The immunological system in hemochromatosis

Journal of Hepatology, Supplement

Volumn 28, Issue 1, 1998, Pages 1-7

  De Sousa, Maria ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HLA ANTIGEN; IRON;

GENE FREQUENCY; GENE MUTATION; GEOGRAPHIC DISTRIBUTION; HEMOCHROMATOSIS; HUMAN; IMMUNE SYSTEM; IRON OVERLOAD; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; AGED, 80 AND OVER; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HEMOCHROMATOSIS; HUMANS; IMMUNITY, CELLULAR; MIDDLE AGED;

EID: 0031982370     PISSN: 01695185     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Delbrück M. Mind from Matter? An Essay on Evolutionary Epistomology. Palo Alto: Blackwell Scientific Publications; 1985.
2. Dubos R. Louis Pasteur. Free Lance of Science New York: Scibner Sons; 1976.
3. De Sousa M. Questioning the value of XIX century paradigms at the end of the end of the XX century. Cascais International Summer Courses, 1996.
4. Simon M, Le Mignon L, Fauchet R, Yaouanq J, David V, Edan G, et al. A study of 609 HLA haplotypes marking for the hemochromatosis gene: (1) mapping of the gene near the HLA-A locus and characters required to define a heterozygous population and (2) hypothesis concerning the underlying cause of the hemochromatosis - HLA association. Am J Hum Genet 1987; 41: 89-107.
5. Feder J, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996; 13: 399.
6. Oliveri N, Brittenham G. Iron-chelating therapy and the treatment of thalassemia. Blood 1997; 89: 739-761.
7. Porto G, de Sousa M. Variation of hemochromatosis prevalence and genotype in national groups. In: Barton JC, Edwards C, editors. Hemochromatosis 1998: in press.
8. Duboule D. The evolution of genomics [editorial]. Science 1997; 278: 555.
9. Dyson F. Imagined Worlds. Cambridge, Mass., London, England: Harvard University Press; 1997.
10. De Sousa M, Porto G, Arosa F, Cardoso C, Cabeda JM, Lacerda R, et al. T lymphocyte expression and function in hemochromatosis. In: Barton JC, Edwards C, editors. Hemochromatosis 1998: in press.
11. Porto G, Alves H, Rodrigues P. Major histocompatibility complex class I associations in iron overload: evidence for a new link between the HFE H63D mutation, HLA-A29 and "non-classical" forms of hemochromatosis. Immunogenetics: ' in press.
12. Ajioka RS, Jorde LB, Gruen JR, Yu P, Dimitrova D, Barrow J, et al. Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes. Am J Hum Genet 1997; 60: 14371447.
13. Reimào R, Porto G, de Sousa M. Stability of CD4/CD8 ratios in man: new correlation between CD4/CD8 profiles and iron overload in idiopathic haemochromatosis patients. CR Acad Sei Paris 1991; 313: 481-7.
14. De Sousa M. Lymphoid cell positioning: a new proposal for the mechanism control of lymphoid cell migration. In: Symp Soc Exp Biol 1978; 32: 393-109.
15. Porto G, Vicente C, Teixeira MA, Martins O, Cabeda JM, Lacerda R, et al. Relative impact of HLA phenôtype and CD4-CD8 ratios on the clinical expression of hemochromatosis. Hepatology 1997; 25: 39702.
16. Porto G, Reimào R, Gonçalves C, Vicente C, Justiça B, de Sousa M. Haemochromatosis as a window into the study of the immunological system: a novel correlation between CD8+ lymphocytes and iron overload. Eur J Haematol 1994; 52: 283-90.
17. De Sousa M, Reimào R, Porto G, Grddy R, Hilgartner MW, Giardina P. Iron and lymphocytes: reciprocal regulatory interactions. In: Albertini A, Lenfant CL, Mannucci PM, Sixma JJ, editors. Biotechnology of Plasma Proteins. Current Studies in Hematology and Blood Transfusion; Basel: S. Karger; 1991. p. 171-7.
18. De Sousa M. T lymphocytes and iron overload: novel correlations of possible significance to the biology of the immunological system. Mem Inst Oswald Cruz 1992; 57: 23-9.
19. Moura E. Uptake and release of iron by monocytes and macrophages. Ph.D. Thesis. University of Utrecht, 1997.
20. Cruz E, Porto G, Fraga J, Moreira R, Castro D, Alves H, et al. Influência do fenötipo HLA e da razào CD4/CD8 na expressào da doença hepätica em bebedores. Revista da Sociedade Portuguesa de Alcoologia 1995; 5: 47-54.
21. Arosa FA, da Suva AJ, Godinho MI, ter Steege JCA, Porto G, Rudd CE, et al. Decreased CD8-p561ck activity in peripheral blood T lymphocytes from patients with hereditary hemochromatosis. Scand J Immunol 1994; 39: 426-32.
22. Arosa FA, Oliveira, L, Porto G, da Silva DM, Kruijer W, Veltman J, et al. Anomalies of the CD8+ T cell pool in haemochromatosis: HLA-A3 linked expansions of CD8+CD28- T cells. Clin Exp Immunol 1997; 107: 548-54.
23. Cabeda JMB, Porto G, Lacerda R, Jeddi-Tehrani M, da Silva B, Gigliotti D, et al. Anomalies of the CD8+ population in. genetic hemochromatosis: characterization of the T-cell repertoire [abstract]. FASEB J 1995; 9: 527.
24. De Sousa M. Immune cell functions in iron overload. Clin Exp Immunol 1989; 75: 1-7.
25. Santos M, de Sousa M. In vitro modulation of T-cell surface molecules by iron. Cell Immunol 1994; 154: 498-506.
26. Arosa FA, de Sousa M. Iron differentially modulates the CD4-lck and CD8-lck complexes in resting peripheral blood T lymphocytes. Cell Immunol 1995; 161: 138-42.
27. Koller BH, Marrack P, Kappler JW, Smithies O. Normal development of mice deficient in lm, MHC-class I proteins, and CD8+ T cells. Science 1990; 348: 738-41.
28. De Sousa M, Reirnao R, Lacerda R, Hugo P, Kaufmann S, Porto G. Iron overload in /0-microglobulin deficient mice. Immunol Lett 1994; 39: 105-11.
29. Santos M, Schilham M, Rademakers LHPM, Marx JJM, de Sousa M, devers H. Defective iron 2-microglobuIin knockout mice recapitulates hereditary hemochromatosis in man. J Exp Med 1996; 184: 1975-80.
30. Wahheed A, Parkkila S, Zhou XY, Tomatsu S, Tsuchihashi Z, Feder J, et al. Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with /?2-microglobulin, intracellular processing, and surface expression of HFE protein in COS-7 cells. Proc Nail Acad Sei USA 1997; 94: 11384-9.