Effect of transfusional iron overload on immune response

Journal of Infectious Diseases

Volumn 182, Issue 3, 2000, Pages S115-S121

  Cunningham Rundles, S ^a   Giardina, P J ^a   Grady, R W ^a   Califano, C ^a   Mc Kenzie, P ^a   De Sousa, M ^b  

^a NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; DEFEROXAMINE; IRON; MITOGENIC AGENT;

ADOLESCENT; ADULT; AGE; BETA THALASSEMIA; BLOOD TRANSFUSION; CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPHENOTYPING; IMMUNOSTIMULATION; INFECTION SENSITIVITY; IRON CHELATION; IRON OVERLOAD; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; SUPPRESSOR CELL;

ADOLESCENT; ADULT; BETA-THALASSEMIA; BLOOD TRANSFUSION; CD8-POSITIVE T-LYMPHOCYTES; CHELATING AGENTS; CHILD; CHILD, PRESCHOOL; DEFEROXAMINE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GREECE; HUMANS; IMMUNOPHENOTYPING; IRON OVERLOAD; ITALY; MALE; MIDDLE AGED; NEW YORK CITY; T-LYMPHOCYTE SUBSETS;

EID: 0033818098     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315919     Document Type: Article

References (73)

1. Iron, anemia, and infection
2. Malnutrition and host defense
3. Influence of iron deficiency on serum IgG subclass and pneumococcal polysaccharides specific IgG subclass antibodies
4. Neutrophil impairment associated with iron therapy in hemodialysis patients with functional iron deficiency
5. The effects of iron deficiency and iron overload on cell-mediated immunity in the mouse
6. Decreased lymphocyte subsets and cell activity in iron deficiency anemia
7. Chronic mucocutaneous candidiasis: Associated abnormalities of iron metabolism
8. Lipid peroxidation and changes in T lymphocyte subsets and lymphocyte proliferative response in experimental iron overload
9. Iron overload alters innate and T helper cell responses to Candida albicans in mice
10. T lymphocytes subsets in experimental iron overload
11. Iron and chronic viral hepatitis: Emerging evidence for an important interaction
12. Transfusion-associated iron overload
13. Hereditary hemochromatosis: Analysis of laboratory expression of the disease by genotype in 18 pedigrees
14. Hemolytic anemia: 1999
15. Genotype-phenotype correlations in betathalassemias
16. Pathophysiology of iron overload
17. The red cell cycle
18. Pathophysiology of iron toxicity
19. The development of diabetes mellitus and chronic liver disease in long-term chelated beta thalassaemic patients
20. Longitudinal study of cardiac function in thalassemia major
21. Chelation therapy in beta-thalassemia - The benefits and limitations of desferrioxamine
22. Transfusion-related immunologic abnormalities in β-thalassemia major
23. Disproportionate lymphoid cell subsets in thalassemia major: The relative contributions of transfusion and splenectomy
24. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
25. Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation
26. Heterogeneity of hemochromatosis in Italy
27. The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C
28. The haemochromatosts mutations do not modify the clinical picture of thalassaemia major in patients regularly transfused and chelated
29. Relative impact of HLA phenotype and CD4-CD8 ratios on the clinical expression of hemochromatosis
30. + lymphocytes and iron overload
31. The immunological system in hemochromatosis
32. Laboratory evaluation of the cellular immune system
33. New variant of MHC class II deficiency with interleukin-2 abnormality
34. Iron and lymphocytes: Reciprocal regulatory interactions
35. Transfusion-related immunomodulation in Chinese children with thalassaemia
36. Assessment of neutrophil chemotaxis and random migration in children with thalassemia major
37. Functional alterations of human blood monocytes after exposure to various nickel compounds in vitro: An effect on the production of hydrogen peroxide
38. RHLA-DP molecules bind cobalt: A possible explanation for the genetic association with hard metal disease
39. Expression of lymphocyte subpopulations, cytokine serum levels, and blood and urinary trace elements in asymptomatic atopic men exposed to an urban environment
40. Mechanisms of adjuvancy: Metal oxides as adjuvants
41. Zinc and immune function: The biological basis of altered resistance to infection
42. Roles of trace metals in the maturation, activation and effector functions of immune cells
43. Trace elements and minerals in HIV infection and AIDS: Implications for host defense
44. A novel iron-dependent repressor in Staphylococcus epidermidis
45. Microbial iron transport: Iron acquisition by pathogenic microorganisms
46. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
47. Overexpression of hemochromatosis protein, HFE, alters transferrin recycling process in human hepatoma cells
48. A role for the immunological system in iron in homeostasis: 'But how?'
49. Cell surface expression of HFE protein in epithelial cells, macrophages, and monocytes
50. Anti-transferrin receptor monoclonal antibody: A novel immunosuppressant
51. Genes that modify the hemochromatosis phenotype in mice
52. Transfusion-transmitted human parvovirus B19 infection in a thalassemic patient
53. Serological monitoring of thalassaemia major patients for transfusion associated viral infections
54. High prevalence of hepatitis G virus infection in multiply transfused children with thalassaemia
55. Transfusion-dependent thalassemia: Viral complications (epidemiology and follow-up)
56. Infection due to Yersinia enterocolitica in a series of patients with beta-thalassemia: Incidence and predisposing factors
57. Prospective study of Yersinia enterocolitica infection in thalassemic patients
58. Fatal Campylobacter jejuni infection in a patient splenectomised for thalassaemia
59. Elevated serum iron predicts poor response to interferon treatment in patients with chronic HCV infection
60. Hepatitis C virus infection in thalassemia patients undergoing allogeneic bone marrow transplantation
61. Effect of iron overload on the response to recombinant interferon-alpha treatment in transfusion-dependent patients with thalassemia major and chronic hepatitis C
62. Pathophysiology of iron toxicity
63. Dose of desferrioxamine and evolution of HIV-1 infection in thalassaemic patients
64. Serum ferritin, desferrioxamine, and evolution of HIV-1 infection in thalassemic patients
65. Homozygous beta-thalassaemia: A review of patients who had splenectomy at the Royal Alexandra Hospital for Children, Sydney
66. Lymphocytes in beta-thalassemia/HbE: Subpopulations and mitogen responses
67. A distinct pattern of cytokine production from blood mononuclear cells in multitransfused patients with beta-thalassaemia
68. Abnormalities in the immune system of children with beta-thalassaemia major
69. Serum levels of cytokines and soluble antigens in polytransfused patients with beta-thalassemia major: Relationship to immune status
70. Transfusion-related immunomodulation in Chinese children with thalassaemia
71. Effect of therapeutic chelation on immune response in transfusion dependent thalassemia
72. A functional defect in hereditary haemochromatosis monocytes and monocyte-derived macrophages