메뉴 건너뛰기




Volumn 21, Issue 7, 2000, Pages 1031-1036

Nociceptin/orphanin FQ in spinal nociceptive mechanisms under normal and pathological conditions

Author keywords

Analgesia; Antinociception; Inflammation; Morphine; Nerve injury; Neuropathic pain; Opioids

Indexed keywords

ANALGESIC AGENT; MORPHINE; NALOXONE; NOCICEPTIN; NOCICEPTIN RECEPTOR; NOCICEPTIN RECEPTOR AGONIST; OPIATE ANTAGONIST; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

EID: 0033811728     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(00)00234-5     Document Type: Article
Times cited : (38)

References (66)
  • 1
    • 0030730929 scopus 로고    scopus 로고
    • 2+ channel current in rat sensory neurons by a G-protein-independent mechanism
    • 2+ channel current in rat sensory neurons by a G-protein-independent mechanism. J Neurosci. 17:1997;8721-8728.
    • (1997) J Neurosci , vol.17 , pp. 8721-8728
    • Abdulla, F.A.1    Smith, P.A.2
  • 2
    • 0032402108 scopus 로고    scopus 로고
    • Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons
    • Abdulla F.A., Smith P.A. Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons. J Neurosci. 18:1998;9685-9694.
    • (1998) J Neurosci , vol.18 , pp. 9685-9694
    • Abdulla, F.A.1    Smith, P.A.2
  • 3
    • 0023936423 scopus 로고
    • Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain
    • Arnér S., Meyerson B.A. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain. 33:1988;11-23.
    • (1988) Pain , vol.33 , pp. 11-23
    • Arnér, S.1    Meyerson, B.A.2
  • 6
    • 0031694279 scopus 로고    scopus 로고
    • Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay
    • Calo G., Rizzi A., Marzola G., et al. Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay. Br J Pharmacol. 125:1998;425-432.
    • (1998) Br J Pharmacol , vol.125 , pp. 425-432
    • Calo, G.1    Rizzi, A.2    Marzola, G.3
  • 7
    • 0031593492 scopus 로고    scopus 로고
    • 2, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord
    • 2, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord. Br J Pharmacol. 125:1998;949-951.
    • (1998) Br J Pharmacol , vol.125 , pp. 949-951
    • Carpenter, K.J.1    Dickenson, A.H.2
  • 8
    • 0030878302 scopus 로고    scopus 로고
    • , Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat
    • Champion H.C., Czapla M.A., Kadowitz P.J. , Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat. Peptides. 18:1997;729-732.
    • (1997) Peptides , vol.18 , pp. 729-732
    • Champion, H.C.1    Czapla, M.A.2    Kadowitz, P.J.3
  • 9
    • 0000983887 scopus 로고    scopus 로고
    • Nociceptin/OFQ gene knockout reveals an antinociceptive role for nociceptin/OFQ in the mouse
    • Chen Z., Inoue M., Hopkins E., et al. Nociceptin/OFQ gene knockout reveals an antinociceptive role for nociceptin/OFQ in the mouse. Soc Neurosci Abstr. 25:1999;1472.
    • (1999) Soc Neurosci Abstr , vol.25 , pp. 1472
    • Chen, Z.1    Inoue, M.2    Hopkins, E.3
  • 10
    • 0030462638 scopus 로고    scopus 로고
    • Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro
    • Connor M., Vaughan C.W., Chieng B., Christie M.J. Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro. Br J Pharmacol. 119:1996;1614-1618.
    • (1996) Br J Pharmacol , vol.119 , pp. 1614-1618
    • Connor, M.1    Vaughan, C.W.2    Chieng, B.3    Christie, M.J.4
  • 11
    • 0032079958 scopus 로고    scopus 로고
    • Orphanin FQ/nociceptin - A role in pain and analgesia, but so much more
    • Darland T., Heinricher M.M., Grandy D.K. Orphanin FQ/nociceptin - a role in pain and analgesia, but so much more. Trends Neurosci. 21:1998;215-221.
