Making central T-cell tolerance efficient: Thymic stromal cells sample distinct self-antigen pools

Current Topics in Microbiology and Immunology

Volumn 251, Issue , 2000, Pages 139-145

  Kyewski, B ^a   Rottinger, B ^a   Klein, L ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; C REACTIVE PROTEIN;

CONFERENCE PAPER; DENDRITIC CELL; EPITHELIUM CELL; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PRIORITY JOURNAL; STROMA CELL; THYMOCYTE;

EID: 0033822440     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-57276-0_18     Document Type: Conference Paper

References (36)

1. Development and selection of T-cells: Facts and puzzles
2. T lymphocyte tolerance: From thymic deletion to peripheral control mechanisms
3. Intrathymic presentation of circulating non-major histocompatibility complex antigens
4. T-cell tolerance by clonal elimination in the thymus
5. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T-cells specific for a blood-borne self-antigen
6. Limited capacity for tolerization of CD4 T-cells specific for a pancreatic β-cell neo-antigen
7. A range of CD4 T-cell tolerance: Partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis
8. Peripheral T-cell tolerance: The contribution of permissive T-cell migration into parenchymal tissues in the neonate
9. The major myelin protein genes are expressed in the human thymus
10. Thymic expression of autoantigens correlates with resistance to autoimmune disease
11. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
12. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
13. Peripheral-antigen-expressing cells in thymic medulla: Factors in self-tolerance and autoimmunity
14. Intrathymic expression of genes involved in organ-specific autoimmune diseases
15. Aberrant expression of tissue-specific proteins in the thymus: A hypothesis for the development of central tolerance
16. Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens
17. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
18. CD4 T-cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium
19. Quantitative impact of thymic clonal deletion on the T-cell repertoire
20. Tolerance induction by thymic medullary epithelium
21. Anergy induced by thymic medullary epithelium
22. Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein. Int. Immunol
23. + thymocytes
24. b complex by isolated thymic stromal cells
25. On the intrathymic intercellular transfer of self-determinants
26. CD4 T-cell tolerance to nuclear proteins induced by medullary thymic epithelium
27. Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines
28. The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway
29. The transcapsular route: A new way for (self-) antigens to by-pass the blood-thymus barrier?
30. The thymus and self tolerance: Co-existence of encephalitogenic S100β-specific T cells and their nominal autoantigen in the normal adult rat thymus
31. Pancreatic gene expression in rare cells of the thymic medulla: Evidence for functional contribution to T cell tolerance
32. Identification of a thymic epithelial cell subset sharing expression of the class 1b HLA-G molecule with fetal trophoblasts
33. An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis
34. Intrathymic deletion of MHC class I-restricted cytotoxic T-cell precursors by constitutive cross-presentation of exogenous antigen
35. Medullary thymic epithelium: A mosaic of epithelial 'self'?
36. Self-antigen presentation by thymic stromal cells: A subtle division of labor