striatum. Nucl Med Biol 26:91-98.
34. Myers R, Hume SP, Ashworth S, Lammertsma AA, Bloomfield PM, Rajeswaran S, Jones T. 1996. Quantification of dopamine receptors and transporters in rat striatum using a small animal PET scanner. In: Myers R, Cunningham V, Bailey D, Jones T, editors. Quantification of brain function using PET. San Diego: Academic Press, p 12-15.
35. 1A) receptors. Neuropsychopharmacology 18:395-398.
36. Ouchi Y, Fukuyama H, Ogawa M, Yamauchi H, Kimura J, Magata Y, Yonekura Y, Konishi J. 1996. Cholinergic projections from the basal forebrain and cerebral glucose metabolism in rats: a dynamic PET study. J Cereb Blood Flow Metab 16:34-41.
37. Paxinos G, Watson C. 1996. The rat brain in stereotaxic coordinates. Compact Third Edition. London: Academic Press.
38. 1A receptors in human brain with PET and [carbonyl-11C]WAY-100635. Eur J Pharmacol 301:R5-7.
39. 11C]WAY-100635 PET study. Am J Psychiatry (in press).
40. Radja F, Daval G, Hamon M, Vergé D. 1992. Pharmacological and physicochemical properties of pre-versus postsynaptic 5-hydroxytryptamine,A receptors binding sites in the rat brain: a quantitative autoradiographic study. J Neurochem 58:1338-1346.
41. Robb RA, Hanson DP. 1991. A software system for interactive and quantitative visualisation of multidimensional biomedical images. Australas Phys Eng Med 14:9-30.
42. Sharp T, Bramwell SR, Grahame-Smith DG. 1989a. 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br J Pharmacol 96:283-290.
43. Sharp T, Bramwell SR, Hjorth S, Grahame-Smith DG. 1989b. Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. Br J Pharmacol 8:989-997.
44. 1B agonists. Synapse 1:3-9.
45. 1 receptor and of catecholamine systems in the behavioral response to 8-hydroxy-2-(di-n-propylamino) tetralin. Eur J Pharmacol 106:271-282.
46. Tyrer P. 1992. Anxiolytics not acting at the benzodiazepine receptor: beta blockers. Prog Neuropsychopharmac Biol Psychiatry 16:17-26.
47. 1A receptors occupied by 5-HT or 8-OH-DPAT to adenylyl cyclase. Naunyn Schmiedebergs Arch Pharmacol 346:367-374.