    • (1998) Trends Neurosci , vol.21 , pp. 215-221
    • Darland, T.1    Heinricher, M.M.2    Grandy, D.K.3
  • 12
    • 0030586364 scopus 로고    scopus 로고
    • The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion
    • Devine D.P., Reinscheid R.K., Monsma F.J. Jr, Civelli O., Akil H. The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion. Brain Res. 727:1996;225-229.
    • (1996) Brain Res , vol.727 , pp. 225-229
    • Devine, D.P.1    Reinscheid, R.K.2    Monsma F.J., Jr.3    Civelli, O.4    Akil, H.5
  • 13
    • 0027943502 scopus 로고
    • Neurophysiology of opioid poorly responsive pain
    • Dickenson A.H. Neurophysiology of opioid poorly responsive pain. Cancer Surv. 21:1994;5-16.
    • (1994) Cancer Surv , vol.21 , pp. 5-16
    • Dickenson, A.H.1
  • 15
    • 0030739616 scopus 로고    scopus 로고
    • Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test
    • Erb K., Liebel J.T., Tegeder I., Zeilhofer H.U., Brune K., Geisslinger G. Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test. NeuroReport. 8:1997;1967-1970.
    • (1997) NeuroReport , vol.8 , pp. 1967-1970
    • Erb, K.1    Liebel, J.T.2    Tegeder, I.3    Zeilhofer, H.U.4    Brune, K.5    Geisslinger, G.6
  • 16
    • 0029818991 scopus 로고    scopus 로고
    • Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro
    • Faber E.S.L., Chambers J.P., Evans R.H., Henderson G. Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro. Br J Pharmacol. 119:1996;189-190.
    • (1996) Br J Pharmacol , vol.119 , pp. 189-190
    • Faber, E.S.L.1    Chambers, J.P.2    Evans, R.H.3    Henderson, G.4
  • 17
    • 0030885415 scopus 로고    scopus 로고
    • Effect of nociceptin on heart rate and blood pressure in anaesthetized rats
    • Giuliani S., Tramontana M., Lecci A., Maggi C.A. Effect of nociceptin on heart rate and blood pressure in anaesthetized rats. Eur J Pharmacol. 333:1997;177-179.
    • (1997) Eur J Pharmacol , vol.333 , pp. 177-179
    • Giuliani, S.1    Tramontana, M.2    Lecci, A.3    Maggi, C.A.4
  • 18
    • 0029804988 scopus 로고    scopus 로고
    • Orphanin Fq acts as a supraspinal, but not a spinal, anti-opioid peptide
    • Grisel J.E., Moril J.S., Belknap J.K. Orphanin Fq acts as a supraspinal, but not a spinal, anti-opioid peptide. NeuroReport. 7:1996;2125-2129.
    • (1996) NeuroReport , vol.7 , pp. 2125-2129
    • Grisel, J.E.1    Moril, J.S.2    Belknap, J.K.3
  • 19
    • 0031974718 scopus 로고    scopus 로고
    • A new selective antagonist of the nociceptin receptor
    • Guerrini R., Calo G., Rizzi A., et al. A new selective antagonist of the nociceptin receptor. Br J Pharmacol. 123:1998;163-165.
    • (1998) Br J Pharmacol , vol.123 , pp. 163-165
    • Guerrini, R.1    Calo, G.2    Rizzi, A.3
  • 20
    • 0031043674 scopus 로고    scopus 로고
    • Lack of cross-tolerance between the antinociceptive effect of intrathecal orphanin FQ and morphine in the rat
    • Hao J.-X., Wiesenfeld-Hallin Z., Xu X.-J. Lack of cross-tolerance between the antinociceptive effect of intrathecal orphanin FQ and morphine in the rat. Neurosci Lett. 223:1997;49-52.
