Alphavirus RNA genome repair and evolution: Molecular characterization of infectious Sindbis virus isolates lacking a known conserved motif at the 3' end of the genome

Journal of Virology

Volumn 74, Issue 20, 2000, Pages 9776-9785

  George, J ^a   Raju, R ^a  

^a MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; POLYADENYLIC ACID; RNA POLYMERASE; VIRUS RNA;

3' UNTRANSLATED REGION; ALPHA VIRUS; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; GENE REPLICATION; NONHUMAN; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA SYNTHESIS; SINDBIS VIRUS; VIRUS GENOME;

3' UNTRANSLATED REGIONS; ANIMAL; BASE SEQUENCE; CELL LINE; CONSERVED SEQUENCE; CYTOPATHOGENIC EFFECT, VIRAL; EVOLUTION; GENOME, VIRAL; MOLECULAR SEQUENCE DATA; RNA, VIRAL; SINDBIS VIRUS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033809466     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.20.9776-9785.2000     Document Type: Article

References (65)

1. An AU-rich sequence element (UUU N[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: Binding of Apobec-1 to this motif in the 3' untranslated region of c-myc increases mRNA stability
2. cis-Acting requirements for the replication of flock house virus RNA 2
3. RNA editing: An overview
4. In vitro recombination and terminal elongation of RNA by Q beta replicase
5. Telomerase
6. Molecular studies of genetic RNA-RNA recombination in brome mosaic virus
7. Recombination in HIV: An important viral evolutionary strategy
8. In vivo restoration of biologically active 3' ends of virus-associated RNAs by nonhomologous RNA recombination and replacement of a terminal motif
9. AU-rich elements: Characterization and importance in mRNA degradation
10. Mutagenic analysis of the 3' cis-acting elements of the rubella virus genome
11. Specific interaction between the hepatitis C virus NS5B RNA polymerase and the 3' end of the viral RNA
12. Retroviridae: The viruses and their replication
13. Diversity of cytoplasmic functions for the 3' untranslated region of eukaryotic transcripts
14. An attempt to unify the structure of polymerases
15. RNA-protein interactions in the control of stability and localization of messenger RNA
16. Intercistronic as well as terminal sequences are required for efficient amplification of brome mosaic virus RNA
17. Alphavirus-based expression vectors: Strategies and applications
18. Recent advances in gene expression using alphavirus vectors
19. Identification of a cis-acting replication element within the poliovirus coding region
20. A review of alphavirus replication in neurons
21. Nonhomologous RNA-RNA recombination events at the 3' nontranslated region of the Sindbis virus genome: Hot spots and utilization of nonviral sequences
22. The versatility of paramyxovirus RNA polymerase stuttering
23. Evolution of the Sindbis virus subgenomic mRNA promoter in cultured cells
24. RNA-RNA recombina tion in Sindbis virus: Roles of the 3' conserved motif, poly(A) tail, and nonviral sequences of template RNAs in polymerase recognition and template switching
25. Rapid evolution of RNA genomes
26. Sindbis virus vectors for expression in animal cells
27. Pseudo-templated transcription in prokaryotic and eukaryotic organisms
28. The polymerase in its labyrinth: Mechanisms and implications of RNA recombination
29. Alphaviruses
30. Multiplication of beet necrotic yellow vein virus RNA 3 lacking a 3' poly(A) tail is accompanied by reappearance of the poly(A) tail and a novel short U-rich tract preceding it
31. Evolution of RNA genomes: Does the high mutation rate necessitate high rate of evolution of viral proteins?
32. Mutagenesis of the 3' nontranslated region of Sindbis virus RNA
33. Infectious RNA transcripts from Ross River virus cDNA clones and the construction and characterization of defined chimeras with Sindbis virus
34. RNA recombination in animal and plant viruses
35. Template-dependent initiation of Sindbis virus RNA replication in vitro
36. Deletion mapping of Sindbis virus DI RNAs derived from cDNAs defines the sequences essential for replication and packaging
37. A new generation of animal cell expression vectors based on the Semliki Forest virus replicon
38. A coding RNA sequence acts as a replication signal in cardioviruses
39. Molecular basis of Sindbis virus neurovirulence in mice
40. The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replication
41. Q beta RNA bacteriophage: Mapping cis-acting elements within an RNA genome
42. A novel 3'-end repair mechanism in an RNA virus
43. The 3'-non-coding regions of alphavirus RNAs contain repeating sequences
44. Multiple binding sites for cellular proteins in the Y end of Sindbis alphavirus minus-sense RNA
45. The alphavirus 3'-nontranslated region: Size heterogeneity and arrangement of repeated sequence elements
46. In vivo addition of poly(A) tail and AU-rich sequences to the 3' terminus of the Sindbis virus RNA genome: A novel 3'-end repair pathway
47. Genesis of Sindbis virus by in vivo recombination of nonreplicative RNA precursors
48. Unusual transcripts in La Crosse virus-infected cells and the site for nucleocapsid assembly
49. Telomeric function of the tRNA-like structure of brome mosaic virus RNA
50. Importance of the positive-strand RNA secondary structure of a murine coronavirus defective interfering RNA internal replication signal in positive-strand RNA synthesis
51. Production of infectious RNA transcripts from Sindbis virus cDNA clones: Mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants
52. Role of 3' end sequences in the infectivity of poliovirus transcripts made in vitro
53. Role of the nonstructural polyproteins in alphavirus RNA synthesis
54. Alphavirus vectors for gene expression and vaccines
55. A glimpse of the machinery
56. RNA-binding proteins as regulators of gene expression
57. Virus evolution
58. Complete nucleotide sequence of the genomic RNA of Sindbis virus
59. The alphaviruses: Gene expression, replication, and evolution
60. A brome mosaic virus intergenic RNA3 replication signal functions with viral replication protein 1a to dramatically stabilize RNA in vivo
61. Replication-competent picornaviruses with complete genomic RNA 3' noncoding region deletions
62. Genetic diversity and slow rates of evolution in New World alphaviruses
63. Influenza - A model of an emerging virus disease
64. Recombination between Sindbis virus RNAs
65. Sindbis virus: An efficient, broad host range vector for gene expression in animal cells