The temporal, profile of calcineurin inhibition by cyclosporine in vivo

Transplantation

Volumn 68, Issue 9, 1999, Pages 1356-1361

  Halloran, Philip F ^a   Helms, Lisa M H ^a   Kung, Lina ^a   Noujaim, Jean ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLOSPORIN;

ARTICLE; BLOOD SAMPLING; CONCENTRATION RESPONSE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MECHANISM; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; MOUSE; NEPHROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN ANALYSIS;

EID: 0033571210     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199911150-00023     Document Type: Article

References (35)

1. Clipstone NA, Crabtree GR. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992; 357: 695.
2. Batiuk TD, Kung L, Halloran PF. Evidence that calcineurin is rate-limiting for primary human lymphocyte activation. J Clin Invest 1997; 100: 1894.
3. Loh C, Shaw KTY, Carew J, et al. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J Biol Chem 1996; 271: 10884.
4. Luo C, Shaw KTY, Raghavan A, et al. Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import. Proc Natl Acad Sci USA 1996; 93: 8907.
5. Luo C, Burgeon E, Carew JA, et al. Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol Cell Biol 1996; 16: 3955.
6. Beals CR, Clipstone NA, Ho SN, Crabtree GR. Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev 1997; 11: 824.
7. Ullman KS, Northrop JP, Admon A, Crabtree GR. Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes. Genes Dev 1993; 7: 188.
8. Rincón M, Flavell RA. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J 1994; 13: 4370.
9. Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994; 77: 727.
10. 2+ influx. Functional synergy between Raf and calcineurin. J Immunol 1996; 157: 5277.
11. Frantz B, Nordby EC, Bren G, et al. Calcineurin acts in synergy with PMA to inactivate IkB/MAD3, an inhibitor of NF-kB. EMBO J 1994; 13: 861.
12. Nolan GP. NF-AT-AP-1 and Rel-bZIP: hybrid vigor and binding under the influence. Cell 1994; 77: 795.
13. Rao A. NFATp, a cyclosplorin-sensitive transcription factor implicated in cytokine gene induction. J Leuk Biol 1995; 57: 536.
14. Fuleihan R, Ramesh N, Horner A, et al. Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. J Clin Invest 1994; 93: 1315.
15. Krönke M, Leonard WJ, Depper JM, et al. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci USA 1984; 81: 5214.
16. Elliot JF, Lin Y, Mizel SB, Bleackley RC, Harnish DG, Paetkau V. Induction of interleukin 2 messenger RNA inhibited by cyclosporine A. Science 1984; 226: 1439.
17. Kronke M, Leonard WJ, Depper JM, et al. Cyclosporine A inhibits T cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci USA 1984; 81: 5214.
18. Schreiber SL, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Immunol Today 1992; 13: 136.
19. Liu J, Farmer JDJr, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991; 66: 807.
20. Tumlin JA. Expression and function of calcineurin in the mammalian nephron: physiological roles, receptor signaling, and ion transport. Am J Kidney Dis 1997; 30: 884.
21. Yatscoff RW, Copeland KR, Faraci CJ, Abbott TD. Monoclonal antibody assay evaluated for measuring cyclosporine in whole blood. Clin Chem 1990; 36: 1969.
22. Fruman DA, Klee CB, Bierer BE, Burakoff SJ. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc Natl Acad Sci USA 1992; 89: 3686.
23. Borel JF. Pharmacology of cyclosporine (Sandimmune) IV. Pharmacological properties in vivo. Pharm Rev 1989; 41: 260.
24. Halloran PF, Stylianos SK, Stubbs M, Dutton D. Expression of Ia in mouse kidney: evidence for expression on resident marrow-derived and nonmarrow derived cells. Transplantation 1980; 30: 264.
25. Borel JF, Feurer C, Gubler HJ, Stahelin H. Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Actions 1976; 6: 468.
26. Batiuk TD, Pazderka F, Halloran PF. How do cells recover from inhibition by cyclosporine? Transplant Proc 1994; 26: 2831.
27. Batiuk TD, Pazderka F, Enns J, DeCastro L, Halloran PF. Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible. J Clin Invest 1995; 96: 1254.
28. Sharom FJ. The P-glycoprotein efflux pump: how does it transport drugs? [review]. J Membr Biol 1997; 160: 161.
29. Kovarik JM, Mueller EA, Richard F, et al. Evidence for earlier stabilization of cyclosporine pharmacokinetics in de novo renal transplant patients receiving a microemulsion formulation. Transplantation 1996; 62: 759.
30. Kahan BD, Welsh M, Schoenberg L, et al. Variable oral absorption of cyclosporine. A biopharmaceutical risk factor for chronic renal allograft rejection. Transplantation 1996; 62: 599.
31. Belitsky P, Ghose T, Givner M, Rowden G, Pope B. Tissue distribution of cyclosporine A in the mouse: a clue to toxicity? Clin Nephrol 1986; 25: S27.
32. Marunaka Y, Niisato N, Shintani Y. Protein phosphatase 2B-dependent pathway of insulin action on single Cl-channel conductance in renal epithelium. J Membr Biol 1998; 161: 235.
33. +-AT-Pase activity in renal tubule cells. Proc Natl Acad Sci USA 1992; 89: 7394.
34. Batiuk TD, Pazderka F, Enns J, DeCastro L, Halloran PF. Cyclosporine inhibition of leukocyte calcineurin is much less in whole blood than in culture medium. Transplantation 1996; 61: 158.
35. 50 for in vivo cyclosporine in mouse. Transplantation 1996; 61: 1618.