    • (1997) Neurosci Lett , vol.223 , pp. 49-52
    • Hao, J.-X.1    Wiesenfeld-Hallin, Z.2    Xu, X.-J.3
  • 21
    • 0032104547 scopus 로고    scopus 로고
    • Anti-hyperalgesic and anti-allodynic effects of intrathecal nociceptin/orphanin FQ in rats after spinal cord injury, peripheral nerve injury and inflammation
    • Hao J.-X., Xu I.S., Wiesenfeld-Hallin Z., Xu X.-J. Anti-hyperalgesic and anti-allodynic effects of intrathecal nociceptin/orphanin FQ in rats after spinal cord injury, peripheral nerve injury and inflammation. Pain. 76:1998;385-393.
    • (1998) Pain , vol.76 , pp. 385-393
    • Hao, J.-X.1    Xu, I.S.2    Wiesenfeld-Hallin, Z.3    Xu, X.-J.4
  • 22
    • 0032493666 scopus 로고    scopus 로고
    • Naltrexone, but not atropine or yohimbine, antagonizes suppression of formalin-induced spinal sensitization by intrathecal nociceptin
    • Hao S., Ogawa H. Naltrexone, but not atropine or yohimbine, antagonizes suppression of formalin-induced spinal sensitization by intrathecal nociceptin. Life Sci. 63:1998;167-173.
    • (1998) Life Sci , vol.63 , pp. 167-173
    • Hao, S.1    Ogawa, H.2
  • 23
    • 8244243943 scopus 로고    scopus 로고
    • Characterization of nociceptin hyperaglesia and allodynia in conscious mice
    • Hara N., Minami T., Okuda-Ashitaka E., et al. Characterization of nociceptin hyperaglesia and allodynia in conscious mice. Br J Pharmacol. 121:1997;401-408.
    • (1997) Br J Pharmacol , vol.121 , pp. 401-408
    • Hara, N.1    Minami, T.2    Okuda-Ashitaka, E.3
  • 24
    • 0030836504 scopus 로고    scopus 로고
    • The orphan opioid receptor and its endogenous ligand-orphanin FQ/nociceptin
    • Henderson G.S., McKnight A.T. The orphan opioid receptor and its endogenous ligand-orphanin FQ/nociceptin. Trends Pharmacol Sci. 18:1997;293-300.
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 293-300
    • Henderson, G.S.1    McKnight, A.T.2
  • 25
    • 0032842949 scopus 로고    scopus 로고
    • Dose-related opposite modulation by nociceptin/orphanin FQ of susbtace P nociception in the nociceptors and spinal cord
    • Inoue M., Shimohira I., Yoshida A., et al. Dose-related opposite modulation by nociceptin/orphanin FQ of susbtace P nociception in the nociceptors and spinal cord. J Pharmacol Exp Ther. 291:1999;308-313.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 308-313
    • Inoue, M.1    Shimohira, I.2    Yoshida, A.3
  • 26
    • 0031463956 scopus 로고    scopus 로고
    • Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress
    • Jenck F., Moreau J.-C., Martin J.R., et al. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress. Proc Natl Acad Sci USA. 94:1997;14854-14858.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14854-14858
    • Jenck, F.1    Moreau, J.-C.2    Martin, J.R.3
  • 27
    • 0032967285 scopus 로고    scopus 로고
    • Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice
    • Kamei J., Ohsawa M., Kashiwazaki T., Nagase H. Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice. Eur J Phamracol. 370:1999;109-116.
    • (1999) Eur J Phamracol , vol.370 , pp. 109-116
    • Kamei, J.1    Ohsawa, M.2    Kashiwazaki, T.3    Nagase, H.4
  • 29
    • 0037802203 scopus 로고    scopus 로고
    • Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice
    • Köster A., Montkowski A., Schulz S., et al. Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice. Proc Natl Acad Sci USA. 96:1999;10444-10449.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10444-10449
    • Köster, A.1    Montkowski, A.2    Schulz, S.3
  • 30
    • 0031563823 scopus 로고    scopus 로고
    • Nociceptin-like immunoreactivity in the rat dorsal horn and inhibition of substantia gelatinosa neurons
    • Lai C.C., Wu S.Y., Dun S.L., Dun N.J. Nociceptin-like immunoreactivity in the rat dorsal horn and inhibition of substantia gelatinosa neurons. Neuroscience. 81:1997;887-891.
