-
3
-
-
0030272487
-
Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: Tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide
-
(1996)
Curr Opin Immunol
, vol.8
, pp. 710-720
-
-
Brazelton, T.R.1
Morris, R.E.2
-
5
-
-
85031610068
-
Immunosuppressive drugs: Non-biologics
-
Primer on Transplantation, edn 2. Edited by Turka LA, Norman DJ. Thorofare, NJ: American Society of Transplantation: in press
-
(2000)
-
-
Klupp, J.1
Morris, R.E.2
-
7
-
-
0026858708
-
Direct stimulation of cytokines (IL-1 beta, TNF-alpha, IL-6, IL-2, IFN-gamma and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation
-
(1992)
Cytokine
, vol.4
, pp. 239-248
-
-
De Groote, D.1
Zangerle, P.F.2
Gevaert, Y.3
Fassotte, M.F.4
Beguin, Y.5
Noizat-Pirenne, F.6
Pirenne, J.7
Gathy, R.8
Lopez, M.9
Dehart, I.10
-
13
-
-
0032823696
-
Differences in type 1 and type 2 intracytoplasmic cytokines, detected by flow cytometry, according to Immunosuppression (cyclosporine A vs. tacrolimus) in stable renal allograft recipients
-
(1999)
Clin Transplant
, vol.13
, pp. 400-409
-
-
Rostaing, L.1
Puyoo, O.2
Tkaczuk, J.3
Peres, C.4
Rouzaud, A.5
Cisterne, J.M.6
De Preval, C.7
Ohayon, E.8
Durand, D.9
Abbal, M.10
-
14
-
-
0031614090
-
Quantification of immunosuppression by flow cytometric measurement of intracellular cytokine synthesis
-
(1998)
Transplant Int
, vol.11
, Issue.SUPPL. 1
-
-
Van den Berg, A.P.1
Twilhaar, W.N.2
Van Son, W.J.3
Van der Bij, W.4
Klompmaker, J.J.5
Slooff, M.J.6
The, T.H.7
De Leij, L.H.8
-
15
-
-
0007905493
-
Quantitation of immunosuppression by FK506 using flow cytometric analysis of IL-2 and INFγ inhibition in peripheral blood T cells
-
(2000)
Transplantation
, vol.69
-
-
Ahmed, M.1
Venkataraman, R.2
Logar, A.J.3
Rao, A.S.4
Bartley, G.P.5
Robert, K.6
Stanton, D.F.7
Richard, S.A.8
Fung, J.J.9
Zeevi, A.10
-
18
-
-
0006986048
-
A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation
-
(1996)
Transplantation
, vol.61
, pp. 1029-1037
-
-
-
19
-
-
0033567122
-
Mycophenolate mofetil in renal transplantation: 3-Year results from the placebo-controlled trial
-
(1999)
Transplantation
, vol.68
, pp. 391-396
-
-
-
30
-
-
0028895151
-
Mycophenolate mofetil: A report of the consensus panel
-
(1995)
Ther Drug Monit
, vol.17
, pp. 690-699
-
-
Shaw, L.M.1
Sollinger, H.W.2
Halloran, P.3
Morris, R.E.4
Yatscoff, R.W.5
Ransom, J.6
Tsina, I.7
Keown, P.8
Holt, D.W.9
Lieberman, R.10
-
33
-
-
0032105481
-
Rapamune (RAPA, rapamycin, sirolimus): Mechanism of action and immunosuppressive effect result from blockade of signal transduction and inhibition of cell cycle progression
-
(1998)
Clin Biochem
, vol.31
, pp. 335-340
-
-
Sehgal, S.N.1
-
38
-
-
0021957656
-
Immunopharmacological profile of a novel isoxazol derivative HWA 486 with potential antirheumatic activity. Disease modifying action on adjuvant arthritis of the rat
-
(1985)
Int J Immunopharmacol
, vol.1
, pp. 7-18
-
-
Bartlett, R.1
Schleyerbach, R.2
-
39
-
-
0033053835
-
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomised, multicentre trial. European Leflunomide Study Group
-
(1999)
Lancet
, vol.353
, pp. 259-266
-
-
Smolen, J.S.1
Kalden, J.R.2
Scott, D.L.3
Rozman, B.4
Kvien, T.K.5
Larsen, A.6
Loew-Friedrich, I.7
Oed, C.8
Rosenburg, R.9
-
43
-
-
0029591467
-
The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1043-1049
-
-
Cherwinski, H.M.1
Cohn, R.G.2
Cheung, P.3
Webster, D.J.4
Xu, Y.Z.5
Caulfield, J.P.6
Young, J.M.7
Nakano, G.8
Ransom J., Jr.9
-
44
-
-
0029127555
-
Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound
-
(1995)
J Biol Chem
, vol.270
, pp. 22467-22472
-
-
Williamson, R.A.1
Yea, C.M.2
Robson, P.A.3
Curnock, A.P.4
Gadher, S.5
Hambleton, A.B.6
Woodward, K.7
Bruneau, J.M.8
Hambleton, P.9
Moss, D.10
-
45
-
-
0029620896
-
Mechanism of the antiproliferative action of leflunomide. A77 1726, the active metabolite of leflunomide, does not block T-cell receptor-mediated signal transduction but its antiproliferative effects are antagonized by pyrimidine nucleosides
-
(1995)
J Heart Lung Transplant
, vol.14
, pp. 1016-1030
-
-
Cao, W.W.1
Kao, P.N.2
Chao, A.C.3
Gardner, P.4
Ng, J.5
Morris, R.E.6
-
48
-
-
0029044545
-
Diagnosis and treatment of inborn errors of purine and pyrimidine metabolism: An overview
-
(1994)
Adv Exp Med Biol
, vol.370
, pp. 1-6
-
-
Simmonds, H.A.1
-
52
-
-
0002596254
-
Monitoring of pharmacodynamic (PD), but not pharmacokinetics (PK), differentiate the relative immunosuppressive potencies of leflunomide and its malononitrilamide (MNA) analogs
-
(1998)
Transplantation
, vol.65
-
-
Silva, H.T.1
Slauson, S.2
Sherwood, S.3
Bryce, T.4
Wade, A.5
Wang, X.6
Cheung, A.7
Wang, Y.8
Shorthouse, R.9
Billingham, M.E.10
Morris, R.E.11
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