    • (1997) Neuroscience , vol.81 , pp. 887-891
    • Lai, C.C.1    Wu, S.Y.2    Dun, S.L.3    Dun, N.J.4
  • 31
    • 0030926028 scopus 로고    scopus 로고
    • Modulation of excitatory synaptic transmission by nociceptin in superficial dorsal horn neurones of the neonatal rat spinal cord
    • Liebel J.T., Swandulla D., Zeilhofer H.U. Modulation of excitatory synaptic transmission by nociceptin in superficial dorsal horn neurones of the neonatal rat spinal cord. Br J Pharmacol. 121:1997;425-432.
    • (1997) Br J Pharmacol , vol.121 , pp. 425-432
    • Liebel, J.T.1    Swandulla, D.2    Zeilhofer, H.U.3
  • 33
    • 0345040171 scopus 로고    scopus 로고
    • Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
    • Neal C.R. Jr, Mansour A., Reinscheid R., et al. Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat. J Comp Neurol. 406:1999;503-547.
    • (1999) J Comp Neurol , vol.406 , pp. 503-547
    • Neal C.R., Jr.1    Mansour, A.2    Reinscheid, R.3
  • 34
    • 0344631766 scopus 로고    scopus 로고
    • Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with 125I-[14Tyr]-orphanin FQ binding
    • Neal C.R. Jr, Mansour A., Reinscheid R., et al. Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system comparison of ORL1 receptor mRNA expression with 125I-[14Tyr]-orphanin FQ binding . J Comp Neurol. 412:1999;563-605.
    • (1999) J Comp Neurol , vol.412 , pp. 563-605
    • Neal C.R., Jr.1    Mansour, A.2    Reinscheid, R.3
  • 35
    • 0030983770 scopus 로고    scopus 로고
    • Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphanin FQ receptor
    • Nishi M., Houtani T., Noda Y., et al. Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphanin FQ receptor. EMBO J. 16:1997;1858-1864.
    • (1997) EMBO J , vol.16 , pp. 1858-1864
    • Nishi, M.1    Houtani, T.2    Noda, Y.3
  • 36
    • 0028971215 scopus 로고
    • Orphanin FQ: A neuropeptide that activates an opioid-like G protein-coupled receptor
    • Reinscheid R.K., Nothacker H.-P., Bourson A., et al. Orphanin FQ a neuropeptide that activates an opioid-like G protein-coupled receptor . Science. 270:1995;792-794.
    • (1995) Science , vol.270 , pp. 792-794
    • Reinscheid, R.K.1    Nothacker, H.-P.2    Bourson, A.3
  • 37
    • 0029767435 scopus 로고    scopus 로고
    • Orphanin FQ/nociceptin-immunoreactive nerve fibers parallel those containing endogenous opioids in rat spinal cord
    • Riedl M., Shuster S., Vulchanova L., Wang J., Loh H.H., Elde R.P. Orphanin FQ/nociceptin-immunoreactive nerve fibers parallel those containing endogenous opioids in rat spinal cord. NeuroReport. 7:1996;1369-1372.
    • (1996) NeuroReport , vol.7 , pp. 1369-1372
    • Riedl, M.1    Shuster, S.2    Vulchanova, L.3    Wang, J.4    Loh, H.H.5    Elde, R.P.6
  • 38
    • 0030454376 scopus 로고    scopus 로고
    • Nociceptin/orphanin FQ, and opioid peptides show overlapping distribution but not colocalization in pain-modulatory brain regions
    • Schulz S., Schreff M., Nüb D., Gramsch C., Höllt V. Nociceptin/orphanin FQ, and opioid peptides show overlapping distribution but not colocalization in pain-modulatory brain regions. NeuroReport. 7:1996;3021-3025.
    • (1996) NeuroReport , vol.7 , pp. 3021-3025
    • Schulz, S.1    Schreff, M.2    Nüb, D.3    Gramsch, C.4    Höllt, V.5
  • 39
    • 0032425809 scopus 로고    scopus 로고
    • Orphanin FQ/nociceptin modulates glutamate- And kainic acid-induced currents in acutely isolated rat spinal dorsal horn neurons
    • Shu Y.-S., Zhao Z.-Q., Li M.-Y., Zhou G.-M. Orphanin FQ/nociceptin modulates glutamate- and kainic acid-induced currents in acutely isolated rat spinal dorsal horn neurons. Neuropeptides. 32:1998;567-571.
    • (1998) Neuropeptides , vol.32 , pp. 567-571
    • Shu, Y.-S.1    Zhao, Z.-Q.2    Li, M.-Y.3    Zhou, G.-M.4
  • 40
    • 0029071354 scopus 로고
    • Spinal opioid systems in inflammation
    • Stanfa L.C., Dickenson A. Spinal opioid systems in inflammation. Inflammation Res. 44:1995;231-241.
    • (1995) Inflammation Res , vol.44 , pp. 231-241
    • Stanfa, L.C.1    Dickenson, A.2
  • 41
    • 0029814363 scopus 로고    scopus 로고
    • Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat in vivo
    • Stanfa L.C., Chapman V., Kerr N., Dickenson A.H. Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat in vivo. Br J Pharmacol. 118:1996;1875-1877.
    • (1996) Br J Pharmacol , vol.118 , pp. 1875-1877
    • Stanfa, L.C.1    Chapman, V.2    Kerr, N.3    Dickenson, A.H.4
  • 42
    • 0032563640 scopus 로고    scopus 로고
    • Nociceptin/orphanin FQ. A new opioid, a new analgesic?
    • Taylor F., Dickenson A.H. Nociceptin/orphanin FQ. A new opioid, a new analgesic? NeuroReport. 12:1998;65-70.
    • (1998) NeuroReport , vol.12 , pp. 65-70
    • Taylor, F.1    Dickenson, A.H.2
  • 43
    • 8044238345 scopus 로고    scopus 로고
    • Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: Antagonism in brain and potentiation in spinal cord of the rat
    • Tian J.-H., Xu W., Fang Y., et al. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia antagonism in brain and potentiation in spinal cord of the rat . Br J Pharmacol. 120:1997;676-680.
    • (1997) Br J Pharmacol , vol.120 , pp. 676-680
    • Tian, J.-H.1    Xu, W.2    Fang, Y.3
  • 44
    • 0030993313 scopus 로고    scopus 로고
    • Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia
    • Tian J.-H., Xu W., Zhang W., et al. Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia. NeuroReport. 8:1997;497-500.
    • (1997) NeuroReport , vol.8 , pp. 497-500
    • Tian, J.-H.1    Xu, W.2    Zhang, W.3
  • 45
    • 0031450208 scopus 로고    scopus 로고
    • Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene
    • Ueda H., Yamaguchi T., Tokuyama S., Inoue M., Nishi M., Takeshima H. Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene. Neurosci Lett. 237:1997;136-138.
    • (1997) Neurosci Lett , vol.237 , pp. 136-138
    • Ueda, H.1    Yamaguchi, T.2    Tokuyama, S.3    Inoue, M.4    Nishi, M.5    Takeshima, H.6
  • 46
    • 0029658923 scopus 로고    scopus 로고
    • Increase by the ORL(1) receptor (opioid receptor-like (1)) ligand, nociceptin, on inwardly rectifying K conductance in dorsal raphe nucleus neurones
    • Vaughan C.W., Christie M.J. Increase by the ORL(1) receptor (opioid receptor-like (1)) ligand, nociceptin, on inwardly rectifying K conductance in dorsal raphe nucleus neurones. Br J Pharmacol. 117:1996;1609-1611.
    • (1996) Br J Pharmacol , vol.117 , pp. 1609-1611
    • Vaughan, C.W.1    Christie, M.J.2
  • 47
    • 0031685394 scopus 로고    scopus 로고
    • Orphanin-FQ/nociceptin: Lack of antinociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats
    • Vanderah T.W., Raffa R.B., Lashbrook J., Burritt A., Hruby V., Porreca F. Orphanin-FQ/nociceptin lack of antinociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats . Eur J Pain. 2:1998;267-278.
    • (1998) Eur J Pain , vol.2 , pp. 267-278
    • Vanderah, T.W.1    Raffa, R.B.2    Lashbrook, J.3    Burritt, A.4    Hruby, V.5    Porreca, F.6
  • 48
    • 0014035514 scopus 로고
    • Effects of lidocaine on the central nervous system
    • Wagman I.H., de Jong R.H., Prince D.A. Effects of lidocaine on the central nervous system. Anesthesiology. 28:1968;155-172.
    • (1968) Anesthesiology , vol.28 , pp. 155-172
    • Wagman, I.H.1    De Jong, R.H.2    Prince, D.A.3
  • 49
    • 10344264470 scopus 로고    scopus 로고
    • 1 (opioid-receptor-like 1) receptor, modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli
    • 1 (opioid-receptor-like 1) receptor, modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli. J Neurophysiol. 76:1996;3568-3572.
    • (1996) J Neurophysiol , vol.76 , pp. 3568-3572
    • Wang, X.-M.1    Zhang, K.M.2    Mokha, S.S.3
  • 50
    • 0032814245 scopus 로고    scopus 로고
    • Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acid and somatosensory stimuli and blocks the substance P-induced facilitation of N-methyl-D-aspartate-evoked responses
    • Wang X.-M., Zhang K.M., Long L.O., Mokha S.S. Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acid and somatosensory stimuli and blocks the substance P-induced facilitation of N-methyl-D-aspartate-evoked responses. Neuroscience. 93:1999;703-712.
    • (1999) Neuroscience , vol.93 , pp. 703-712
    • Wang, X.-M.1    Zhang, K.M.2    Long, L.O.3    Mokha, S.S.4
  • 51
    • 0032810169 scopus 로고    scopus 로고
    • Distinct effect of intracerebroventricular and intrathecal injections of nociceptin/orphanin FQ in the rat formalin test
    • Wang J.-L., Zhu C.-B., Cao X.-D., Wu G.-C. Distinct effect of intracerebroventricular and intrathecal injections of nociceptin/orphanin FQ in the rat formalin test. Regul Pept. 79:1999;159-163.
    • (1999) Regul Pept , vol.79 , pp. 159-163
    • Wang, J.-L.1    Zhu, C.-B.2    Cao, X.-D.3    Wu, G.-C.4
  • 54
    • 0030603863 scopus 로고    scopus 로고
    • The role of cholecystokinin in nociception, neuropathic pain and opiate tolerance
    • Wiesenfeld-Hallin Z., Xu X.-J. The role of cholecystokinin in nociception, neuropathic pain and opiate tolerance. Regul Pept. 65:1996;23-28.
    • (1996) Regul Pept , vol.65 , pp. 23-28
    • Wiesenfeld-Hallin, Z.1    Xu, X.-J.2
  • 55
    • 0032549699 scopus 로고    scopus 로고
    • Release of nociceptin-like substances from the rat spinal cord dorsal horn
    • Williams C.A., Wu S.Y., Cook J., Dun N.J. Release of nociceptin-like substances from the rat spinal cord dorsal horn. Neurosci Lett. 244:1998;141-144.
    • (1998) Neurosci Lett , vol.244 , pp. 141-144
    • Williams, C.A.1    Wu, S.Y.2    Cook, J.3    Dun, N.J.4
  • 56
    • 0025860818 scopus 로고
    • The threshold for the depressive effect of intrathecal morphine on the spinal nociceptive flexor reflex is increased during autotomy after sciatic nerve section in rats
    • Xu X.-J., Wiesenfeld-Hallin Z. The threshold for the depressive effect of intrathecal morphine on the spinal nociceptive flexor reflex is increased during autotomy after sciatic nerve section in rats. Pain. 46:1991;223-229.
    • (1991) Pain , vol.46 , pp. 223-229
    • Xu, X.-J.1    Wiesenfeld-Hallin, Z.2
  • 57
    • 0029806549 scopus 로고    scopus 로고
    • Nociceptin or antinociceptin: Potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat
    • Xu X.-J., Hao J.-X., Wiesenfeld-Hallin Z. Nociceptin or antinociceptin potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat . NeuroReport. 7:1996;2092-2094.
    • (1996) NeuroReport , vol.7 , pp. 2092-2094
    • Xu, X.-J.1    Hao, J.-X.2    Wiesenfeld-Hallin, Z.3
  • 58
    • 0032546651 scopus 로고    scopus 로고
    • [Phe1 Ψ (CH2-NH)Gly2]-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord
    • Xu I.S., Wiesenfeld-Hallin Z., Xu X.-J. [Phe1 Ψ (CH2-NH)Gly2]-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci Lett. 249:1998;127-130.
    • (1998) Neurosci Lett , vol.249 , pp. 127-130
    • Xu, I.S.1    Wiesenfeld-Hallin, Z.2    Xu, X.-J.3
  • 59
    • 0032920104 scopus 로고    scopus 로고
    • Effects of intrathecal orphanin FQ on a flexor reflex in the rat after inflammation or peripheral nerve section
    • Xu I.S., Grass S., Wiesenfeld-Hallin Z., Xu X.-J. Effects of intrathecal orphanin FQ on a flexor reflex in the rat after inflammation or peripheral nerve section. Eur J Pharmacol. 370:1999;17-22.
    • (1999) Eur J Pharmacol , vol.370 , pp. 17-22
    • Xu, I.S.1    Grass, S.2    Wiesenfeld-Hallin, Z.3    Xu, X.-J.4
  • 60
    • 0023186524 scopus 로고
    • Opioid receptor systems and the endorphins: A review of their spinal organization
    • Yaksh T.L. Opioid receptor systems and the endorphins a review of their spinal organization . J Neurosurg. 67:1987;157-176.
    • (1987) J Neurosurg , vol.67 , pp. 157-176
    • Yaksh, T.L.1
  • 61
    • 0024602581 scopus 로고
    • Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effect of modulatory receptor systems and excitatory amino acid antagonists
    • Yaksh T.L. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition effect of modulatory receptor systems and excitatory amino acid antagonists . Pain. 37:1989;111-123.
    • (1989) Pain , vol.37 , pp. 111-123
    • Yaksh, T.L.1
  • 62
    • 0030937927 scopus 로고    scopus 로고
    • 1) receptor agonist, on the thermal hyperalgesia induced by carageenan injection into the rat paw
    • 1) receptor agonist, on the thermal hyperalgesia induced by carageenan injection into the rat paw. Brain Res. 754:1997;329-332.
    • (1997) Brain Res , vol.754 , pp. 329-332
    • Yamamoto, T.1    Nozaki-Taguchi, N.2    Kimura, S.3
  • 63
    • 0030945213 scopus 로고    scopus 로고
    • 1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat
    • 1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat. Neurosci Lett. 224:1997;107-110.
    • (1997) Neurosci Lett , vol.224 , pp. 107-110
    • Yamamoto, T.1    Nozaki-Taguchi, N.2    Kimura, S.3
  • 64
    • 0030830192 scopus 로고    scopus 로고
    • Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like receptor agonist, in the rat formalin test
    • Yamamoto T., Nozaki-Taguchi N., Kimura S. Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like receptor agonist, in the rat formalin test. Neuroscience. 81:1997;249-254.
    • (1997) Neuroscience , vol.81 , pp. 249-254
    • Yamamoto, T.1    Nozaki-Taguchi, N.2    Kimura, S.3
  • 66
    • 0030921750 scopus 로고    scopus 로고
    • Down-regulation of μ-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy
    • Zhang X., Bao L., Shi T.J., Ju G., Elde R., Hokfelt T. Down-regulation of μ-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy. Neuroscience. 82:1998;223-240.
    • (1998) Neuroscience , vol.82 , pp. 223-240
    • Zhang, X.1    Bao, L.2    Shi, T.J.3    Ju, G.4    Elde, R.5    Hokfelt, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.